Alcohol-related cerebellar degeneration: not all down to toxicity? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-03

AUTHORS

Priya D. Shanmugarajah, Nigel Hoggard, Stuart Currie, Daniel P. Aeschlimann, Pascale C. Aeschlimann, Dermot C. Gleeson, Mohammed Karajeh, Nicola Woodroofe, Richard A. Grünewald, Marios Hadjivassiliou

ABSTRACT

BackgroundAlcohol-related cerebellar degeneration is one of the commonest acquired forms of cerebellar ataxia. The exact pathogenic mechanisms by which alcohol leads to cerebellar damage remain unknown. Possible autoreactive immune mediated mechanisms have not been explored previously. In this study, we aim to investigate the potential role of alcohol-induced immune mediated cerebellar degeneration.MethodsPatients with ataxia and a history of alcohol misuse were recruited from the Ataxia and Hepatology tertiary clinics at Sheffield Teaching Hospitals NHS Trust. We determined the pattern of cerebellar involvement both on clinical (SARA score) and imaging (MRI volumetry and MR spectroscopy) parameters. In addition, HLA genotyping, serological markers for gluten-related disorders and serological reactivity on rat cerebellar tissue using indirect immunohistochemistry were assessed.ResultsThirty-eight patients were included in the study all of whom had ataxia. The gait (97 %), stance (89 %) and heel-shin slide (89 %) were the predominant SARA elements affected. MRI volumetric and spectroscopy techniques demonstrated significant structural, volumetric and functional deficits of the cerebellum with particular involvement of the cerebellar vermis. Circulating anti-gliadin antibodies were detected in 34 % patients vs. 12 % in healthy controls. Antibodies to transglutaminase 6 (TG6) were detected in 39 % of patients and 4 % of healthy control subjects. Using immunohistochemistry, Purkinje cell and/or granular layer reactivity was demonstrated in 71 % of patient sera.ConclusionsAlcohol induced tissue injury to the CNS leading to cerebellar degeneration may also involve immune mediated mechanisms, including sensitisation to gluten. More... »

PAGES

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40673-016-0055-1

DOI

http://dx.doi.org/10.1186/s40673-016-0055-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007403324

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27729985


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shanmugarajah", 
        "givenName": "Priya D.", 
        "id": "sg:person.01273701327.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273701327.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Unit of Radiology, University of Sheffield, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Radiology, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoggard", 
        "givenName": "Nigel", 
        "id": "sg:person.0610025364.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610025364.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Unit of Radiology, University of Sheffield, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Unit of Radiology, University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Currie", 
        "givenName": "Stuart", 
        "id": "sg:person.01255541046.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255541046.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aeschlimann", 
        "givenName": "Daniel P.", 
        "id": "sg:person.01007061523.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007061523.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK", 
          "id": "http://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aeschlimann", 
        "givenName": "Pascale C.", 
        "id": "sg:person.01107523472.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107523472.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Department of Hepatology, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Department of Hepatology, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gleeson", 
        "givenName": "Dermot C.", 
        "id": "sg:person.01307202357.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307202357.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Department of Hepatology, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Department of Hepatology, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karajeh", 
        "givenName": "Mohammed", 
        "id": "sg:person.01154706724.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154706724.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.5884.1", 
          "name": [
            "Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woodroofe", 
        "givenName": "Nicola", 
        "id": "sg:person.0764125027.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764125027.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00fcnewald", 
        "givenName": "Richard A.", 
        "id": "sg:person.01130424341.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130424341.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hadjivassiliou", 
        "givenName": "Marios", 
        "id": "sg:person.01354423242.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354423242.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12311-012-0405-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028615619", 
          "https://doi.org/10.1007/s12311-012-0405-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12311-008-0034-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018097761", 
          "https://doi.org/10.1007/s12311-008-0034-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-007-9874-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034443862", 
          "https://doi.org/10.1007/s10620-007-9874-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12311-012-0415-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006835328", 
          "https://doi.org/10.1007/s12311-012-0415-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-006-0059-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013681204", 
          "https://doi.org/10.1007/s00401-006-0059-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1233-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012149371", 
          "https://doi.org/10.1007/s00401-013-1233-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12311-009-0141-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036666950", 
          "https://doi.org/10.1007/s12311-009-0141-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-10-03", 
    "datePublishedReg": "2016-10-03", 
    "description": "BackgroundAlcohol-related cerebellar degeneration is one of the commonest acquired forms of cerebellar ataxia. The exact pathogenic mechanisms by which alcohol leads to cerebellar damage remain unknown. Possible autoreactive immune mediated mechanisms have not been explored previously. In this study, we aim to investigate the potential role of alcohol-induced immune mediated cerebellar degeneration.MethodsPatients with ataxia and a history of alcohol misuse were recruited from the Ataxia and Hepatology tertiary clinics at Sheffield Teaching Hospitals NHS Trust. We determined the pattern of cerebellar involvement both on clinical (SARA score) and imaging (MRI volumetry and MR spectroscopy) parameters. In addition, HLA genotyping, serological markers for gluten-related disorders and serological reactivity on rat cerebellar tissue using indirect immunohistochemistry were assessed.ResultsThirty-eight patients were included in the study all of whom had ataxia. The gait (97\u00a0%), stance (89\u00a0%) and heel-shin slide (89\u00a0%) were the predominant SARA elements affected. MRI volumetric and spectroscopy techniques demonstrated significant structural, volumetric and functional deficits of the cerebellum with particular involvement of the cerebellar vermis. Circulating anti-gliadin antibodies were detected in 34\u00a0% patients vs. 12\u00a0% in healthy controls. Antibodies to transglutaminase 6 (TG6) were detected in 39\u00a0% of patients and 4\u00a0% of healthy control subjects. Using immunohistochemistry, Purkinje cell and/or granular layer reactivity was demonstrated in 71\u00a0% of patient sera.ConclusionsAlcohol induced tissue injury to the CNS leading to cerebellar degeneration may also involve immune mediated mechanisms, including sensitisation to gluten.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s40673-016-0055-1", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1051116", 
        "issn": [
          "2053-8871"
        ], 
        "name": "Cerebellum & Ataxias", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "immune mediated mechanisms", 
      "cerebellar degeneration", 
      "ResultsThirty-eight patients", 
      "mediated mechanisms", 
      "healthy control subjects", 
      "exact pathogenic mechanism", 
      "anti-gliadin antibodies", 
      "Sheffield Teaching Hospitals NHS Trust", 
      "Hospitals NHS Trust", 
      "rat cerebellar tissue", 
      "tertiary clinic", 
      "serological markers", 
      "control subjects", 
      "functional deficits", 
      "healthy controls", 
      "tissue injury", 
      "patient sera", 
      "indirect immunohistochemistry", 
      "cerebellar vermis", 
      "pathogenic mechanisms", 
      "alcohol misuse", 
      "cerebellar involvement", 
      "cerebellar ataxia", 
      "Purkinje cells", 
      "cerebellar damage", 
      "cerebellar tissue", 
      "patients", 
      "NHS Trust", 
      "serological reactivity", 
      "degeneration", 
      "ataxia", 
      "particular involvement", 
      "potential role", 
      "immunohistochemistry", 
      "antibodies", 
      "involvement", 
      "MethodsPatients", 
      "HLA", 
      "clinic", 
      "injury", 
      "CNS", 
      "commonest", 
      "vermis", 
      "cerebellum", 
      "ConclusionsAlcohol", 
      "MRI", 
      "serum", 
      "sensitisation", 
      "disorders", 
      "BackgroundAlcohol", 
      "gait", 
      "markers", 
      "tissue", 
      "deficits", 
      "study", 
      "toxicity", 
      "subjects", 
      "mechanism", 
      "cells", 
      "misuse", 
      "reactivity", 
      "damage", 
      "history", 
      "control", 
      "role", 
      "slides", 
      "alcohol", 
      "patterns", 
      "addition", 
      "stance", 
      "form", 
      "technique", 
      "trust", 
      "parameters", 
      "elements", 
      "spectroscopy techniques"
    ], 
    "name": "Alcohol-related cerebellar degeneration: not all down to toxicity?", 
    "pagination": "17", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007403324"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40673-016-0055-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27729985"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40673-016-0055-1", 
      "https://app.dimensions.ai/details/publication/pub.1007403324"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_706.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s40673-016-0055-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40673-016-0055-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40673-016-0055-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40673-016-0055-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40673-016-0055-1'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      21 PREDICATES      108 URIs      93 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40673-016-0055-1 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nad68ff8c7fd5450aa8c52410ac461d5b
4 schema:citation sg:pub.10.1007/s00401-006-0059-7
5 sg:pub.10.1007/s00401-013-1233-3
6 sg:pub.10.1007/s10620-007-9874-5
7 sg:pub.10.1007/s12311-008-0034-z
8 sg:pub.10.1007/s12311-009-0141-5
9 sg:pub.10.1007/s12311-012-0405-3
10 sg:pub.10.1007/s12311-012-0415-1
11 schema:datePublished 2016-10-03
12 schema:datePublishedReg 2016-10-03
13 schema:description BackgroundAlcohol-related cerebellar degeneration is one of the commonest acquired forms of cerebellar ataxia. The exact pathogenic mechanisms by which alcohol leads to cerebellar damage remain unknown. Possible autoreactive immune mediated mechanisms have not been explored previously. In this study, we aim to investigate the potential role of alcohol-induced immune mediated cerebellar degeneration.MethodsPatients with ataxia and a history of alcohol misuse were recruited from the Ataxia and Hepatology tertiary clinics at Sheffield Teaching Hospitals NHS Trust. We determined the pattern of cerebellar involvement both on clinical (SARA score) and imaging (MRI volumetry and MR spectroscopy) parameters. In addition, HLA genotyping, serological markers for gluten-related disorders and serological reactivity on rat cerebellar tissue using indirect immunohistochemistry were assessed.ResultsThirty-eight patients were included in the study all of whom had ataxia. The gait (97 %), stance (89 %) and heel-shin slide (89 %) were the predominant SARA elements affected. MRI volumetric and spectroscopy techniques demonstrated significant structural, volumetric and functional deficits of the cerebellum with particular involvement of the cerebellar vermis. Circulating anti-gliadin antibodies were detected in 34 % patients vs. 12 % in healthy controls. Antibodies to transglutaminase 6 (TG6) were detected in 39 % of patients and 4 % of healthy control subjects. Using immunohistochemistry, Purkinje cell and/or granular layer reactivity was demonstrated in 71 % of patient sera.ConclusionsAlcohol induced tissue injury to the CNS leading to cerebellar degeneration may also involve immune mediated mechanisms, including sensitisation to gluten.
14 schema:genre article
15 schema:isAccessibleForFree true
16 schema:isPartOf N1d94fd241acf4155b342eb52487df11d
17 N6cdb79e2187b4db580eaaa05be2c3811
18 sg:journal.1051116
19 schema:keywords BackgroundAlcohol
20 CNS
21 ConclusionsAlcohol
22 HLA
23 Hospitals NHS Trust
24 MRI
25 MethodsPatients
26 NHS Trust
27 Purkinje cells
28 ResultsThirty-eight patients
29 Sheffield Teaching Hospitals NHS Trust
30 addition
31 alcohol
32 alcohol misuse
33 anti-gliadin antibodies
34 antibodies
35 ataxia
36 cells
37 cerebellar ataxia
38 cerebellar damage
39 cerebellar degeneration
40 cerebellar involvement
41 cerebellar tissue
42 cerebellar vermis
43 cerebellum
44 clinic
45 commonest
46 control
47 control subjects
48 damage
49 deficits
50 degeneration
51 disorders
52 elements
53 exact pathogenic mechanism
54 form
55 functional deficits
56 gait
57 healthy control subjects
58 healthy controls
59 history
60 immune mediated mechanisms
61 immunohistochemistry
62 indirect immunohistochemistry
63 injury
64 involvement
65 markers
66 mechanism
67 mediated mechanisms
68 misuse
69 parameters
70 particular involvement
71 pathogenic mechanisms
72 patient sera
73 patients
74 patterns
75 potential role
76 rat cerebellar tissue
77 reactivity
78 role
79 sensitisation
80 serological markers
81 serological reactivity
82 serum
83 slides
84 spectroscopy techniques
85 stance
86 study
87 subjects
88 technique
89 tertiary clinic
90 tissue
91 tissue injury
92 toxicity
93 trust
94 vermis
95 schema:name Alcohol-related cerebellar degeneration: not all down to toxicity?
96 schema:pagination 17
97 schema:productId N3034667b0b69499a91fbec33a5abd98b
98 N510324a7be24414d8ab74e86ec7eb871
99 Na8dad2ec52054125b2283e3bbb5a7cf1
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007403324
101 https://doi.org/10.1186/s40673-016-0055-1
102 schema:sdDatePublished 2022-09-02T16:00
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N51267beff3c848c1b64600e454b14d4d
105 schema:url https://doi.org/10.1186/s40673-016-0055-1
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N1d94fd241acf4155b342eb52487df11d schema:volumeNumber 3
110 rdf:type schema:PublicationVolume
111 N249d31e5aa784ae1b510ca87df6257a0 rdf:first sg:person.01154706724.69
112 rdf:rest Ne0ec97c3219547d8b5a228988102eab7
113 N3034667b0b69499a91fbec33a5abd98b schema:name pubmed_id
114 schema:value 27729985
115 rdf:type schema:PropertyValue
116 N42d56b425d224adea8600878d963f631 rdf:first sg:person.01255541046.35
117 rdf:rest N620d50d116e041bd87350073a8371e55
118 N4854155f5931400489769fceeef27b99 rdf:first sg:person.01107523472.96
119 rdf:rest Nef93b0d752be42a29bef516a26b45876
120 N510324a7be24414d8ab74e86ec7eb871 schema:name dimensions_id
121 schema:value pub.1007403324
122 rdf:type schema:PropertyValue
123 N51267beff3c848c1b64600e454b14d4d schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N620d50d116e041bd87350073a8371e55 rdf:first sg:person.01007061523.54
126 rdf:rest N4854155f5931400489769fceeef27b99
127 N6cdb79e2187b4db580eaaa05be2c3811 schema:issueNumber 1
128 rdf:type schema:PublicationIssue
129 Na8dad2ec52054125b2283e3bbb5a7cf1 schema:name doi
130 schema:value 10.1186/s40673-016-0055-1
131 rdf:type schema:PropertyValue
132 Nad68ff8c7fd5450aa8c52410ac461d5b rdf:first sg:person.01273701327.13
133 rdf:rest Nf8f8ba2a647246549f8bde01fddcf32b
134 Ne0ec97c3219547d8b5a228988102eab7 rdf:first sg:person.0764125027.18
135 rdf:rest Nf40023349d0c401d8abd8a7445f6c4e6
136 Nea89915fe71c4cbeafaa56adcb4fe287 rdf:first sg:person.01354423242.83
137 rdf:rest rdf:nil
138 Nef93b0d752be42a29bef516a26b45876 rdf:first sg:person.01307202357.72
139 rdf:rest N249d31e5aa784ae1b510ca87df6257a0
140 Nf40023349d0c401d8abd8a7445f6c4e6 rdf:first sg:person.01130424341.44
141 rdf:rest Nea89915fe71c4cbeafaa56adcb4fe287
142 Nf8f8ba2a647246549f8bde01fddcf32b rdf:first sg:person.0610025364.39
143 rdf:rest N42d56b425d224adea8600878d963f631
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
148 schema:name Neurosciences
149 rdf:type schema:DefinedTerm
150 sg:journal.1051116 schema:issn 2053-8871
151 schema:name Cerebellum & Ataxias
152 schema:publisher Springer Nature
153 rdf:type schema:Periodical
154 sg:person.01007061523.54 schema:affiliation grid-institutes:grid.5600.3
155 schema:familyName Aeschlimann
156 schema:givenName Daniel P.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007061523.54
158 rdf:type schema:Person
159 sg:person.01107523472.96 schema:affiliation grid-institutes:grid.5600.3
160 schema:familyName Aeschlimann
161 schema:givenName Pascale C.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107523472.96
163 rdf:type schema:Person
164 sg:person.01130424341.44 schema:affiliation grid-institutes:grid.11835.3e
165 schema:familyName Grünewald
166 schema:givenName Richard A.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130424341.44
168 rdf:type schema:Person
169 sg:person.01154706724.69 schema:affiliation grid-institutes:grid.11835.3e
170 schema:familyName Karajeh
171 schema:givenName Mohammed
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154706724.69
173 rdf:type schema:Person
174 sg:person.01255541046.35 schema:affiliation grid-institutes:grid.11835.3e
175 schema:familyName Currie
176 schema:givenName Stuart
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255541046.35
178 rdf:type schema:Person
179 sg:person.01273701327.13 schema:affiliation grid-institutes:grid.11835.3e
180 schema:familyName Shanmugarajah
181 schema:givenName Priya D.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273701327.13
183 rdf:type schema:Person
184 sg:person.01307202357.72 schema:affiliation grid-institutes:grid.11835.3e
185 schema:familyName Gleeson
186 schema:givenName Dermot C.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307202357.72
188 rdf:type schema:Person
189 sg:person.01354423242.83 schema:affiliation grid-institutes:grid.11835.3e
190 schema:familyName Hadjivassiliou
191 schema:givenName Marios
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354423242.83
193 rdf:type schema:Person
194 sg:person.0610025364.39 schema:affiliation grid-institutes:grid.11835.3e
195 schema:familyName Hoggard
196 schema:givenName Nigel
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610025364.39
198 rdf:type schema:Person
199 sg:person.0764125027.18 schema:affiliation grid-institutes:grid.5884.1
200 schema:familyName Woodroofe
201 schema:givenName Nicola
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764125027.18
203 rdf:type schema:Person
204 sg:pub.10.1007/s00401-006-0059-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013681204
205 https://doi.org/10.1007/s00401-006-0059-7
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/s00401-013-1233-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012149371
208 https://doi.org/10.1007/s00401-013-1233-3
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/s10620-007-9874-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034443862
211 https://doi.org/10.1007/s10620-007-9874-5
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s12311-008-0034-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1018097761
214 https://doi.org/10.1007/s12311-008-0034-z
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s12311-009-0141-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036666950
217 https://doi.org/10.1007/s12311-009-0141-5
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s12311-012-0405-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028615619
220 https://doi.org/10.1007/s12311-012-0405-3
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s12311-012-0415-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006835328
223 https://doi.org/10.1007/s12311-012-0415-1
224 rdf:type schema:CreativeWork
225 grid-institutes:grid.11835.3e schema:alternateName Academic Department of Hepatology, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK
226 Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK
227 Academic Unit of Radiology, University of Sheffield, Sheffield, UK
228 schema:name Academic Department of Hepatology, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK
229 Academic Department of Neurosciences, Royal Hallamshire Hospital, and University of Sheffield, Sheffield, UK
230 Academic Unit of Radiology, University of Sheffield, Sheffield, UK
231 rdf:type schema:Organization
232 grid-institutes:grid.5600.3 schema:alternateName Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK
233 schema:name Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK
234 rdf:type schema:Organization
235 grid-institutes:grid.5884.1 schema:alternateName Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK
236 schema:name Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...