Type I Hyperprolinemia: A Study of the Intestinal Absorption of Proline, Hydroxyproline, and Glycine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1976-05

AUTHORS

J P Farriaux, J L Dhondt

ABSTRACT

Intestinal absorption of proline, hydroxyproline, and glycine was interpreted by investigation of a type I hyperprolinemia patient and six control subjects. Intestinal perfusion was performed. When proline (Pro), hydroxyproline (OH-Pro), and glycine (Gly) were infused together, an increase in proline concentration did not alter aminoacid uptake in the control subjects; however, in the hyperprolinemia patient, uptake of aminoacids became negliglible (Pro, 17--6 muM/min; OH-Pro, 15--0.3 muM/min; and Gly, 13.5--0 muM/min). When each aminoacid was infused alone at increasing concentrations aminoacid uptake increased in controls; in the hyperprolinemic patient, intestinal absorption was less for glycine and hydroxyproline but aminoacid uptake increased with substrate concentration; however, for proline, the uptake remained constant (1l.5--17 muM/min/20 cm of intestinal test segment) (Table 1). When hydroxyproline was infused with an increased concentration of proline in the hyperprolinemic patient, hydroxyproline uptake first increased (9.8--14.3 muM/min/20 cm) then decreased to its basal value, whereas, in the control subjects, uptake increased without decreasing subsequently. More... »

PAGES

550

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197605000-00009

DOI

http://dx.doi.org/10.1203/00006450-197605000-00009

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045683536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/934727


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