Bivalent Influenza Vaccine In Children With Cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1977-04

AUTHORS

Ciro V Sumaya, Thomas E Williams, Philip A Brunell

ABSTRACT

Although it has been recommended that children with malignant diseases be immunized against influenza, few data are available to indicate the immune response or reactions that might be expected from this group. In this study, 46 children with malignant diseases received varying dosages of killed split or whole bivalent (A/New Jersey/76 and A/Victoria/75) influenza vaccine or a placebo by the intramuscular route. Two doses were administered four weeks apart. The children were receiving standard cancer chemotherapy regimens of the Children's Cancer Study Group. The response to immunization in the children with malignant diseases was similar to that found in normal children who received aliquots of the same antigen preparations as killed monovalent A/New Jersey/76 vaccine. Reactions after vaccine administration were minimal. It is concluded that the dose of influenza antigen in the vaccine recommended for normal children would appear to be appropriate for children with malignant diseases. In addition to immunization against A/New Jersey/76 it has been recommended that the children with malignant diseases receive antigen preparations of other prevalent influenzal strains. More... »

PAGES

507

Journal

TITLE

Pediatric Research

ISSUE

4

VOLUME

11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197704000-00826

DOI

http://dx.doi.org/10.1203/00006450-197704000-00826

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039355223


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