An MRI-guided HIFU-triggered wax-coated capsule for supertargeted drug release: a proof-of-concept study View Full Text


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Article Info

DATE

2019-12

AUTHORS

Simon Matoori, Maurizio Roveri, Peter Tiefenboeck, Annatina Romagna, Olha Wuerthinger, Orpheus Kolokythas, Johannes M. Froehlich

ABSTRACT

BACKGROUND: Externally controlling and monitoring drug release at a desired time and location is currently lacking in the gastrointestinal tract. The aim of the study was to develop a thermoresponsive wax-coated capsule and to trigger its release upon applying a magnetic resonance imaging (MRI)-guided high-intensity focused ultrasound (HIFU) pulse. METHODS: Capsules containing a lyophilised gadolinium-based contrast agent (GBCA) were coated with a 1:1 (mass/mass) mixture of lanolin and cetyl alcohol (melting point ≈43 °C) and exposed to simulated gastric and intestinal fluids (United States Pharmacopoeia) at 37 °C for 2 and 24 h, respectively. In a HIFU gel phantom, wax-coated capsules (n = 3) were tracked based on their T1- and T2-hypointensity by 1.5-T T1- and T2-weighted MRI pre- and post-exposure to an MRI-guided HIFU pulse. RESULTS: Lanolin/cetyl alcohol-coated capsules showed high resistance to simulated gastrointestinal fluids. In a gel phantom, an MRI-guided HIFU pulse punctured the wax coating, resulting in the hydration and release of the encapsulated lyophilised GBCA and yielding a T1-hyperintense signal close to the wax-coated capsule. CONCLUSION: We provide the proof-of-concept of applying a non-invasive MRI-guided HIFU pulse to actively induce the disintegration of the wax-coated capsule, and a method to monitor the release of the cargo via T1-weighted MRI based on the hydration of an encapsulated lyophilised GBCA. The wax-coated capsule platform enables temporally and spatially supertargeted drug release via the oral route and promises to address a currently unmet clinical need for personalised local therapy in gastrointestinal diseases such as inflammatory bowel diseases and cancer. More... »

PAGES

11

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s41747-019-0090-9

    DOI

    http://dx.doi.org/10.1186/s41747-019-0090-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112548112

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30838465


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