Metagenomic discovery and co-infection of diverse wobbly possum disease viruses and a novel hepacivirus in Australian brushtail possums View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12-12

AUTHORS

Wei-Shan Chang, John-Sebastian Eden, William J. Hartley, Mang Shi, Karrie Rose, Edward C. Holmes

ABSTRACT

BackgroundAustralian brushtail possums (Trichosurus vulpecula) are an introduced pest species in New Zealand, but native to Australia where they are protected for biodiversity conservation. Wobbly possum disease (WPD) is a fatal neurological disease of Australian brushtail possums described in New Zealand populations that has been associated with infection by the arterivirus (Arteriviridae) wobbly possum disease virus (WPDV-NZ). Clinically, WPD-infected possums present with chronic meningoencephalitis, choroiditis and multifocal neurological symptoms including ataxia, incoordination, and abnormal gait.MethodsWe conducted a retrospective investigation to characterise WPD in native Australian brushtail possums, and used a bulk meta-transcriptomic approach (i.e. total RNA-sequencing) to investigate its potential viral aetiology. PCR assays were developed for case diagnosis and full genome recovery in the face of extensive genetic variation.ResultsWe identified genetically distinct lineages of arteriviruses from archival tissues of WPD-infected possums in Australia, termed wobbly possum disease virus AU1 and AU2. Phylogenetically, WPDV-AU1 and WPDV-AU2 shared only ~ 70% nucleotide similarity to each other and the WPDV-NZ strain, suggestive of a relatively ancient divergence. Notably, we also identified a novel and divergent hepacivirus (Flaviviridae) - the first in a marsupial - in both WPD-infected and uninfected possums, indicative of virus co-infection.ConclusionsWe have identified marsupial-specific lineages of arteriviruses in mainland Australia that are genetically distinct from that in New Zealand, in some cases co-infecting animals with a novel hepacivirus. Our study provides new insight into the hidden genetic diversity of arteriviruses, the capacity for virus co-infection, and highlights the utility of meta-transcriptomics for disease investigation in a One Health context. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s42522-019-0006-x

DOI

http://dx.doi.org/10.1186/s42522-019-0006-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123292378

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33829126


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/05", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Environmental Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0502", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Environmental Science and Management", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Wei-Shan", 
        "id": "sg:person.015521525167.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015521525167.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westmead Institute for Medical Research, Centre for Virus Research, Westmead, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/grid.452919.2", 
          "name": [
            "Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia", 
            "Westmead Institute for Medical Research, Centre for Virus Research, Westmead, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eden", 
        "givenName": "John-Sebastian", 
        "id": "sg:person.01026045267.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026045267.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/grid.452876.a", 
          "name": [
            "Australian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hartley", 
        "givenName": "William J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Mang", 
        "id": "sg:person.0636064674.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636064674.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, QLD, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1011.1", 
          "name": [
            "Australian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, NSW, Australia", 
            "College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, QLD, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rose", 
        "givenName": "Karrie", 
        "id": "sg:person.0620241420.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620241420.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holmes", 
        "givenName": "Edward C.", 
        "id": "sg:person.012501436222.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012501436222.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s007050070124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025975836", 
          "https://doi.org/10.1007/s007050070124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature20167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024156938", 
          "https://doi.org/10.1038/nature20167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0012-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101862110", 
          "https://doi.org/10.1038/s41586-018-0012-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2013.084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051115056", 
          "https://doi.org/10.1038/nprot.2013.084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-006-0838-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006034186", 
          "https://doi.org/10.1007/s00705-006-0838-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-015-2672-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037366800", 
          "https://doi.org/10.1007/s00705-015-2672-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12-12", 
    "datePublishedReg": "2019-12-12", 
    "description": "BackgroundAustralian brushtail possums (Trichosurus vulpecula) are an introduced pest species in New Zealand, but native to Australia where they are protected for biodiversity conservation. Wobbly possum disease (WPD) is a fatal neurological disease of Australian brushtail possums described in New Zealand populations that has been associated with infection by the arterivirus (Arteriviridae) wobbly possum disease virus (WPDV-NZ). Clinically, WPD-infected possums present with chronic meningoencephalitis, choroiditis and multifocal neurological symptoms including ataxia, incoordination, and abnormal gait.MethodsWe conducted a retrospective investigation to characterise WPD in native Australian brushtail possums, and used a bulk meta-transcriptomic approach (i.e. total RNA-sequencing) to investigate its potential viral aetiology. PCR assays were developed for case diagnosis and full genome recovery in the face of extensive genetic variation.ResultsWe identified genetically distinct lineages of arteriviruses from archival tissues of WPD-infected possums in Australia, termed wobbly possum disease virus AU1 and AU2. Phylogenetically, WPDV-AU1 and WPDV-AU2 shared only ~\u200970% nucleotide similarity to each other and the WPDV-NZ strain, suggestive of a relatively ancient divergence. Notably, we also identified a novel and divergent hepacivirus (Flaviviridae) - the first in a marsupial - in both WPD-infected and uninfected possums, indicative of virus co-infection.ConclusionsWe have identified marsupial-specific lineages of arteriviruses in mainland Australia that are genetically distinct from that in New Zealand, in some cases co-infecting animals with a novel hepacivirus. Our study provides new insight into the hidden genetic diversity of arteriviruses, the capacity for virus co-infection, and highlights the utility of meta-transcriptomics for disease investigation in a One Health context.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s42522-019-0006-x", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6809668", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1336339", 
        "issn": [
          "2524-4655"
        ], 
        "name": "One Health Outlook", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "keywords": [
      "wobbly possum disease", 
      "Australian brushtail possum", 
      "brushtail possum", 
      "novel hepacivirus", 
      "hidden genetic diversity", 
      "meta-transcriptomic approach", 
      "extensive genetic variation", 
      "wobbly possum disease (WPD) virus", 
      "ancient divergence", 
      "metagenomic discovery", 
      "divergent hepacivirus", 
      "pest species", 
      "genetic diversity", 
      "distinct lineages", 
      "genetic variation", 
      "genome recovery", 
      "disease virus", 
      "biodiversity conservation", 
      "arteriviruses", 
      "nucleotide similarity", 
      "mainland Australia", 
      "possums", 
      "lineages", 
      "New Zealand population", 
      "Co-infected animals", 
      "hepacivirus", 
      "fatal neurological disease", 
      "PCR assays", 
      "new insights", 
      "New Zealand", 
      "multifocal neurological symptoms", 
      "potential viral etiology", 
      "marsupials", 
      "virus", 
      "disease investigation", 
      "species", 
      "diversity", 
      "neurological diseases", 
      "conservation", 
      "divergence", 
      "Australia", 
      "assays", 
      "Zealand", 
      "discovery", 
      "similarity", 
      "archival tissue", 
      "strains", 
      "tissue", 
      "animals", 
      "insights", 
      "population", 
      "chronic meningoencephalitis", 
      "disease", 
      "variation", 
      "ataxia", 
      "ConclusionsWe", 
      "infection", 
      "MethodsWe", 
      "ResultsWe", 
      "investigation", 
      "capacity", 
      "Au1", 
      "study", 
      "recovery", 
      "utility", 
      "etiology", 
      "context", 
      "approach", 
      "meningoencephalitis", 
      "viral etiology", 
      "face", 
      "abnormal gait", 
      "Au2", 
      "health context", 
      "neurological symptoms", 
      "incoordination", 
      "symptoms", 
      "diagnosis", 
      "retrospective investigation", 
      "case diagnosis", 
      "gait", 
      "choroiditis"
    ], 
    "name": "Metagenomic discovery and co-infection of diverse wobbly possum disease viruses and a novel hepacivirus in Australian brushtail possums", 
    "pagination": "5", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1123292378"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s42522-019-0006-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33829126"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s42522-019-0006-x", 
      "https://app.dimensions.ai/details/publication/pub.1123292378"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_824.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s42522-019-0006-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s42522-019-0006-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s42522-019-0006-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s42522-019-0006-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s42522-019-0006-x'


 

This table displays all metadata directly associated to this object as RDF triples.

229 TRIPLES      21 PREDICATES      117 URIs      99 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s42522-019-0006-x schema:about anzsrc-for:05
2 anzsrc-for:0502
3 anzsrc-for:06
4 anzsrc-for:0604
5 anzsrc-for:11
6 anzsrc-for:1108
7 schema:author Ne809690787e54c4499d0eb1b00363109
8 schema:citation sg:pub.10.1007/s00705-006-0838-4
9 sg:pub.10.1007/s00705-015-2672-z
10 sg:pub.10.1007/s007050070124
11 sg:pub.10.1038/nature20167
12 sg:pub.10.1038/nprot.2013.084
13 sg:pub.10.1038/s41586-018-0012-7
14 schema:datePublished 2019-12-12
15 schema:datePublishedReg 2019-12-12
16 schema:description BackgroundAustralian brushtail possums (Trichosurus vulpecula) are an introduced pest species in New Zealand, but native to Australia where they are protected for biodiversity conservation. Wobbly possum disease (WPD) is a fatal neurological disease of Australian brushtail possums described in New Zealand populations that has been associated with infection by the arterivirus (Arteriviridae) wobbly possum disease virus (WPDV-NZ). Clinically, WPD-infected possums present with chronic meningoencephalitis, choroiditis and multifocal neurological symptoms including ataxia, incoordination, and abnormal gait.MethodsWe conducted a retrospective investigation to characterise WPD in native Australian brushtail possums, and used a bulk meta-transcriptomic approach (i.e. total RNA-sequencing) to investigate its potential viral aetiology. PCR assays were developed for case diagnosis and full genome recovery in the face of extensive genetic variation.ResultsWe identified genetically distinct lineages of arteriviruses from archival tissues of WPD-infected possums in Australia, termed wobbly possum disease virus AU1 and AU2. Phylogenetically, WPDV-AU1 and WPDV-AU2 shared only ~ 70% nucleotide similarity to each other and the WPDV-NZ strain, suggestive of a relatively ancient divergence. Notably, we also identified a novel and divergent hepacivirus (Flaviviridae) - the first in a marsupial - in both WPD-infected and uninfected possums, indicative of virus co-infection.ConclusionsWe have identified marsupial-specific lineages of arteriviruses in mainland Australia that are genetically distinct from that in New Zealand, in some cases co-infecting animals with a novel hepacivirus. Our study provides new insight into the hidden genetic diversity of arteriviruses, the capacity for virus co-infection, and highlights the utility of meta-transcriptomics for disease investigation in a One Health context.
17 schema:genre article
18 schema:isAccessibleForFree true
19 schema:isPartOf N0e13797ed3ba41c3b66b0e74a2380933
20 N9d32160b5c454210813d97c3c295d27d
21 sg:journal.1336339
22 schema:keywords Au1
23 Au2
24 Australia
25 Australian brushtail possum
26 Co-infected animals
27 ConclusionsWe
28 MethodsWe
29 New Zealand
30 New Zealand population
31 PCR assays
32 ResultsWe
33 Zealand
34 abnormal gait
35 ancient divergence
36 animals
37 approach
38 archival tissue
39 arteriviruses
40 assays
41 ataxia
42 biodiversity conservation
43 brushtail possum
44 capacity
45 case diagnosis
46 choroiditis
47 chronic meningoencephalitis
48 conservation
49 context
50 diagnosis
51 discovery
52 disease
53 disease investigation
54 disease virus
55 distinct lineages
56 divergence
57 divergent hepacivirus
58 diversity
59 etiology
60 extensive genetic variation
61 face
62 fatal neurological disease
63 gait
64 genetic diversity
65 genetic variation
66 genome recovery
67 health context
68 hepacivirus
69 hidden genetic diversity
70 incoordination
71 infection
72 insights
73 investigation
74 lineages
75 mainland Australia
76 marsupials
77 meningoencephalitis
78 meta-transcriptomic approach
79 metagenomic discovery
80 multifocal neurological symptoms
81 neurological diseases
82 neurological symptoms
83 new insights
84 novel hepacivirus
85 nucleotide similarity
86 pest species
87 population
88 possums
89 potential viral etiology
90 recovery
91 retrospective investigation
92 similarity
93 species
94 strains
95 study
96 symptoms
97 tissue
98 utility
99 variation
100 viral etiology
101 virus
102 wobbly possum disease
103 wobbly possum disease (WPD) virus
104 schema:name Metagenomic discovery and co-infection of diverse wobbly possum disease viruses and a novel hepacivirus in Australian brushtail possums
105 schema:pagination 5
106 schema:productId N0d642a3b7daf4c4faa7251bdbd9ce23f
107 N9b9fb7b22c6a44748cc0d383f8e80a2f
108 Nc7588f46531a478b9c4a0c04ac8b7c4a
109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123292378
110 https://doi.org/10.1186/s42522-019-0006-x
111 schema:sdDatePublished 2022-08-04T17:07
112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
113 schema:sdPublisher Nec8268cb19094a93b8ddb635e8606913
114 schema:url https://doi.org/10.1186/s42522-019-0006-x
115 sgo:license sg:explorer/license/
116 sgo:sdDataset articles
117 rdf:type schema:ScholarlyArticle
118 N0d642a3b7daf4c4faa7251bdbd9ce23f schema:name dimensions_id
119 schema:value pub.1123292378
120 rdf:type schema:PropertyValue
121 N0e13797ed3ba41c3b66b0e74a2380933 schema:volumeNumber 1
122 rdf:type schema:PublicationVolume
123 N0f9f861dfd7f4854be9418cb2882321a rdf:first sg:person.01026045267.97
124 rdf:rest N3bdf9f5de054490c888f713d3fa8388d
125 N129f7a2e90d047eb8a8a5711cb56f30f schema:affiliation grid-institutes:grid.452876.a
126 schema:familyName Hartley
127 schema:givenName William J.
128 rdf:type schema:Person
129 N3bdf9f5de054490c888f713d3fa8388d rdf:first N129f7a2e90d047eb8a8a5711cb56f30f
130 rdf:rest N6b854a514fbe44488d0f34cf3e044ced
131 N4137b9840beb4ca1b0fe4c34f8f4340a rdf:first sg:person.012501436222.04
132 rdf:rest rdf:nil
133 N6b854a514fbe44488d0f34cf3e044ced rdf:first sg:person.0636064674.00
134 rdf:rest Nb99722c8f71f455b8b10e368fde18773
135 N9b9fb7b22c6a44748cc0d383f8e80a2f schema:name pubmed_id
136 schema:value 33829126
137 rdf:type schema:PropertyValue
138 N9d32160b5c454210813d97c3c295d27d schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 Nb99722c8f71f455b8b10e368fde18773 rdf:first sg:person.0620241420.20
141 rdf:rest N4137b9840beb4ca1b0fe4c34f8f4340a
142 Nc7588f46531a478b9c4a0c04ac8b7c4a schema:name doi
143 schema:value 10.1186/s42522-019-0006-x
144 rdf:type schema:PropertyValue
145 Ne809690787e54c4499d0eb1b00363109 rdf:first sg:person.015521525167.73
146 rdf:rest N0f9f861dfd7f4854be9418cb2882321a
147 Nec8268cb19094a93b8ddb635e8606913 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 anzsrc-for:05 schema:inDefinedTermSet anzsrc-for:
150 schema:name Environmental Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:0502 schema:inDefinedTermSet anzsrc-for:
153 schema:name Environmental Science and Management
154 rdf:type schema:DefinedTerm
155 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
156 schema:name Biological Sciences
157 rdf:type schema:DefinedTerm
158 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
159 schema:name Genetics
160 rdf:type schema:DefinedTerm
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical Microbiology
166 rdf:type schema:DefinedTerm
167 sg:grant.6809668 http://pending.schema.org/fundedItem sg:pub.10.1186/s42522-019-0006-x
168 rdf:type schema:MonetaryGrant
169 sg:journal.1336339 schema:issn 2524-4655
170 schema:name One Health Outlook
171 schema:publisher Springer Nature
172 rdf:type schema:Periodical
173 sg:person.01026045267.97 schema:affiliation grid-institutes:grid.452919.2
174 schema:familyName Eden
175 schema:givenName John-Sebastian
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026045267.97
177 rdf:type schema:Person
178 sg:person.012501436222.04 schema:affiliation grid-institutes:grid.1013.3
179 schema:familyName Holmes
180 schema:givenName Edward C.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012501436222.04
182 rdf:type schema:Person
183 sg:person.015521525167.73 schema:affiliation grid-institutes:grid.1013.3
184 schema:familyName Chang
185 schema:givenName Wei-Shan
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015521525167.73
187 rdf:type schema:Person
188 sg:person.0620241420.20 schema:affiliation grid-institutes:grid.1011.1
189 schema:familyName Rose
190 schema:givenName Karrie
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620241420.20
192 rdf:type schema:Person
193 sg:person.0636064674.00 schema:affiliation grid-institutes:grid.1013.3
194 schema:familyName Shi
195 schema:givenName Mang
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636064674.00
197 rdf:type schema:Person
198 sg:pub.10.1007/s00705-006-0838-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006034186
199 https://doi.org/10.1007/s00705-006-0838-4
200 rdf:type schema:CreativeWork
201 sg:pub.10.1007/s00705-015-2672-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037366800
202 https://doi.org/10.1007/s00705-015-2672-z
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s007050070124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025975836
205 https://doi.org/10.1007/s007050070124
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/nature20167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024156938
208 https://doi.org/10.1038/nature20167
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/nprot.2013.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051115056
211 https://doi.org/10.1038/nprot.2013.084
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/s41586-018-0012-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101862110
214 https://doi.org/10.1038/s41586-018-0012-7
215 rdf:type schema:CreativeWork
216 grid-institutes:grid.1011.1 schema:alternateName College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, QLD, Australia
217 schema:name Australian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, NSW, Australia
218 College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, QLD, Australia
219 rdf:type schema:Organization
220 grid-institutes:grid.1013.3 schema:alternateName Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia
221 schema:name Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia
222 rdf:type schema:Organization
223 grid-institutes:grid.452876.a schema:alternateName Australian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, NSW, Australia
224 schema:name Australian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, NSW, Australia
225 rdf:type schema:Organization
226 grid-institutes:grid.452919.2 schema:alternateName Westmead Institute for Medical Research, Centre for Virus Research, Westmead, NSW, Australia
227 schema:name Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia
228 Westmead Institute for Medical Research, Centre for Virus Research, Westmead, NSW, Australia
229 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...