Influence of Intravenous Nutrients on Bilirubin Transport. II. Emulsified Lipid Solutions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1977-03

AUTHORS

M Michael Thaler, Richard P Wennberg

ABSTRACT

Summary: The effects of an emulsified intravenous fat preparation (Intralipid) on bilirubin transport were analyzed by cholestyramine extraction, spectrophotometric analysis, Sephadex gel filtration, peroxidase assay, bilirubin uptake by red blood cells, and by toxicity in tissue culture (L-929) cells. Intralipid is capable of binding bilirubin, but does not compete effectively with bilirubin bound to high affinity sites on albumin. The emulsified fat appears to have a higher affinity for bilirubin than for cell membranes. Red blood cells become coated with Intralipid, resulting in an increased association of bilirubin with the cell surface, but a drecrease in pigment actually incorporated into the red cell membrane. In tissue culture experiments, Intralipid protected the cells from bilirubin toxicity. it is conculuded that Intralipid may enhance the carrying capacity of serum for bilirubin, and thus exert a protective effect a protective effect on tissues.Speculation: Emulsified fat appears to interact with serum bilirubin not bound (or loosely bound) to albumin. Higher affinity for bilirubin of Intralipid compared with celluar surface membranes suggests that emulsified fat infusions may act as a temparary barrier to entry of bilirubin of Intralipid compared with cellular surface membranes suggests that emulsified fat infusions may act as temporary barrier to entry of bilirubin into tissues. More... »

PAGES

167-171

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197703000-00004

DOI

http://dx.doi.org/10.1203/00006450-197703000-00004

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030695210

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/402630


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