A randomised phase II trial to examine feasibility of standardised, early palliative (STEP) care for patients with advanced cancer and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jennifer Philip, Anna Collins, Brian Le, Vijaya Sundararajan, Caroline Brand, Susan Hanson, Jon Emery, Peter Hudson, Linda Mileshkin, Soula Ganiatsas

ABSTRACT

Background: Current international consensus is that 'early' referral to palliative care services improves cancer patient and family carer outcomes; however, in practice, these referrals are not routine. Uncertainty about the 'best time' to refer has been highlighted as contributing to care variation. Previous work has identified clear disease-specific transition points in the cancer illness which heralded subsequent poor prognosis (less than 6 months) and which, we contest, represent times when palliative care should be routinely introduced as a standardised approach, if not already in place, to maximise patient and carer benefit. This protocol details a trial that will test the feasibility of a novel standardised outpatient model of early palliative care [Standardised Early Palliative Care (STEP Care)] for advanced cancer patients and their family carers, with referrals occurring at the defined disease-specific evidence-based transition points.The aims of this study are to (1) determine the feasibility of conducting a definitive phase 3 randomised trial, which evaluates effectiveness of STEP Care (compared to usual best practice cancer care) for patients with advanced breast or prostate cancer or high grade glioma; (2) examine preliminary efficacy of STEP Care on patient/family caregiver outcomes, including quality of life, mood, symptoms, illness understanding and overall survival; (3) document the impact of STEP Care on quality of end-of-life care; and (4) evaluate the timing of palliative care introduction according to patients, families and health care professionals. Methods: Phase 2, multicenter, open-label, parallel-arm, randomised controlled trial (RCT) of STEP Care plus standard best practice cancer care versus standard best practice cancer care alone. Discussion: The research will test the feasibility of standardised palliative care introduction based on illness transitions and provide guidance on subsequent development of phase 3 studies of integration. This will directly address the current uncertainty about palliative care timing. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12617000534381. More... »

PAGES

44

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40814-019-0424-7

DOI

http://dx.doi.org/10.1186/s40814-019-0424-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112758393

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30915228


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40814-019-0424-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40814-019-0424-7'

Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40814-019-0424-7'


 

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290 rdf:type schema:Organization
291 https://www.grid.ac/institutes/grid.413105.2 schema:alternateName St Vincent's Hospital
292 schema:name Centre for Palliative Care, St Vincent’s Hospital Melbourne, Melbourne, Australia
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.453129.8 schema:alternateName Cancer Australia
295 schema:name Cancer Australia, Surry Hills, Australia
296 rdf:type schema:Organization
 




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