A case report of fibrolamellar hepatocellular carcinoma, with particular reference to preoperative diagnosis, value of molecular genetic diagnosis, and cell ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-09-17

AUTHORS

Atsushi Takahashi, Hiroshi Imamura, Ryota Ito, Fumihiro Kawano, Yu Gyoda, Hirofumi Ichida, Ryuji Yoshioka, Yoshihiro Mise, Yuki Fukumura, Katsuhiro Sano, Akio Saiura

ABSTRACT

BackgroundFibrolamellar hepatocellular carcinoma (FL-HCC) is a liver tumor that occurs almost exclusively in young adults without underlying liver disease. In spite of its distinct clinical characteristics and specific imaging findings, preoperative diagnosis is often difficult due to the extremely low incidence of the tumor. Although FL-HCC shows particular morphological features on H&E-stained tissue sections, differential diagnosis from ordinary HCC, especially the scirrhous variant of HCC, and intrahepatic cholangiocarcinoma needs additional immunohistochemical (IHC) analyses and/or molecular genetic testing.Case presentationA 21-year-old male patient was referred to our hospital for further evaluation of a large liver mass. Abdominal ultrasound examination, contrast-enhanced computed tomography, and magnetic resonance imaging revealed a well-defined hypervascular lobulated liver mass, 11 × 11 cm in diameter, with a central scar and calcification, in segments 5/8. Under the diagnosis of FL-HCC, we carried out extended anterior sectorectomy, including a part of segment 4. On microscopic examination, the tumor was composed of proliferating polygonal cells with abundant eosinophilic granular cytoplasm containing nuclei with vesicular chromatin and enlarged nucleoli, in an abundant stroma. Collagen fibers arranged in a parallel lamellar pattern were seen in the tumor stroma. These findings, together with the results of subsequent IHC analyses using HAS, CK7, and CD 67, we made the diagnosis of FL-HCC, which was further confirmed by detection of the DNAJB1-PRKACA fusion gene in the tumor cells by RT-PCR.ConclusionFL-HCC shows distinct imaging appearances. Although it also has characteristic morphological features, combined use of IHC and/or molecular genetic studies are necessary for the final diagnosis. More... »

PAGES

208

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40792-021-01295-4

DOI

http://dx.doi.org/10.1186/s40792-021-01295-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141192487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34533614


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Atsushi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imamura", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0644576333.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644576333.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Ryota", 
        "id": "sg:person.013175715410.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013175715410.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawano", 
        "givenName": "Fumihiro", 
        "id": "sg:person.07634506273.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07634506273.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gyoda", 
        "givenName": "Yu", 
        "id": "sg:person.011063504320.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011063504320.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichida", 
        "givenName": "Hirofumi", 
        "id": "sg:person.012714453755.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012714453755.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshioka", 
        "givenName": "Ryuji", 
        "id": "sg:person.01111072103.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111072103.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mise", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0626665021.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukumura", 
        "givenName": "Yuki", 
        "id": "sg:person.01356013435.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356013435.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sano", 
        "givenName": "Katsuhiro", 
        "id": "sg:person.01202024031.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202024031.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saiura", 
        "givenName": "Akio", 
        "id": "sg:person.0612301703.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s40644-018-0143-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101279343", 
          "https://doi.org/10.1186/s40644-018-0143-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2016.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043763738", 
          "https://doi.org/10.1038/modpathol.2016.59"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/79238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034260511", 
          "https://doi.org/10.1038/79238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00595-013-0653-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014902260", 
          "https://doi.org/10.1007/s00595-013-0653-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2017.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091407666", 
          "https://doi.org/10.1038/modpathol.2017.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2009.440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044652591", 
          "https://doi.org/10.1038/ajg.2009.440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029936537", 
          "https://doi.org/10.1038/modpathol.2010.207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009900912", 
          "https://doi.org/10.1038/modpathol.2010.105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00247-021-05058-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1137196769", 
          "https://doi.org/10.1007/s00247-021-05058-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep44653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084132533", 
          "https://doi.org/10.1038/srep44653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms9070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040734156", 
          "https://doi.org/10.1038/ncomms9070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2015.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046074811", 
          "https://doi.org/10.1038/modpathol.2015.4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-09-17", 
    "datePublishedReg": "2021-09-17", 
    "description": "BackgroundFibrolamellar hepatocellular carcinoma (FL-HCC) is a liver tumor that occurs almost exclusively in young adults without underlying liver disease. In spite of its distinct clinical characteristics and specific imaging findings, preoperative diagnosis is often difficult due to the extremely low incidence of the tumor. Although FL-HCC shows particular morphological features on H&E-stained tissue sections, differential diagnosis from ordinary HCC, especially the scirrhous variant of HCC, and intrahepatic cholangiocarcinoma needs additional immunohistochemical (IHC) analyses and/or molecular genetic testing.Case presentationA 21-year-old male patient was referred to our hospital for further evaluation of a large liver mass. Abdominal ultrasound examination, contrast-enhanced computed tomography, and magnetic resonance imaging revealed a well-defined hypervascular lobulated liver mass, 11\u2009\u00d7\u200911\u00a0cm in diameter, with a central scar and calcification, in segments 5/8. Under the diagnosis of FL-HCC, we carried out extended anterior sectorectomy, including a part of segment 4. On microscopic examination, the tumor was composed of proliferating polygonal cells with abundant eosinophilic granular cytoplasm containing nuclei with vesicular chromatin and enlarged nucleoli, in an abundant stroma. Collagen fibers arranged in a parallel lamellar pattern were seen in the tumor stroma. These findings, together with the results of subsequent IHC analyses using HAS, CK7, and CD 67, we made the diagnosis of FL-HCC, which was further confirmed by detection of the DNAJB1-PRKACA fusion gene in the tumor cells by RT-PCR.ConclusionFL-HCC shows distinct imaging appearances. Although it also has characteristic morphological features, combined use of IHC and/or molecular genetic studies are necessary for the final diagnosis.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s40792-021-01295-4", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1052102", 
        "issn": [
          "2198-7793"
        ], 
        "name": "Surgical Case Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "FL-HCC", 
      "preoperative diagnosis", 
      "hepatocellular carcinoma", 
      "liver mass", 
      "contrast-enhanced computed tomography", 
      "distinct clinical characteristics", 
      "abdominal ultrasound examination", 
      "use of IHC", 
      "large liver mass", 
      "fibrolamellar hepatocellular carcinoma", 
      "additional immunohistochemical analysis", 
      "abundant eosinophilic granular cytoplasm", 
      "eosinophilic granular cytoplasm", 
      "magnetic resonance imaging", 
      "molecular genetic testing", 
      "ordinary HCC", 
      "scirrhous variant", 
      "segment 5/8", 
      "clinical characteristics", 
      "Case presentationA", 
      "male patients", 
      "liver disease", 
      "final diagnosis", 
      "case report", 
      "imaging appearances", 
      "ultrasound examination", 
      "lower incidence", 
      "differential diagnosis", 
      "liver tumors", 
      "IHC analysis", 
      "central scar", 
      "tumor stroma", 
      "immunohistochemical analysis", 
      "computed tomography", 
      "vesicular chromatin", 
      "abundant stroma", 
      "molecular genetic diagnosis", 
      "resonance imaging", 
      "cell origin", 
      "genetic testing", 
      "further evaluation", 
      "tumor cells", 
      "granular cytoplasm", 
      "diagnosis", 
      "characteristic morphological features", 
      "young adults", 
      "tumors", 
      "RT-PCR", 
      "polygonal cells", 
      "microscopic examination", 
      "tissue sections", 
      "carcinoma", 
      "genetic diagnosis", 
      "segment 4", 
      "HCC", 
      "fusion gene", 
      "molecular genetic studies", 
      "stroma", 
      "collagen fibers", 
      "examination", 
      "morphological features", 
      "sectorectomy", 
      "cells", 
      "patients", 
      "CK7", 
      "hospital", 
      "findings", 
      "incidence", 
      "IHC", 
      "disease", 
      "calcification", 
      "genetic studies", 
      "adults", 
      "tomography", 
      "scar", 
      "report", 
      "imaging", 
      "lamellar pattern", 
      "particular morphological features", 
      "mass", 
      "cytoplasm", 
      "HAS", 
      "testing", 
      "particular reference", 
      "evaluation", 
      "variants", 
      "nucleoli", 
      "genes", 
      "study", 
      "nucleus", 
      "appearance", 
      "analysis", 
      "features", 
      "use", 
      "spite", 
      "patterns", 
      "detection", 
      "fibers", 
      "diameter", 
      "origin", 
      "sections", 
      "results", 
      "characteristics", 
      "part", 
      "values", 
      "reference", 
      "chromatin"
    ], 
    "name": "A case report of fibrolamellar hepatocellular carcinoma, with particular reference to preoperative diagnosis, value of molecular genetic diagnosis, and cell origin", 
    "pagination": "208", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1141192487"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40792-021-01295-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34533614"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40792-021-01295-4", 
      "https://app.dimensions.ai/details/publication/pub.1141192487"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_923.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s40792-021-01295-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40792-021-01295-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40792-021-01295-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40792-021-01295-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40792-021-01295-4'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      144 URIs      124 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40792-021-01295-4 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nb2d448d26d0a40618747bd41315be1e8
4 schema:citation sg:pub.10.1007/s00247-021-05058-z
5 sg:pub.10.1007/s00595-013-0653-y
6 sg:pub.10.1038/79238
7 sg:pub.10.1038/ajg.2009.440
8 sg:pub.10.1038/modpathol.2010.105
9 sg:pub.10.1038/modpathol.2010.207
10 sg:pub.10.1038/modpathol.2015.4
11 sg:pub.10.1038/modpathol.2016.59
12 sg:pub.10.1038/modpathol.2017.103
13 sg:pub.10.1038/ncomms9070
14 sg:pub.10.1038/srep44653
15 sg:pub.10.1186/s40644-018-0143-y
16 schema:datePublished 2021-09-17
17 schema:datePublishedReg 2021-09-17
18 schema:description BackgroundFibrolamellar hepatocellular carcinoma (FL-HCC) is a liver tumor that occurs almost exclusively in young adults without underlying liver disease. In spite of its distinct clinical characteristics and specific imaging findings, preoperative diagnosis is often difficult due to the extremely low incidence of the tumor. Although FL-HCC shows particular morphological features on H&E-stained tissue sections, differential diagnosis from ordinary HCC, especially the scirrhous variant of HCC, and intrahepatic cholangiocarcinoma needs additional immunohistochemical (IHC) analyses and/or molecular genetic testing.Case presentationA 21-year-old male patient was referred to our hospital for further evaluation of a large liver mass. Abdominal ultrasound examination, contrast-enhanced computed tomography, and magnetic resonance imaging revealed a well-defined hypervascular lobulated liver mass, 11 × 11 cm in diameter, with a central scar and calcification, in segments 5/8. Under the diagnosis of FL-HCC, we carried out extended anterior sectorectomy, including a part of segment 4. On microscopic examination, the tumor was composed of proliferating polygonal cells with abundant eosinophilic granular cytoplasm containing nuclei with vesicular chromatin and enlarged nucleoli, in an abundant stroma. Collagen fibers arranged in a parallel lamellar pattern were seen in the tumor stroma. These findings, together with the results of subsequent IHC analyses using HAS, CK7, and CD 67, we made the diagnosis of FL-HCC, which was further confirmed by detection of the DNAJB1-PRKACA fusion gene in the tumor cells by RT-PCR.ConclusionFL-HCC shows distinct imaging appearances. Although it also has characteristic morphological features, combined use of IHC and/or molecular genetic studies are necessary for the final diagnosis.
19 schema:genre article
20 schema:isAccessibleForFree true
21 schema:isPartOf N144446b2e573434fbaa8c4575483d19a
22 N21d803c8b9d348b4852629c3e21c0b1c
23 sg:journal.1052102
24 schema:keywords CK7
25 Case presentationA
26 FL-HCC
27 HAS
28 HCC
29 IHC
30 IHC analysis
31 RT-PCR
32 abdominal ultrasound examination
33 abundant eosinophilic granular cytoplasm
34 abundant stroma
35 additional immunohistochemical analysis
36 adults
37 analysis
38 appearance
39 calcification
40 carcinoma
41 case report
42 cell origin
43 cells
44 central scar
45 characteristic morphological features
46 characteristics
47 chromatin
48 clinical characteristics
49 collagen fibers
50 computed tomography
51 contrast-enhanced computed tomography
52 cytoplasm
53 detection
54 diagnosis
55 diameter
56 differential diagnosis
57 disease
58 distinct clinical characteristics
59 eosinophilic granular cytoplasm
60 evaluation
61 examination
62 features
63 fibers
64 fibrolamellar hepatocellular carcinoma
65 final diagnosis
66 findings
67 further evaluation
68 fusion gene
69 genes
70 genetic diagnosis
71 genetic studies
72 genetic testing
73 granular cytoplasm
74 hepatocellular carcinoma
75 hospital
76 imaging
77 imaging appearances
78 immunohistochemical analysis
79 incidence
80 lamellar pattern
81 large liver mass
82 liver disease
83 liver mass
84 liver tumors
85 lower incidence
86 magnetic resonance imaging
87 male patients
88 mass
89 microscopic examination
90 molecular genetic diagnosis
91 molecular genetic studies
92 molecular genetic testing
93 morphological features
94 nucleoli
95 nucleus
96 ordinary HCC
97 origin
98 part
99 particular morphological features
100 particular reference
101 patients
102 patterns
103 polygonal cells
104 preoperative diagnosis
105 reference
106 report
107 resonance imaging
108 results
109 scar
110 scirrhous variant
111 sections
112 sectorectomy
113 segment 4
114 segment 5/8
115 spite
116 stroma
117 study
118 testing
119 tissue sections
120 tomography
121 tumor cells
122 tumor stroma
123 tumors
124 ultrasound examination
125 use
126 use of IHC
127 values
128 variants
129 vesicular chromatin
130 young adults
131 schema:name A case report of fibrolamellar hepatocellular carcinoma, with particular reference to preoperative diagnosis, value of molecular genetic diagnosis, and cell origin
132 schema:pagination 208
133 schema:productId N2472ecc08c734696a676d94d0563e5aa
134 N697e877b753b44769b9eb0497f54ba59
135 Nc6f3caee617b4da09b406bf618949c7b
136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141192487
137 https://doi.org/10.1186/s40792-021-01295-4
138 schema:sdDatePublished 2022-09-02T16:07
139 schema:sdLicense https://scigraph.springernature.com/explorer/license/
140 schema:sdPublisher N93314360f2a546d2ae6b7bee66541b9a
141 schema:url https://doi.org/10.1186/s40792-021-01295-4
142 sgo:license sg:explorer/license/
143 sgo:sdDataset articles
144 rdf:type schema:ScholarlyArticle
145 N0f27b0bfa0094fc98a31ccd21926bfb3 schema:affiliation grid-institutes:grid.258269.2
146 schema:familyName Takahashi
147 schema:givenName Atsushi
148 rdf:type schema:Person
149 N144446b2e573434fbaa8c4575483d19a schema:issueNumber 1
150 rdf:type schema:PublicationIssue
151 N21d803c8b9d348b4852629c3e21c0b1c schema:volumeNumber 7
152 rdf:type schema:PublicationVolume
153 N2472ecc08c734696a676d94d0563e5aa schema:name dimensions_id
154 schema:value pub.1141192487
155 rdf:type schema:PropertyValue
156 N2797885e9d314ba488096730d5bba806 rdf:first sg:person.01111072103.14
157 rdf:rest N7a9986f18159442f938c666581cf5fdb
158 N34453879acaf4256a8359f8c33ee2b84 rdf:first sg:person.01202024031.99
159 rdf:rest Nec0302b45ef740369e5afd89efde7d02
160 N697e877b753b44769b9eb0497f54ba59 schema:name doi
161 schema:value 10.1186/s40792-021-01295-4
162 rdf:type schema:PropertyValue
163 N79aae280be8e4a6d8ad584aa1edb1ac1 rdf:first sg:person.012714453755.53
164 rdf:rest N2797885e9d314ba488096730d5bba806
165 N7a9986f18159442f938c666581cf5fdb rdf:first sg:person.0626665021.66
166 rdf:rest Nac1cc2090e5d46a0b7c260046c1019d7
167 N8513e964a3c8420a952d7bb1a1d92420 rdf:first sg:person.07634506273.15
168 rdf:rest Nc8d8271fde2c46deb87857acaa79562a
169 N93314360f2a546d2ae6b7bee66541b9a schema:name Springer Nature - SN SciGraph project
170 rdf:type schema:Organization
171 N9341fe77cc714394801111dd3e81cd5e rdf:first sg:person.0644576333.24
172 rdf:rest Nc14134d312b442c98c011e62cfcff32d
173 Nac1cc2090e5d46a0b7c260046c1019d7 rdf:first sg:person.01356013435.21
174 rdf:rest N34453879acaf4256a8359f8c33ee2b84
175 Nb2d448d26d0a40618747bd41315be1e8 rdf:first N0f27b0bfa0094fc98a31ccd21926bfb3
176 rdf:rest N9341fe77cc714394801111dd3e81cd5e
177 Nc14134d312b442c98c011e62cfcff32d rdf:first sg:person.013175715410.19
178 rdf:rest N8513e964a3c8420a952d7bb1a1d92420
179 Nc6f3caee617b4da09b406bf618949c7b schema:name pubmed_id
180 schema:value 34533614
181 rdf:type schema:PropertyValue
182 Nc8d8271fde2c46deb87857acaa79562a rdf:first sg:person.011063504320.29
183 rdf:rest N79aae280be8e4a6d8ad584aa1edb1ac1
184 Nec0302b45ef740369e5afd89efde7d02 rdf:first sg:person.0612301703.87
185 rdf:rest rdf:nil
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
190 schema:name Oncology and Carcinogenesis
191 rdf:type schema:DefinedTerm
192 sg:journal.1052102 schema:issn 2198-7793
193 schema:name Surgical Case Reports
194 schema:publisher Springer Nature
195 rdf:type schema:Periodical
196 sg:person.011063504320.29 schema:affiliation grid-institutes:grid.258269.2
197 schema:familyName Gyoda
198 schema:givenName Yu
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011063504320.29
200 rdf:type schema:Person
201 sg:person.01111072103.14 schema:affiliation grid-institutes:grid.258269.2
202 schema:familyName Yoshioka
203 schema:givenName Ryuji
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111072103.14
205 rdf:type schema:Person
206 sg:person.01202024031.99 schema:affiliation grid-institutes:grid.258269.2
207 schema:familyName Sano
208 schema:givenName Katsuhiro
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202024031.99
210 rdf:type schema:Person
211 sg:person.012714453755.53 schema:affiliation grid-institutes:grid.258269.2
212 schema:familyName Ichida
213 schema:givenName Hirofumi
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012714453755.53
215 rdf:type schema:Person
216 sg:person.013175715410.19 schema:affiliation grid-institutes:grid.258269.2
217 schema:familyName Ito
218 schema:givenName Ryota
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013175715410.19
220 rdf:type schema:Person
221 sg:person.01356013435.21 schema:affiliation grid-institutes:grid.258269.2
222 schema:familyName Fukumura
223 schema:givenName Yuki
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356013435.21
225 rdf:type schema:Person
226 sg:person.0612301703.87 schema:affiliation grid-institutes:grid.258269.2
227 schema:familyName Saiura
228 schema:givenName Akio
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87
230 rdf:type schema:Person
231 sg:person.0626665021.66 schema:affiliation grid-institutes:grid.258269.2
232 schema:familyName Mise
233 schema:givenName Yoshihiro
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66
235 rdf:type schema:Person
236 sg:person.0644576333.24 schema:affiliation grid-institutes:grid.258269.2
237 schema:familyName Imamura
238 schema:givenName Hiroshi
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644576333.24
240 rdf:type schema:Person
241 sg:person.07634506273.15 schema:affiliation grid-institutes:grid.258269.2
242 schema:familyName Kawano
243 schema:givenName Fumihiro
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07634506273.15
245 rdf:type schema:Person
246 sg:pub.10.1007/s00247-021-05058-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1137196769
247 https://doi.org/10.1007/s00247-021-05058-z
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s00595-013-0653-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1014902260
250 https://doi.org/10.1007/s00595-013-0653-y
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/79238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034260511
253 https://doi.org/10.1038/79238
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/ajg.2009.440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044652591
256 https://doi.org/10.1038/ajg.2009.440
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/modpathol.2010.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009900912
259 https://doi.org/10.1038/modpathol.2010.105
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/modpathol.2010.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029936537
262 https://doi.org/10.1038/modpathol.2010.207
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/modpathol.2015.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046074811
265 https://doi.org/10.1038/modpathol.2015.4
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/modpathol.2016.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043763738
268 https://doi.org/10.1038/modpathol.2016.59
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/modpathol.2017.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091407666
271 https://doi.org/10.1038/modpathol.2017.103
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/ncomms9070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040734156
274 https://doi.org/10.1038/ncomms9070
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/srep44653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084132533
277 https://doi.org/10.1038/srep44653
278 rdf:type schema:CreativeWork
279 sg:pub.10.1186/s40644-018-0143-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1101279343
280 https://doi.org/10.1186/s40644-018-0143-y
281 rdf:type schema:CreativeWork
282 grid-institutes:grid.258269.2 schema:alternateName Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan
283 Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
284 Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan
285 schema:name Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, 3-1-1 Hongo, Bunkyo-Ku, 113-0033, Tokyo, Japan
286 Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
287 Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...