Influence of Intravenous Nutrients on Bilirubin Transport. III. Emulsified Fat Infusion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1977-03

AUTHORS

M M Thaler, A Pelger

ABSTRACT

Summary: Infusions and injections of Intralipid were administered to congenitally jaundiced rats (Gunn) in whom the total body bilirubin pool was uniformly labeled with radioactive bilirubin. These isotopic studies indicated that Inlralipid treatment had no effect on the kinetics of biliruhin formation, transport, tissue distribution, and clearance. There were no significant differences between control and fat emulsion-treated animals in the total bilirubin pool, plasma bilirubin pool, biologic half-life of bilirubin, fractional turnover, and exponential decline in plasma bilirubin specific activity at steady state. Bilirubin concentrations in blood, plasma, liver, kidneys, brain, adipose tissue, and muscle were unaltered during the course of continuous infusions (up to 24 hr) of Intralipid. These results indicate that Intralipid administered in clinically applicable doses and regimens has no discernible effects on biiirubin metabolism in jaundiced rats.Speculation: These experimental procedures and results obtained in unperturbed animals provide a basis for studies of the effects of Intralipid infusion on bilirubin metabolism in presence of experimentally induced hypoxia, hypoglycemia, metabolic acidosis, and starvation. More... »

PAGES

171-174

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197703000-00005

DOI

http://dx.doi.org/10.1203/00006450-197703000-00005

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028597276

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/402631


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