Targeted 11C–choline PET-CT/TRUS software fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI after previous negative biopsy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Massimo Lazzeri, Egesta Lopci, Giovanni Lughezzani, Piergiuseppe Colombo, Paolo Casale, Rodolfo Hurle, Alberto Saita, Lorenzo Leonardi, Giuliana Lista, Roberto Peschechera, Luisa Pasini, Marcello Rodari, Silvia Zandegiacomo, Alessio Benetti, Pasquale Cardone, Federica Mrakic, Luca Balzarini, Arturo Chiti, Giorgio Guazzoni, Nicolò Maria Buffi

ABSTRACT

Background: We evaluated the feasibility and accuracy of 11C-choline PET-CT/TRUS fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI or contraindication to MRI, after previous negative biopsy. Clinical data were part of a prospective on-going observational clinical study: "Diagnostic accuracy of target mpMRI/US fusion biopsy in patients with suspected prostate cancer after initial negative biopsy". Patients with a negative biopsy and negative mpMRI (PI-RADS v.2 < 3) or absolute contraindications to MRI and persistently elevated PSA, were included. All patients underwent 11C-choline PET with dedicated acquisition of the pelvis and PET-CT/TRUS-guided prostate biopsy by Bio-Jet™ fusion system (D&K Technologies, Germany). The primary endpoint was to assess the accuracy of 11C-choline PET-CT to determine the presence and the topographical distribution of PCa. Results: Overall, 15 patients (median age 71 yrs. ± 8.89; tPSA 13.5 ng/ml ± 4.3) were analysed. Fourteen had a positive PET scan, which revealed 30 lesions. PCa was detected in 7/15 patients (46.7%) and four patients presented a clinically significant PCa: GS > 6. Over 58 cores, 25 (43.1%) were positive. No statistically significant difference in terms of mean and median values for SUVmax and SUVratio between benign and malignant lesions was found. PCa lesions with GS 3 + 3 (n = 3) showed a median SUVmax and SUVratio of 4.01 and 1.46, compared to 5.45 and 1.57, respectively for lesions with GS >6 (n = 4). Conclusion: Software PET-CT/TRUS fusion-guided target biopsy could be a diagnostic alternative in patients with a suspected primary PCa and negative mpMRI, but its specificity appeared low. More... »

PAGES

9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s41824-017-0011-1

DOI

http://dx.doi.org/10.1186/s41824-017-0011-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092219680

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29782590


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lazzeri", 
        "givenName": "Massimo", 
        "id": "sg:person.01343775502.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343775502.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Nuclear-Medicine, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopci", 
        "givenName": "Egesta", 
        "id": "sg:person.01056543264.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056543264.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lughezzani", 
        "givenName": "Giovanni", 
        "id": "sg:person.01171354345.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171354345.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Pathology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colombo", 
        "givenName": "Piergiuseppe", 
        "id": "sg:person.015774565752.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015774565752.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casale", 
        "givenName": "Paolo", 
        "id": "sg:person.0741147201.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741147201.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hurle", 
        "givenName": "Rodolfo", 
        "id": "sg:person.01201617620.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201617620.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saita", 
        "givenName": "Alberto", 
        "id": "sg:person.01116676471.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116676471.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Nuclear-Medicine, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leonardi", 
        "givenName": "Lorenzo", 
        "id": "sg:person.0737725611.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737725611.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lista", 
        "givenName": "Giuliana", 
        "id": "sg:person.01147162411.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147162411.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peschechera", 
        "givenName": "Roberto", 
        "id": "sg:person.01363303113.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363303113.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pasini", 
        "givenName": "Luisa", 
        "id": "sg:person.01020006161.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020006161.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Nuclear-Medicine, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodari", 
        "givenName": "Marcello", 
        "id": "sg:person.01347103311.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347103311.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zandegiacomo", 
        "givenName": "Silvia", 
        "id": "sg:person.01263565636.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263565636.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benetti", 
        "givenName": "Alessio", 
        "id": "sg:person.0775052044.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775052044.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardone", 
        "givenName": "Pasquale", 
        "id": "sg:person.012605336215.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012605336215.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Radiology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mrakic", 
        "givenName": "Federica", 
        "id": "sg:person.07524251440.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07524251440.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Radiology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balzarini", 
        "givenName": "Luca", 
        "id": "sg:person.01326061714.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326061714.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas University", 
          "id": "https://www.grid.ac/institutes/grid.452490.e", 
          "name": [
            "Department of Nuclear-Medicine, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy", 
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy", 
            "Department of Pathology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy", 
            "Department of Radiology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy", 
            "Humanitas University, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiti", 
        "givenName": "Arturo", 
        "id": "sg:person.01100100171.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100100171.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas University", 
          "id": "https://www.grid.ac/institutes/grid.452490.e", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy", 
            "Department of Pathology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy", 
            "Department of Radiology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy", 
            "Humanitas University, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guazzoni", 
        "givenName": "Giorgio", 
        "id": "sg:person.01012376700.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012376700.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buffi", 
        "givenName": "Nicol\u00f2 Maria", 
        "id": "sg:person.0744540445.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744540445.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00259-007-0686-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001437922", 
          "https://doi.org/10.1007/s00259-007-0686-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000173646.99337.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003431780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000173646.99337.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003431780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000173646.99337.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003431780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004173308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2014.08.079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013301564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.23038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025462686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.29874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026993924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2014.11.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028488063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0190-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029809553", 
          "https://doi.org/10.1007/s00259-006-0190-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0190-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029809553", 
          "https://doi.org/10.1007/s00259-006-0190-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2015.08.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030259789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/iju.12643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032112285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2014.10.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032840355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.109.063396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039159972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-015-1525-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041823705", 
          "https://doi.org/10.1007/s00345-015-1525-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-015-1711-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043740413", 
          "https://doi.org/10.1007/s00345-015-1711-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1344(200002)43:2<195::aid-jlcr316>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045731091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-015-1671-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047526013", 
          "https://doi.org/10.1007/s00345-015-1671-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2015.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049128446"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Background: We evaluated the feasibility and accuracy of 11C-choline PET-CT/TRUS fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI or contraindication to MRI, after previous negative biopsy. Clinical data were part of a prospective on-going observational clinical study: \"Diagnostic accuracy of target mpMRI/US fusion biopsy in patients with suspected prostate cancer after initial negative biopsy\". Patients with a negative biopsy and negative mpMRI (PI-RADS v.2\u00a0<\u00a03) or absolute contraindications to MRI and persistently elevated PSA, were included. All patients underwent 11C-choline PET with dedicated acquisition of the pelvis and PET-CT/TRUS-guided prostate biopsy by Bio-Jet\u2122 fusion system (D&K Technologies, Germany). The primary endpoint was to assess the accuracy of 11C-choline PET-CT to determine the presence and the topographical distribution of PCa.\nResults: Overall, 15 patients (median age 71\u00a0yrs. \u00b1 8.89; tPSA 13.5\u00a0ng/ml\u00a0\u00b1\u00a04.3) were analysed. Fourteen had a positive PET scan, which revealed 30 lesions. PCa was detected in 7/15 patients (46.7%) and four patients presented a clinically significant PCa: GS\u00a0>\u00a06. Over 58 cores, 25 (43.1%) were positive. No statistically significant difference in terms of mean and median values for SUVmax and SUVratio between benign and malignant lesions was found. PCa lesions with GS 3\u00a0+\u00a03 (n\u00a0=\u00a03) showed a median SUVmax and SUVratio of 4.01 and 1.46, compared to 5.45 and 1.57, respectively for lesions with GS >6 (n\u00a0=\u00a04).\nConclusion: Software PET-CT/TRUS fusion-guided target biopsy could be a diagnostic alternative in patients with a suspected primary PCa and negative mpMRI, but its specificity appeared low.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s41824-017-0011-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1300093", 
        "issn": [
          "2510-3636"
        ], 
        "name": "European Journal of Hybrid Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Targeted 11C\u2013choline PET-CT/TRUS software fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI after previous negative biopsy", 
    "pagination": "9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e8bf9a09ba8f42058e331bfc7d22d4632b2778a9ee3455ebcbc6030c902f8ac0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29782590"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101724113"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s41824-017-0011-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092219680"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s41824-017-0011-1", 
      "https://app.dimensions.ai/details/publication/pub.1092219680"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000573.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs41824-017-0011-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s41824-017-0011-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s41824-017-0011-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s41824-017-0011-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s41824-017-0011-1'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      46 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s41824-017-0011-1 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N64dc18a878f245259de2f579017e0507
4 schema:citation sg:pub.10.1007/s00259-006-0190-7
5 sg:pub.10.1007/s00259-007-0686-9
6 sg:pub.10.1007/s00345-015-1525-4
7 sg:pub.10.1007/s00345-015-1671-8
8 sg:pub.10.1007/s00345-015-1711-4
9 https://doi.org/10.1002/(sici)1099-1344(200002)43:2<195::aid-jlcr316>3.0.co;2-p
10 https://doi.org/10.1002/cncr.29874
11 https://doi.org/10.1002/pros.23038
12 https://doi.org/10.1016/j.eururo.2014.08.079
13 https://doi.org/10.1016/j.eururo.2014.10.033
14 https://doi.org/10.1016/j.eururo.2014.11.037
15 https://doi.org/10.1016/j.eururo.2015.01.013
16 https://doi.org/10.1016/j.eururo.2015.08.052
17 https://doi.org/10.1097/01.pas.0000173646.99337.b1
18 https://doi.org/10.1111/iju.12643
19 https://doi.org/10.1158/1078-0432.ccr-10-2093
20 https://doi.org/10.2967/jnumed.109.063396
21 schema:datePublished 2017-12
22 schema:datePublishedReg 2017-12-01
23 schema:description Background: We evaluated the feasibility and accuracy of 11C-choline PET-CT/TRUS fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI or contraindication to MRI, after previous negative biopsy. Clinical data were part of a prospective on-going observational clinical study: "Diagnostic accuracy of target mpMRI/US fusion biopsy in patients with suspected prostate cancer after initial negative biopsy". Patients with a negative biopsy and negative mpMRI (PI-RADS v.2 < 3) or absolute contraindications to MRI and persistently elevated PSA, were included. All patients underwent 11C-choline PET with dedicated acquisition of the pelvis and PET-CT/TRUS-guided prostate biopsy by Bio-Jet™ fusion system (D&K Technologies, Germany). The primary endpoint was to assess the accuracy of 11C-choline PET-CT to determine the presence and the topographical distribution of PCa. Results: Overall, 15 patients (median age 71 yrs. ± 8.89; tPSA 13.5 ng/ml ± 4.3) were analysed. Fourteen had a positive PET scan, which revealed 30 lesions. PCa was detected in 7/15 patients (46.7%) and four patients presented a clinically significant PCa: GS > 6. Over 58 cores, 25 (43.1%) were positive. No statistically significant difference in terms of mean and median values for SUVmax and SUVratio between benign and malignant lesions was found. PCa lesions with GS 3 + 3 (n = 3) showed a median SUVmax and SUVratio of 4.01 and 1.46, compared to 5.45 and 1.57, respectively for lesions with GS >6 (n = 4). Conclusion: Software PET-CT/TRUS fusion-guided target biopsy could be a diagnostic alternative in patients with a suspected primary PCa and negative mpMRI, but its specificity appeared low.
24 schema:genre research_article
25 schema:inLanguage en
26 schema:isAccessibleForFree true
27 schema:isPartOf N9a078724e6d946038bf73bce087ea322
28 Ne36e31f52cbc4f27b786f3a5910621bc
29 sg:journal.1300093
30 schema:name Targeted 11C–choline PET-CT/TRUS software fusion-guided prostate biopsy in men with persistently elevated PSA and negative mpMRI after previous negative biopsy
31 schema:pagination 9
32 schema:productId N24d7e11d97024c2f90ab6a4a05729404
33 N5ad6b56e371549d8aa8b61b069e4dc16
34 N77d23f2d48e64a74acfaebbefced0683
35 N984e952db1994719ae41f6d6f3259f88
36 Nd795064c199b476499b2d595c7f774f3
37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092219680
38 https://doi.org/10.1186/s41824-017-0011-1
39 schema:sdDatePublished 2019-04-10T17:41
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher Nbdc774dfab3d4ad385c1f602729c27e5
42 schema:url https://link.springer.com/10.1186%2Fs41824-017-0011-1
43 sgo:license sg:explorer/license/
44 sgo:sdDataset articles
45 rdf:type schema:ScholarlyArticle
46 N08430b47dfa147f89ba3d11819d91e45 rdf:first sg:person.012605336215.99
47 rdf:rest Ncdffe4e5e94443e0ad66e99b97da6583
48 N24d7e11d97024c2f90ab6a4a05729404 schema:name nlm_unique_id
49 schema:value 101724113
50 rdf:type schema:PropertyValue
51 N2c84fe063d3e4a9ba994d268d7a30de3 rdf:first sg:person.01056543264.10
52 rdf:rest N4e9cbe1967074a1ca893dc17308e6a40
53 N37b11b594b154a6a883e7bfaf91a2a96 rdf:first sg:person.01263565636.84
54 rdf:rest Nd0f0ae2221124641a416fa012500944e
55 N4e9cbe1967074a1ca893dc17308e6a40 rdf:first sg:person.01171354345.16
56 rdf:rest N8550217c68674e6ab073a1337cbdfe5c
57 N5560dd4aa75d4e55b585a5b0c7a8962c rdf:first sg:person.01326061714.10
58 rdf:rest Nfcee913803644689b9b4e53b5f9af3bc
59 N599f5cf341ca429a98fead8ce561d13a rdf:first sg:person.01201617620.87
60 rdf:rest N63eac122adda4e33a8ab550dad9f53b7
61 N5ad6b56e371549d8aa8b61b069e4dc16 schema:name dimensions_id
62 schema:value pub.1092219680
63 rdf:type schema:PropertyValue
64 N5ce4aec2e0714fa69068a65e4e5225d5 rdf:first sg:person.0737725611.44
65 rdf:rest Nf8bd7ae2a559443d87eaf75fc25ba658
66 N63eac122adda4e33a8ab550dad9f53b7 rdf:first sg:person.01116676471.71
67 rdf:rest N5ce4aec2e0714fa69068a65e4e5225d5
68 N64dc18a878f245259de2f579017e0507 rdf:first sg:person.01343775502.78
69 rdf:rest N2c84fe063d3e4a9ba994d268d7a30de3
70 N67a041932158420c8d10a6ef38d0aac7 rdf:first sg:person.01020006161.53
71 rdf:rest N8c65066a3f31468680a555a124c567b9
72 N6dc717445cfa4adfbb2e0393c8d3d2da rdf:first sg:person.01363303113.09
73 rdf:rest N67a041932158420c8d10a6ef38d0aac7
74 N77d23f2d48e64a74acfaebbefced0683 schema:name doi
75 schema:value 10.1186/s41824-017-0011-1
76 rdf:type schema:PropertyValue
77 N8550217c68674e6ab073a1337cbdfe5c rdf:first sg:person.015774565752.13
78 rdf:rest Naa11672e92f0451c98aa2c9b938cd2c4
79 N8c65066a3f31468680a555a124c567b9 rdf:first sg:person.01347103311.14
80 rdf:rest N37b11b594b154a6a883e7bfaf91a2a96
81 N984e952db1994719ae41f6d6f3259f88 schema:name pubmed_id
82 schema:value 29782590
83 rdf:type schema:PropertyValue
84 N9a078724e6d946038bf73bce087ea322 schema:volumeNumber 1
85 rdf:type schema:PublicationVolume
86 Naa11672e92f0451c98aa2c9b938cd2c4 rdf:first sg:person.0741147201.80
87 rdf:rest N599f5cf341ca429a98fead8ce561d13a
88 Nbdc774dfab3d4ad385c1f602729c27e5 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 Ncdffe4e5e94443e0ad66e99b97da6583 rdf:first sg:person.07524251440.90
91 rdf:rest N5560dd4aa75d4e55b585a5b0c7a8962c
92 Nd0f0ae2221124641a416fa012500944e rdf:first sg:person.0775052044.10
93 rdf:rest N08430b47dfa147f89ba3d11819d91e45
94 Nd795064c199b476499b2d595c7f774f3 schema:name readcube_id
95 schema:value e8bf9a09ba8f42058e331bfc7d22d4632b2778a9ee3455ebcbc6030c902f8ac0
96 rdf:type schema:PropertyValue
97 Ne36e31f52cbc4f27b786f3a5910621bc schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 Nea3f27cf56f4480f84e1a0e492aeecc9 rdf:first sg:person.01012376700.19
100 rdf:rest Nedd2e6a4220646bca3c2abbf576a73af
101 Nedd2e6a4220646bca3c2abbf576a73af rdf:first sg:person.0744540445.73
102 rdf:rest rdf:nil
103 Nf8bd7ae2a559443d87eaf75fc25ba658 rdf:first sg:person.01147162411.11
104 rdf:rest N6dc717445cfa4adfbb2e0393c8d3d2da
105 Nfcee913803644689b9b4e53b5f9af3bc rdf:first sg:person.01100100171.76
106 rdf:rest Nea3f27cf56f4480f84e1a0e492aeecc9
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
111 schema:name Clinical Sciences
112 rdf:type schema:DefinedTerm
113 sg:journal.1300093 schema:issn 2510-3636
114 schema:name European Journal of Hybrid Imaging
115 rdf:type schema:Periodical
116 sg:person.01012376700.19 schema:affiliation https://www.grid.ac/institutes/grid.452490.e
117 schema:familyName Guazzoni
118 schema:givenName Giorgio
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012376700.19
120 rdf:type schema:Person
121 sg:person.01020006161.53 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
122 schema:familyName Pasini
123 schema:givenName Luisa
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020006161.53
125 rdf:type schema:Person
126 sg:person.01056543264.10 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
127 schema:familyName Lopci
128 schema:givenName Egesta
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056543264.10
130 rdf:type schema:Person
131 sg:person.01100100171.76 schema:affiliation https://www.grid.ac/institutes/grid.452490.e
132 schema:familyName Chiti
133 schema:givenName Arturo
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100100171.76
135 rdf:type schema:Person
136 sg:person.01116676471.71 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
137 schema:familyName Saita
138 schema:givenName Alberto
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116676471.71
140 rdf:type schema:Person
141 sg:person.01147162411.11 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
142 schema:familyName Lista
143 schema:givenName Giuliana
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147162411.11
145 rdf:type schema:Person
146 sg:person.01171354345.16 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
147 schema:familyName Lughezzani
148 schema:givenName Giovanni
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171354345.16
150 rdf:type schema:Person
151 sg:person.01201617620.87 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
152 schema:familyName Hurle
153 schema:givenName Rodolfo
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201617620.87
155 rdf:type schema:Person
156 sg:person.012605336215.99 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
157 schema:familyName Cardone
158 schema:givenName Pasquale
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012605336215.99
160 rdf:type schema:Person
161 sg:person.01263565636.84 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
162 schema:familyName Zandegiacomo
163 schema:givenName Silvia
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263565636.84
165 rdf:type schema:Person
166 sg:person.01326061714.10 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
167 schema:familyName Balzarini
168 schema:givenName Luca
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326061714.10
170 rdf:type schema:Person
171 sg:person.01343775502.78 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
172 schema:familyName Lazzeri
173 schema:givenName Massimo
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343775502.78
175 rdf:type schema:Person
176 sg:person.01347103311.14 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
177 schema:familyName Rodari
178 schema:givenName Marcello
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347103311.14
180 rdf:type schema:Person
181 sg:person.01363303113.09 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
182 schema:familyName Peschechera
183 schema:givenName Roberto
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363303113.09
185 rdf:type schema:Person
186 sg:person.015774565752.13 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
187 schema:familyName Colombo
188 schema:givenName Piergiuseppe
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015774565752.13
190 rdf:type schema:Person
191 sg:person.0737725611.44 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
192 schema:familyName Leonardi
193 schema:givenName Lorenzo
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737725611.44
195 rdf:type schema:Person
196 sg:person.0741147201.80 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
197 schema:familyName Casale
198 schema:givenName Paolo
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741147201.80
200 rdf:type schema:Person
201 sg:person.0744540445.73 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
202 schema:familyName Buffi
203 schema:givenName Nicolò Maria
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744540445.73
205 rdf:type schema:Person
206 sg:person.07524251440.90 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
207 schema:familyName Mrakic
208 schema:givenName Federica
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07524251440.90
210 rdf:type schema:Person
211 sg:person.0775052044.10 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
212 schema:familyName Benetti
213 schema:givenName Alessio
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775052044.10
215 rdf:type schema:Person
216 sg:pub.10.1007/s00259-006-0190-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029809553
217 https://doi.org/10.1007/s00259-006-0190-7
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s00259-007-0686-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001437922
220 https://doi.org/10.1007/s00259-007-0686-9
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s00345-015-1525-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041823705
223 https://doi.org/10.1007/s00345-015-1525-4
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s00345-015-1671-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047526013
226 https://doi.org/10.1007/s00345-015-1671-8
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s00345-015-1711-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043740413
229 https://doi.org/10.1007/s00345-015-1711-4
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/(sici)1099-1344(200002)43:2<195::aid-jlcr316>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1045731091
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/cncr.29874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026993924
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/pros.23038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025462686
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.eururo.2014.08.079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013301564
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.eururo.2014.10.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032840355
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.eururo.2014.11.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028488063
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.eururo.2015.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049128446
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.eururo.2015.08.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030259789
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1097/01.pas.0000173646.99337.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003431780
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/iju.12643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032112285
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1158/1078-0432.ccr-10-2093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004173308
252 rdf:type schema:CreativeWork
253 https://doi.org/10.2967/jnumed.109.063396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039159972
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.417728.f schema:alternateName Humanitas Research Hospital
256 schema:name Department of Nuclear-Medicine, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy
257 Department of Pathology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy
258 Department of Radiology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy
259 Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.452490.e schema:alternateName Humanitas University
262 schema:name Department of Nuclear-Medicine, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy
263 Department of Pathology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy
264 Department of Radiology, Humanitas Clinical and Research Hospital, Milan, Rozzano, Italy
265 Department of Urology, Humanitas Clinical and Research Hospital, via Manzoni 56, 20089, Milan, Rozzano, Italy
266 Humanitas University, Milan, Rozzano, Italy
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...