Effects of acetaldehyde-induced DNA lesions on DNA metabolism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-06

AUTHORS

Haruka Tsuruta, Yuina Sonohara, Kosuke Tohashi, Narumi Aoki Shioi, Shigenori Iwai, Isao Kuraoka

ABSTRACT

BackgroundAcetaldehyde, produced upon exposure to alcohol, cigarette smoke, polluted air and sugar, is a highly reactive compound that is carcinogenic to humans and causes a variety of DNA lesions in living human cells. Previously, we reported that acetaldehyde reacts with adjacent deoxyguanosine residues on oligonucleotides, but not with single deoxyguanosine residues or other deoxyadenosine, deoxycytosine, or thymidine residues, and revealed that it forms reversible intrastrand crosslinks with the dGpdG sequence (GG dimer).ResultsHere, we show that restriction enzymes that recognize a GG sequence digested acetaldehyde-treated plasmid DNA with low but significant efficiencies, whereas restriction enzymes that recognize other sequences were able to digest such DNA. This suggested that acetaldehyde produced GG dimers in plasmid DNA. Additionally, acetaldehyde-treated oligonucleotides were efficient in preventing digestion by the exonuclease function of T4 DNA polymerase compared to non-treated oligonucleotides, suggesting structural distortions of DNA caused by acetaldehyde-treatment. Neither in vitro DNA synthesis reactions of phi29 DNA polymerase nor in vitro RNA synthesis reactions of T7 RNA polymerase were observed when acetaldehyde-treated plasmid DNA was used, compared to when non-treated plasmid DNA was used, suggesting that acetaldehyde-induced DNA lesions inhibited replication and transcription in DNA metabolism.ConclusionsAcetaldehyde-induced DNA lesions could affect the relative resistance to endo- and exo-nucleolytic activity and also inhibit in vitro replication and in vitro transcription. Thus, investigating the effects of acetaldehyde-induced DNA lesions may enable a better understanding of the toxicity and carcinogenicity of acetaldehyde. More... »

PAGES

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s41021-019-0142-7

DOI

http://dx.doi.org/10.1186/s41021-019-0142-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123836768

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31921374


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Microbiology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411497.e", 
          "name": [
            "Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuruta", 
        "givenName": "Haruka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sonohara", 
        "givenName": "Yuina", 
        "id": "sg:person.012343462551.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343462551.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tohashi", 
        "givenName": "Kosuke", 
        "id": "sg:person.010757217265.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010757217265.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411497.e", 
          "name": [
            "Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki Shioi", 
        "givenName": "Narumi", 
        "id": "sg:person.012476302015.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012476302015.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwai", 
        "givenName": "Shigenori", 
        "id": "sg:person.0727600052.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727600052.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411497.e", 
          "name": [
            "Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuraoka", 
        "givenName": "Isao", 
        "id": "sg:person.0647362317.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647362317.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/s41598-018-37239-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111638691", 
          "https://doi.org/10.1038/s41598-018-37239-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004200719", 
          "https://doi.org/10.1038/sj.onc.1205803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s41021-015-0014-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017875448", 
          "https://doi.org/10.1186/s41021-015-0014-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1007-887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035608922", 
          "https://doi.org/10.1038/nsmb1007-887"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-01-06", 
    "datePublishedReg": "2020-01-06", 
    "description": "BackgroundAcetaldehyde, produced upon exposure to alcohol, cigarette smoke, polluted air and sugar, is a highly reactive compound that is carcinogenic to humans and causes a variety of DNA lesions in living human cells. Previously, we reported that acetaldehyde reacts with adjacent deoxyguanosine residues on oligonucleotides, but not with single deoxyguanosine residues or other deoxyadenosine, deoxycytosine, or thymidine residues, and revealed that it forms reversible intrastrand crosslinks with the dGpdG sequence (GG dimer).ResultsHere, we show that restriction enzymes that recognize a GG sequence digested acetaldehyde-treated plasmid DNA with low but significant efficiencies, whereas restriction enzymes that recognize other sequences were able to digest such DNA. This suggested that acetaldehyde produced GG dimers in plasmid DNA. Additionally, acetaldehyde-treated oligonucleotides were efficient in preventing digestion by the exonuclease function of T4 DNA polymerase compared to non-treated oligonucleotides, suggesting structural distortions of DNA caused by acetaldehyde-treatment. Neither in vitro DNA synthesis reactions of phi29 DNA polymerase nor in vitro RNA synthesis reactions of T7 RNA polymerase were observed when acetaldehyde-treated plasmid DNA was used, compared to when non-treated plasmid DNA was used, suggesting that acetaldehyde-induced DNA lesions inhibited replication and transcription in DNA metabolism.ConclusionsAcetaldehyde-induced DNA lesions could affect the relative resistance to endo- and exo-nucleolytic activity and also inhibit in vitro replication and in vitro transcription. Thus, investigating the effects of acetaldehyde-induced DNA lesions may enable a better understanding of the toxicity and carcinogenicity of acetaldehyde.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s41021-019-0142-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7212915", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8429333", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9198049", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6151657", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5898202", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1037587", 
        "issn": [
          "1880-7046", 
          "1880-7062"
        ], 
        "name": "Genes and Environment", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "keywords": [
      "carcinogenicity of acetaldehyde", 
      "cigarette smoke", 
      "lesions", 
      "plasmid DNA", 
      "relative resistance", 
      "DNA lesions", 
      "metabolism", 
      "human cells", 
      "replication", 
      "carcinogenicity", 
      "toxicity", 
      "exposure", 
      "DNA", 
      "DNA polymerase", 
      "smoke", 
      "restriction enzymes", 
      "effect", 
      "better understanding", 
      "cells", 
      "DNA metabolism", 
      "enzyme", 
      "humans", 
      "transcription", 
      "intrastrand crosslinks", 
      "ResultsHere", 
      "RNA synthesis reactions", 
      "exonuclease function", 
      "polymerase", 
      "activity", 
      "reactive compounds", 
      "alcohol", 
      "acetaldehyde", 
      "deoxyadenosine", 
      "oligonucleotide", 
      "resistance", 
      "such DNA", 
      "function", 
      "polluted air", 
      "digestion", 
      "sugars", 
      "reaction", 
      "RNA polymerase", 
      "GG dimer", 
      "T7 RNA polymerase", 
      "deoxyguanosine residues", 
      "variety", 
      "understanding", 
      "sequence", 
      "compounds", 
      "residues", 
      "significant efficiency", 
      "endo", 
      "deoxycytosine", 
      "DNA synthesis reaction", 
      "crosslinks", 
      "air", 
      "thymidine residues", 
      "GG sequence", 
      "T4 DNA polymerase", 
      "dimers", 
      "phi29 DNA polymerase", 
      "efficiency", 
      "distortion", 
      "synthesis reaction", 
      "structural distortion"
    ], 
    "name": "Effects of acetaldehyde-induced DNA lesions on DNA metabolism", 
    "pagination": "2", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1123836768"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s41021-019-0142-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31921374"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s41021-019-0142-7", 
      "https://app.dimensions.ai/details/publication/pub.1123836768"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_841.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s41021-019-0142-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s41021-019-0142-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s41021-019-0142-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s41021-019-0142-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s41021-019-0142-7'


 

This table displays all metadata directly associated to this object as RDF triples.

190 TRIPLES      22 PREDICATES      95 URIs      83 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s41021-019-0142-7 schema:about anzsrc-for:06
2 anzsrc-for:0605
3 schema:author N570993ff21ee4ccc8c7528b02df1d303
4 schema:citation sg:pub.10.1038/nsmb1007-887
5 sg:pub.10.1038/s41598-018-37239-6
6 sg:pub.10.1038/sj.onc.1205803
7 sg:pub.10.1186/s41021-015-0014-8
8 schema:datePublished 2020-01-06
9 schema:datePublishedReg 2020-01-06
10 schema:description BackgroundAcetaldehyde, produced upon exposure to alcohol, cigarette smoke, polluted air and sugar, is a highly reactive compound that is carcinogenic to humans and causes a variety of DNA lesions in living human cells. Previously, we reported that acetaldehyde reacts with adjacent deoxyguanosine residues on oligonucleotides, but not with single deoxyguanosine residues or other deoxyadenosine, deoxycytosine, or thymidine residues, and revealed that it forms reversible intrastrand crosslinks with the dGpdG sequence (GG dimer).ResultsHere, we show that restriction enzymes that recognize a GG sequence digested acetaldehyde-treated plasmid DNA with low but significant efficiencies, whereas restriction enzymes that recognize other sequences were able to digest such DNA. This suggested that acetaldehyde produced GG dimers in plasmid DNA. Additionally, acetaldehyde-treated oligonucleotides were efficient in preventing digestion by the exonuclease function of T4 DNA polymerase compared to non-treated oligonucleotides, suggesting structural distortions of DNA caused by acetaldehyde-treatment. Neither in vitro DNA synthesis reactions of phi29 DNA polymerase nor in vitro RNA synthesis reactions of T7 RNA polymerase were observed when acetaldehyde-treated plasmid DNA was used, compared to when non-treated plasmid DNA was used, suggesting that acetaldehyde-induced DNA lesions inhibited replication and transcription in DNA metabolism.ConclusionsAcetaldehyde-induced DNA lesions could affect the relative resistance to endo- and exo-nucleolytic activity and also inhibit in vitro replication and in vitro transcription. Thus, investigating the effects of acetaldehyde-induced DNA lesions may enable a better understanding of the toxicity and carcinogenicity of acetaldehyde.
11 schema:genre article
12 schema:inLanguage en
13 schema:isAccessibleForFree true
14 schema:isPartOf N863199d0ff13450d8e2f6ba2d1c7c6fa
15 Na7680693b167493bb35b68fada80453a
16 sg:journal.1037587
17 schema:keywords DNA
18 DNA lesions
19 DNA metabolism
20 DNA polymerase
21 DNA synthesis reaction
22 GG dimer
23 GG sequence
24 RNA polymerase
25 RNA synthesis reactions
26 ResultsHere
27 T4 DNA polymerase
28 T7 RNA polymerase
29 acetaldehyde
30 activity
31 air
32 alcohol
33 better understanding
34 carcinogenicity
35 carcinogenicity of acetaldehyde
36 cells
37 cigarette smoke
38 compounds
39 crosslinks
40 deoxyadenosine
41 deoxycytosine
42 deoxyguanosine residues
43 digestion
44 dimers
45 distortion
46 effect
47 efficiency
48 endo
49 enzyme
50 exonuclease function
51 exposure
52 function
53 human cells
54 humans
55 intrastrand crosslinks
56 lesions
57 metabolism
58 oligonucleotide
59 phi29 DNA polymerase
60 plasmid DNA
61 polluted air
62 polymerase
63 reaction
64 reactive compounds
65 relative resistance
66 replication
67 residues
68 resistance
69 restriction enzymes
70 sequence
71 significant efficiency
72 smoke
73 structural distortion
74 such DNA
75 sugars
76 synthesis reaction
77 thymidine residues
78 toxicity
79 transcription
80 understanding
81 variety
82 schema:name Effects of acetaldehyde-induced DNA lesions on DNA metabolism
83 schema:pagination 2
84 schema:productId N569c24408ea44badbf755ac6132f5036
85 N6e87ff5a4c7049aba784f9387b5ffddc
86 Nfa6cf4428c504ef68a795dabb0b75747
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123836768
88 https://doi.org/10.1186/s41021-019-0142-7
89 schema:sdDatePublished 2022-05-20T07:36
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N1cd85d455415417a852c0de76cb3caa8
92 schema:url https://doi.org/10.1186/s41021-019-0142-7
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N00a1e94f93f846cfba46f154fc1ba464 rdf:first sg:person.012343462551.69
97 rdf:rest N2e7b2c038547455c95445f1538008996
98 N1cd85d455415417a852c0de76cb3caa8 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N2e7b2c038547455c95445f1538008996 rdf:first sg:person.010757217265.61
101 rdf:rest N910cae9e6a854fef808ba5e2c9ee4a6f
102 N47a33631a6724c1cab5cc98ab28bf09f rdf:first sg:person.0647362317.51
103 rdf:rest rdf:nil
104 N569c24408ea44badbf755ac6132f5036 schema:name doi
105 schema:value 10.1186/s41021-019-0142-7
106 rdf:type schema:PropertyValue
107 N570993ff21ee4ccc8c7528b02df1d303 rdf:first Nf5caacbeccbb470ca6e001d07d2e08cd
108 rdf:rest N00a1e94f93f846cfba46f154fc1ba464
109 N6e87ff5a4c7049aba784f9387b5ffddc schema:name pubmed_id
110 schema:value 31921374
111 rdf:type schema:PropertyValue
112 N863199d0ff13450d8e2f6ba2d1c7c6fa schema:issueNumber 1
113 rdf:type schema:PublicationIssue
114 N910cae9e6a854fef808ba5e2c9ee4a6f rdf:first sg:person.012476302015.51
115 rdf:rest Nde93d8cd9a1046e3ae32cac24cca1ec5
116 Na7680693b167493bb35b68fada80453a schema:volumeNumber 42
117 rdf:type schema:PublicationVolume
118 Nde93d8cd9a1046e3ae32cac24cca1ec5 rdf:first sg:person.0727600052.12
119 rdf:rest N47a33631a6724c1cab5cc98ab28bf09f
120 Nf5caacbeccbb470ca6e001d07d2e08cd schema:affiliation grid-institutes:grid.411497.e
121 schema:familyName Tsuruta
122 schema:givenName Haruka
123 rdf:type schema:Person
124 Nfa6cf4428c504ef68a795dabb0b75747 schema:name dimensions_id
125 schema:value pub.1123836768
126 rdf:type schema:PropertyValue
127 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
128 schema:name Biological Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
131 schema:name Microbiology
132 rdf:type schema:DefinedTerm
133 sg:grant.5898202 http://pending.schema.org/fundedItem sg:pub.10.1186/s41021-019-0142-7
134 rdf:type schema:MonetaryGrant
135 sg:grant.6151657 http://pending.schema.org/fundedItem sg:pub.10.1186/s41021-019-0142-7
136 rdf:type schema:MonetaryGrant
137 sg:grant.7212915 http://pending.schema.org/fundedItem sg:pub.10.1186/s41021-019-0142-7
138 rdf:type schema:MonetaryGrant
139 sg:grant.8429333 http://pending.schema.org/fundedItem sg:pub.10.1186/s41021-019-0142-7
140 rdf:type schema:MonetaryGrant
141 sg:grant.9198049 http://pending.schema.org/fundedItem sg:pub.10.1186/s41021-019-0142-7
142 rdf:type schema:MonetaryGrant
143 sg:journal.1037587 schema:issn 1880-7046
144 1880-7062
145 schema:name Genes and Environment
146 schema:publisher Springer Nature
147 rdf:type schema:Periodical
148 sg:person.010757217265.61 schema:affiliation grid-institutes:grid.136593.b
149 schema:familyName Tohashi
150 schema:givenName Kosuke
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010757217265.61
152 rdf:type schema:Person
153 sg:person.012343462551.69 schema:affiliation grid-institutes:grid.136593.b
154 schema:familyName Sonohara
155 schema:givenName Yuina
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343462551.69
157 rdf:type schema:Person
158 sg:person.012476302015.51 schema:affiliation grid-institutes:grid.411497.e
159 schema:familyName Aoki Shioi
160 schema:givenName Narumi
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012476302015.51
162 rdf:type schema:Person
163 sg:person.0647362317.51 schema:affiliation grid-institutes:grid.411497.e
164 schema:familyName Kuraoka
165 schema:givenName Isao
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647362317.51
167 rdf:type schema:Person
168 sg:person.0727600052.12 schema:affiliation grid-institutes:grid.136593.b
169 schema:familyName Iwai
170 schema:givenName Shigenori
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727600052.12
172 rdf:type schema:Person
173 sg:pub.10.1038/nsmb1007-887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035608922
174 https://doi.org/10.1038/nsmb1007-887
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/s41598-018-37239-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111638691
177 https://doi.org/10.1038/s41598-018-37239-6
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/sj.onc.1205803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004200719
180 https://doi.org/10.1038/sj.onc.1205803
181 rdf:type schema:CreativeWork
182 sg:pub.10.1186/s41021-015-0014-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017875448
183 https://doi.org/10.1186/s41021-015-0014-8
184 rdf:type schema:CreativeWork
185 grid-institutes:grid.136593.b schema:alternateName Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan
186 schema:name Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan
187 rdf:type schema:Organization
188 grid-institutes:grid.411497.e schema:alternateName Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan
189 schema:name Department of Chemistry, Faculty of Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan
190 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...