Expression regulation and functional analysis of RGS2 and RGS4 in adipogenic and osteogenic differentiation of human mesenchymal stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Alma Madrigal, Lun Tan, Yuanxiang Zhao

ABSTRACT

BACKGROUND: Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells and develop therapeutic treatments for bone- or adipose-related diseases. In this study, the role of RGS2 and RGS4, two members of the regulators of G protein signaling (RGS) family, was investigated during adipogenenic and osteogenenic differentiation of human mesenchymal stem cells (hMSCs). RESULTS: Expression of RGS2 and RGS4 were found to be inversely regulated during adipogenesis induced by dexamethasone (DEX) and 3-isobutyl-methylxanthine, regardless if insulin was present, with RGS2 up-regulated and RGS4 down-regulated in response to adipogenic induction. RGS2 expression was also up-regulated during osteogenesis at a level similar to that induced by treatment of DEX alone, a shared component of adipogenic and osteogenic differentiation inducing media, but significantly lower than the level induced by adipogenic inducing media. RGS4 expression was down-regulated during the first 48 h of osteogenesis but up-regulated afterwards, in both cases at levels similar to that induced by DEX alone. Expression knock-down using small interfering RNA against RGS2 resulted in decreased differentiation efficiency during both adipogenesis and osteogenesis. On the other hand, expression knock-down of RGS4 also resulted in decreased adipogenic differentiation but increased osteogenic differentiation. CONCLUSIONS: RGS2 and RGS4 are differentially regulated during adipogenic and osteogenic differentiation of hMSCs. In addition, both RGS2 and RGS4 play positive roles during adipogenesis but opposing roles during osteogenesis, with RGS2 as a positive regulator and RGS4 as a negative regulator. These results imply that members of RGS proteins may play multifaceted roles during human adipogenesis and osteogenesis to balance or counterbalance each other's function during those processes. More... »

PAGES

43

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40659-017-0148-1

DOI

http://dx.doi.org/10.1186/s40659-017-0148-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100079869

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29279050


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RGS Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "Biological Sciences Department, California State Polytechnic University at Pomona, 3801 W. Temple Ave., 91768, Pomona, CA, USA", 
            "Center for Biomedicine and Genetics, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd., 91010, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madrigal", 
        "givenName": "Alma", 
        "id": "sg:person.011246661547.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011246661547.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "California State Polytechnic University", 
          "id": "https://www.grid.ac/institutes/grid.155203.0", 
          "name": [
            "Biological Sciences Department, California State Polytechnic University at Pomona, 3801 W. Temple Ave., 91768, Pomona, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Lun", 
        "id": "sg:person.016425105147.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016425105147.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "California State Polytechnic University", 
          "id": "https://www.grid.ac/institutes/grid.155203.0", 
          "name": [
            "Biological Sciences Department, California State Polytechnic University at Pomona, 3801 W. Temple Ave., 91768, Pomona, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Yuanxiang", 
        "id": "sg:person.01272726001.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272726001.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.febslet.2009.10.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000607421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.pmbts.2015.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001368592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-011-9461-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001942564", 
          "https://doi.org/10.1007/s00223-011-9461-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2014-1024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001979924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b908315d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003184518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2004.06.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003529612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208819200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004222959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.10.4221-4228.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006139684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2011.0040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007403409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00003.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008060887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00003.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008060887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1022203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008542349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0149543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009290881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0149543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009290881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0149543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009290881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.14.1654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011379069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90006-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013158443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(00)00823-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014282593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-3564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016004464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1534-5807(04)00075-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016167288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2013.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016721129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2013.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016726979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.6.3549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016820322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.64.070195.002021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017112958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0037162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017847931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.24075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017987195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1011513223894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018871641", 
          "https://doi.org/10.1023/a:1011513223894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.90920.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020071828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11684-013-0252-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020583552", 
          "https://doi.org/10.1007/s11684-013-0252-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-213x-10-47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020626950", 
          "https://doi.org/10.1186/1471-213x-10-47"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/282745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020678898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-016-2462-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021097082", 
          "https://doi.org/10.1007/s00441-016-2462-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-016-2462-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021097082", 
          "https://doi.org/10.1007/s00441-016-2462-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e09-07-0541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021852795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002281-200307000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021958964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002281-200307000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021958964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024600139", 
          "https://doi.org/10.1038/nrm3198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-015-0079-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025074902", 
          "https://doi.org/10.1007/s00223-015-0079-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-015-0079-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025074902", 
          "https://doi.org/10.1007/s00223-015-0079-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2011.06.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026009509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2005.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026588252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2012.04903.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027112118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027346999", 
          "https://doi.org/10.1038/nrg3185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031418878", 
          "https://doi.org/10.1038/nm.3074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.115.102210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032256844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.24278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032486147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2015.168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033921991", 
          "https://doi.org/10.1038/cdd.2015.168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00622-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033966649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1100/2012/793823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034239843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20110615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034593079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20110615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034593079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2012.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035354374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2011.03.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036229899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0086031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036260114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2010.01224.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036707502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1099-1573(200008)14:5<344::aid-ptr586>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037006686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80257-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037520667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/scrt328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040179932", 
          "https://doi.org/10.1186/scrt328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12248-015-9847-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040462656", 
          "https://doi.org/10.1208/s12248-015-9847-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00211-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040542836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9728.2004.00127.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040740678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2006-7-10-r100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040889351", 
          "https://doi.org/10.1186/gb-2006-7-10-r100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms4368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041956868", 
          "https://doi.org/10.1038/ncomms4368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.070612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042100934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5411.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.061007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043583617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pharmtox.40.1.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043888268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2007.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045099377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045255888", 
          "https://doi.org/10.1007/s001250051630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045255888", 
          "https://doi.org/10.1007/s001250051630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045452808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045493560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msl145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045761561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.69.1.795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047604660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11914-013-0135-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047982677", 
          "https://doi.org/10.1007/s11914-013-0135-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.079699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048587305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.pmbts.2015.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049304371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ocr.12080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051629979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c100272200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051745308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0030256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051842652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2010.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052464035", 
          "https://doi.org/10.1038/nrendo.2010.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2010.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052464035", 
          "https://doi.org/10.1038/nrendo.2010.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0703407104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052598708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80306-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052731075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0132594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052846811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197110000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060155815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197110000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060155815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197110000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060155815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.54.3.527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062438748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2003-0746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064246279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2004-0735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064246925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2008-0717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064249516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-1477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12688/f1000research.8963.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064612731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12688/f1000research.8963.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064612731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157488807781696267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069215691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/2296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070914620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/4232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070916397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4252/wjsc.v6.i2.94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072402275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/ijbs.1.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073618564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076185256", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1574888x11666160921121555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079330235"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells and develop therapeutic treatments for bone- or adipose-related diseases. In this study, the role of RGS2 and RGS4, two members of the regulators of G protein signaling (RGS) family, was investigated during adipogenenic and osteogenenic differentiation of human mesenchymal stem cells (hMSCs).\nRESULTS: Expression of RGS2 and RGS4 were found to be inversely regulated during adipogenesis induced by dexamethasone (DEX) and 3-isobutyl-methylxanthine, regardless if insulin was present, with RGS2 up-regulated and RGS4 down-regulated in response to adipogenic induction. RGS2 expression was also up-regulated during osteogenesis at a level similar to that induced by treatment of DEX alone, a shared component of adipogenic and osteogenic differentiation inducing media, but significantly lower than the level induced by adipogenic inducing media. RGS4 expression was down-regulated during the first 48\u00a0h of osteogenesis but up-regulated afterwards, in both cases at levels similar to that induced by DEX alone. Expression knock-down using small interfering RNA against RGS2 resulted in decreased differentiation efficiency during both adipogenesis and osteogenesis. On the other hand, expression knock-down of RGS4 also resulted in decreased adipogenic differentiation but increased osteogenic differentiation.\nCONCLUSIONS: RGS2 and RGS4 are differentially regulated during adipogenic and osteogenic differentiation of hMSCs. In addition, both RGS2 and RGS4 play positive roles during adipogenesis but opposing roles during osteogenesis, with RGS2 as a positive regulator and RGS4 as a negative regulator. These results imply that members of RGS proteins may play multifaceted roles during human adipogenesis and osteogenesis to balance or counterbalance each other's function during those processes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40659-017-0148-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3932375", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4898548", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2680040", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015240", 
        "issn": [
          "0716-9760", 
          "0717-6287"
        ], 
        "name": "Biological Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "50"
      }
    ], 
    "name": "Expression regulation and functional analysis of RGS2 and RGS4 in adipogenic and osteogenic differentiation of human mesenchymal stem cells", 
    "pagination": "43", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f034d68162699fb62a297ae82a02b2f4e2618919aba8786b888fdc726877edd4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29279050"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9308271"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40659-017-0148-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100079869"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40659-017-0148-1", 
      "https://app.dimensions.ai/details/publication/pub.1100079869"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s40659-017-0148-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40659-017-0148-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40659-017-0148-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40659-017-0148-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40659-017-0148-1'


 

This table displays all metadata directly associated to this object as RDF triples.

411 TRIPLES      21 PREDICATES      127 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40659-017-0148-1 schema:about N0335a562cebf4d64b6a3f169e0e924f3
2 N152ebc1bb6bd4f0593fb4ee8677c1525
3 N40a96e410aea437c8ff17792a5fc638f
4 N6376731579854859b91f01b1bb8683e5
5 N692eb13e724243e792cf4906a80c38da
6 Nae6c755c4fed448ba6aac9cb8525b8d1
7 Ne9edee473fa345d3bf91426b5015db23
8 Nea1387bd531e468a84009b11585eca00
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author Nd4cb57d3fc894b53afcc2a6b3e9adbfa
12 schema:citation sg:pub.10.1007/s001250051630
13 sg:pub.10.1007/s00223-011-9461-9
14 sg:pub.10.1007/s00223-015-0079-1
15 sg:pub.10.1007/s00441-016-2462-2
16 sg:pub.10.1007/s11684-013-0252-8
17 sg:pub.10.1007/s11914-013-0135-6
18 sg:pub.10.1023/a:1011513223894
19 sg:pub.10.1038/cdd.2015.168
20 sg:pub.10.1038/ncomms4368
21 sg:pub.10.1038/nm.3074
22 sg:pub.10.1038/nrendo.2010.20
23 sg:pub.10.1038/nrg3185
24 sg:pub.10.1038/nrm3198
25 sg:pub.10.1186/1471-213x-10-47
26 sg:pub.10.1186/gb-2006-7-10-r100
27 sg:pub.10.1186/scrt328
28 sg:pub.10.1208/s12248-015-9847-0
29 https://app.dimensions.ai/details/publication/pub.1076185256
30 https://doi.org/10.1002/1099-1573(200008)14:5<344::aid-ptr586>3.0.co;2-3
31 https://doi.org/10.1002/jcp.20299
32 https://doi.org/10.1002/jcp.24075
33 https://doi.org/10.1002/jcp.24278
34 https://doi.org/10.1016/0092-8674(94)90006-x
35 https://doi.org/10.1016/bs.pmbts.2015.02.001
36 https://doi.org/10.1016/bs.pmbts.2015.02.002
37 https://doi.org/10.1016/j.biocel.2013.02.013
38 https://doi.org/10.1016/j.bone.2011.06.030
39 https://doi.org/10.1016/j.cellsig.2005.08.010
40 https://doi.org/10.1016/j.cellsig.2007.11.012
41 https://doi.org/10.1016/j.cellsig.2011.03.020
42 https://doi.org/10.1016/j.febslet.2009.10.036
43 https://doi.org/10.1016/j.gene.2004.06.044
44 https://doi.org/10.1016/j.molcel.2012.10.018
45 https://doi.org/10.1016/j.str.2013.02.011
46 https://doi.org/10.1016/s0092-8674(00)80257-3
47 https://doi.org/10.1016/s0092-8674(01)00622-5
48 https://doi.org/10.1016/s0960-9822(00)00823-x
49 https://doi.org/10.1016/s1097-2765(00)80306-8
50 https://doi.org/10.1016/s1097-2765(01)00211-8
51 https://doi.org/10.1016/s1534-5807(04)00075-9
52 https://doi.org/10.1039/b908315d
53 https://doi.org/10.1042/bst20110615
54 https://doi.org/10.1073/pnas.0703407104
55 https://doi.org/10.1074/jbc.274.6.3549
56 https://doi.org/10.1074/jbc.c100272200
57 https://doi.org/10.1074/jbc.m208819200
58 https://doi.org/10.1089/scd.2011.0040
59 https://doi.org/10.1091/mbc.e09-07-0541
60 https://doi.org/10.1093/molbev/msl145
61 https://doi.org/10.1097/00002281-200307000-00013
62 https://doi.org/10.1097/00003086-197110000-00021
63 https://doi.org/10.1100/2012/793823
64 https://doi.org/10.1101/gad.1022203
65 https://doi.org/10.1101/gad.8.14.1654
66 https://doi.org/10.1111/j.1474-9728.2004.00127.x
67 https://doi.org/10.1111/j.1538-7836.2012.04903.x
68 https://doi.org/10.1111/j.1582-4934.2010.01224.x
69 https://doi.org/10.1111/ocr.12080
70 https://doi.org/10.1124/mol.115.102210
71 https://doi.org/10.1124/pr.54.3.527
72 https://doi.org/10.1126/science.284.5411.143
73 https://doi.org/10.1128/mcb.25.10.4221-4228.2005
74 https://doi.org/10.1146/annurev.bi.64.070195.002021
75 https://doi.org/10.1146/annurev.biochem.69.1.795
76 https://doi.org/10.1146/annurev.pharmtox.40.1.235
77 https://doi.org/10.1152/ajpendo.90920.2008
78 https://doi.org/10.1152/physrev.00003.2005
79 https://doi.org/10.1155/2011/282745
80 https://doi.org/10.1158/0008-5472.can-08-3564
81 https://doi.org/10.1210/en.2003-0746
82 https://doi.org/10.1210/en.2004-0735
83 https://doi.org/10.1210/en.2008-0717
84 https://doi.org/10.1210/er.2014-1024
85 https://doi.org/10.1210/jc.2012-1477
86 https://doi.org/10.1242/jcs.00902
87 https://doi.org/10.1242/jcs.079699
88 https://doi.org/10.12688/f1000research.8963.1
89 https://doi.org/10.1359/jbmr.061007
90 https://doi.org/10.1359/jbmr.070612
91 https://doi.org/10.1371/journal.pone.0030256
92 https://doi.org/10.1371/journal.pone.0037162
93 https://doi.org/10.1371/journal.pone.0086031
94 https://doi.org/10.1371/journal.pone.0132594
95 https://doi.org/10.1371/journal.pone.0149543
96 https://doi.org/10.2174/157488807781696267
97 https://doi.org/10.2174/1574888x11666160921121555
98 https://doi.org/10.2741/2296
99 https://doi.org/10.2741/4232
100 https://doi.org/10.4252/wjsc.v6.i2.94
101 https://doi.org/10.7150/ijbs.1.51
102 schema:datePublished 2017-12
103 schema:datePublishedReg 2017-12-01
104 schema:description BACKGROUND: Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells and develop therapeutic treatments for bone- or adipose-related diseases. In this study, the role of RGS2 and RGS4, two members of the regulators of G protein signaling (RGS) family, was investigated during adipogenenic and osteogenenic differentiation of human mesenchymal stem cells (hMSCs). RESULTS: Expression of RGS2 and RGS4 were found to be inversely regulated during adipogenesis induced by dexamethasone (DEX) and 3-isobutyl-methylxanthine, regardless if insulin was present, with RGS2 up-regulated and RGS4 down-regulated in response to adipogenic induction. RGS2 expression was also up-regulated during osteogenesis at a level similar to that induced by treatment of DEX alone, a shared component of adipogenic and osteogenic differentiation inducing media, but significantly lower than the level induced by adipogenic inducing media. RGS4 expression was down-regulated during the first 48 h of osteogenesis but up-regulated afterwards, in both cases at levels similar to that induced by DEX alone. Expression knock-down using small interfering RNA against RGS2 resulted in decreased differentiation efficiency during both adipogenesis and osteogenesis. On the other hand, expression knock-down of RGS4 also resulted in decreased adipogenic differentiation but increased osteogenic differentiation. CONCLUSIONS: RGS2 and RGS4 are differentially regulated during adipogenic and osteogenic differentiation of hMSCs. In addition, both RGS2 and RGS4 play positive roles during adipogenesis but opposing roles during osteogenesis, with RGS2 as a positive regulator and RGS4 as a negative regulator. These results imply that members of RGS proteins may play multifaceted roles during human adipogenesis and osteogenesis to balance or counterbalance each other's function during those processes.
105 schema:genre research_article
106 schema:inLanguage en
107 schema:isAccessibleForFree true
108 schema:isPartOf N019e2af1111046ee83d75c53ca695adb
109 N6999d1860b3d4ed890399bd09a3d6f70
110 sg:journal.1015240
111 schema:name Expression regulation and functional analysis of RGS2 and RGS4 in adipogenic and osteogenic differentiation of human mesenchymal stem cells
112 schema:pagination 43
113 schema:productId N3271d5435ca948c5a90898aa9ab0dffd
114 N4d351e1a40b34049a216906e862e03a1
115 N9fde7fa278494d86a82211e16354600e
116 Nc7a52f410dee4355b16b81a7a5a5e8e9
117 Ne3c53ae23cbc47f6be08f9a580301ae9
118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100079869
119 https://doi.org/10.1186/s40659-017-0148-1
120 schema:sdDatePublished 2019-04-10T23:20
121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
122 schema:sdPublisher N0e2129f0143c45fbbdd5659ea7ec3163
123 schema:url http://link.springer.com/10.1186/s40659-017-0148-1
124 sgo:license sg:explorer/license/
125 sgo:sdDataset articles
126 rdf:type schema:ScholarlyArticle
127 N019e2af1111046ee83d75c53ca695adb schema:volumeNumber 50
128 rdf:type schema:PublicationVolume
129 N0335a562cebf4d64b6a3f169e0e924f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Gene Expression Regulation
131 rdf:type schema:DefinedTerm
132 N0e2129f0143c45fbbdd5659ea7ec3163 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N152ebc1bb6bd4f0593fb4ee8677c1525 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Time Factors
136 rdf:type schema:DefinedTerm
137 N3271d5435ca948c5a90898aa9ab0dffd schema:name doi
138 schema:value 10.1186/s40659-017-0148-1
139 rdf:type schema:PropertyValue
140 N40a96e410aea437c8ff17792a5fc638f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Humans
142 rdf:type schema:DefinedTerm
143 N4d351e1a40b34049a216906e862e03a1 schema:name dimensions_id
144 schema:value pub.1100079869
145 rdf:type schema:PropertyValue
146 N6376731579854859b91f01b1bb8683e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mesenchymal Stromal Cells
148 rdf:type schema:DefinedTerm
149 N692eb13e724243e792cf4906a80c38da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Osteogenesis
151 rdf:type schema:DefinedTerm
152 N6999d1860b3d4ed890399bd09a3d6f70 schema:issueNumber 1
153 rdf:type schema:PublicationIssue
154 N79996d63bbf9482c9905439aaf0d9873 rdf:first sg:person.016425105147.85
155 rdf:rest Na42bf8c3f0514d0b99d9bff476f7245e
156 N9fde7fa278494d86a82211e16354600e schema:name pubmed_id
157 schema:value 29279050
158 rdf:type schema:PropertyValue
159 Na42bf8c3f0514d0b99d9bff476f7245e rdf:first sg:person.01272726001.01
160 rdf:rest rdf:nil
161 Nae6c755c4fed448ba6aac9cb8525b8d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Osteocytes
163 rdf:type schema:DefinedTerm
164 Nc7a52f410dee4355b16b81a7a5a5e8e9 schema:name readcube_id
165 schema:value f034d68162699fb62a297ae82a02b2f4e2618919aba8786b888fdc726877edd4
166 rdf:type schema:PropertyValue
167 Nd4cb57d3fc894b53afcc2a6b3e9adbfa rdf:first sg:person.011246661547.51
168 rdf:rest N79996d63bbf9482c9905439aaf0d9873
169 Ne3c53ae23cbc47f6be08f9a580301ae9 schema:name nlm_unique_id
170 schema:value 9308271
171 rdf:type schema:PropertyValue
172 Ne9edee473fa345d3bf91426b5015db23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name RGS Proteins
174 rdf:type schema:DefinedTerm
175 Nea1387bd531e468a84009b11585eca00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Adipogenesis
177 rdf:type schema:DefinedTerm
178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biological Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biochemistry and Cell Biology
183 rdf:type schema:DefinedTerm
184 sg:grant.2680040 http://pending.schema.org/fundedItem sg:pub.10.1186/s40659-017-0148-1
185 rdf:type schema:MonetaryGrant
186 sg:grant.3932375 http://pending.schema.org/fundedItem sg:pub.10.1186/s40659-017-0148-1
187 rdf:type schema:MonetaryGrant
188 sg:grant.4898548 http://pending.schema.org/fundedItem sg:pub.10.1186/s40659-017-0148-1
189 rdf:type schema:MonetaryGrant
190 sg:journal.1015240 schema:issn 0716-9760
191 0717-6287
192 schema:name Biological Research
193 rdf:type schema:Periodical
194 sg:person.011246661547.51 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
195 schema:familyName Madrigal
196 schema:givenName Alma
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011246661547.51
198 rdf:type schema:Person
199 sg:person.01272726001.01 schema:affiliation https://www.grid.ac/institutes/grid.155203.0
200 schema:familyName Zhao
201 schema:givenName Yuanxiang
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272726001.01
203 rdf:type schema:Person
204 sg:person.016425105147.85 schema:affiliation https://www.grid.ac/institutes/grid.155203.0
205 schema:familyName Tan
206 schema:givenName Lun
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016425105147.85
208 rdf:type schema:Person
209 sg:pub.10.1007/s001250051630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045255888
210 https://doi.org/10.1007/s001250051630
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/s00223-011-9461-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001942564
213 https://doi.org/10.1007/s00223-011-9461-9
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s00223-015-0079-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025074902
216 https://doi.org/10.1007/s00223-015-0079-1
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s00441-016-2462-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021097082
219 https://doi.org/10.1007/s00441-016-2462-2
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/s11684-013-0252-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020583552
222 https://doi.org/10.1007/s11684-013-0252-8
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s11914-013-0135-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047982677
225 https://doi.org/10.1007/s11914-013-0135-6
226 rdf:type schema:CreativeWork
227 sg:pub.10.1023/a:1011513223894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018871641
228 https://doi.org/10.1023/a:1011513223894
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/cdd.2015.168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033921991
231 https://doi.org/10.1038/cdd.2015.168
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/ncomms4368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041956868
234 https://doi.org/10.1038/ncomms4368
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nm.3074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031418878
237 https://doi.org/10.1038/nm.3074
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nrendo.2010.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052464035
240 https://doi.org/10.1038/nrendo.2010.20
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nrg3185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027346999
243 https://doi.org/10.1038/nrg3185
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nrm3198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024600139
246 https://doi.org/10.1038/nrm3198
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/1471-213x-10-47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626950
249 https://doi.org/10.1186/1471-213x-10-47
250 rdf:type schema:CreativeWork
251 sg:pub.10.1186/gb-2006-7-10-r100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040889351
252 https://doi.org/10.1186/gb-2006-7-10-r100
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/scrt328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040179932
255 https://doi.org/10.1186/scrt328
256 rdf:type schema:CreativeWork
257 sg:pub.10.1208/s12248-015-9847-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040462656
258 https://doi.org/10.1208/s12248-015-9847-0
259 rdf:type schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1076185256 schema:CreativeWork
261 https://doi.org/10.1002/1099-1573(200008)14:5<344::aid-ptr586>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037006686
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/jcp.20299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045452808
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/jcp.24075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017987195
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/jcp.24278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032486147
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0092-8674(94)90006-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013158443
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/bs.pmbts.2015.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049304371
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/bs.pmbts.2015.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001368592
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.biocel.2013.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016721129
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.bone.2011.06.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026009509
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.cellsig.2005.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026588252
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.cellsig.2007.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045099377
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.cellsig.2011.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036229899
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.febslet.2009.10.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000607421
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.gene.2004.06.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003529612
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.molcel.2012.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035354374
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.str.2013.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016726979
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0092-8674(00)80257-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037520667
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0092-8674(01)00622-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033966649
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0960-9822(00)00823-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014282593
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s1097-2765(00)80306-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052731075
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s1097-2765(01)00211-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040542836
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s1534-5807(04)00075-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016167288
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1039/b908315d schema:sameAs https://app.dimensions.ai/details/publication/pub.1003184518
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1042/bst20110615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034593079
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.0703407104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052598708
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1074/jbc.274.6.3549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016820322
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1074/jbc.c100272200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051745308
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1074/jbc.m208819200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004222959
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1089/scd.2011.0040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007403409
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1091/mbc.e09-07-0541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021852795
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/molbev/msl145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045761561
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1097/00002281-200307000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021958964
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1097/00003086-197110000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060155815
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1100/2012/793823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034239843
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1101/gad.1022203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008542349
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1101/gad.8.14.1654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011379069
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/j.1474-9728.2004.00127.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040740678
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1111/j.1538-7836.2012.04903.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027112118
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1582-4934.2010.01224.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036707502
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1111/ocr.12080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051629979
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1124/mol.115.102210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032256844
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1124/pr.54.3.527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062438748
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1126/science.284.5411.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379237
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1128/mcb.25.10.4221-4228.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006139684
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1146/annurev.bi.64.070195.002021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017112958
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1146/annurev.biochem.69.1.795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047604660
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1146/annurev.pharmtox.40.1.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043888268
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1152/ajpendo.90920.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020071828
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1152/physrev.00003.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008060887
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1155/2011/282745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020678898
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1158/0008-5472.can-08-3564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016004464
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1210/en.2003-0746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064246279
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1210/en.2004-0735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064246925
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1210/en.2008-0717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249516
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1210/er.2014-1024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001979924
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1210/jc.2012-1477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293503
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1242/jcs.00902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045493560
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1242/jcs.079699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048587305
376 rdf:type schema:CreativeWork
377 https://doi.org/10.12688/f1000research.8963.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064612731
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1359/jbmr.061007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043583617
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1359/jbmr.070612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042100934
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1371/journal.pone.0030256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051842652
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1371/journal.pone.0037162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017847931
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1371/journal.pone.0086031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036260114
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1371/journal.pone.0132594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052846811
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1371/journal.pone.0149543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009290881
392 rdf:type schema:CreativeWork
393 https://doi.org/10.2174/157488807781696267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069215691
394 rdf:type schema:CreativeWork
395 https://doi.org/10.2174/1574888x11666160921121555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079330235
396 rdf:type schema:CreativeWork
397 https://doi.org/10.2741/2296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914620
398 rdf:type schema:CreativeWork
399 https://doi.org/10.2741/4232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070916397
400 rdf:type schema:CreativeWork
401 https://doi.org/10.4252/wjsc.v6.i2.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072402275
402 rdf:type schema:CreativeWork
403 https://doi.org/10.7150/ijbs.1.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073618564
404 rdf:type schema:CreativeWork
405 https://www.grid.ac/institutes/grid.155203.0 schema:alternateName California State Polytechnic University
406 schema:name Biological Sciences Department, California State Polytechnic University at Pomona, 3801 W. Temple Ave., 91768, Pomona, CA, USA
407 rdf:type schema:Organization
408 https://www.grid.ac/institutes/grid.410425.6 schema:alternateName City Of Hope National Medical Center
409 schema:name Biological Sciences Department, California State Polytechnic University at Pomona, 3801 W. Temple Ave., 91768, Pomona, CA, USA
410 Center for Biomedicine and Genetics, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd., 91010, Duarte, CA, USA
411 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...