Mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after trastuzumab-based chemotherapy for HER2-positive gastric cancer: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-08

AUTHORS

Hiromi Nagata, Hironori Tsujimoto, Yoshihisa Yaguchi, Keita Kouzu, Yujiro Itazaki, Yusuke Ishibashi, Satoshi Tsuchiya, Takao Sugihara, Nozomi Ito, Manabu Harada, Shinsuke Nomura, Yoshitaka Utsumi, Hideyuki Shimazaki, Yoji Kishi, Hideki Ueno

ABSTRACT

BACKGROUND: Trastuzumab (T-mab)-based chemotherapy is a standard regimen for human epithelial growth factor 2 (HER2)-positive gastric cancer. However, some patients have demonstrated a change in HER2 status after T-mab-based treatment of breast cancer. We report a rare case of mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after T-mab-based chemotherapy for HER2-positive gastric cancer. CASE PRESENTATION: A 60-year-old man presented with a mass of the upper abdomen, which was diagnosed as adenocarcinoma with a HER2 score of 3+ by endoscopic biopsy. He received seven cycles of combination chemotherapy with capecitabine, cisplatin, and T-mab. Subsequently, he underwent open total gastrectomy, distal pancreatosplenectomy, and extended left hepatic lobectomy as a conversion surgery. The surgically resected specimen demonstrated both adenocarcinoma and neuroendocrine components; therefore, it was diagnosed as HER2-negative mixed adenoneuroendocrine carcinoma. Although the patient received additional chemotherapy, multiple liver metastases appeared at 3 months postoperatively and he died at 6 months postoperatively because of the rapidly progressing metastatic tumor. CONCLUSIONS: We encountered a rare case of rapidly progressive mixed adenoneuroendocrine carcinoma that was negative for HER2 expression after T-mab treatment combined with chemotherapy. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40792-020-0774-7

DOI

http://dx.doi.org/10.1186/s40792-020-0774-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123954174

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31916037


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