Recognition and management of rapid-onset gluten ataxias: case series View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-06-13

AUTHORS

Laurence Newrick, Nigel Hoggard, Marios Hadjivassiliou

ABSTRACT

BackgroundMost immune-mediated cerebellar ataxias, including those associated with gluten sensitivity (Gluten Ataxia), tend to present subacutely and usually progress gradually. Acute presentations with rapid progression outside the context of paraneoplastic cerebellar degeneration require prompt diagnosis and early access to disease-modifying immunotherapy in order to avert severe and permanent neurological disability.Case presentationsWe describe three cases of rapid-onset Gluten Ataxia, an immune-mediated cerebellar ataxia due to gluten sensitivity. We detail their presentation, clinical and neuroimaging findings, and our treatment strategy with immunotherapy.ConclusionsOur cases highlight the potential for immune-mediated cerebellar ataxias to present acutely, with rapid-onset symptoms and devastating neurological consequences. We caution against the diagnosis of ‘post-infective cerebellitis’ in adults, and advocate early consideration of an immune-mediated cerebellar ataxia and initiation of immunotherapy to prevent irreversible cerebellar damage. More... »

PAGES

16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40673-021-00139-z

DOI

http://dx.doi.org/10.1186/s40673-021-00139-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138848287

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34120658


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Academic department of neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.31410.37", 
          "name": [
            "Academic department of neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Newrick", 
        "givenName": "Laurence", 
        "id": "sg:person.01301046514.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301046514.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Department of Neuroradiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.416126.6", 
          "name": [
            "Academic Department of Neuroradiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoggard", 
        "givenName": "Nigel", 
        "id": "sg:person.0610025364.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610025364.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic department of neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.31410.37", 
          "name": [
            "Academic department of neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hadjivassiliou", 
        "givenName": "Marios", 
        "id": "sg:person.01354423242.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354423242.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12311-020-01132-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1126922911", 
          "https://doi.org/10.1007/s12311-020-01132-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40673-015-0034-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024291047", 
          "https://doi.org/10.1186/s40673-015-0034-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12311-020-01152-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1128395600", 
          "https://doi.org/10.1007/s12311-020-01152-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-030-19515-1_19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1120310825", 
          "https://doi.org/10.1007/978-3-030-19515-1_19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13104-017-2935-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092903616", 
          "https://doi.org/10.1186/s13104-017-2935-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2053-8871-1-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010244213", 
          "https://doi.org/10.1186/2053-8871-1-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12311-015-0664-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014293149", 
          "https://doi.org/10.1007/s12311-015-0664-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-06-13", 
    "datePublishedReg": "2021-06-13", 
    "description": "BackgroundMost immune-mediated cerebellar ataxias, including those associated with gluten sensitivity (Gluten Ataxia), tend to present subacutely and usually progress gradually. Acute presentations with rapid progression outside the context of paraneoplastic cerebellar degeneration require prompt diagnosis and early access to disease-modifying immunotherapy in order to avert severe and permanent neurological disability.Case presentationsWe describe three cases of rapid-onset Gluten Ataxia, an immune-mediated cerebellar ataxia due to gluten sensitivity. We detail their presentation, clinical and neuroimaging findings, and our treatment strategy with immunotherapy.ConclusionsOur cases highlight the potential for immune-mediated cerebellar ataxias to present acutely, with rapid-onset symptoms and devastating neurological consequences. We caution against the diagnosis of \u2018post-infective cerebellitis\u2019 in adults, and advocate early consideration of an immune-mediated cerebellar ataxia and initiation of immunotherapy to prevent irreversible cerebellar damage.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s40673-021-00139-z", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1051116", 
        "issn": [
          "2053-8871"
        ], 
        "name": "Cerebellum & Ataxias", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "cerebellar ataxia", 
      "gluten ataxia", 
      "gluten sensitivity", 
      "disease-modifying immunotherapy", 
      "rapid-onset symptoms", 
      "initiation of immunotherapy", 
      "permanent neurological disability", 
      "paraneoplastic cerebellar degeneration", 
      "devastating neurological consequences", 
      "Case presentationsWe", 
      "acute presentation", 
      "prompt diagnosis", 
      "neurological disability", 
      "ConclusionsOur case", 
      "case series", 
      "neurological consequences", 
      "rapid progression", 
      "treatment strategies", 
      "cerebellar degeneration", 
      "immunotherapy", 
      "cerebellar damage", 
      "ataxia", 
      "early access", 
      "early consideration", 
      "diagnosis", 
      "presentation", 
      "cerebellitis", 
      "symptoms", 
      "degeneration", 
      "progression", 
      "adults", 
      "disability", 
      "cases", 
      "sensitivity", 
      "initiation", 
      "findings", 
      "damage", 
      "management", 
      "access", 
      "consequences", 
      "strategies", 
      "potential", 
      "series", 
      "recognition", 
      "consideration", 
      "context", 
      "order"
    ], 
    "name": "Recognition and management of rapid-onset gluten ataxias: case series", 
    "pagination": "16", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1138848287"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40673-021-00139-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34120658"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40673-021-00139-z", 
      "https://app.dimensions.ai/details/publication/pub.1138848287"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_875.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s40673-021-00139-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40673-021-00139-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40673-021-00139-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40673-021-00139-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40673-021-00139-z'


 

This table displays all metadata directly associated to this object as RDF triples.

152 TRIPLES      21 PREDICATES      79 URIs      64 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40673-021-00139-z schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nc100f0cff25b44539af306ecf6259d97
4 schema:citation sg:pub.10.1007/978-3-030-19515-1_19
5 sg:pub.10.1007/s12311-015-0664-x
6 sg:pub.10.1007/s12311-020-01132-8
7 sg:pub.10.1007/s12311-020-01152-4
8 sg:pub.10.1186/2053-8871-1-11
9 sg:pub.10.1186/s13104-017-2935-8
10 sg:pub.10.1186/s40673-015-0034-y
11 schema:datePublished 2021-06-13
12 schema:datePublishedReg 2021-06-13
13 schema:description BackgroundMost immune-mediated cerebellar ataxias, including those associated with gluten sensitivity (Gluten Ataxia), tend to present subacutely and usually progress gradually. Acute presentations with rapid progression outside the context of paraneoplastic cerebellar degeneration require prompt diagnosis and early access to disease-modifying immunotherapy in order to avert severe and permanent neurological disability.Case presentationsWe describe three cases of rapid-onset Gluten Ataxia, an immune-mediated cerebellar ataxia due to gluten sensitivity. We detail their presentation, clinical and neuroimaging findings, and our treatment strategy with immunotherapy.ConclusionsOur cases highlight the potential for immune-mediated cerebellar ataxias to present acutely, with rapid-onset symptoms and devastating neurological consequences. We caution against the diagnosis of ‘post-infective cerebellitis’ in adults, and advocate early consideration of an immune-mediated cerebellar ataxia and initiation of immunotherapy to prevent irreversible cerebellar damage.
14 schema:genre article
15 schema:isAccessibleForFree true
16 schema:isPartOf Nc4938b71b2c04dab9a59c82f6d166a72
17 Ne9d376ef983b40d0a5517ff587cbdd6d
18 sg:journal.1051116
19 schema:keywords Case presentationsWe
20 ConclusionsOur case
21 access
22 acute presentation
23 adults
24 ataxia
25 case series
26 cases
27 cerebellar ataxia
28 cerebellar damage
29 cerebellar degeneration
30 cerebellitis
31 consequences
32 consideration
33 context
34 damage
35 degeneration
36 devastating neurological consequences
37 diagnosis
38 disability
39 disease-modifying immunotherapy
40 early access
41 early consideration
42 findings
43 gluten ataxia
44 gluten sensitivity
45 immunotherapy
46 initiation
47 initiation of immunotherapy
48 management
49 neurological consequences
50 neurological disability
51 order
52 paraneoplastic cerebellar degeneration
53 permanent neurological disability
54 potential
55 presentation
56 progression
57 prompt diagnosis
58 rapid progression
59 rapid-onset symptoms
60 recognition
61 sensitivity
62 series
63 strategies
64 symptoms
65 treatment strategies
66 schema:name Recognition and management of rapid-onset gluten ataxias: case series
67 schema:pagination 16
68 schema:productId N13b2a91c67bc42ecb0cb8e7adba381b2
69 N3325c52c1e7d486bbe7f9142b7666c29
70 N668bd8243b5a44f785dd922378f4f6de
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1138848287
72 https://doi.org/10.1186/s40673-021-00139-z
73 schema:sdDatePublished 2022-12-01T06:42
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N7cb6865327d744b89424f7c4acb5f883
76 schema:url https://doi.org/10.1186/s40673-021-00139-z
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N13b2a91c67bc42ecb0cb8e7adba381b2 schema:name dimensions_id
81 schema:value pub.1138848287
82 rdf:type schema:PropertyValue
83 N3325c52c1e7d486bbe7f9142b7666c29 schema:name doi
84 schema:value 10.1186/s40673-021-00139-z
85 rdf:type schema:PropertyValue
86 N668bd8243b5a44f785dd922378f4f6de schema:name pubmed_id
87 schema:value 34120658
88 rdf:type schema:PropertyValue
89 N7cb6865327d744b89424f7c4acb5f883 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N955b39a93827431fa3b35a38112325e2 rdf:first sg:person.0610025364.39
92 rdf:rest Nc2c2d0076e1f4cdd864f3126a890cfe6
93 Nc100f0cff25b44539af306ecf6259d97 rdf:first sg:person.01301046514.14
94 rdf:rest N955b39a93827431fa3b35a38112325e2
95 Nc2c2d0076e1f4cdd864f3126a890cfe6 rdf:first sg:person.01354423242.83
96 rdf:rest rdf:nil
97 Nc4938b71b2c04dab9a59c82f6d166a72 schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 Ne9d376ef983b40d0a5517ff587cbdd6d schema:volumeNumber 8
100 rdf:type schema:PublicationVolume
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
105 schema:name Immunology
106 rdf:type schema:DefinedTerm
107 sg:journal.1051116 schema:issn 2053-8871
108 schema:name Cerebellum & Ataxias
109 schema:publisher Springer Nature
110 rdf:type schema:Periodical
111 sg:person.01301046514.14 schema:affiliation grid-institutes:grid.31410.37
112 schema:familyName Newrick
113 schema:givenName Laurence
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301046514.14
115 rdf:type schema:Person
116 sg:person.01354423242.83 schema:affiliation grid-institutes:grid.31410.37
117 schema:familyName Hadjivassiliou
118 schema:givenName Marios
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354423242.83
120 rdf:type schema:Person
121 sg:person.0610025364.39 schema:affiliation grid-institutes:grid.416126.6
122 schema:familyName Hoggard
123 schema:givenName Nigel
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610025364.39
125 rdf:type schema:Person
126 sg:pub.10.1007/978-3-030-19515-1_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120310825
127 https://doi.org/10.1007/978-3-030-19515-1_19
128 rdf:type schema:CreativeWork
129 sg:pub.10.1007/s12311-015-0664-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014293149
130 https://doi.org/10.1007/s12311-015-0664-x
131 rdf:type schema:CreativeWork
132 sg:pub.10.1007/s12311-020-01132-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1126922911
133 https://doi.org/10.1007/s12311-020-01132-8
134 rdf:type schema:CreativeWork
135 sg:pub.10.1007/s12311-020-01152-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128395600
136 https://doi.org/10.1007/s12311-020-01152-4
137 rdf:type schema:CreativeWork
138 sg:pub.10.1186/2053-8871-1-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010244213
139 https://doi.org/10.1186/2053-8871-1-11
140 rdf:type schema:CreativeWork
141 sg:pub.10.1186/s13104-017-2935-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092903616
142 https://doi.org/10.1186/s13104-017-2935-8
143 rdf:type schema:CreativeWork
144 sg:pub.10.1186/s40673-015-0034-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1024291047
145 https://doi.org/10.1186/s40673-015-0034-y
146 rdf:type schema:CreativeWork
147 grid-institutes:grid.31410.37 schema:alternateName Academic department of neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
148 schema:name Academic department of neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
149 rdf:type schema:Organization
150 grid-institutes:grid.416126.6 schema:alternateName Academic Department of Neuroradiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK
151 schema:name Academic Department of Neuroradiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK
152 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...