Use Of 1 Alpha-Hydroxyvitamin D3 On Children With Chronic Renal Failure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1974-04

AUTHORS

James C M Chan, Susan B Oldham, Michael F Holick, Hector F DeLuca, Wellington Hung

ABSTRACT

It is now well accepted that the kidney activates 25-hydroxyvitamin D3 to the highly potent metabolite, 1,25-dlhydroxyvitamin D3. Impaired activation in uremia may contribute to renal osteodystrophy.Recently, we tested the short-term effects of a highly potent analog, 1 alpha-hydroxyvitamin D3 (1α-OH-D3) which is relatively inexpensive to synthesize. Thirty-two mineral balance studies, each comprising a 3 day period, were performed before, during and after oral administration of 1α-OH-D3 (1-4 micrograms/day) to four children, aged 11 to 16 years, with renal osteodystrophy and stable chronic uremia (BUN > 60mg% and creatinine > 5mg%). Serial determinations of iPTH were measured. The results showed that physiological amounts of 1α-OH-D3 stimulated increased absorption of calcium in the gastrointestinal tract and promoted positive calcium balances. In addition, serum calcium levels returned to normal and iPTH secretion was suppressed. No complications were encountered.These data would infer that 1Pα-OH-D3 has major therapeutic value in the treatment of renal osteodystrophy. More... »

PAGES

454-454

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197404000-00684

DOI

http://dx.doi.org/10.1203/00006450-197404000-00684

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033483845


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