Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-16

AUTHORS

Zhaowei Zhou, Zhiqiang Li, Can Wang, Xinde Li, Xiaoyu Cheng, Changgui Li, Yongyong Shi

ABSTRACT

BackgroundSerum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, SLC28A2, exerts susceptibility for SUA fluctuation and incidence of HUA and gout in the Han Chinese population.ResultsThree sample sets of 1376 gout patients, 1290 long-term HUA subjects (no gout attack) and 1349 normouricemic controls were recruited for this study. Eight polymorphisms in the SLC28A2 gene were genotyped using the ligase detection reaction-polymerase chain reaction (LDR-PCR) technology. Rs16941238 showed the most significant associations with SUA level (minor allele “A”, BETA = − 13.84 μmol/L, P = 0.0041, Pperm = 0.0042) and HUA (OR = 0.7734, P = 0.0033, Pperm = 0.0020), but not with gout (OR = 0.8801, P = 0.1315, Pperm = 0.1491). Rs2271437 was significantly associated with gout (minor allele “G”, OR = 1.387, P = 0.0277, Pperm = 0.0288), and was further confirmed in the meta-analysis with the previously published gout GWAS dataset (OR = 1.3221, P = 0.0089). Each variant basically conferred consistent OR direction on gout and HUA, compared with the normouricemic control.ConclusionsOur findings support the associations of the SLC28A2 gene with the SUA level, the HUA phenotype and gout in Han Chinese. More... »

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URI

http://scigraph.springernature.com/pub.10.1186/s41065-018-0078-0

DOI

http://dx.doi.org/10.1186/s41065-018-0078-0

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https://app.dimensions.ai/details/publication/pub.1111461253

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30679935


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41 SUA levels
42 acid
43 acid levels
44 association
45 candidate genes
46 common variants
47 complex traits
48 control
49 dataset
50 direction
51 findings
52 fluctuations
53 genes
54 gout
55 gout patients
56 heritability
57 high heritability
58 hyperuricemia
59 incidence
60 incidence of hyperuricemia
61 levels
62 normouricemic controls
63 patients
64 phenotype
65 polymorphism
66 population
67 reaction technology
68 sample set
69 serum uric acid levels
70 set
71 significant association
72 study
73 subjects
74 susceptibility
75 technology
76 traits
77 uric acid
78 uric acid levels
79 variants
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