Further evidence for the genetic association between CACNA1I and schizophrenia View Full Text


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Article Info

DATE

2018-12

AUTHORS

Yijun Xie, Di Huang, Li Wei, Xiong-Jian Luo

ABSTRACT

Background: Recent large-scale genome-wide association studies (GWAS) have showed that the neuronal calcium signaling has pivotal roles in schizophrenia (SCZ) in populations of European of ancestry. However, it is not known if calcium signaling pathway genes are also associated with SCZ in Han Chinese population. Methods: Here we investigated the association between genetic variants in three calcium signaling pathway genes (CACNB2, CACNA1C and CACNA1I) and SCZ in 1615 SCZ cases and 1597 controls. Results: A single nucleotide polymorphism (SNP) (rs4522708) in CACNA1I is significantly associated with SCZ in our Chinese sample (ORA allele = 1.19, corrected P = 0.042), suggesting that CACNA1I may also be a risk gene for SCZ in Chinese population. Of note, the risk allele (A allele) of SNP rs4522708 is same in European and Chinese populations. Meta-analysis of Chinese and European samples further strengthened the association of rs4522708 with SCZ (ORA allele = 1.074, P = 6.26 × 10-11). Expression analysis showed that CACNA1I was significantly up-regulated in hippocampus of SCZ cases compared with controls, implying that dysregulation of CACNA1I may have a role in schizophrenia pathogenesis. Conclusions: Our study suggests that CACNA1I is a risk gene for SCZ in Chinese population and provides further evidence that supports the potential role of neuronal calcium signaling in schizophrenia. More... »

PAGES

16

References to SciGraph publications

  • 2010-10. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia in MOLECULAR PSYCHIATRY
  • 2008-09. Identification of loci associated with schizophrenia by genome-wide association and follow-up in NATURE GENETICS
  • 2011-12. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2 in NATURE GENETICS
  • 2014-07. Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene in MOLECULAR PSYCHIATRY
  • 2012-08. Genetic architectures of psychiatric disorders: the emerging picture and its implications in NATURE REVIEWS GENETICS
  • 2008-07. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database in NATURE GENETICS
  • 2011-12. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia in NATURE GENETICS
  • 2009-08. Meta-analysis of 32 genome-wide linkage studies of schizophrenia in MOLECULAR PSYCHIATRY
  • 2013-10. Genome-wide association analysis identifies 13 new risk loci for schizophrenia in NATURE GENETICS
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2018-12. Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population in HEREDITAS
  • 2010-02. CACNA1C (rs1006737) is associated with schizophrenia in MOLECULAR PSYCHIATRY
  • 2017-11. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia in NATURE GENETICS
  • 2014-07. Biological insights from 108 schizophrenia-associated genetic loci in NATURE
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    http://scigraph.springernature.com/pub.10.1186/s41065-017-0054-0

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    http://dx.doi.org/10.1186/s41065-017-0054-0

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29308060


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    47 schema:description Background: Recent large-scale genome-wide association studies (GWAS) have showed that the neuronal calcium signaling has pivotal roles in schizophrenia (SCZ) in populations of European of ancestry. However, it is not known if calcium signaling pathway genes are also associated with SCZ in Han Chinese population. Methods: Here we investigated the association between genetic variants in three calcium signaling pathway genes (CACNB2, CACNA1C and CACNA1I) and SCZ in 1615 SCZ cases and 1597 controls. Results: A single nucleotide polymorphism (SNP) (rs4522708) in CACNA1I is significantly associated with SCZ in our Chinese sample (ORA allele = 1.19, corrected P = 0.042), suggesting that CACNA1I may also be a risk gene for SCZ in Chinese population. Of note, the risk allele (A allele) of SNP rs4522708 is same in European and Chinese populations. Meta-analysis of Chinese and European samples further strengthened the association of rs4522708 with SCZ (ORA allele = 1.074, P = 6.26 × 10-11). Expression analysis showed that CACNA1I was significantly up-regulated in hippocampus of SCZ cases compared with controls, implying that dysregulation of CACNA1I may have a role in schizophrenia pathogenesis. Conclusions: Our study suggests that CACNA1I is a risk gene for SCZ in Chinese population and provides further evidence that supports the potential role of neuronal calcium signaling in schizophrenia.
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