Ontology type: schema:ScholarlyArticle Open Access: True
2015-11-01
AUTHORSKatsuhito Kino, Masayo Suzuki, Masayuki Morikawa, Takanobu Kobayashi, Shigenori Iwai, Hiroshi Miyazawa
ABSTRACTIntroduction2,2,4-Triamino-5(2H)-oxazolone (Oz) in a DNA strand is an oxidation product of guanine and 8-oxo-7, 8-dihydroguanine, and such a lesion can cause G-to-C transversions. Previously, Fpg/Nei and Nth were shown to have incision activity on Oz.FindingsWe investigated the activities of chlorella virus pyrimidine dimer glycosylase (cvPDG) and Escherichia coli endonucleases IV (Nfo) and V (Nfi) on Oz. Although the three enzymes have different repair mechanisms from Fpg/Nei and Nth, they still had incision activity on Oz.ConclusionsGiven the incision activities of cvPDG, Nfo and Nfi on Oz in addition to Fpg/Nei and Nth, Oz is DNA damage that can be repaired by diverse enzymes. More... »
PAGES22
http://scigraph.springernature.com/pub.10.1186/s41021-015-0022-8
DOIhttp://dx.doi.org/10.1186/s41021-015-0022-8
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27350817
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