A case of a long-term survival achieved by surgical treatment and chemotherapy for late recurrence of AFP-producing gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-07-01

AUTHORS

Manabu Harada, Hironori Tsujimoto, Takashi Ichikura, Hiromi Nagata, Nozomi Ito, Shinsuke Nomura, Hiroyuki Horiguchi, Yoshihisa Yaguchi, Yoji Kishi, Hideki Ueno

ABSTRACT

BACKGROUND: Alpha-fetoprotein-producing gastric cancer (AFP-GC) is a relatively rare disease, with a dismal prognosis. CASE PRESENTATION: We report the case of a patient with long-term survival after surgery for the recurrence of AFP-GC. A 71-year-old man was diagnosed with gastric cancer and underwent distal gastrectomy with D2 lymphadenectomy (pT3N2M0). Pathological examination of the resected specimen revealed AFP-GC. Fifteen years after the gastrectomy, the patient experienced anorexia and was admitted with a mass located at the mesentery of the small intestine. Following a diagnosis of gastrointestinal stromal tumor of the mesentery, a tumor resection with partial small intestine was performed. The final histopathological diagnosis was AFP-GC's recurrence in the small-bowel mesentery. Two months later, multiple liver metastases were identified, and serum AFP level was found to be extremely high (17,447 ng/mL). Chemotherapy with S-1+CDDP (SP) was initiated for liver metastasis. However, owing to anorexia and fatigue, SP therapy was discontinued following the patient's request at the end of two courses. A CT scan at 1 month after the discontinuation of chemotherapy did not reveal liver metastasis, and serum AFP level decreased to the normal range. He is alive at present with no re-recurrence and no elevation of serum AFP level at 7 years after the second surgery without any chemotherapy. CONCLUSION: Even if recurrence of AFP-GC is diagnosed, radical resection and chemotherapy are effective, as noted in the present case. More... »

PAGES

106

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40792-019-0664-z

DOI

http://dx.doi.org/10.1186/s40792-019-0664-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117679708

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31264022


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