Effect of the Antiviral Drug, Cytosine Arabinoside, on the Developing Nervous System View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1974-12

AUTHORS

Stephen Ashwal, Milton Finegold, Irving Fish, Gleb Budzilovich, Philip A Brunell

ABSTRACT

Extract: Cytosine arabinoside (which is used to treat congenital viral infections) produced neurologic and retinal damage in infant mice. Station and gait abnormalities could be related to hypoplasia and marked microscopic changes in the cerebellum of treated animals. These, as well as microscopic changes in the retina, appeared to be irreversible. The damage produced appeared to result from destruction of primordial cells during a critical period of differentiation.Speculation: The potential for producing neurologic and other damage by treatment with DNA inhibitors during this period of rapid growth must be considered when contemplating the use of these DNA inhibitors for treatment of congenital virus infections. More... »

PAGES

945-950

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197412000-00006

DOI

http://dx.doi.org/10.1203/00006450-197412000-00006

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051799672

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4444864


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