System evaluation of automated production and inhalation of 15O-labeled gaseous radiopharmaceuticals for the rapid 15O-oxygen PET examinations View Full Text


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Article Info

DATE

2018-12-19

AUTHORS

Satoshi Iguchi, Tetsuaki Moriguchi, Makoto Yamazaki, Yuki Hori, Kazuhiro Koshino, Kazunori Toyoda, Jarmo Teuho, Saeka Shimochi, Yusuke Terakawa, Tetsuya Fukuda, Jun C. Takahashi, Jyoji Nakagawara, Shigehiko Kanaya, Hidehiro Iida

ABSTRACT

Background15O-oxygen inhalation PET is unique in its ability to provide fundamental information regarding cerebral hemodynamics and energy metabolism in man. However, the use of 15O-oxygen has been limited in a clinical environment largely attributed to logistical complexity, in relation to a long study period, and the need to produce and inhale three sets of radiopharmaceuticals. Despite the recent works that enabled shortening of the PET examination period, radiopharmaceutical production has still been a limiting factor. This study was aimed to evaluate a recently developed radiosynthesis/inhalation system that automatically supplies a series of 15O-labeled gaseous radiopharmaceuticals of C15O, 15O2, and C15O2 at short intervals.MethodsThe system consists of a radiosynthesizer which produces C15O, 15O2, and C15O2; an inhalation controller; and an inhalation/scavenging unit. All three parts are controlled by a common sequencer, enabling automated production and inhalation at intervals less than 4.5 min. The gas inhalation/scavenging unit controls to sequentially supply of qualified radiopharmaceuticals at given radioactivity for given periods at given intervals. The unit also scavenges effectively the non-inhaled radioactive gases. Performance and reproducibility are evaluated.ResultsUsing an 15O-dedicated cyclotron with deuteron of 3.5 MeV at 40 μA, C15O, 15O2, and C15O2 were sequentially produced at a constant rate of 1400, 2400, and 2000 MBq/min, respectively. Each of radiopharmaceuticals were stably inhaled at < 4.5 min intervals with negligible contamination from the previous supply. The two-hole two-layered face mask with scavenging device minimized the gaseous radioactivity surrounding subject’s face, while maintaining the normocapnia during examination periods. Quantitative assessment of net administration doses could be assessed using a pair of radio-detectors at inlet and scavenging tubes, as 541 ± 149, 320 ± 103, 523 ± 137 MBq corresponding to 2-min supply of 2574 ± 255 MBq for C15O, and 1-min supply of 2220 ± 766 and 1763 ± 174 for 15O2 and C15O2, respectively.ConclusionsThe present system allowed for automated production and inhalation of series of 15O-labeled radiopharmaceuticals as required in the rapid 15O-Oxygen PET protocol. The production and inhalation were reproducible and improved logistical complexity, and thus the use of 15O-oxygen might have become practically applicable in clinical environments. More... »

PAGES

37

References to SciGraph publications

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  • 2014-12-10. Brain aerobic glycolysis functions and Alzheimer’s disease in CLINICAL AND TRANSLATIONAL IMAGING
  • 2004-02. PET measurements of CBF, OEF, and CMRO2 without arterial sampling in hyperacute ischemic stroke: Method and error analysis in ANNALS OF NUCLEAR MEDICINE
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    http://dx.doi.org/10.1186/s40658-018-0236-5

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30569426


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    9 schema:description Background15O-oxygen inhalation PET is unique in its ability to provide fundamental information regarding cerebral hemodynamics and energy metabolism in man. However, the use of 15O-oxygen has been limited in a clinical environment largely attributed to logistical complexity, in relation to a long study period, and the need to produce and inhale three sets of radiopharmaceuticals. Despite the recent works that enabled shortening of the PET examination period, radiopharmaceutical production has still been a limiting factor. This study was aimed to evaluate a recently developed radiosynthesis/inhalation system that automatically supplies a series of 15O-labeled gaseous radiopharmaceuticals of C15O, 15O2, and C15O2 at short intervals.MethodsThe system consists of a radiosynthesizer which produces C15O, 15O2, and C15O2; an inhalation controller; and an inhalation/scavenging unit. All three parts are controlled by a common sequencer, enabling automated production and inhalation at intervals less than 4.5 min. The gas inhalation/scavenging unit controls to sequentially supply of qualified radiopharmaceuticals at given radioactivity for given periods at given intervals. The unit also scavenges effectively the non-inhaled radioactive gases. Performance and reproducibility are evaluated.ResultsUsing an 15O-dedicated cyclotron with deuteron of 3.5 MeV at 40 μA, C15O, 15O2, and C15O2 were sequentially produced at a constant rate of 1400, 2400, and 2000 MBq/min, respectively. Each of radiopharmaceuticals were stably inhaled at < 4.5 min intervals with negligible contamination from the previous supply. The two-hole two-layered face mask with scavenging device minimized the gaseous radioactivity surrounding subject’s face, while maintaining the normocapnia during examination periods. Quantitative assessment of net administration doses could be assessed using a pair of radio-detectors at inlet and scavenging tubes, as 541 ± 149, 320 ± 103, 523 ± 137 MBq corresponding to 2-min supply of 2574 ± 255 MBq for C15O, and 1-min supply of 2220 ± 766 and 1763 ± 174 for 15O2 and C15O2, respectively.ConclusionsThe present system allowed for automated production and inhalation of series of 15O-labeled radiopharmaceuticals as required in the rapid 15O-Oxygen PET protocol. The production and inhalation were reproducible and improved logistical complexity, and thus the use of 15O-oxygen might have become practically applicable in clinical environments.
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    16 schema:keywords C15O
    17 C15O2
    18 MBq
    19 MeV
    20 MethodsThe system
    21 PET
    22 PET examinations
    23 PET protocol
    24 ability
    25 administration doses
    26 assessment
    27 cerebral hemodynamics
    28 clinical environment
    29 complexity
    30 constant rate
    31 contamination
    32 controller
    33 cyclotron
    34 deuterons
    35 devices
    36 doses
    37 energy metabolism
    38 environment
    39 evaluation
    40 examination
    41 examination period
    42 face
    43 face mask
    44 factors
    45 fundamental information
    46 gaseous radioactivity
    47 gases
    48 hemodynamics
    49 information
    50 inhalation
    51 inhalation system
    52 inlet
    53 interval
    54 logistical complexity
    55 long study period
    56 mask
    57 men
    58 metabolism
    59 min
    60 min intervals
    61 need
    62 negligible contamination
    63 normocapnia
    64 pairs
    65 part
    66 performance
    67 period
    68 present system
    69 previous supply
    70 production
    71 protocol
    72 quantitative assessment
    73 radioactive gases
    74 radioactivity
    75 radiopharmaceutical production
    76 radiopharmaceuticals
    77 radiosynthesizer
    78 rate
    79 recent work
    80 relation
    81 reproducibility
    82 scavenging devices
    83 sequencer
    84 series
    85 set
    86 short intervals
    87 shortening
    88 study
    89 study period
    90 subject's face
    91 supply
    92 system
    93 system evaluation
    94 tube
    95 two
    96 units
    97 use
    98 work
    99 μA
    100 schema:name System evaluation of automated production and inhalation of 15O-labeled gaseous radiopharmaceuticals for the rapid 15O-oxygen PET examinations
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