Obesity-Related Genetic Variants and their Associations with Physical Activity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Harold Lee, Garrett I. Ash, Theodore J. Angelopoulos, Paul M. Gordon, Niall M. Moyna, Paul S. Visich, Robert F. Zoeller, Heather Gordish-Dressman, Ved Deshpande, Ming-Hui Chen, Paul D. Thompson, Eric P. Hoffman, Joseph M. Devaney, Linda S. Pescatello

ABSTRACT

BACKGROUND: Meta-analysis of genome-wide association studies identified obesity-related genetic variants. Due to the pleiotropic effects of related phenotypes, we tested six of these obesity-related genetic variants for their association with physical activity: fat mass and obesity-associated (FTO)(rs9939609)T>A, potassium channel tetramerization domain containing (KCTD15) (rs11084753)G>A, melanocortin receptor4 (MC4R)(rs17782313)T>C, neuronal growth regulator 1 (NEGR1)(rs2815752)A>G, SH2B adapter protein 1 (SH2B1)(rs7498665)A>G, and transmembrane protein18 (TMEM18)(rs6548238)C>T. METHOD: European-American women (n = 263) and men (n = 229) (23.5 ± 0.3 years, 24.6 ± 0.2 kg/m2) were genotyped and completed the Paffenbarger physical activity Questionnaire. Physical activity volume in metabolic energy equivalents [MET]-hour/week was derived from the summed time spent (hour/week) times the given MET value for vigorous, moderate, and light intensity physical activity, and sitting and sleeping, respectively. Multivariable adjusted [(age, sex, and body mass index (BMI)] linear regression tested associations among genotype (dominant/recessive model) and the log of physical activity volume. RESULT: MC4R (rs17782313)T>C explained 1.1 % (p = 0.02), TMEM18(rs6548238)C>T 1.2 % (p = 0.01), and SH2B1 (rs7498665)A>G 0.6 % (p = 0.08) of the variability in physical activity volume. Subjects with the MC4R C allele spent 3.5 % less MET-hour/week than those with the TT genotype (p = 0.02). Subjects with the TMEM18 T allele spent 4.1 % less MET-hour/week than those with the CC genotype (p = 0.01). Finally, subjects with the SH2B1 GG genotype spent 3.6 % less MET-hour/week than A allele carriers (p = 0.08). CONCLUSION: Our findings suggest a shared genetic influence among some obesity-related gene loci and physical activity phenotypes that should be explored further. Physical activity volume differences by genotype have public health importance equating to 11-13 lb weight difference annually. More... »

PAGES

34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40798-015-0036-6

DOI

http://dx.doi.org/10.1186/s40798-015-0036-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038507778

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26495240


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Brown University", 
          "id": "https://www.grid.ac/institutes/grid.40263.33", 
          "name": [
            "Department of Behavioral and Social Sciences, Brown University School of Public Health, Box G-S121-2, 02912, Providence, RI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Harold", 
        "id": "sg:person.01350262761.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350262761.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Connecticut", 
          "id": "https://www.grid.ac/institutes/grid.63054.34", 
          "name": [
            "Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ash", 
        "givenName": "Garrett I.", 
        "id": "sg:person.01021630552.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021630552.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory and Henry College", 
          "id": "https://www.grid.ac/institutes/grid.420991.7", 
          "name": [
            "Obesity Center & School of Health Sciences, Emory & Henry College, 24354, Marion, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Angelopoulos", 
        "givenName": "Theodore J.", 
        "id": "sg:person.01042242061.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042242061.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor University", 
          "id": "https://www.grid.ac/institutes/grid.252890.4", 
          "name": [
            "Department of Health, Human Performance and Recreation, Baylor University, 76798, Waco, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gordon", 
        "givenName": "Paul M.", 
        "id": "sg:person.01133413356.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133413356.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dublin City University", 
          "id": "https://www.grid.ac/institutes/grid.15596.3e", 
          "name": [
            "Department of Sport Science and Health, Dublin City University, 7008802, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moyna", 
        "givenName": "Niall M.", 
        "id": "sg:person.013227602507.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013227602507.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of New England", 
          "id": "https://www.grid.ac/institutes/grid.266826.e", 
          "name": [
            "Exercise & Sport Performance, University of New England, 04005, Biddeford, ME, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Visich", 
        "givenName": "Paul S.", 
        "id": "sg:person.01045616231.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045616231.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Florida Atlantic University", 
          "id": "https://www.grid.ac/institutes/grid.255951.f", 
          "name": [
            "Department of Exercise Science and Health Promotion, Florida Atlantic University, 33431, Boca Raton, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zoeller", 
        "givenName": "Robert F.", 
        "id": "sg:person.01137055613.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137055613.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Research Center for Genetic Medicine, Children\u2019s National Medical Center, 20010, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gordish-Dressman", 
        "givenName": "Heather", 
        "id": "sg:person.01250747034.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250747034.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Connecticut", 
          "id": "https://www.grid.ac/institutes/grid.63054.34", 
          "name": [
            "Department of Statistics, University of Connecticut, 06269, Storrs, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deshpande", 
        "givenName": "Ved", 
        "id": "sg:person.010213122261.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010213122261.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Connecticut", 
          "id": "https://www.grid.ac/institutes/grid.63054.34", 
          "name": [
            "Department of Statistics, University of Connecticut, 06269, Storrs, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Ming-Hui", 
        "id": "sg:person.01215273665.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215273665.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hartford Hospital", 
          "id": "https://www.grid.ac/institutes/grid.277313.3", 
          "name": [
            "Division of Cardiology, Henry Low Heart Center, Hartford Hospital, 06102, Hartford, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Paul D.", 
        "id": "sg:person.01041506467.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041506467.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Research Center for Genetic Medicine, Children\u2019s National Medical Center, 20010, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoffman", 
        "givenName": "Eric P.", 
        "id": "sg:person.010565461017.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010565461017.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Research Center for Genetic Medicine, Children\u2019s National Medical Center, 20010, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Devaney", 
        "givenName": "Joseph M.", 
        "id": "sg:person.011202345405.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011202345405.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Connecticut", 
          "id": "https://www.grid.ac/institutes/grid.63054.34", 
          "name": [
            "Institute for Systems Genomics, University of Connecticut, 06269, Storrs, CT, USA", 
            "Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pescatello", 
        "givenName": "Linda S.", 
        "id": "sg:person.01070742413.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070742413.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/j.1550-8528.1994.tb00069.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001984820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1375/twin.14.1.25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002043879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e31821ece12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003123564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e31821ece12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003123564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001648-199001000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003424423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001648-199001000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003424423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001648-199001000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003424423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/adc.2009.175927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009624234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/01.mss.0000132274.26612.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010209292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/01.mss.0000132274.26612.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010209292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/01.mss.0000132274.26612.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010209292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/01.mss.0000132274.26612.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010209292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjmed.2011.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010822868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0278-6133.19.suppl1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011543908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1550-8528.1993.tb00623.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012963828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2014.732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013269363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017293702", 
          "https://doi.org/10.1038/nature04226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017293702", 
          "https://doi.org/10.1038/nature04226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017293702", 
          "https://doi.org/10.1038/nature04226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.2009.27781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018040949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc06-1966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018453989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1986.03380010055024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019603908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.1976.tb04887.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019792826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jes.0b013e3181e373ee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019797670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jes.0b013e3181e373ee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019797670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jes.0b013e3181e373ee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019797670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0803839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019955875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1001116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022190137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022623339", 
          "https://doi.org/10.1038/nrg3461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026795787", 
          "https://doi.org/10.1038/ng.140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026939578", 
          "https://doi.org/10.1038/ng.287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1001618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027554467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/a0013111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028667638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61721-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028736230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029265610", 
          "https://doi.org/10.1038/nrg2949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e3180616b27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035084854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e3180616b27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035084854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2009.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035228307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2009.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035228307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2006.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035324738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e3182155d21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035660736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e3182155d21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035660736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035942809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2011.176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037259668", 
          "https://doi.org/10.1038/ejhg.2011.176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-590241-0.50006-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037963278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbr.2010.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038233283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-355-8_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038715550", 
          "https://doi.org/10.1007/978-1-60761-355-8_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-355-8_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038715550", 
          "https://doi.org/10.1007/978-1-60761-355-8_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2008.511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038893477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039771806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbr.2009.05.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041230579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1241244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042633878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002130100857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044934292", 
          "https://doi.org/10.1007/s002130100857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.163.11.1343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046104024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2010.180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046369278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e3181949333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049363428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e3181949333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049363428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/mss.0b013e3181949333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049363428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/jn.110.127290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051399222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2196/jmir.1100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069285629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/88.3.612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077723479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a112608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082136661"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Meta-analysis of genome-wide association studies identified obesity-related genetic variants. Due to the pleiotropic effects of related phenotypes, we tested six of these obesity-related genetic variants for their association with physical activity: fat mass and obesity-associated (FTO)(rs9939609)T>A, potassium channel tetramerization domain containing (KCTD15) (rs11084753)G>A, melanocortin receptor4 (MC4R)(rs17782313)T>C, neuronal growth regulator 1 (NEGR1)(rs2815752)A>G, SH2B adapter protein 1 (SH2B1)(rs7498665)A>G, and transmembrane protein18 (TMEM18)(rs6548238)C>T.\nMETHOD: European-American women (n\u2009=\u2009263) and men (n\u2009=\u2009229) (23.5\u2009\u00b1\u20090.3\u00a0years, 24.6\u2009\u00b1\u20090.2\u00a0kg/m2) were genotyped and completed the Paffenbarger physical activity Questionnaire. Physical activity volume in metabolic energy equivalents [MET]-hour/week was derived from the summed time spent (hour/week) times the given MET value for vigorous, moderate, and light intensity physical activity, and sitting and sleeping, respectively. Multivariable adjusted [(age, sex, and body mass index (BMI)] linear regression tested associations among genotype (dominant/recessive model) and the log of physical activity volume.\nRESULT: MC4R (rs17782313)T>C explained 1.1\u00a0% (p\u2009=\u20090.02), TMEM18(rs6548238)C>T 1.2\u00a0% (p\u2009=\u20090.01), and SH2B1 (rs7498665)A>G 0.6\u00a0% (p\u2009=\u20090.08) of the variability in physical activity volume. Subjects with the MC4R C allele spent 3.5\u00a0% less MET-hour/week than those with the TT genotype (p\u2009=\u20090.02). Subjects with the TMEM18 T allele spent 4.1\u00a0% less MET-hour/week than those with the CC genotype (p\u2009=\u20090.01). Finally, subjects with the SH2B1 GG genotype spent 3.6\u00a0% less MET-hour/week than A allele carriers (p\u2009=\u20090.08).\nCONCLUSION: Our findings suggest a shared genetic influence among some obesity-related gene loci and physical activity phenotypes that should be explored further. Physical activity volume differences by genotype have public health importance equating to 11-13\u00a0lb weight difference annually.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40798-015-0036-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2559608", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1052131", 
        "issn": [
          "2199-1170", 
          "2198-9761"
        ], 
        "name": "Sports Medicine - Open", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Obesity-Related Genetic Variants and their Associations with Physical Activity", 
    "pagination": "34", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b76f35128e72a97ec5f0245fe3d95502ef1c0c5103393a15b1d4363fa0283e7d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26495240"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101662568"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40798-015-0036-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038507778"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40798-015-0036-6", 
      "https://app.dimensions.ai/details/publication/pub.1038507778"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88242_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs40798-015-0036-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40798-015-0036-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40798-015-0036-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40798-015-0036-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40798-015-0036-6'


 

This table displays all metadata directly associated to this object as RDF triples.

334 TRIPLES      21 PREDICATES      75 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40798-015-0036-6 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N935ccb3cf42a474ca158f1c031665452
4 schema:citation sg:pub.10.1007/978-1-60761-355-8_5
5 sg:pub.10.1007/s002130100857
6 sg:pub.10.1038/ejhg.2011.176
7 sg:pub.10.1038/nature04226
8 sg:pub.10.1038/ng.140
9 sg:pub.10.1038/ng.287
10 sg:pub.10.1038/nrg2949
11 sg:pub.10.1038/nrg3461
12 https://doi.org/10.1001/archinte.163.11.1343
13 https://doi.org/10.1001/jama.1986.03380010055024
14 https://doi.org/10.1001/jama.2014.732
15 https://doi.org/10.1002/j.1550-8528.1993.tb00623.x
16 https://doi.org/10.1002/j.1550-8528.1994.tb00069.x
17 https://doi.org/10.1016/b978-0-12-590241-0.50006-x
18 https://doi.org/10.1016/j.amjmed.2011.04.016
19 https://doi.org/10.1016/j.bbr.2009.05.034
20 https://doi.org/10.1016/j.bbr.2010.02.016
21 https://doi.org/10.1016/s0140-6736(07)61721-8
22 https://doi.org/10.1037/0278-6133.19.suppl1.5
23 https://doi.org/10.1037/a0013111
24 https://doi.org/10.1038/oby.2006.71
25 https://doi.org/10.1038/oby.2008.511
26 https://doi.org/10.1038/oby.2009.52
27 https://doi.org/10.1038/oby.2010.180
28 https://doi.org/10.1056/nejmoa0803839
29 https://doi.org/10.1093/ajcn/88.3.612
30 https://doi.org/10.1093/oxfordjournals.aje.a112608
31 https://doi.org/10.1097/00001648-199001000-00014
32 https://doi.org/10.1097/jes.0b013e3181e373ee
33 https://doi.org/10.1111/j.1651-2227.1976.tb04887.x
34 https://doi.org/10.1126/science.1241244
35 https://doi.org/10.1136/adc.2009.175927
36 https://doi.org/10.1249/01.mss.0000132274.26612.23
37 https://doi.org/10.1249/mss.0b013e3180616b27
38 https://doi.org/10.1249/mss.0b013e3181949333
39 https://doi.org/10.1249/mss.0b013e3182155d21
40 https://doi.org/10.1249/mss.0b013e31821ece12
41 https://doi.org/10.1371/journal.pgen.1003607
42 https://doi.org/10.1371/journal.pmed.1000332
43 https://doi.org/10.1371/journal.pmed.1001116
44 https://doi.org/10.1371/journal.pmed.1001618
45 https://doi.org/10.1375/twin.14.1.25
46 https://doi.org/10.2196/jmir.1100
47 https://doi.org/10.2337/dc06-1966
48 https://doi.org/10.3945/ajcn.2009.27781
49 https://doi.org/10.3945/jn.110.127290
50 schema:datePublished 2015-12
51 schema:datePublishedReg 2015-12-01
52 schema:description BACKGROUND: Meta-analysis of genome-wide association studies identified obesity-related genetic variants. Due to the pleiotropic effects of related phenotypes, we tested six of these obesity-related genetic variants for their association with physical activity: fat mass and obesity-associated (FTO)(rs9939609)T>A, potassium channel tetramerization domain containing (KCTD15) (rs11084753)G>A, melanocortin receptor4 (MC4R)(rs17782313)T>C, neuronal growth regulator 1 (NEGR1)(rs2815752)A>G, SH2B adapter protein 1 (SH2B1)(rs7498665)A>G, and transmembrane protein18 (TMEM18)(rs6548238)C>T. METHOD: European-American women (n = 263) and men (n = 229) (23.5 ± 0.3 years, 24.6 ± 0.2 kg/m2) were genotyped and completed the Paffenbarger physical activity Questionnaire. Physical activity volume in metabolic energy equivalents [MET]-hour/week was derived from the summed time spent (hour/week) times the given MET value for vigorous, moderate, and light intensity physical activity, and sitting and sleeping, respectively. Multivariable adjusted [(age, sex, and body mass index (BMI)] linear regression tested associations among genotype (dominant/recessive model) and the log of physical activity volume. RESULT: MC4R (rs17782313)T>C explained 1.1 % (p = 0.02), TMEM18(rs6548238)C>T 1.2 % (p = 0.01), and SH2B1 (rs7498665)A>G 0.6 % (p = 0.08) of the variability in physical activity volume. Subjects with the MC4R C allele spent 3.5 % less MET-hour/week than those with the TT genotype (p = 0.02). Subjects with the TMEM18 T allele spent 4.1 % less MET-hour/week than those with the CC genotype (p = 0.01). Finally, subjects with the SH2B1 GG genotype spent 3.6 % less MET-hour/week than A allele carriers (p = 0.08). CONCLUSION: Our findings suggest a shared genetic influence among some obesity-related gene loci and physical activity phenotypes that should be explored further. Physical activity volume differences by genotype have public health importance equating to 11-13 lb weight difference annually.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N62e6bf190c0641f8927a37ade2c439af
57 N90fafb110ebd4edebe37c0d3974ded80
58 sg:journal.1052131
59 schema:name Obesity-Related Genetic Variants and their Associations with Physical Activity
60 schema:pagination 34
61 schema:productId N72882079b27048298f54ffcba364d9da
62 Nb1d583719c1f4ce489e053f8079e0fc3
63 Ne430940649f441dc851270f2f1750360
64 Ne56cc266c76b4ce287da892b0f6d4266
65 Nfc58acecc53d4423a8d42c6206ec660e
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038507778
67 https://doi.org/10.1186/s40798-015-0036-6
68 schema:sdDatePublished 2019-04-11T13:10
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N65c15f73a7ab4b019eca6a29a590926e
71 schema:url http://link.springer.com/10.1186%2Fs40798-015-0036-6
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N05d323f2c35d42a59340c2e3eccfca51 rdf:first sg:person.01042242061.49
76 rdf:rest Nb059d98937bc4c5b8b441efff3d71ee7
77 N2f5dc8b9e69a43fbbd02c614ccce94de rdf:first sg:person.01021630552.04
78 rdf:rest N05d323f2c35d42a59340c2e3eccfca51
79 N32c6b35975804e2182d528b38dab3564 rdf:first sg:person.01041506467.97
80 rdf:rest Nf11ea86d9c8943448758af1c9f01f260
81 N3ce8298cb8b643e9944fb7186cadd39f rdf:first sg:person.01070742413.12
82 rdf:rest rdf:nil
83 N4f591d54359b48bfb186cb1181ebb8c0 rdf:first sg:person.01215273665.28
84 rdf:rest N32c6b35975804e2182d528b38dab3564
85 N62e6bf190c0641f8927a37ade2c439af schema:issueNumber 1
86 rdf:type schema:PublicationIssue
87 N65c15f73a7ab4b019eca6a29a590926e schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N72882079b27048298f54ffcba364d9da schema:name doi
90 schema:value 10.1186/s40798-015-0036-6
91 rdf:type schema:PropertyValue
92 N765b84fc678f461f911c3a21e313bddc rdf:first sg:person.011202345405.05
93 rdf:rest N3ce8298cb8b643e9944fb7186cadd39f
94 N7a0a2dd9ad2547ab96aa8f966ad344ba rdf:first sg:person.01250747034.44
95 rdf:rest Na915d4461de242ac982e5193c7262825
96 N8eab095aad5145b690b688fa3372a8b0 rdf:first sg:person.01137055613.52
97 rdf:rest N7a0a2dd9ad2547ab96aa8f966ad344ba
98 N90fafb110ebd4edebe37c0d3974ded80 schema:volumeNumber 1
99 rdf:type schema:PublicationVolume
100 N935ccb3cf42a474ca158f1c031665452 rdf:first sg:person.01350262761.52
101 rdf:rest N2f5dc8b9e69a43fbbd02c614ccce94de
102 Na915d4461de242ac982e5193c7262825 rdf:first sg:person.010213122261.23
103 rdf:rest N4f591d54359b48bfb186cb1181ebb8c0
104 Nb059d98937bc4c5b8b441efff3d71ee7 rdf:first sg:person.01133413356.55
105 rdf:rest Nc403e337f915435c86aeebf90e4a79f5
106 Nb1d583719c1f4ce489e053f8079e0fc3 schema:name nlm_unique_id
107 schema:value 101662568
108 rdf:type schema:PropertyValue
109 Nb6330e6efa024292b019ba066fd5cc28 rdf:first sg:person.01045616231.54
110 rdf:rest N8eab095aad5145b690b688fa3372a8b0
111 Nc403e337f915435c86aeebf90e4a79f5 rdf:first sg:person.013227602507.44
112 rdf:rest Nb6330e6efa024292b019ba066fd5cc28
113 Ne430940649f441dc851270f2f1750360 schema:name pubmed_id
114 schema:value 26495240
115 rdf:type schema:PropertyValue
116 Ne56cc266c76b4ce287da892b0f6d4266 schema:name dimensions_id
117 schema:value pub.1038507778
118 rdf:type schema:PropertyValue
119 Nf11ea86d9c8943448758af1c9f01f260 rdf:first sg:person.010565461017.59
120 rdf:rest N765b84fc678f461f911c3a21e313bddc
121 Nfc58acecc53d4423a8d42c6206ec660e schema:name readcube_id
122 schema:value b76f35128e72a97ec5f0245fe3d95502ef1c0c5103393a15b1d4363fa0283e7d
123 rdf:type schema:PropertyValue
124 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
125 schema:name Biological Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
128 schema:name Genetics
129 rdf:type schema:DefinedTerm
130 sg:grant.2559608 http://pending.schema.org/fundedItem sg:pub.10.1186/s40798-015-0036-6
131 rdf:type schema:MonetaryGrant
132 sg:journal.1052131 schema:issn 2198-9761
133 2199-1170
134 schema:name Sports Medicine - Open
135 rdf:type schema:Periodical
136 sg:person.010213122261.23 schema:affiliation https://www.grid.ac/institutes/grid.63054.34
137 schema:familyName Deshpande
138 schema:givenName Ved
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010213122261.23
140 rdf:type schema:Person
141 sg:person.01021630552.04 schema:affiliation https://www.grid.ac/institutes/grid.63054.34
142 schema:familyName Ash
143 schema:givenName Garrett I.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021630552.04
145 rdf:type schema:Person
146 sg:person.01041506467.97 schema:affiliation https://www.grid.ac/institutes/grid.277313.3
147 schema:familyName Thompson
148 schema:givenName Paul D.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041506467.97
150 rdf:type schema:Person
151 sg:person.01042242061.49 schema:affiliation https://www.grid.ac/institutes/grid.420991.7
152 schema:familyName Angelopoulos
153 schema:givenName Theodore J.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042242061.49
155 rdf:type schema:Person
156 sg:person.01045616231.54 schema:affiliation https://www.grid.ac/institutes/grid.266826.e
157 schema:familyName Visich
158 schema:givenName Paul S.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045616231.54
160 rdf:type schema:Person
161 sg:person.010565461017.59 schema:affiliation https://www.grid.ac/institutes/grid.239560.b
162 schema:familyName Hoffman
163 schema:givenName Eric P.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010565461017.59
165 rdf:type schema:Person
166 sg:person.01070742413.12 schema:affiliation https://www.grid.ac/institutes/grid.63054.34
167 schema:familyName Pescatello
168 schema:givenName Linda S.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070742413.12
170 rdf:type schema:Person
171 sg:person.011202345405.05 schema:affiliation https://www.grid.ac/institutes/grid.239560.b
172 schema:familyName Devaney
173 schema:givenName Joseph M.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011202345405.05
175 rdf:type schema:Person
176 sg:person.01133413356.55 schema:affiliation https://www.grid.ac/institutes/grid.252890.4
177 schema:familyName Gordon
178 schema:givenName Paul M.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133413356.55
180 rdf:type schema:Person
181 sg:person.01137055613.52 schema:affiliation https://www.grid.ac/institutes/grid.255951.f
182 schema:familyName Zoeller
183 schema:givenName Robert F.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137055613.52
185 rdf:type schema:Person
186 sg:person.01215273665.28 schema:affiliation https://www.grid.ac/institutes/grid.63054.34
187 schema:familyName Chen
188 schema:givenName Ming-Hui
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215273665.28
190 rdf:type schema:Person
191 sg:person.01250747034.44 schema:affiliation https://www.grid.ac/institutes/grid.239560.b
192 schema:familyName Gordish-Dressman
193 schema:givenName Heather
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250747034.44
195 rdf:type schema:Person
196 sg:person.013227602507.44 schema:affiliation https://www.grid.ac/institutes/grid.15596.3e
197 schema:familyName Moyna
198 schema:givenName Niall M.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013227602507.44
200 rdf:type schema:Person
201 sg:person.01350262761.52 schema:affiliation https://www.grid.ac/institutes/grid.40263.33
202 schema:familyName Lee
203 schema:givenName Harold
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350262761.52
205 rdf:type schema:Person
206 sg:pub.10.1007/978-1-60761-355-8_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038715550
207 https://doi.org/10.1007/978-1-60761-355-8_5
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/s002130100857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044934292
210 https://doi.org/10.1007/s002130100857
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/ejhg.2011.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037259668
213 https://doi.org/10.1038/ejhg.2011.176
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nature04226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017293702
216 https://doi.org/10.1038/nature04226
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/ng.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026795787
219 https://doi.org/10.1038/ng.140
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/ng.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026939578
222 https://doi.org/10.1038/ng.287
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nrg2949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029265610
225 https://doi.org/10.1038/nrg2949
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nrg3461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022623339
228 https://doi.org/10.1038/nrg3461
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1001/archinte.163.11.1343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046104024
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1001/jama.1986.03380010055024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019603908
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1001/jama.2014.732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013269363
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/j.1550-8528.1993.tb00623.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012963828
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/j.1550-8528.1994.tb00069.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001984820
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/b978-0-12-590241-0.50006-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037963278
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.amjmed.2011.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010822868
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.bbr.2009.05.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041230579
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.bbr.2010.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038233283
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0140-6736(07)61721-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028736230
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1037/0278-6133.19.suppl1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011543908
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1037/a0013111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028667638
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1038/oby.2006.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035324738
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1038/oby.2008.511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038893477
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1038/oby.2009.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035228307
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1038/oby.2010.180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046369278
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1056/nejmoa0803839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019955875
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/ajcn/88.3.612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077723479
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1093/oxfordjournals.aje.a112608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082136661
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1097/00001648-199001000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003424423
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1097/jes.0b013e3181e373ee schema:sameAs https://app.dimensions.ai/details/publication/pub.1019797670
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1651-2227.1976.tb04887.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019792826
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1126/science.1241244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042633878
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1136/adc.2009.175927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009624234
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1249/01.mss.0000132274.26612.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010209292
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1249/mss.0b013e3180616b27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035084854
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1249/mss.0b013e3181949333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049363428
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1249/mss.0b013e3182155d21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035660736
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1249/mss.0b013e31821ece12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003123564
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1371/journal.pgen.1003607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039771806
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1371/journal.pmed.1000332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035942809
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1371/journal.pmed.1001116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022190137
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1371/journal.pmed.1001618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027554467
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1375/twin.14.1.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002043879
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2196/jmir.1100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069285629
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2337/dc06-1966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018453989
301 rdf:type schema:CreativeWork
302 https://doi.org/10.3945/ajcn.2009.27781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018040949
303 rdf:type schema:CreativeWork
304 https://doi.org/10.3945/jn.110.127290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051399222
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.15596.3e schema:alternateName Dublin City University
307 schema:name Department of Sport Science and Health, Dublin City University, 7008802, Dublin, Ireland
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.239560.b schema:alternateName Children’s National Health System
310 schema:name Research Center for Genetic Medicine, Children’s National Medical Center, 20010, Washington, DC, USA
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.252890.4 schema:alternateName Baylor University
313 schema:name Department of Health, Human Performance and Recreation, Baylor University, 76798, Waco, TX, USA
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.255951.f schema:alternateName Florida Atlantic University
316 schema:name Department of Exercise Science and Health Promotion, Florida Atlantic University, 33431, Boca Raton, FL, USA
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.266826.e schema:alternateName University of New England
319 schema:name Exercise & Sport Performance, University of New England, 04005, Biddeford, ME, USA
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.277313.3 schema:alternateName Hartford Hospital
322 schema:name Division of Cardiology, Henry Low Heart Center, Hartford Hospital, 06102, Hartford, CT, USA
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.40263.33 schema:alternateName Brown University
325 schema:name Department of Behavioral and Social Sciences, Brown University School of Public Health, Box G-S121-2, 02912, Providence, RI, USA
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.420991.7 schema:alternateName Emory and Henry College
328 schema:name Obesity Center & School of Health Sciences, Emory & Henry College, 24354, Marion, VA, USA
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.63054.34 schema:alternateName University of Connecticut
331 schema:name Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA
332 Department of Statistics, University of Connecticut, 06269, Storrs, CT, USA
333 Institute for Systems Genomics, University of Connecticut, 06269, Storrs, CT, USA
334 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...