Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Boon-Peng Hoh, Thuhairah Abdul Rahman, Khalid Yusoff

ABSTRACT

Prevalence of hypertension (HTN) varies substantially across different populations. HTN is not only common - affecting at least one third of the world's adult population - but is also the most important driver for cardiovascular diseases. Yet up to a third of hypertensive patients are resistant to therapy, contributed by secondary hypertension but more commonly the hitherto inability to precisely predict response to specific antihypertensive agents. Population and individual genomics information could be useful in guiding the selection and predicting the response to treatment - an approach known as precision medicine. However this cannot be achieved without the knowledge of genetic variations that influence blood pressure (BP). A number of evolutionary factors including population demographics and forces of natural selection may be involved. This article explores some ideas on how natural selection influences BP regulation in ethnically and geographically diverse populations that could lead to them being susceptible to HTN. We explore how such evolutionary factors could impact the implementation of precision medicine in HTN. Finally, in order to ensure the success of precision medicine in HTN, we call for more initiatives to understand the genetic architecture within and between diverse populations with ancestry from different parts of the world, and to precisely classify the intermediate phenotypes of HTN. More... »

PAGES

1

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s41065-019-0080-1

DOI

http://dx.doi.org/10.1186/s41065-019-0080-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111225237

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30636949


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Evolution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetics, Population", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precision Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Selection, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shanghai Institutes for Biological Sciences", 
          "id": "https://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Faculty of Medicine and Health Sciences, UCSI University, Cheras, 56000, Kuala Lumpur, Malaysia", 
            "Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, CAS, 200031, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoh", 
        "givenName": "Boon-Peng", 
        "id": "sg:person.01104105532.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104105532.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Teknologi MARA", 
          "id": "https://www.grid.ac/institutes/grid.412259.9", 
          "name": [
            "Clinical Pathology Diagnostic Centre Research Laboratory, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abdul Rahman", 
        "givenName": "Thuhairah", 
        "id": "sg:person.0634563630.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634563630.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UCSI University", 
          "id": "https://www.grid.ac/institutes/grid.444472.5", 
          "name": [
            "Faculty of Medicine and Health Sciences, UCSI University, Cheras, 56000, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yusoff", 
        "givenName": "Khalid", 
        "id": "sg:person.01317076544.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317076544.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.coi.2014.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000468965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.113.01423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001520293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.113.01423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001520293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.113.01423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001520293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1525/tran.2005.13.2.119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001551424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jhg.2012.147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003619200", 
          "https://doi.org/10.1038/jhg.2012.147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0b013e318245fac5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003821452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-007-0004-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004986735", 
          "https://doi.org/10.1007/s11906-007-0004-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-3623(83)90123-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005397306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-3623(83)90123-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005397306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.12.6438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005834896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/icb/39.2.189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006460235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0000000000001099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006529620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0000000000001099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006529620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/pme.12.100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006676726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2012.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006929655", 
          "https://doi.org/10.1038/hr.2012.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.308763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007142180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.308763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007142180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.308763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007142180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjh.0000173515.83481.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007407600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjh.0000173515.83481.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007407600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjh.0000173515.83481.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007407600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjh.0000173515.83481.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007407600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/578578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009568730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2005.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009864462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fca.11.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010911979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10641963.2015.1116543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011760571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10641963.2015.1116543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011760571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e318045bedb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011966601", 
          "https://doi.org/10.1203/pdr.0b013e318045bedb"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e318045bedb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011966601", 
          "https://doi.org/10.1203/pdr.0b013e318045bedb"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.20.6.788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012580794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddp135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015689209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-8-s1-s3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016002729", 
          "https://doi.org/10.1186/1471-2350-8-s1-s3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.162.9.1051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018001914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018961918", 
          "https://doi.org/10.1038/nm.2541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-017-0699-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020258166", 
          "https://doi.org/10.1007/s11906-017-0699-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-017-0699-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020258166", 
          "https://doi.org/10.1007/s11906-017-0699-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-014-0461-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020600969", 
          "https://doi.org/10.1007/s11906-014-0461-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2012.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021045787", 
          "https://doi.org/10.1038/hr.2012.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-9-103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022599985", 
          "https://doi.org/10.1186/1471-2350-9-103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0039760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022634900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328348fd95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023276684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328348fd95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023276684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-014-1525-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024693724", 
          "https://doi.org/10.1007/s00439-014-1525-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-014-1525-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024693724", 
          "https://doi.org/10.1007/s00439-014-1525-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027360374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12889-015-1384-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027861245", 
          "https://doi.org/10.1186/s12889-015-1384-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12889-015-1384-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027861245", 
          "https://doi.org/10.1186/s12889-015-1384-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00241-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029883534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/era.10.226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030015126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/gfu275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032413900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e32835e2a71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034261557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e32835e2a71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034261557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198501313120505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036950262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0010082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036971774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328332031a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038383935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328332031a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038383935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328332031a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038383935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328338cd36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038831956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328338cd36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038831956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328338cd36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038831956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.110.012237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038835624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2015.176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038927978", 
          "https://doi.org/10.1038/nrneph.2015.176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00421-014-2823-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039286526", 
          "https://doi.org/10.1007/s00421-014-2823-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-014-1459-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039298505", 
          "https://doi.org/10.1007/s00439-014-1459-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-014-1459-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039298505", 
          "https://doi.org/10.1007/s00439-014-1459-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000255165.84684.9d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041842377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000255165.84684.9d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041842377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0055686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041981030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042508938", 
          "https://doi.org/10.1038/nm.3384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042830889", 
          "https://doi.org/10.1038/nrg1967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042830889", 
          "https://doi.org/10.1038/nrg1967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/07435809609043762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044593823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-010-0167-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045147529", 
          "https://doi.org/10.1007/s11906-010-0167-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-010-0167-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045147529", 
          "https://doi.org/10.1007/s11906-010-0167-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.1029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045397210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3283410390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045472303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3283410390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045472303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3283410390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045472303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.114.03132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047424955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.114.03132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047424955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048198889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.111.189100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048877033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.111.189100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048877033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fcimb.2014.00121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050827958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2010.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052170259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.2009.29028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052323469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2010.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054752116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/420793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058711781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/426406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058714690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00149831-200606000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060315602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00149831-200606000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060315602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00149831-200606000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060315602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00149831-200606000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060315602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00149831-200606000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060315602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjr.0000192744.88854.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060330141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.hjr.0000192744.88854.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060330141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3283333532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3283333532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3283333532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3283333532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3283333532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2063193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062520432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.27.1.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063339221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074248255", 
          "https://doi.org/10.1038/ng.3768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074248255", 
          "https://doi.org/10.1038/ng.3768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078325380", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.08252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083811765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.08252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083811765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00026.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083841702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2017.21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129783", 
          "https://doi.org/10.1038/nrneph.2017.21"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.08632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084235258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.08632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084235258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.117.08740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084235273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.117.08740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084235273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.117.09306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085765199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.117.09306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085765199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pharmtox-010617-052446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091998473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pharmtox-010617-052446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091998473"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Prevalence of hypertension (HTN) varies substantially across different populations. HTN is not only common - affecting at least one third of the world's adult population - but is also the most important driver for cardiovascular diseases. Yet up to a third of hypertensive patients are resistant to therapy, contributed by secondary hypertension but more commonly the hitherto inability to precisely predict response to specific antihypertensive agents. Population and individual genomics information could be useful in guiding the selection and predicting the response to treatment - an approach known as precision medicine. However this cannot be achieved without the knowledge of genetic variations that influence\u00a0blood pressure (BP). A number of evolutionary factors including population demographics and forces of natural selection may be involved. This article explores some ideas on how natural selection influences BP regulation in ethnically and geographically diverse populations that could lead to them being susceptible to HTN. We explore how such evolutionary factors could impact the implementation of precision medicine in HTN. Finally, in order to ensure the success of precision medicine in HTN, we call for more initiatives to understand the genetic architecture within and between diverse populations with ancestry from different parts of the world, and to precisely classify the intermediate phenotypes of HTN.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s41065-019-0080-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017631", 
        "issn": [
          "0018-0661", 
          "1601-5223"
        ], 
        "name": "Hereditas", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "156"
      }
    ], 
    "name": "Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension", 
    "pagination": "1", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bb87b6fe0024fa4dd9c00c0a6d23e3c6586233a058993e5cdb5bee14aa629ec9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30636949"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0374654"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s41065-019-0080-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111225237"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s41065-019-0080-1", 
      "https://app.dimensions.ai/details/publication/pub.1111225237"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60367_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs41065-019-0080-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s41065-019-0080-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s41065-019-0080-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s41065-019-0080-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s41065-019-0080-1'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      114 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s41065-019-0080-1 schema:about N091213e27f85403eb3ed13cfbb0e6640
2 N0aeb8736c94640139ee91cf7183c708f
3 N14e57681275b46e6902a4843b8a238bb
4 N4c976ad1c5f2471d840fb004fa067056
5 N5faeeef6195c4148b7b37a232c71d9f3
6 N66ca1d5b08d1425eb75d93d11ce98e96
7 N7f1856bfe05e40dea418404a8c6733e1
8 N81d62462c7be48cb8e7654a352abaf75
9 Nef20105e96dc4c339851fa70b06b6c54
10 anzsrc-for:06
11 anzsrc-for:0604
12 schema:author N9dac12a81b364cd89af916b280a59f0c
13 schema:citation sg:pub.10.1007/s00421-014-2823-z
14 sg:pub.10.1007/s00439-014-1459-8
15 sg:pub.10.1007/s00439-014-1525-2
16 sg:pub.10.1007/s11906-007-0004-8
17 sg:pub.10.1007/s11906-010-0167-6
18 sg:pub.10.1007/s11906-014-0461-9
19 sg:pub.10.1007/s11906-017-0699-0
20 sg:pub.10.1038/hr.2012.43
21 sg:pub.10.1038/hr.2012.44
22 sg:pub.10.1038/jhg.2012.147
23 sg:pub.10.1038/ng.3768
24 sg:pub.10.1038/nm.2541
25 sg:pub.10.1038/nm.3384
26 sg:pub.10.1038/nrg1967
27 sg:pub.10.1038/nrneph.2015.176
28 sg:pub.10.1038/nrneph.2017.21
29 sg:pub.10.1186/1471-2350-8-s1-s3
30 sg:pub.10.1186/1471-2350-9-103
31 sg:pub.10.1186/s12889-015-1384-3
32 sg:pub.10.1203/pdr.0b013e318045bedb
33 https://app.dimensions.ai/details/publication/pub.1078325380
34 https://doi.org/10.1001/archinte.162.9.1051
35 https://doi.org/10.1002/gepi.1029
36 https://doi.org/10.1016/0306-3623(83)90123-4
37 https://doi.org/10.1016/j.bbadis.2010.02.011
38 https://doi.org/10.1016/j.coi.2014.06.004
39 https://doi.org/10.1016/j.tig.2005.08.007
40 https://doi.org/10.1016/j.trstmh.2010.01.013
41 https://doi.org/10.1016/s0092-8674(01)00241-0
42 https://doi.org/10.1056/nejm198501313120505
43 https://doi.org/10.1073/pnas.94.12.6438
44 https://doi.org/10.1080/07435809609043762
45 https://doi.org/10.1086/420793
46 https://doi.org/10.1086/426406
47 https://doi.org/10.1093/hmg/ddp135
48 https://doi.org/10.1093/icb/39.2.189
49 https://doi.org/10.1093/ndt/gfu275
50 https://doi.org/10.1097/00149831-200606000-00021
51 https://doi.org/10.1097/01.hjh.0000173515.83481.d4
52 https://doi.org/10.1097/01.hjr.0000192744.88854.32
53 https://doi.org/10.1097/fpc.0b013e3283333532
54 https://doi.org/10.1097/hjh.0000000000001099
55 https://doi.org/10.1097/hjh.0b013e328332031a
56 https://doi.org/10.1097/hjh.0b013e328338cd36
57 https://doi.org/10.1097/hjh.0b013e3283410390
58 https://doi.org/10.1097/hjh.0b013e328348fd95
59 https://doi.org/10.1097/hjh.0b013e32835e2a71
60 https://doi.org/10.1126/science.2063193
61 https://doi.org/10.1146/annurev-pharmtox-010617-052446
62 https://doi.org/10.1152/physiol.00026.2016
63 https://doi.org/10.1155/2013/578578
64 https://doi.org/10.1161/01.hyp.0000255165.84684.9d
65 https://doi.org/10.1161/01.hyp.20.6.788
66 https://doi.org/10.1161/01.hyp.27.1.108
67 https://doi.org/10.1161/cir.0b013e318245fac5
68 https://doi.org/10.1161/circresaha.116.308763
69 https://doi.org/10.1161/circulationaha.110.012237
70 https://doi.org/10.1161/hypertensionaha.111.189100
71 https://doi.org/10.1161/hypertensionaha.113.01423
72 https://doi.org/10.1161/hypertensionaha.114.03132
73 https://doi.org/10.1161/hypertensionaha.116.08252
74 https://doi.org/10.1161/hypertensionaha.116.08632
75 https://doi.org/10.1161/hypertensionaha.117.08740
76 https://doi.org/10.1161/hypertensionaha.117.09306
77 https://doi.org/10.1371/journal.pgen.0010082
78 https://doi.org/10.1371/journal.pgen.1003509
79 https://doi.org/10.1371/journal.pone.0039760
80 https://doi.org/10.1371/journal.pone.0055686
81 https://doi.org/10.1371/journal.ppat.1000427
82 https://doi.org/10.1525/tran.2005.13.2.119
83 https://doi.org/10.1586/era.10.226
84 https://doi.org/10.2217/fca.11.33
85 https://doi.org/10.2217/pme.12.100
86 https://doi.org/10.3109/10641963.2015.1116543
87 https://doi.org/10.3389/fcimb.2014.00121
88 https://doi.org/10.3945/ajcn.2009.29028
89 schema:datePublished 2019-12
90 schema:datePublishedReg 2019-12-01
91 schema:description Prevalence of hypertension (HTN) varies substantially across different populations. HTN is not only common - affecting at least one third of the world's adult population - but is also the most important driver for cardiovascular diseases. Yet up to a third of hypertensive patients are resistant to therapy, contributed by secondary hypertension but more commonly the hitherto inability to precisely predict response to specific antihypertensive agents. Population and individual genomics information could be useful in guiding the selection and predicting the response to treatment - an approach known as precision medicine. However this cannot be achieved without the knowledge of genetic variations that influence blood pressure (BP). A number of evolutionary factors including population demographics and forces of natural selection may be involved. This article explores some ideas on how natural selection influences BP regulation in ethnically and geographically diverse populations that could lead to them being susceptible to HTN. We explore how such evolutionary factors could impact the implementation of precision medicine in HTN. Finally, in order to ensure the success of precision medicine in HTN, we call for more initiatives to understand the genetic architecture within and between diverse populations with ancestry from different parts of the world, and to precisely classify the intermediate phenotypes of HTN.
92 schema:genre research_article
93 schema:inLanguage en
94 schema:isAccessibleForFree true
95 schema:isPartOf N75cc6ba0029b40be8955e12c3ebc5f64
96 Nbf10d7d0dfc64828b7dd624b5e768bf6
97 sg:journal.1017631
98 schema:name Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
99 schema:pagination 1
100 schema:productId N14a07f43b34044c8bb3359c21d9ae3ca
101 N5287142ff072406d8e58b8d8f0a8fd01
102 N6e45167ef8554c179d8b32eb4859d329
103 Nc5c0c3bd78ef40389bf80d9284dd188a
104 Nfa876a560c9f40fca292731efd3e41ce
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111225237
106 https://doi.org/10.1186/s41065-019-0080-1
107 schema:sdDatePublished 2019-04-11T11:05
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N1eef0300decc43fab3229b9b56af26c4
110 schema:url https://link.springer.com/10.1186%2Fs41065-019-0080-1
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N091213e27f85403eb3ed13cfbb0e6640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Antihypertensive Agents
116 rdf:type schema:DefinedTerm
117 N0aeb8736c94640139ee91cf7183c708f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N14a07f43b34044c8bb3359c21d9ae3ca schema:name pubmed_id
121 schema:value 30636949
122 rdf:type schema:PropertyValue
123 N14e57681275b46e6902a4843b8a238bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Genetics, Population
125 rdf:type schema:DefinedTerm
126 N1eef0300decc43fab3229b9b56af26c4 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N4c976ad1c5f2471d840fb004fa067056 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Biological Evolution
130 rdf:type schema:DefinedTerm
131 N5287142ff072406d8e58b8d8f0a8fd01 schema:name doi
132 schema:value 10.1186/s41065-019-0080-1
133 rdf:type schema:PropertyValue
134 N5faeeef6195c4148b7b37a232c71d9f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Selection, Genetic
136 rdf:type schema:DefinedTerm
137 N66ca1d5b08d1425eb75d93d11ce98e96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Hypertension
139 rdf:type schema:DefinedTerm
140 N6e45167ef8554c179d8b32eb4859d329 schema:name readcube_id
141 schema:value bb87b6fe0024fa4dd9c00c0a6d23e3c6586233a058993e5cdb5bee14aa629ec9
142 rdf:type schema:PropertyValue
143 N75cc6ba0029b40be8955e12c3ebc5f64 schema:issueNumber 1
144 rdf:type schema:PublicationIssue
145 N7f1856bfe05e40dea418404a8c6733e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Phenotype
147 rdf:type schema:DefinedTerm
148 N81d62462c7be48cb8e7654a352abaf75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Blood Pressure
150 rdf:type schema:DefinedTerm
151 N9b1814c408bb4c54ad93edd8e7159168 rdf:first sg:person.01317076544.58
152 rdf:rest rdf:nil
153 N9dac12a81b364cd89af916b280a59f0c rdf:first sg:person.01104105532.69
154 rdf:rest Ne591b4c25a2d426f9ec3b026d2a9dbef
155 Nbf10d7d0dfc64828b7dd624b5e768bf6 schema:volumeNumber 156
156 rdf:type schema:PublicationVolume
157 Nc5c0c3bd78ef40389bf80d9284dd188a schema:name dimensions_id
158 schema:value pub.1111225237
159 rdf:type schema:PropertyValue
160 Ne591b4c25a2d426f9ec3b026d2a9dbef rdf:first sg:person.0634563630.12
161 rdf:rest N9b1814c408bb4c54ad93edd8e7159168
162 Nef20105e96dc4c339851fa70b06b6c54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Precision Medicine
164 rdf:type schema:DefinedTerm
165 Nfa876a560c9f40fca292731efd3e41ce schema:name nlm_unique_id
166 schema:value 0374654
167 rdf:type schema:PropertyValue
168 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
169 schema:name Biological Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
172 schema:name Genetics
173 rdf:type schema:DefinedTerm
174 sg:journal.1017631 schema:issn 0018-0661
175 1601-5223
176 schema:name Hereditas
177 rdf:type schema:Periodical
178 sg:person.01104105532.69 schema:affiliation https://www.grid.ac/institutes/grid.419092.7
179 schema:familyName Hoh
180 schema:givenName Boon-Peng
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104105532.69
182 rdf:type schema:Person
183 sg:person.01317076544.58 schema:affiliation https://www.grid.ac/institutes/grid.444472.5
184 schema:familyName Yusoff
185 schema:givenName Khalid
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317076544.58
187 rdf:type schema:Person
188 sg:person.0634563630.12 schema:affiliation https://www.grid.ac/institutes/grid.412259.9
189 schema:familyName Abdul Rahman
190 schema:givenName Thuhairah
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634563630.12
192 rdf:type schema:Person
193 sg:pub.10.1007/s00421-014-2823-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039286526
194 https://doi.org/10.1007/s00421-014-2823-z
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s00439-014-1459-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039298505
197 https://doi.org/10.1007/s00439-014-1459-8
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/s00439-014-1525-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024693724
200 https://doi.org/10.1007/s00439-014-1525-2
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s11906-007-0004-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004986735
203 https://doi.org/10.1007/s11906-007-0004-8
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/s11906-010-0167-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045147529
206 https://doi.org/10.1007/s11906-010-0167-6
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s11906-014-0461-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020600969
209 https://doi.org/10.1007/s11906-014-0461-9
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s11906-017-0699-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020258166
212 https://doi.org/10.1007/s11906-017-0699-0
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/hr.2012.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006929655
215 https://doi.org/10.1038/hr.2012.43
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/hr.2012.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021045787
218 https://doi.org/10.1038/hr.2012.44
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/jhg.2012.147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003619200
221 https://doi.org/10.1038/jhg.2012.147
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/ng.3768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074248255
224 https://doi.org/10.1038/ng.3768
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/nm.2541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018961918
227 https://doi.org/10.1038/nm.2541
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/nm.3384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042508938
230 https://doi.org/10.1038/nm.3384
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nrg1967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042830889
233 https://doi.org/10.1038/nrg1967
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/nrneph.2015.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038927978
236 https://doi.org/10.1038/nrneph.2015.176
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nrneph.2017.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129783
239 https://doi.org/10.1038/nrneph.2017.21
240 rdf:type schema:CreativeWork
241 sg:pub.10.1186/1471-2350-8-s1-s3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016002729
242 https://doi.org/10.1186/1471-2350-8-s1-s3
243 rdf:type schema:CreativeWork
244 sg:pub.10.1186/1471-2350-9-103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022599985
245 https://doi.org/10.1186/1471-2350-9-103
246 rdf:type schema:CreativeWork
247 sg:pub.10.1186/s12889-015-1384-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027861245
248 https://doi.org/10.1186/s12889-015-1384-3
249 rdf:type schema:CreativeWork
250 sg:pub.10.1203/pdr.0b013e318045bedb schema:sameAs https://app.dimensions.ai/details/publication/pub.1011966601
251 https://doi.org/10.1203/pdr.0b013e318045bedb
252 rdf:type schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1078325380 schema:CreativeWork
254 https://doi.org/10.1001/archinte.162.9.1051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018001914
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/gepi.1029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045397210
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0306-3623(83)90123-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005397306
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.bbadis.2010.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052170259
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.coi.2014.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000468965
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.tig.2005.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009864462
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.trstmh.2010.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054752116
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0092-8674(01)00241-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029883534
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1056/nejm198501313120505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036950262
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1073/pnas.94.12.6438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005834896
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1080/07435809609043762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044593823
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1086/420793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058711781
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1086/426406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058714690
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1093/hmg/ddp135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015689209
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1093/icb/39.2.189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006460235
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1093/ndt/gfu275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032413900
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1097/00149831-200606000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060315602
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1097/01.hjh.0000173515.83481.d4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007407600
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1097/01.hjr.0000192744.88854.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060330141
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/fpc.0b013e3283333532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340772
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/hjh.0000000000001099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006529620
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/hjh.0b013e328332031a schema:sameAs https://app.dimensions.ai/details/publication/pub.1038383935
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/hjh.0b013e328338cd36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038831956
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1097/hjh.0b013e3283410390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045472303
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1097/hjh.0b013e328348fd95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023276684
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1097/hjh.0b013e32835e2a71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034261557
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1126/science.2063193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062520432
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1146/annurev-pharmtox-010617-052446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091998473
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1152/physiol.00026.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083841702
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1155/2013/578578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009568730
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1161/01.hyp.0000255165.84684.9d schema:sameAs https://app.dimensions.ai/details/publication/pub.1041842377
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1161/01.hyp.20.6.788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012580794
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1161/01.hyp.27.1.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063339221
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1161/cir.0b013e318245fac5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003821452
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1161/circresaha.116.308763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007142180
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1161/circulationaha.110.012237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038835624
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1161/hypertensionaha.111.189100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048877033
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1161/hypertensionaha.113.01423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001520293
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1161/hypertensionaha.114.03132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047424955
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1161/hypertensionaha.116.08252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083811765
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1161/hypertensionaha.116.08632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084235258
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1161/hypertensionaha.117.08740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084235273
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1161/hypertensionaha.117.09306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085765199
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1371/journal.pgen.0010082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036971774
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1371/journal.pgen.1003509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048198889
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1371/journal.pone.0039760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022634900
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1371/journal.pone.0055686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041981030
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1371/journal.ppat.1000427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027360374
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1525/tran.2005.13.2.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001551424
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1586/era.10.226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030015126
353 rdf:type schema:CreativeWork
354 https://doi.org/10.2217/fca.11.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010911979
355 rdf:type schema:CreativeWork
356 https://doi.org/10.2217/pme.12.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006676726
357 rdf:type schema:CreativeWork
358 https://doi.org/10.3109/10641963.2015.1116543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011760571
359 rdf:type schema:CreativeWork
360 https://doi.org/10.3389/fcimb.2014.00121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050827958
361 rdf:type schema:CreativeWork
362 https://doi.org/10.3945/ajcn.2009.29028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052323469
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.412259.9 schema:alternateName Universiti Teknologi MARA
365 schema:name Clinical Pathology Diagnostic Centre Research Laboratory, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.419092.7 schema:alternateName Shanghai Institutes for Biological Sciences
368 schema:name Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, CAS, 200031, Shanghai, China
369 Faculty of Medicine and Health Sciences, UCSI University, Cheras, 56000, Kuala Lumpur, Malaysia
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.444472.5 schema:alternateName UCSI University
372 schema:name Faculty of Medicine and Health Sciences, UCSI University, Cheras, 56000, Kuala Lumpur, Malaysia
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...