Classical (Distal) Renal Tubular Acidosis: Endogenous Acid Production View Full Text


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Article Info

DATE

1974-04

AUTHORS

S Lin, J C M Chan, Wellington Hung

ABSTRACT

It has been shown by McSherry et al (Clin Res 21:229, 1973), that children with classical (distal) renal tubular acidosis (cRTA) can achieve normal growth with sustained correction of acidemia by aggressive alkali therapy of up to 6-10 mEq/kg/day. To test the hypothesis that such patients have a marked increase in endogenous production of non-volatile, non-carbonic acid, incident to “catch-up” growth, three children aged 3-10 years with cRTA were each studied for three weeks by the methods of Relman et al (JCI 40:1621, 1961) regarding the rate of endogenous acid production.Mean values of patients and the twelve controls (in brackets) are presented in mEq/kg/day: sulfuric acid production, 2.5 ± 0.2 (1.3 ± 0.3); hydrogen ion production incident to incomplete oxidation of organic acid, 0.9 ± 0.2 (1.0 ± 0.4) and total net acid production, 3.4 ± 0.2 (2.3 ± 0.1). Stepwise increments of the bicarbonate therapy from 2 to 6 mEq/kg/day corrected the acidemia but did not alter the rate of endogenous acid production.The data indicate that the rate of endogenous acid production in these children with cRTA is 30% higher than comparable, healthy children and the increased sulfuric acid production accounts, in large part, for this elevation. It is concluded that the metabolism of sulfur-containing amino acids is accelerated, the exact mechanism of which requires further study. More... »

PAGES

457-457

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197404000-00704

DOI

http://dx.doi.org/10.1203/00006450-197404000-00704

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026715255


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