An alternative methodology for the determination of the radiochemical purity of 11C-methionine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Javier Giglio, Gabriela Rosas, Martín Basso, Andrea Boné, Eduardo Savio, Henry Engler

ABSTRACT

[11C]Methionine ([11C]MET) acts as an oncological radiopharmaceutical for measuring increased protein synthesis in brain tumours while having low uptake in normal brain an. In several Latin American countries, the official pharmacopoeias are the United States of America Pharmacopoeia (USP) and the European Pharmacopoeia (EP). For determination of the radiochemical purity, we used the monograph of L-methionine injection ([11C] methyl-methionine) of the EP (01/2002: 1617) because it is not available in the USP. We present herein an alternative methodology for the determination of the radiochemical purity, which allows the assessment of the [11C]CH3I and of the degradation radioactive products. The proposed method enabled a greater number of impurities to be determined than could be identified using the EP method. Under the conditions proposed by EP, it is not possible to determine the presence of [11C]CH3I or other lipophilic radiochemical impurities in the final product. For the determination of enantiomeric purity according to EP a chiral thin-layer chromatography (TLC) allows the determination of D and L methionine between the established limits. This is a slow method and presents an inadequate detection due to the decay of the sample. An alternative HPLC method was optimized. The proposed radiochemical purity method allowed the identification of a greater number of radiochemical impurities compared to the method proposed by the EP monograph in 16 min. The proposed enantiomeric purity method enables to perform the determination in a reasonable amount of time. A discussion concerning the limit of 95% radiochemical purity proposed by the EP is necessary. If more radiochemical impurities can be detected, it is more reasonable to propose a limit of 90% for this parameter to perform clinical examinations. More... »

PAGES

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s41181-018-0053-0

DOI

http://dx.doi.org/10.1186/s41181-018-0053-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110911780


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Analytical Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giglio", 
        "givenName": "Javier", 
        "id": "sg:person.01107161625.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107161625.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosas", 
        "givenName": "Gabriela", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basso", 
        "givenName": "Mart\u00edn", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bon\u00e9", 
        "givenName": "Andrea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Savio", 
        "givenName": "Eduardo", 
        "id": "sg:person.012621701763.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012621701763.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engler", 
        "givenName": "Henry", 
        "id": "sg:person.0601313723.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601313723.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0020-708x(76)90088-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004038673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0020-708x(76)90088-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004038673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10967-011-0995-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007792752", 
          "https://doi.org/10.1007/s10967-011-0995-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1344(199908)42:8<715::aid-jlcr224>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014026035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002590050597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017231697", 
          "https://doi.org/10.1007/s002590050597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(00)00604-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020401045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apradiso.2004.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030449783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apradiso.2006.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039468141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-005-0008-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040297773", 
          "https://doi.org/10.1007/s00259-005-0008-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-005-0008-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040297773", 
          "https://doi.org/10.1007/s00259-005-0008-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s1068162011020051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043746230", 
          "https://doi.org/10.1134/s1068162011020051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlcr.1483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047434213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2011.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050288899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apradiso.2006.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050457411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e3282ffb44c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050518653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e3282ffb44c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050518653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1023964712999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051108138", 
          "https://doi.org/10.1023/a:1023964712999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074808902", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077151736", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079647206", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s41181-017-0032-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092062649", 
          "https://doi.org/10.1186/s41181-017-0032-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "[11C]Methionine ([11C]MET) acts as an oncological radiopharmaceutical for measuring increased protein synthesis in brain tumours while having low uptake in normal brain an. In several Latin American countries, the official pharmacopoeias are the United States of America Pharmacopoeia (USP) and the European Pharmacopoeia (EP). For determination of the radiochemical purity, we used the monograph of L-methionine injection ([11C] methyl-methionine) of the EP (01/2002: 1617) because it is not available in the USP. We present herein an alternative methodology for the determination of the radiochemical purity, which allows the assessment of the [11C]CH3I and of the degradation radioactive products. The proposed method enabled a greater number of impurities to be determined than could be identified using the EP method. Under the conditions proposed by EP, it is not possible to determine the presence of [11C]CH3I or other lipophilic radiochemical impurities in the final product. For the determination of enantiomeric purity according to EP a chiral thin-layer chromatography (TLC) allows the determination of D and L methionine between the established limits. This is a slow method and presents an inadequate detection due to the decay of the sample. An alternative HPLC method was optimized. The proposed radiochemical purity method allowed the identification of a greater number of radiochemical impurities compared to the method proposed by the EP monograph in 16 min. The proposed enantiomeric purity method enables to perform the determination in a reasonable amount of time. A discussion concerning the limit of 95% radiochemical purity proposed by the EP is necessary. If more radiochemical impurities can be detected, it is more reasonable to propose a limit of 90% for this parameter to perform clinical examinations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s41181-018-0053-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1157056", 
        "issn": [
          "2365-421X"
        ], 
        "name": "EJNMMI Radiopharmacy and Chemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "An alternative methodology for the determination of the radiochemical purity of 11C-methionine", 
    "pagination": "15", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s41181-018-0053-0"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fe99264b46d0aa55063b25b5f5ed6616827db2939e53a0fcdef0279c07873863"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110911780"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s41181-018-0053-0", 
      "https://app.dimensions.ai/details/publication/pub.1110911780"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56179_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs41181-018-0053-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s41181-018-0053-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s41181-018-0053-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s41181-018-0053-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s41181-018-0053-0'


 

This table displays all metadata directly associated to this object as RDF triples.

158 TRIPLES      21 PREDICATES      45 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s41181-018-0053-0 schema:about anzsrc-for:03
2 anzsrc-for:0301
3 schema:author Nd0a86cbdd9e04d2eb7d8bab78f570198
4 schema:citation sg:pub.10.1007/s00259-005-0008-z
5 sg:pub.10.1007/s002590050597
6 sg:pub.10.1007/s10967-011-0995-0
7 sg:pub.10.1023/a:1023964712999
8 sg:pub.10.1134/s1068162011020051
9 sg:pub.10.1186/s41181-017-0032-x
10 https://app.dimensions.ai/details/publication/pub.1074808902
11 https://app.dimensions.ai/details/publication/pub.1077151736
12 https://app.dimensions.ai/details/publication/pub.1079647206
13 https://doi.org/10.1002/(sici)1099-1344(199908)42:8<715::aid-jlcr224>3.0.co;2-3
14 https://doi.org/10.1002/jlcr.1483
15 https://doi.org/10.1016/0020-708x(76)90088-0
16 https://doi.org/10.1016/j.apradiso.2004.07.006
17 https://doi.org/10.1016/j.apradiso.2006.03.001
18 https://doi.org/10.1016/j.apradiso.2006.10.011
19 https://doi.org/10.1016/j.nucmedbio.2011.10.016
20 https://doi.org/10.1016/s0360-3016(00)00604-0
21 https://doi.org/10.1097/mnm.0b013e3282ffb44c
22 schema:datePublished 2018-12
23 schema:datePublishedReg 2018-12-01
24 schema:description [11C]Methionine ([11C]MET) acts as an oncological radiopharmaceutical for measuring increased protein synthesis in brain tumours while having low uptake in normal brain an. In several Latin American countries, the official pharmacopoeias are the United States of America Pharmacopoeia (USP) and the European Pharmacopoeia (EP). For determination of the radiochemical purity, we used the monograph of L-methionine injection ([11C] methyl-methionine) of the EP (01/2002: 1617) because it is not available in the USP. We present herein an alternative methodology for the determination of the radiochemical purity, which allows the assessment of the [11C]CH3I and of the degradation radioactive products. The proposed method enabled a greater number of impurities to be determined than could be identified using the EP method. Under the conditions proposed by EP, it is not possible to determine the presence of [11C]CH3I or other lipophilic radiochemical impurities in the final product. For the determination of enantiomeric purity according to EP a chiral thin-layer chromatography (TLC) allows the determination of D and L methionine between the established limits. This is a slow method and presents an inadequate detection due to the decay of the sample. An alternative HPLC method was optimized. The proposed radiochemical purity method allowed the identification of a greater number of radiochemical impurities compared to the method proposed by the EP monograph in 16 min. The proposed enantiomeric purity method enables to perform the determination in a reasonable amount of time. A discussion concerning the limit of 95% radiochemical purity proposed by the EP is necessary. If more radiochemical impurities can be detected, it is more reasonable to propose a limit of 90% for this parameter to perform clinical examinations.
25 schema:genre research_article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N695aadedeafa4abaa362fe04732d71b1
29 Nb55ada5dec764380939f5501c767dd27
30 sg:journal.1157056
31 schema:name An alternative methodology for the determination of the radiochemical purity of 11C-methionine
32 schema:pagination 15
33 schema:productId N81c8d6d2eccd4587bbe7cd1436c41a39
34 Na8f18e60d4ae421586a597fd26543c6b
35 Nc26620770dbe44c18c4956be2d64b9f3
36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110911780
37 https://doi.org/10.1186/s41181-018-0053-0
38 schema:sdDatePublished 2019-04-15T09:20
39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
40 schema:sdPublisher N783e4d1d62d84e43bf6dd0e430694560
41 schema:url https://link.springer.com/10.1186%2Fs41181-018-0053-0
42 sgo:license sg:explorer/license/
43 sgo:sdDataset articles
44 rdf:type schema:ScholarlyArticle
45 N1add0c1c5e3d43c69cb37d53d58d869c rdf:first sg:person.0601313723.59
46 rdf:rest rdf:nil
47 N31e9db8d54734dd1a9827c7e10377e98 schema:name Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay
48 rdf:type schema:Organization
49 N3c2da2e4c80c4c0d8b7fbc945a6c2bf3 rdf:first N8c4aa10820424c50abb5e9e1673d125c
50 rdf:rest N40436c797d6e442da34b69ae27793e53
51 N40436c797d6e442da34b69ae27793e53 rdf:first sg:person.012621701763.82
52 rdf:rest N1add0c1c5e3d43c69cb37d53d58d869c
53 N41a5221175cf4fed820101528bd4e124 rdf:first Na05d280d9a4b4b688ce02fccf3ad6f53
54 rdf:rest N3c2da2e4c80c4c0d8b7fbc945a6c2bf3
55 N479fd6ea430e42a5bf1158f952587a92 schema:name Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay
56 rdf:type schema:Organization
57 N4f00aa67e5094c29a2cbda0c33485082 schema:affiliation N8de3b083eb8145f9b548424ad004f775
58 schema:familyName Rosas
59 schema:givenName Gabriela
60 rdf:type schema:Person
61 N695aadedeafa4abaa362fe04732d71b1 schema:issueNumber 1
62 rdf:type schema:PublicationIssue
63 N6a5e3c35ba234674ac0ff9ebb6826d41 schema:name Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay
64 rdf:type schema:Organization
65 N7064ad57250547ccb941b841837dad7f schema:name Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay
66 rdf:type schema:Organization
67 N783e4d1d62d84e43bf6dd0e430694560 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N7f9ad8c08bdc4f57a6c06d5e2073c019 rdf:first N4f00aa67e5094c29a2cbda0c33485082
70 rdf:rest N41a5221175cf4fed820101528bd4e124
71 N81c8d6d2eccd4587bbe7cd1436c41a39 schema:name dimensions_id
72 schema:value pub.1110911780
73 rdf:type schema:PropertyValue
74 N8c4aa10820424c50abb5e9e1673d125c schema:affiliation Ne8c9544a5e684ccca23adc497f45febf
75 schema:familyName Boné
76 schema:givenName Andrea
77 rdf:type schema:Person
78 N8de3b083eb8145f9b548424ad004f775 schema:name Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay
79 rdf:type schema:Organization
80 Na05d280d9a4b4b688ce02fccf3ad6f53 schema:affiliation N479fd6ea430e42a5bf1158f952587a92
81 schema:familyName Basso
82 schema:givenName Martín
83 rdf:type schema:Person
84 Na8f18e60d4ae421586a597fd26543c6b schema:name readcube_id
85 schema:value fe99264b46d0aa55063b25b5f5ed6616827db2939e53a0fcdef0279c07873863
86 rdf:type schema:PropertyValue
87 Nb55ada5dec764380939f5501c767dd27 schema:volumeNumber 3
88 rdf:type schema:PublicationVolume
89 Nc26620770dbe44c18c4956be2d64b9f3 schema:name doi
90 schema:value 10.1186/s41181-018-0053-0
91 rdf:type schema:PropertyValue
92 Nd0a86cbdd9e04d2eb7d8bab78f570198 rdf:first sg:person.01107161625.04
93 rdf:rest N7f9ad8c08bdc4f57a6c06d5e2073c019
94 Ne8c9544a5e684ccca23adc497f45febf schema:name Uruguayan Centre of Molecular Imaging (CUDIM), Ricaldoni 2010, 11600, Montevideo, Uruguay
95 rdf:type schema:Organization
96 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
97 schema:name Chemical Sciences
98 rdf:type schema:DefinedTerm
99 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
100 schema:name Analytical Chemistry
101 rdf:type schema:DefinedTerm
102 sg:journal.1157056 schema:issn 2365-421X
103 schema:name EJNMMI Radiopharmacy and Chemistry
104 rdf:type schema:Periodical
105 sg:person.01107161625.04 schema:affiliation N7064ad57250547ccb941b841837dad7f
106 schema:familyName Giglio
107 schema:givenName Javier
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107161625.04
109 rdf:type schema:Person
110 sg:person.012621701763.82 schema:affiliation N6a5e3c35ba234674ac0ff9ebb6826d41
111 schema:familyName Savio
112 schema:givenName Eduardo
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012621701763.82
114 rdf:type schema:Person
115 sg:person.0601313723.59 schema:affiliation N31e9db8d54734dd1a9827c7e10377e98
116 schema:familyName Engler
117 schema:givenName Henry
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601313723.59
119 rdf:type schema:Person
120 sg:pub.10.1007/s00259-005-0008-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1040297773
121 https://doi.org/10.1007/s00259-005-0008-z
122 rdf:type schema:CreativeWork
123 sg:pub.10.1007/s002590050597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017231697
124 https://doi.org/10.1007/s002590050597
125 rdf:type schema:CreativeWork
126 sg:pub.10.1007/s10967-011-0995-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007792752
127 https://doi.org/10.1007/s10967-011-0995-0
128 rdf:type schema:CreativeWork
129 sg:pub.10.1023/a:1023964712999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051108138
130 https://doi.org/10.1023/a:1023964712999
131 rdf:type schema:CreativeWork
132 sg:pub.10.1134/s1068162011020051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043746230
133 https://doi.org/10.1134/s1068162011020051
134 rdf:type schema:CreativeWork
135 sg:pub.10.1186/s41181-017-0032-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1092062649
136 https://doi.org/10.1186/s41181-017-0032-x
137 rdf:type schema:CreativeWork
138 https://app.dimensions.ai/details/publication/pub.1074808902 schema:CreativeWork
139 https://app.dimensions.ai/details/publication/pub.1077151736 schema:CreativeWork
140 https://app.dimensions.ai/details/publication/pub.1079647206 schema:CreativeWork
141 https://doi.org/10.1002/(sici)1099-1344(199908)42:8<715::aid-jlcr224>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014026035
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1002/jlcr.1483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047434213
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1016/0020-708x(76)90088-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004038673
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/j.apradiso.2004.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030449783
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/j.apradiso.2006.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039468141
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/j.apradiso.2006.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050457411
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.nucmedbio.2011.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050288899
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/s0360-3016(00)00604-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020401045
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1097/mnm.0b013e3282ffb44c schema:sameAs https://app.dimensions.ai/details/publication/pub.1050518653
158 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...