Cortisol Binding to Proteins in Plasma in the Human Neonate and Infant View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1975-01

AUTHORS

A J Hadjian, M Chedin, C Cochet, E M Chambaz

ABSTRACT

Extract: The binding of cortisol to plasma proteins was studied by a methodology allowing the determination of the apparent affinity constant (Ka) and the specific binding capacity (Ns) for transcortin in different blood compartments in normal pregnant women at term, in the umbilical cord blood, and in normal neonates and infants throughout the first year of life. Removal of endogenous steroids appeared to be necessary for these binding studies, especially in the cord plasma. Both an equilibrium dialysis and an adsorbent technique were used, inasmuch as it has been established that they yield similar results for corticosteroid-binding globulin (CBG) binding parameters. More... »

PAGES

40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197501000-00008

DOI

http://dx.doi.org/10.1203/00006450-197501000-00008

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038847732


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