Free fatty acid-based low-impedance liver image: a characteristic appearance in nonalcoholic steatohepatitis (NASH) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-23

AUTHORS

Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Tetsuhiro Chiba, Naoya Kato, Masayuki Ohtsuka, Kazuyo Ito, Tadashi Yamaguchi, Shuichiro Shiina

ABSTRACT

BackgroundTo examine in vitro acoustic property of nonalcoholic fatty disease in mouse and human liver to identify nonalcoholic steatohepatitis (NASH).MethodsThe acoustic impedance (× 106 kg/m2/s) was measured in 35 free fatty acids (FFAs, 500 mmol/L) and histologically-diagnosed liver samples of twelve mice (four control, four simple steatosis [SS], and four NASH) and eight humans (two control, three SS, and three NASH), using 80-MHz acoustic microscopy. The sum of percentage (SP) composition of FFAs (SP-FFAs) was also assessed.ResultsMedian impedance of all FFAs was 0.7 (5 FFAs with impedance 0.7); 17 FFAs with impedance < 0.7 were classified as low-impedance group; and, 13 FFAs with impedance > 0.7 were classified as high-impedance group. The median impedance of the mouse liver decreased from control (1.715), to SS (1.68), to NASH (1.635) (control versus NASH, p = 0.039 without significant differences for the other comparisons, p ≥ 0.1). Similarly, the median impedance of human liver showed decreased from control (1.825), to SS (1.788), to NASH (1.76) (control versus SS, p = 0.023; control versus NASH, p = 0.003; SS versus NASH, p = 0.050). The ratio of SP-FFAs between the low-impedance and high-impedance groups showed an increase in both mice and humans, with significant differences in mice (control versus SS, p < 0.001; control versus NASH, p < 0.001; SS versus NASH, p = 0.003), without significant differences in humans (p ≥ 0.671).ConclusionLower acoustic impedance based on the intrahepatic composition of FFAs may be characteristic of NASH. More... »

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http://scigraph.springernature.com/pub.10.1186/s41747-019-0137-y

DOI

http://dx.doi.org/10.1186/s41747-019-0137-y

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https://app.dimensions.ai/details/publication/pub.1124277943

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31975290


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