Immune Complex Nephritis Associated With Chronic Bacteremia (Shunt Nephritis) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1974-04

AUTHORS

C Frederic Strife, A James McAdams, Clark D West

ABSTRACT

Although the evidence to date suggests that, as in lupus nephritis, the diffuse proliferative nephritis associated with chronic bacteremia from infected ventriculoatrial shunts is produced by circulating immune complexes, the antigen in the complexes has not been demonstrated. A complement reactive cryoglobulin composed of IgG, IgM, C3 and C4 was isolated from a patient with shunt nephritis due to staphylococcal epidermidis. Antibody produced in rabbits to the patient's washed cryoglobulin reacted by double diffusion in agarose to the techoic acid isolated from the infecting Staphylococcal epidermidis. In vitro, the cryoglobulin activated complement by the classical pathway. Both the patient's serum and the cryoglobulin contained heat stable Clq precipitins (Agnello, et.al., JEM 134:228s, 1971). Serum C3, C4 and properdin levels were initially depressed while C5 and C3 proactivator levels were normal. Following removal of the infected shunt, the C3 level rose into the normal range in 10 days while the C4 and properdin levels became normal after 3 weeks. More... »

PAGES

461

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197404000-00728

DOI

http://dx.doi.org/10.1203/00006450-197404000-00728

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031869195


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