Realizing flexible bioelectronic medicines for accessing the peripheral nerves – technology considerations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Vasiliki Giagka, Wouter A. Serdijn

ABSTRACT

Patients suffering from conditions such as paralysis, diabetes or rheumatoid arthritis could in the future be treated in a personalised manner using bioelectronic medicines (BEms) (Nat Rev Drug Discov 13:399–400, 2013, Proc Natl Acad Sci USA 113:8284–9, 2016, J Intern Med 282:37–45, 2017). To deliver this personalised therapy based on electricity, BEms need to target various sites in the human body and operate in a closed-loop manner. The specific conditions and anatomy of the targeted sites pose unique challenges in the development of BEms. With a focus on BEms based on flexible substrates for accessing small peripheral nerves, this paper discusses several system-level technology considerations related to the development of such devices. The focus is mainly on miniaturisation and long-term operation. We present an overview of common substrate and electrode materials, related processing methods, and discuss assembly, miniaturisation and long-term stability issues. More... »

PAGES

8

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s42234-018-0010-y

    DOI

    http://dx.doi.org/10.1186/s42234-018-0010-y

    DIMENSIONS

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