Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Lukas O. Dialer, Andreas Jodal, Roger Schibli, Simon M. Ametamey, Martin Béhé

ABSTRACT

Background: Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an 18F-labeled silicon containing exendin-4 peptide (18F-2) and to evaluate its in vitro and in vivo behavior in CHL-GLP-1 receptor positive tumor-bearing mice. 18F-labeled silicon containing exendin-4 peptide (18F-2) was prepared via one-step nucleophilic substitution of a silane precursor with 18F-fluoride in the presence of acetic acid and K222. 18F-2 was then administered to tumor-bearing mice for PET imaging and ex vivo biodistribution experiments. Results: 18F-2 was produced in a radiochemical yield (decay corrected) of 1.5% and a molar activity of max. 16 GBq/μmol. The GLP-1R positive tumors were clearly visualized by PET imaging. Biodistribution studies showed reduced uptake of 18F-2 in the kidneys compared to radiometal labeled exendin-4 derivatives. The radiotracer showed specific tumour uptake which remained steady over 2 h. Conclusions: This exendin-4 analogue, 18F-2, is a potential probe for imaging GLP-1R positive tumors. More... »

PAGES

1

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s41181-017-0036-6

DOI

http://dx.doi.org/10.1186/s41181-017-0036-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100169580

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29503858


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Swiss Federal Institute of Technology in Zurich", 
          "id": "https://www.grid.ac/institutes/grid.5801.c", 
          "name": [
            "Center for Radiopharmaceutical Sciences (CRS) of ETH, PSI and USZ, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH H\u00f6nggerberg, ETH Zurich, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dialer", 
        "givenName": "Lukas O.", 
        "id": "sg:person.01253723361.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253723361.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Scherrer Institute", 
          "id": "https://www.grid.ac/institutes/grid.5991.4", 
          "name": [
            "Center for Radiopharmaceutical Sciences (CRS), Research Department Biology and Chemistry, Paul Scherrer Institut, CH-5232, Villigen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jodal", 
        "givenName": "Andreas", 
        "id": "sg:person.01072377306.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072377306.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Scherrer Institute", 
          "id": "https://www.grid.ac/institutes/grid.5991.4", 
          "name": [
            "Center for Radiopharmaceutical Sciences (CRS) of ETH, PSI and USZ, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH H\u00f6nggerberg, ETH Zurich, Zurich, Switzerland", 
            "Center for Radiopharmaceutical Sciences (CRS), Research Department Biology and Chemistry, Paul Scherrer Institut, CH-5232, Villigen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schibli", 
        "givenName": "Roger", 
        "id": "sg:person.0756753557.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756753557.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swiss Federal Institute of Technology in Zurich", 
          "id": "https://www.grid.ac/institutes/grid.5801.c", 
          "name": [
            "Center for Radiopharmaceutical Sciences (CRS) of ETH, PSI and USZ, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH H\u00f6nggerberg, ETH Zurich, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ametamey", 
        "givenName": "Simon M.", 
        "id": "sg:person.0755403164.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755403164.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Scherrer Institute", 
          "id": "https://www.grid.ac/institutes/grid.5991.4", 
          "name": [
            "Center for Radiopharmaceutical Sciences (CRS), Research Department Biology and Chemistry, Paul Scherrer Institut, CH-5232, Villigen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e9h\u00e9", 
        "givenName": "Martin", 
        "id": "sg:person.01143734226.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143734226.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2967/jnumed.110.085142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000527103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0950-3528(96)90017-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001644211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suc.2004.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002301973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-003-1184-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006099585", 
          "https://doi.org/10.1007/s00259-003-1184-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-003-1184-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006099585", 
          "https://doi.org/10.1007/s00259-003-1184-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199504273321707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012552714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200705854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013440923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13550-016-0243-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013879093", 
          "https://doi.org/10.1186/s13550-016-0243-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13550-016-0243-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013879093", 
          "https://doi.org/10.1186/s13550-016-0243-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1363-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015567221", 
          "https://doi.org/10.1007/s00259-009-1363-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1363-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015567221", 
          "https://doi.org/10.1007/s00259-009-1363-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ejic.201100142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016277166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e3283614187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016361408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e3283614187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016361408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.05.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016467602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/384508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016527057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fon.09.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018051303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.201003234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019752639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.201003234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019752639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/1061186x.2015.1020808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019876174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020692698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.5280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020692698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07435800.2010.525085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022392101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2004.053314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022672146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp200141x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023900681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp200141x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023900681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-016-3592-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024840582", 
          "https://doi.org/10.1007/s00259-016-3592-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-016-3592-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024840582", 
          "https://doi.org/10.1007/s00259-016-3592-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(94)00553-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026648151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpg.2005.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026864829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpg.2005.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026864829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-0115(94)90158-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028028591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp5001857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028147620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/thno.5276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030700368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.110.074914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033749757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fendo.2012.00158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034219056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc200660z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035815582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/open.201200014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036637528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.109694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038296331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(99)90090-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040982524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2016.01.184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041238441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200600795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043720825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0123443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043890428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0123443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043890428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beem.2004.11.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044751465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-011-1980-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046177228", 
          "https://doi.org/10.1007/s00259-011-1980-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ddr.1195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051817622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc0802045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052047724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2011.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052462711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.regpep.2006.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053443027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc100316c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055154442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc100316c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055154442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc200525x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055154756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc700195y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055155294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc700195y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055155294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc800157h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055155520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc800157h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055155520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076805174", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077330948", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078171200", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083315763", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Background: Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an 18F-labeled silicon containing exendin-4 peptide (18F-2) and to evaluate its in vitro and in vivo behavior in CHL-GLP-1 receptor positive tumor-bearing mice. 18F-labeled silicon containing exendin-4 peptide (18F-2) was prepared via one-step nucleophilic substitution of a silane precursor with 18F-fluoride in the presence of acetic acid and K222. 18F-2 was then administered to tumor-bearing mice for PET imaging and ex vivo biodistribution experiments.\nResults: 18F-2 was produced in a radiochemical yield (decay corrected) of 1.5% and a molar activity of max. 16\u00a0GBq/\u03bcmol. The GLP-1R positive tumors were clearly visualized by PET imaging. Biodistribution studies showed reduced uptake of 18F-2 in the kidneys compared to radiometal labeled exendin-4 derivatives. The radiotracer showed specific tumour uptake which remained steady over 2\u00a0h.\nConclusions: This exendin-4 analogue, 18F-2, is a potential probe for imaging GLP-1R positive tumors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s41181-017-0036-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3777409", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3800058", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1157056", 
        "issn": [
          "2365-421X"
        ], 
        "name": "EJNMMI Radiopharmacy and Chemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Radiosynthesis and evaluation of an 18F\u2013labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma", 
    "pagination": "1", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "06d9f035d12d4525ad8e86177666415b28301a314355d12a783802ab0494f5e2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29503858"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101714628"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s41181-017-0036-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100169580"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s41181-017-0036-6", 
      "https://app.dimensions.ai/details/publication/pub.1100169580"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000484.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s41181-017-0036-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s41181-017-0036-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s41181-017-0036-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s41181-017-0036-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s41181-017-0036-6'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s41181-017-0036-6 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author Na0938dae4f90401785db131d86cc2be6
4 schema:citation sg:pub.10.1007/s00259-003-1184-3
5 sg:pub.10.1007/s00259-009-1363-y
6 sg:pub.10.1007/s00259-011-1980-0
7 sg:pub.10.1007/s00259-016-3592-1
8 sg:pub.10.1186/s13550-016-0243-2
9 https://app.dimensions.ai/details/publication/pub.1076805174
10 https://app.dimensions.ai/details/publication/pub.1077330948
11 https://app.dimensions.ai/details/publication/pub.1078171200
12 https://app.dimensions.ai/details/publication/pub.1083315763
13 https://doi.org/10.1002/anie.200600795
14 https://doi.org/10.1002/anie.200705854
15 https://doi.org/10.1002/bjs.5280
16 https://doi.org/10.1002/chem.201003234
17 https://doi.org/10.1002/ddr.1195
18 https://doi.org/10.1002/ejic.201100142
19 https://doi.org/10.1002/open.201200014
20 https://doi.org/10.1016/0014-5793(94)00553-2
21 https://doi.org/10.1016/0167-0115(94)90158-9
22 https://doi.org/10.1016/j.bbrc.2016.01.184
23 https://doi.org/10.1016/j.beem.2004.11.013
24 https://doi.org/10.1016/j.bpg.2005.05.008
25 https://doi.org/10.1016/j.nucmedbio.2011.07.011
26 https://doi.org/10.1016/j.regpep.2006.07.005
27 https://doi.org/10.1016/j.suc.2004.02.004
28 https://doi.org/10.1016/s0026-0495(99)90090-2
29 https://doi.org/10.1016/s0950-3528(96)90017-2
30 https://doi.org/10.1021/bc100316c
31 https://doi.org/10.1021/bc200525x
32 https://doi.org/10.1021/bc200660z
33 https://doi.org/10.1021/bc700195y
34 https://doi.org/10.1021/bc800157h
35 https://doi.org/10.1021/mp200141x
36 https://doi.org/10.1021/mp5001857
37 https://doi.org/10.1053/j.gastro.2008.05.047
38 https://doi.org/10.1056/nejm199504273321707
39 https://doi.org/10.1056/nejmc0802045
40 https://doi.org/10.1097/mnm.0b013e3283614187
41 https://doi.org/10.1136/gut.2004.053314
42 https://doi.org/10.1155/2013/384508
43 https://doi.org/10.1371/journal.pone.0123443
44 https://doi.org/10.2217/fon.09.165
45 https://doi.org/10.2967/jnumed.110.074914
46 https://doi.org/10.2967/jnumed.110.085142
47 https://doi.org/10.2967/jnumed.112.109694
48 https://doi.org/10.3109/07435800.2010.525085
49 https://doi.org/10.3109/1061186x.2015.1020808
50 https://doi.org/10.3389/fendo.2012.00158
51 https://doi.org/10.7150/thno.5276
52 schema:datePublished 2018-12
53 schema:datePublishedReg 2018-12-01
54 schema:description Background: Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an 18F-labeled silicon containing exendin-4 peptide (18F-2) and to evaluate its in vitro and in vivo behavior in CHL-GLP-1 receptor positive tumor-bearing mice. 18F-labeled silicon containing exendin-4 peptide (18F-2) was prepared via one-step nucleophilic substitution of a silane precursor with 18F-fluoride in the presence of acetic acid and K222. 18F-2 was then administered to tumor-bearing mice for PET imaging and ex vivo biodistribution experiments. Results: 18F-2 was produced in a radiochemical yield (decay corrected) of 1.5% and a molar activity of max. 16 GBq/μmol. The GLP-1R positive tumors were clearly visualized by PET imaging. Biodistribution studies showed reduced uptake of 18F-2 in the kidneys compared to radiometal labeled exendin-4 derivatives. The radiotracer showed specific tumour uptake which remained steady over 2 h. Conclusions: This exendin-4 analogue, 18F-2, is a potential probe for imaging GLP-1R positive tumors.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N792eb19469ee43aea27e3176d12e72e5
59 Nefe7d65c45dd475e874deca50610261c
60 sg:journal.1157056
61 schema:name Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma
62 schema:pagination 1
63 schema:productId N43fd2ab6108d440fb7de1a4ea06c549f
64 N4d244ee9e59c49ee8a3f47641250735b
65 Nb9c704a5bbfe4edf8b9a1d2ea5667e56
66 Ncf8f7e1ed23d43c39be9172acf3d1f68
67 Ne107611536344b8cb03c3f96659892ae
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100169580
69 https://doi.org/10.1186/s41181-017-0036-6
70 schema:sdDatePublished 2019-04-10T14:02
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Nfc7b62df5975464e9875f586edc7675a
73 schema:url http://link.springer.com/10.1186/s41181-017-0036-6
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N1692947144f4458293f25618680fac2c rdf:first sg:person.0756753557.77
78 rdf:rest Nf4777ae8adb94e3e884aa723a6c1566c
79 N43fd2ab6108d440fb7de1a4ea06c549f schema:name dimensions_id
80 schema:value pub.1100169580
81 rdf:type schema:PropertyValue
82 N4d244ee9e59c49ee8a3f47641250735b schema:name nlm_unique_id
83 schema:value 101714628
84 rdf:type schema:PropertyValue
85 N6cfdaea43e7543d9851c274e3ac15aaa rdf:first sg:person.01072377306.04
86 rdf:rest N1692947144f4458293f25618680fac2c
87 N792eb19469ee43aea27e3176d12e72e5 schema:issueNumber 1
88 rdf:type schema:PublicationIssue
89 Na0938dae4f90401785db131d86cc2be6 rdf:first sg:person.01253723361.17
90 rdf:rest N6cfdaea43e7543d9851c274e3ac15aaa
91 Nb9c704a5bbfe4edf8b9a1d2ea5667e56 schema:name doi
92 schema:value 10.1186/s41181-017-0036-6
93 rdf:type schema:PropertyValue
94 Ncf8f7e1ed23d43c39be9172acf3d1f68 schema:name readcube_id
95 schema:value 06d9f035d12d4525ad8e86177666415b28301a314355d12a783802ab0494f5e2
96 rdf:type schema:PropertyValue
97 Nd00df5758b894ae1b5dcc59cc053864d rdf:first sg:person.01143734226.69
98 rdf:rest rdf:nil
99 Ne107611536344b8cb03c3f96659892ae schema:name pubmed_id
100 schema:value 29503858
101 rdf:type schema:PropertyValue
102 Nefe7d65c45dd475e874deca50610261c schema:volumeNumber 3
103 rdf:type schema:PublicationVolume
104 Nf4777ae8adb94e3e884aa723a6c1566c rdf:first sg:person.0755403164.88
105 rdf:rest Nd00df5758b894ae1b5dcc59cc053864d
106 Nfc7b62df5975464e9875f586edc7675a schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
112 schema:name Pharmacology and Pharmaceutical Sciences
113 rdf:type schema:DefinedTerm
114 sg:grant.3777409 http://pending.schema.org/fundedItem sg:pub.10.1186/s41181-017-0036-6
115 rdf:type schema:MonetaryGrant
116 sg:grant.3800058 http://pending.schema.org/fundedItem sg:pub.10.1186/s41181-017-0036-6
117 rdf:type schema:MonetaryGrant
118 sg:journal.1157056 schema:issn 2365-421X
119 schema:name EJNMMI Radiopharmacy and Chemistry
120 rdf:type schema:Periodical
121 sg:person.01072377306.04 schema:affiliation https://www.grid.ac/institutes/grid.5991.4
122 schema:familyName Jodal
123 schema:givenName Andreas
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072377306.04
125 rdf:type schema:Person
126 sg:person.01143734226.69 schema:affiliation https://www.grid.ac/institutes/grid.5991.4
127 schema:familyName Béhé
128 schema:givenName Martin
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143734226.69
130 rdf:type schema:Person
131 sg:person.01253723361.17 schema:affiliation https://www.grid.ac/institutes/grid.5801.c
132 schema:familyName Dialer
133 schema:givenName Lukas O.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253723361.17
135 rdf:type schema:Person
136 sg:person.0755403164.88 schema:affiliation https://www.grid.ac/institutes/grid.5801.c
137 schema:familyName Ametamey
138 schema:givenName Simon M.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755403164.88
140 rdf:type schema:Person
141 sg:person.0756753557.77 schema:affiliation https://www.grid.ac/institutes/grid.5991.4
142 schema:familyName Schibli
143 schema:givenName Roger
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756753557.77
145 rdf:type schema:Person
146 sg:pub.10.1007/s00259-003-1184-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006099585
147 https://doi.org/10.1007/s00259-003-1184-3
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s00259-009-1363-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015567221
150 https://doi.org/10.1007/s00259-009-1363-y
151 rdf:type schema:CreativeWork
152 sg:pub.10.1007/s00259-011-1980-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046177228
153 https://doi.org/10.1007/s00259-011-1980-0
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s00259-016-3592-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024840582
156 https://doi.org/10.1007/s00259-016-3592-1
157 rdf:type schema:CreativeWork
158 sg:pub.10.1186/s13550-016-0243-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013879093
159 https://doi.org/10.1186/s13550-016-0243-2
160 rdf:type schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1076805174 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1077330948 schema:CreativeWork
163 https://app.dimensions.ai/details/publication/pub.1078171200 schema:CreativeWork
164 https://app.dimensions.ai/details/publication/pub.1083315763 schema:CreativeWork
165 https://doi.org/10.1002/anie.200600795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043720825
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1002/anie.200705854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013440923
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1002/bjs.5280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020692698
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1002/chem.201003234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019752639
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1002/ddr.1195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051817622
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/ejic.201100142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016277166
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/open.201200014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036637528
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0014-5793(94)00553-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026648151
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0167-0115(94)90158-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028028591
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.bbrc.2016.01.184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041238441
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.beem.2004.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044751465
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.bpg.2005.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026864829
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.nucmedbio.2011.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052462711
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.regpep.2006.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053443027
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.suc.2004.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002301973
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0026-0495(99)90090-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040982524
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0950-3528(96)90017-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001644211
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1021/bc100316c schema:sameAs https://app.dimensions.ai/details/publication/pub.1055154442
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1021/bc200525x schema:sameAs https://app.dimensions.ai/details/publication/pub.1055154756
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1021/bc200660z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035815582
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1021/bc700195y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055155294
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1021/bc800157h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055155520
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1021/mp200141x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023900681
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1021/mp5001857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028147620
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1053/j.gastro.2008.05.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016467602
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1056/nejm199504273321707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012552714
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1056/nejmc0802045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052047724
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1097/mnm.0b013e3283614187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016361408
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1136/gut.2004.053314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022672146
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1155/2013/384508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016527057
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1371/journal.pone.0123443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043890428
226 rdf:type schema:CreativeWork
227 https://doi.org/10.2217/fon.09.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018051303
228 rdf:type schema:CreativeWork
229 https://doi.org/10.2967/jnumed.110.074914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033749757
230 rdf:type schema:CreativeWork
231 https://doi.org/10.2967/jnumed.110.085142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000527103
232 rdf:type schema:CreativeWork
233 https://doi.org/10.2967/jnumed.112.109694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038296331
234 rdf:type schema:CreativeWork
235 https://doi.org/10.3109/07435800.2010.525085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022392101
236 rdf:type schema:CreativeWork
237 https://doi.org/10.3109/1061186x.2015.1020808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019876174
238 rdf:type schema:CreativeWork
239 https://doi.org/10.3389/fendo.2012.00158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034219056
240 rdf:type schema:CreativeWork
241 https://doi.org/10.7150/thno.5276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030700368
242 rdf:type schema:CreativeWork
243 https://www.grid.ac/institutes/grid.5801.c schema:alternateName Swiss Federal Institute of Technology in Zurich
244 schema:name Center for Radiopharmaceutical Sciences (CRS) of ETH, PSI and USZ, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Hönggerberg, ETH Zurich, Zurich, Switzerland
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.5991.4 schema:alternateName Paul Scherrer Institute
247 schema:name Center for Radiopharmaceutical Sciences (CRS) of ETH, PSI and USZ, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Hönggerberg, ETH Zurich, Zurich, Switzerland
248 Center for Radiopharmaceutical Sciences (CRS), Research Department Biology and Chemistry, Paul Scherrer Institut, CH-5232, Villigen, Switzerland
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...