Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Konstantinos Vardas, Stavroula Ilia, Amalia Sertedaki, Evangelia Charmandari, Efrossini Briassouli, Dimitris Goukos, Kleovoulos Apostolou, Katerina Psarra, Efthimia Botoula, Stylianos Tsagarakis, Eleni Magira, Christina Routsi, Constantine A. Stratakis, Serafim Nanas, George Briassoulis

ABSTRACT

BACKGROUND: The purposes of this study are to examine if the human glucocorticoid receptor (hGR) isoform-α mRNA and hGR protein expressions are deficient in the acute phase of sepsis (S) compared to systemic inflammatory response syndrome (SIRS) and healthy subjects (H) and to evaluate if the hGRα and hGR alterations are associated with cortisol changes and if they are related to (1) extracellular and intracellular heat shock proteins (HSP) 72 and 90α; (2) ACTH, prolactin, and interleukins (ILs); and (3) outcome. METHODS: Patients consecutively admitted to a university hospital intensive care unit (ICU) with S (n = 48) or SIRS (n = 40) were enrolled in the study. Thirty-five H were also included. Total mRNA was isolated from peripheral blood samples and cDNA was prepared. RT-PCR was performed. Intracellular hGR and HSP expression in monocytes and/or neutrophils was evaluated using four-colour flow cytometry. Serum prolactin, ACTH, and cortisol concentrations were also measured. ELISA was used to evaluate serum ILs and extracellular (e) HSPs (eHSP72, eHSP90α). RESULTS: hGR protein was higher in S compared to H and SIRS; hGRα mRNA was higher in S compared to H (p < 0.05). In sepsis, hGR protein and eHSP72 were higher among non-survivors compared to survivors (p < 0.05). The hGR MFI and hGRα mRNA fold changes were significantly related to each other (r s = 0.64, p < 0.001). Monocyte hGR protein expression was positively correlated with extracellular and intracellular HSPs, cortisol, and ILs and negatively to organ dysfunction (p < 0.05). HSPs, hGR, and cortisol were able to discriminate sepsis from SIRS (AUROC > 0.85, p < 0.05). In sepsis, monocyte-hGR protein and eHSP72 were strong predictors of mortality (AUROC > 0.95, p < 0.04). CONCLUSIONS: Acute-phase sepsis is associated with increased hGR expression and cortisol concentrations, possibly implying no need for exogenous steroids. At this stage, hGR is able to predict sepsis and outcome and is related to stress-activated bio-molecules and organ dysfunction. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40635-017-0123-8

DOI

http://dx.doi.org/10.1186/s40635-017-0123-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083855427

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28224564


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "First Critical Care Department, National and Kapodistrian University of Athens, Athens, Greece", 
            "Pediatric Intensive Care Unit, University Hospital, University of Crete, 71500, Heraklion, Crete, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vardas", 
        "givenName": "Konstantinos", 
        "id": "sg:person.01251101244.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251101244.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pediatric Intensive Care Unit, University Hospital, University of Crete, 71500, Heraklion, Crete, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ilia", 
        "givenName": "Stavroula", 
        "id": "sg:person.01307403261.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307403261.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, \u2018Aghia Sophia\u2019 Children\u2019s Hospital and Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sertedaki", 
        "givenName": "Amalia", 
        "id": "sg:person.01110547716.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110547716.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, \u2018Aghia Sophia\u2019 Children\u2019s Hospital and Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charmandari", 
        "givenName": "Evangelia", 
        "id": "sg:person.01336250633.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336250633.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "First Department of Internal Medicine-Propaedeutic, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Briassouli", 
        "givenName": "Efrossini", 
        "id": "sg:person.01260527770.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260527770.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "First Department of Internal Medicine-Propaedeutic, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goukos", 
        "givenName": "Dimitris", 
        "id": "sg:person.01241740470.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241740470.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "First Critical Care Department, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Apostolou", 
        "givenName": "Kleovoulos", 
        "id": "sg:person.01055624437.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055624437.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evangelismos Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414655.7", 
          "name": [
            "Immunology-Histocompatibility Department, Evangelismos Hospital, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Psarra", 
        "givenName": "Katerina", 
        "id": "sg:person.0716332464.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716332464.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evangelismos Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414655.7", 
          "name": [
            "Department of Endocrinology-Diabetes, Evangelismos Hospital, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Botoula", 
        "givenName": "Efthimia", 
        "id": "sg:person.01300572766.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300572766.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Evangelismos Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414655.7", 
          "name": [
            "Department of Endocrinology-Diabetes, Evangelismos Hospital, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsagarakis", 
        "givenName": "Stylianos", 
        "id": "sg:person.01356343314.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356343314.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "First Critical Care Department, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magira", 
        "givenName": "Eleni", 
        "id": "sg:person.0742512021.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742512021.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "First Critical Care Department, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Routsi", 
        "givenName": "Christina", 
        "id": "sg:person.0636361130.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636361130.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stratakis", 
        "givenName": "Constantine A.", 
        "id": "sg:person.011151216517.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "First Critical Care Department, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nanas", 
        "givenName": "Serafim", 
        "id": "sg:person.0764005243.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764005243.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pediatric Intensive Care Unit, University Hospital, University of Crete, 71500, Heraklion, Crete, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Briassoulis", 
        "givenName": "George", 
        "id": "sg:person.01266644372.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266644372.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1210200110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002827355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000348290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006156776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/803561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011791035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.39.27857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012320535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000145996.57901.d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012371555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000145996.57901.d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012371555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/med.0000000000000066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013406054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/med.0000000000000066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013406054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013961581", 
          "https://doi.org/10.1038/sj.cdd.4401456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013961581", 
          "https://doi.org/10.1038/sj.cdd.4401456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrc.2007.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019937057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.0289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021634419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.1995.tb01915.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024437863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-4804(03)00214-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024676810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-4804(03)00214-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024676810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.04.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026160207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2015.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026615430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0025612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027136740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027346999", 
          "https://doi.org/10.1038/nrg3185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1468-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029251915", 
          "https://doi.org/10.1007/s00134-009-1468-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1468-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029251915", 
          "https://doi.org/10.1007/s00134-009-1468-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029887770", 
          "https://doi.org/10.1186/cc12774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40635-015-0059-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032920300", 
          "https://doi.org/10.1186/s40635-015-0059-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40635-015-0059-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032920300", 
          "https://doi.org/10.1186/s40635-015-0059-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2008.03443.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034959124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/806042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035787852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2014.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037468671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0300-9084(91)90074-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038311317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0300-9084(91)90074-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038311317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1810207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038450432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1810207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038450432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198510000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039110630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1415236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039137824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2006.07.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040671260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.steroids.2009.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040773355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc10537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042649115", 
          "https://doi.org/10.1186/cc10537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.0287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045696843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31825b8ebc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047562115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31825b8ebc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047562115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurjhf/hfq120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049340356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00363.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051346930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01709751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052044737", 
          "https://doi.org/10.1007/bf01709751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01709751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052044737", 
          "https://doi.org/10.1007/bf01709751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199510000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060171232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199510000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060171232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199510000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060171232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2001077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062682217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00509.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063196699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.80.6.7775626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064319564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2010-0073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078054011", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078054011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078054011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078054011"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: The purposes of this study are to examine if the human glucocorticoid receptor (hGR) isoform-\u03b1 mRNA and hGR protein expressions are deficient in the acute phase of sepsis (S) compared to systemic inflammatory response syndrome (SIRS) and healthy subjects (H) and to evaluate if the hGR\u03b1 and hGR alterations are associated with cortisol changes and if they are related to (1) extracellular and intracellular heat shock proteins (HSP) 72 and 90\u03b1; (2) ACTH, prolactin, and interleukins (ILs); and (3) outcome.\nMETHODS: Patients consecutively admitted to a university hospital intensive care unit (ICU) with S (n\u2009=\u200948) or SIRS (n\u2009=\u200940) were enrolled in the study. Thirty-five H were also included. Total mRNA was isolated from peripheral blood samples and cDNA was prepared. RT-PCR was performed. Intracellular hGR and HSP expression in monocytes and/or neutrophils was evaluated using four-colour flow cytometry. Serum prolactin, ACTH, and cortisol concentrations were also measured. ELISA was used to evaluate serum ILs and extracellular (e) HSPs (eHSP72, eHSP90\u03b1).\nRESULTS: hGR protein was higher in S compared to H and SIRS; hGR\u03b1 mRNA was higher in S compared to H (p\u2009<\u20090.05). In sepsis, hGR protein and eHSP72 were higher among non-survivors compared to survivors (p\u2009<\u20090.05). The hGR MFI and hGR\u03b1 mRNA fold changes were significantly related to each other (r s\u2009=\u20090.64, p\u2009<\u20090.001). Monocyte hGR protein expression was positively correlated with extracellular and intracellular HSPs, cortisol, and ILs and negatively to organ dysfunction (p\u2009<\u20090.05). HSPs, hGR, and cortisol were able to discriminate sepsis from SIRS (AUROC\u2009>\u20090.85, p\u2009<\u20090.05). In sepsis, monocyte-hGR protein and eHSP72 were strong predictors of mortality (AUROC\u2009>\u20090.95, p\u2009<\u20090.04).\nCONCLUSIONS: Acute-phase sepsis is associated with increased hGR expression and cortisol concentrations, possibly implying no need for exogenous steroids. At this stage, hGR is able to predict sepsis and outcome and is related to stress-activated bio-molecules and organ dysfunction.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40635-017-0123-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2725681", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1050905", 
        "issn": [
          "2197-425X"
        ], 
        "name": "Intensive Care Medicine Experimental", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality", 
    "pagination": "10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0ed7df35a5c21d4c453dde2730519c69d5364e4c4823696e7b752dd90d98f664"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28224564"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101645149"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40635-017-0123-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1083855427"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40635-017-0123-8", 
      "https://app.dimensions.ai/details/publication/pub.1083855427"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89822_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40635-017-0123-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40635-017-0123-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40635-017-0123-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40635-017-0123-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40635-017-0123-8'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      69 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40635-017-0123-8 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N7bd91b1688cf4ce8b339599c2c92fde1
4 schema:citation sg:pub.10.1007/bf01709751
5 sg:pub.10.1007/s00134-009-1468-6
6 sg:pub.10.1038/nrg3185
7 sg:pub.10.1038/sj.cdd.4401456
8 sg:pub.10.1186/cc10537
9 sg:pub.10.1186/cc12774
10 sg:pub.10.1186/s40635-015-0059-9
11 https://app.dimensions.ai/details/publication/pub.1078054011
12 https://doi.org/10.1001/jama.2016.0287
13 https://doi.org/10.1001/jama.2016.0289
14 https://doi.org/10.1016/0300-9084(91)90074-b
15 https://doi.org/10.1016/j.cell.2014.04.038
16 https://doi.org/10.1016/j.jcrc.2007.11.004
17 https://doi.org/10.1016/j.jinf.2014.03.011
18 https://doi.org/10.1016/j.molimm.2006.07.303
19 https://doi.org/10.1016/j.pharmthera.2015.05.001
20 https://doi.org/10.1016/j.steroids.2009.09.002
21 https://doi.org/10.1016/s0022-4804(03)00214-2
22 https://doi.org/10.1056/nejmoa1415236
23 https://doi.org/10.1073/pnas.1210200110
24 https://doi.org/10.1074/jbc.274.39.27857
25 https://doi.org/10.1093/eurjhf/hfq120
26 https://doi.org/10.1097/00003246-198510000-00009
27 https://doi.org/10.1097/00003246-199510000-00007
28 https://doi.org/10.1097/01.ccm.0000145996.57901.d7
29 https://doi.org/10.1097/ccm.0b013e31825b8ebc
30 https://doi.org/10.1097/med.0000000000000066
31 https://doi.org/10.1111/j.1365-2265.1995.tb01915.x
32 https://doi.org/10.1111/j.1365-2265.2008.03443.x
33 https://doi.org/10.1126/scisignal.2001077
34 https://doi.org/10.1152/ajpcell.00363.2001
35 https://doi.org/10.1152/ajpregu.00509.2001
36 https://doi.org/10.1155/2014/803561
37 https://doi.org/10.1155/2015/806042
38 https://doi.org/10.1159/000348290
39 https://doi.org/10.1177/0310057x1003800122
40 https://doi.org/10.1210/jcem.80.6.7775626
41 https://doi.org/10.1210/me.2010-0073
42 https://doi.org/10.1371/journal.pone.0025612
43 https://doi.org/10.1677/joe.0.1810207
44 schema:datePublished 2017-12
45 schema:datePublishedReg 2017-12-01
46 schema:description BACKGROUND: The purposes of this study are to examine if the human glucocorticoid receptor (hGR) isoform-α mRNA and hGR protein expressions are deficient in the acute phase of sepsis (S) compared to systemic inflammatory response syndrome (SIRS) and healthy subjects (H) and to evaluate if the hGRα and hGR alterations are associated with cortisol changes and if they are related to (1) extracellular and intracellular heat shock proteins (HSP) 72 and 90α; (2) ACTH, prolactin, and interleukins (ILs); and (3) outcome. METHODS: Patients consecutively admitted to a university hospital intensive care unit (ICU) with S (n = 48) or SIRS (n = 40) were enrolled in the study. Thirty-five H were also included. Total mRNA was isolated from peripheral blood samples and cDNA was prepared. RT-PCR was performed. Intracellular hGR and HSP expression in monocytes and/or neutrophils was evaluated using four-colour flow cytometry. Serum prolactin, ACTH, and cortisol concentrations were also measured. ELISA was used to evaluate serum ILs and extracellular (e) HSPs (eHSP72, eHSP90α). RESULTS: hGR protein was higher in S compared to H and SIRS; hGRα mRNA was higher in S compared to H (p < 0.05). In sepsis, hGR protein and eHSP72 were higher among non-survivors compared to survivors (p < 0.05). The hGR MFI and hGRα mRNA fold changes were significantly related to each other (r s = 0.64, p < 0.001). Monocyte hGR protein expression was positively correlated with extracellular and intracellular HSPs, cortisol, and ILs and negatively to organ dysfunction (p < 0.05). HSPs, hGR, and cortisol were able to discriminate sepsis from SIRS (AUROC > 0.85, p < 0.05). In sepsis, monocyte-hGR protein and eHSP72 were strong predictors of mortality (AUROC > 0.95, p < 0.04). CONCLUSIONS: Acute-phase sepsis is associated with increased hGR expression and cortisol concentrations, possibly implying no need for exogenous steroids. At this stage, hGR is able to predict sepsis and outcome and is related to stress-activated bio-molecules and organ dysfunction.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N5c5a744d571f46fa9a409003cbc1ddce
51 Neb0e436733304cac8dc06684dba86676
52 sg:journal.1050905
53 schema:name Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality
54 schema:pagination 10
55 schema:productId N054a12e83bbd42509a6b47994317e87f
56 Ncba2db6b0790442682c12a7c80eca8ea
57 Ncd118b851e7e42f9b91e80a0bf1940ad
58 Nd998493a43bb427ab2de054e881c9eab
59 Ndca965a756974ee2992f55bbb8fba227
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083855427
61 https://doi.org/10.1186/s40635-017-0123-8
62 schema:sdDatePublished 2019-04-11T10:02
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N970c311c189046f88d0335f656d3053a
65 schema:url https://link.springer.com/10.1186%2Fs40635-017-0123-8
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N054a12e83bbd42509a6b47994317e87f schema:name readcube_id
70 schema:value 0ed7df35a5c21d4c453dde2730519c69d5364e4c4823696e7b752dd90d98f664
71 rdf:type schema:PropertyValue
72 N0dbdee09129c4e68ac7b81b813f46099 rdf:first sg:person.01356343314.23
73 rdf:rest Nf21f3b09d7124758838abb66f8a611e1
74 N1a3cc3f5d36e4ee1b9a7c7908e80f38b schema:name Pediatric Intensive Care Unit, University Hospital, University of Crete, 71500, Heraklion, Crete, Greece
75 rdf:type schema:Organization
76 N1c4f2746521a4e2a84b5923e4cae1e29 rdf:first sg:person.01260527770.11
77 rdf:rest Nac23b1fc4fcc4bccaf38dee864b660e2
78 N25567d4a770046e4acce7cb0fcc53143 rdf:first sg:person.011151216517.08
79 rdf:rest Nf4d9aa5ba1fd4d0c949f0da141eb200f
80 N25b32ee689a546b99f01057f8af0c729 rdf:first sg:person.01110547716.09
81 rdf:rest N94e1030e1d0a410db545113c88e7bcdb
82 N5c5a744d571f46fa9a409003cbc1ddce schema:issueNumber 1
83 rdf:type schema:PublicationIssue
84 N713f48bb56b24eeea255f32edf3bd521 rdf:first sg:person.01266644372.77
85 rdf:rest rdf:nil
86 N7a577e5feaef4daa93c140562733d313 rdf:first sg:person.0636361130.65
87 rdf:rest N25567d4a770046e4acce7cb0fcc53143
88 N7b12251c6e0240a5ae180b0e465d8268 rdf:first sg:person.01307403261.07
89 rdf:rest N25b32ee689a546b99f01057f8af0c729
90 N7bd91b1688cf4ce8b339599c2c92fde1 rdf:first sg:person.01251101244.98
91 rdf:rest N7b12251c6e0240a5ae180b0e465d8268
92 N868515cc7aff4a5896eb4277018b4603 schema:name Pediatric Intensive Care Unit, University Hospital, University of Crete, 71500, Heraklion, Crete, Greece
93 rdf:type schema:Organization
94 N94e1030e1d0a410db545113c88e7bcdb rdf:first sg:person.01336250633.32
95 rdf:rest N1c4f2746521a4e2a84b5923e4cae1e29
96 N970c311c189046f88d0335f656d3053a schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 Nac23b1fc4fcc4bccaf38dee864b660e2 rdf:first sg:person.01241740470.87
99 rdf:rest Nefd1bca989ac4dec90f6981a426431d2
100 Ncba2db6b0790442682c12a7c80eca8ea schema:name pubmed_id
101 schema:value 28224564
102 rdf:type schema:PropertyValue
103 Ncd118b851e7e42f9b91e80a0bf1940ad schema:name dimensions_id
104 schema:value pub.1083855427
105 rdf:type schema:PropertyValue
106 Nd998493a43bb427ab2de054e881c9eab schema:name doi
107 schema:value 10.1186/s40635-017-0123-8
108 rdf:type schema:PropertyValue
109 Ndca965a756974ee2992f55bbb8fba227 schema:name nlm_unique_id
110 schema:value 101645149
111 rdf:type schema:PropertyValue
112 Neb0e436733304cac8dc06684dba86676 schema:volumeNumber 5
113 rdf:type schema:PublicationVolume
114 Ned085ca6e5a049b29486f3ae58126f9a rdf:first sg:person.01300572766.48
115 rdf:rest N0dbdee09129c4e68ac7b81b813f46099
116 Nefd1bca989ac4dec90f6981a426431d2 rdf:first sg:person.01055624437.92
117 rdf:rest Nfcd44b0e5e0b4fdcb4228166fa52b56c
118 Nf21f3b09d7124758838abb66f8a611e1 rdf:first sg:person.0742512021.20
119 rdf:rest N7a577e5feaef4daa93c140562733d313
120 Nf4d9aa5ba1fd4d0c949f0da141eb200f rdf:first sg:person.0764005243.58
121 rdf:rest N713f48bb56b24eeea255f32edf3bd521
122 Nfcd44b0e5e0b4fdcb4228166fa52b56c rdf:first sg:person.0716332464.69
123 rdf:rest Ned085ca6e5a049b29486f3ae58126f9a
124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
125 schema:name Medical and Health Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
128 schema:name Clinical Sciences
129 rdf:type schema:DefinedTerm
130 sg:grant.2725681 http://pending.schema.org/fundedItem sg:pub.10.1186/s40635-017-0123-8
131 rdf:type schema:MonetaryGrant
132 sg:journal.1050905 schema:issn 2197-425X
133 schema:name Intensive Care Medicine Experimental
134 rdf:type schema:Periodical
135 sg:person.01055624437.92 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
136 schema:familyName Apostolou
137 schema:givenName Kleovoulos
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055624437.92
139 rdf:type schema:Person
140 sg:person.01110547716.09 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
141 schema:familyName Sertedaki
142 schema:givenName Amalia
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110547716.09
144 rdf:type schema:Person
145 sg:person.011151216517.08 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
146 schema:familyName Stratakis
147 schema:givenName Constantine A.
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08
149 rdf:type schema:Person
150 sg:person.01241740470.87 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
151 schema:familyName Goukos
152 schema:givenName Dimitris
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241740470.87
154 rdf:type schema:Person
155 sg:person.01251101244.98 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
156 schema:familyName Vardas
157 schema:givenName Konstantinos
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251101244.98
159 rdf:type schema:Person
160 sg:person.01260527770.11 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
161 schema:familyName Briassouli
162 schema:givenName Efrossini
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260527770.11
164 rdf:type schema:Person
165 sg:person.01266644372.77 schema:affiliation N868515cc7aff4a5896eb4277018b4603
166 schema:familyName Briassoulis
167 schema:givenName George
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266644372.77
169 rdf:type schema:Person
170 sg:person.01300572766.48 schema:affiliation https://www.grid.ac/institutes/grid.414655.7
171 schema:familyName Botoula
172 schema:givenName Efthimia
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300572766.48
174 rdf:type schema:Person
175 sg:person.01307403261.07 schema:affiliation N1a3cc3f5d36e4ee1b9a7c7908e80f38b
176 schema:familyName Ilia
177 schema:givenName Stavroula
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307403261.07
179 rdf:type schema:Person
180 sg:person.01336250633.32 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
181 schema:familyName Charmandari
182 schema:givenName Evangelia
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336250633.32
184 rdf:type schema:Person
185 sg:person.01356343314.23 schema:affiliation https://www.grid.ac/institutes/grid.414655.7
186 schema:familyName Tsagarakis
187 schema:givenName Stylianos
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356343314.23
189 rdf:type schema:Person
190 sg:person.0636361130.65 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
191 schema:familyName Routsi
192 schema:givenName Christina
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636361130.65
194 rdf:type schema:Person
195 sg:person.0716332464.69 schema:affiliation https://www.grid.ac/institutes/grid.414655.7
196 schema:familyName Psarra
197 schema:givenName Katerina
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716332464.69
199 rdf:type schema:Person
200 sg:person.0742512021.20 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
201 schema:familyName Magira
202 schema:givenName Eleni
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742512021.20
204 rdf:type schema:Person
205 sg:person.0764005243.58 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
206 schema:familyName Nanas
207 schema:givenName Serafim
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764005243.58
209 rdf:type schema:Person
210 sg:pub.10.1007/bf01709751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052044737
211 https://doi.org/10.1007/bf01709751
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s00134-009-1468-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029251915
214 https://doi.org/10.1007/s00134-009-1468-6
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nrg3185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027346999
217 https://doi.org/10.1038/nrg3185
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/sj.cdd.4401456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013961581
220 https://doi.org/10.1038/sj.cdd.4401456
221 rdf:type schema:CreativeWork
222 sg:pub.10.1186/cc10537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042649115
223 https://doi.org/10.1186/cc10537
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/cc12774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029887770
226 https://doi.org/10.1186/cc12774
227 rdf:type schema:CreativeWork
228 sg:pub.10.1186/s40635-015-0059-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032920300
229 https://doi.org/10.1186/s40635-015-0059-9
230 rdf:type schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1078054011 schema:CreativeWork
232 https://doi.org/10.1001/jama.2016.0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045696843
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1001/jama.2016.0289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021634419
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0300-9084(91)90074-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1038311317
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.cell.2014.04.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026160207
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.jcrc.2007.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019937057
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.jinf.2014.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037468671
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.molimm.2006.07.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040671260
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.pharmthera.2015.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026615430
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.steroids.2009.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040773355
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s0022-4804(03)00214-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024676810
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1056/nejmoa1415236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039137824
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.1210200110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002827355
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1074/jbc.274.39.27857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012320535
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1093/eurjhf/hfq120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049340356
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/00003246-198510000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039110630
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/00003246-199510000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060171232
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1097/01.ccm.0000145996.57901.d7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012371555
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1097/ccm.0b013e31825b8ebc schema:sameAs https://app.dimensions.ai/details/publication/pub.1047562115
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1097/med.0000000000000066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013406054
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1365-2265.1995.tb01915.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024437863
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1365-2265.2008.03443.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034959124
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1126/scisignal.2001077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682217
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1152/ajpcell.00363.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051346930
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1152/ajpregu.00509.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063196699
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1155/2014/803561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011791035
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1155/2015/806042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035787852
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1159/000348290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006156776
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1177/0310057x1003800122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078054011
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1210/jcem.80.6.7775626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064319564
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1210/me.2010-0073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328501
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1371/journal.pone.0025612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027136740
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1677/joe.0.1810207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038450432
295 rdf:type schema:CreativeWork
296 https://www.grid.ac/institutes/grid.414655.7 schema:alternateName Evangelismos Hospital
297 schema:name Department of Endocrinology-Diabetes, Evangelismos Hospital, Athens, Greece
298 Immunology-Histocompatibility Department, Evangelismos Hospital, Athens, Greece
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.420089.7 schema:alternateName National Institute of Child Health and Human Development
301 schema:name Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, 20892, Bethesda, MD, USA
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
304 schema:name Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital and Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, National and Kapodistrian University of Athens, Athens, Greece
305 First Critical Care Department, National and Kapodistrian University of Athens, Athens, Greece
306 First Department of Internal Medicine-Propaedeutic, National and Kapodistrian University of Athens, Athens, Greece
307 Pediatric Intensive Care Unit, University Hospital, University of Crete, 71500, Heraklion, Crete, Greece
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...