Which orally administered antithrombotic agent is most effective for preventing venous thromboembolism after total knee arthroplasty? A propensity score-matching analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-03-20

AUTHORS

Seonpyo Jang, Woo Cheol Shin, Min Ku Song, Hyuk-Soo Han, Myung Chul Lee, Du Hyun Ro

ABSTRACT

PurposeEven today, total knee arthroplasty (TKA) is associated with venous thromboembolism (VTE). The purpose of our study is to report the incidence of postoperative VTE and to compare the efficacy of commonly used orally administered antithrombotic agents.Materials and methodsSeven hundred ad ninety-nine patients who underwent primary TKA were retrospectively reviewed. The patients were prescribed one of three antithrombotic agents: aspirin (n = 168), rivaroxaban (n = 117), or apixaban (n = 514). Before surgery, patient demographics and risk factors were matched via propensity scoring. After surgery, all three groups took the agent for 7 days and underwent ultrasonography to check for VTE.ResultsThe overall incidence of postoperative VTE was 15.4% (123/799). Only one patient developed symptomatic VTE. Female sex and staged bilateral TKA were risk factors for postoperative VTE. The postoperative VTE rates in the aspirin, rivaroxaban, and apixaban groups were 16.2%, 6.0%, and 17.1%, respectively, significantly lower in the rivaroxaban group (p < 0.02). The majority of VTEs in all three groups were calf-vein thromboses.ConclusionsAll agents showed enough efficacy as antithrombotic agents. Considering that aspirin is inexpensive, aspirin is a cost-effective option for preventing postoperative VTE. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s43019-021-00093-4

DOI

http://dx.doi.org/10.1186/s43019-021-00093-4

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https://app.dimensions.ai/details/publication/pub.1136557165

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33743830


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