Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 ... View Full Text


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Article Info

DATE

2018-12

AUTHORS

Lindsay Fernández-Rhodes, Annie Green Howard, Mariaelisa Graff, Carmen R. Isasi, Heather M. Highland, Kristin L. Young, Esteban Parra, Jennifer E. Below, Qibin Qi, Robert C. Kaplan, Anne E. Justice, George Papanicolaou, Cathy C. Laurie, Struan F. A. Grant, Christopher Haiman, Ruth J. F. Loos, Kari E. North

ABSTRACT

Background: Genome-wide association studies have implicated the transcription factor 7-like 2 (TCF7L2) gene in type 2 diabetes risk, and more recently, in decreased body mass index. Given the contrary direction of genetic effects on these two traits, it has been suggested that the observed association with body mass index may reflect either selection bias or a complex underlying biology at TCF7L2. Methods: Using 9031 Hispanic/Latino adults (21-76 years) with complete weight history and genetic data from the community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Baseline 2008-2011), we estimated the multivariable association between the additive number of type 2 diabetes increasing-alleles at TCF7L2 (rs7903146-T) and body mass index. We then used structural equation models to simultaneously model the genetic association on changes in body mass index across the life course and estimate the odds of type 2 diabetes per TCF7L2 risk allele. Results: We observed both significant increases in type 2 diabetes prevalence at examination (independent of body mass index) and decreases in mean body mass index and waist circumference across genotypes at rs7903146. We observed a significant multivariable association between the additive number of type 2 diabetes-risk alleles and lower body mass index at examination. In our structured modeling, we observed non-significant inverse direct associations between rs7903146-T and body mass index at ages 21 and 45 years, and a significant positive association between rs7903146-T and type 2 diabetes onset in both middle and late adulthood. Conclusions: Herein, we replicated the protective effect of rs7930146-T on body mass index at multiple time points in the life course, and observed that these effects were not explained by past type 2 diabetes status in our structured modeling. The robust replication of the negative effects of TCF7L2 on body mass index in multiple samples, including in our diverse Hispanic/Latino community-based sample, supports a growing body of literature on the complex biologic mechanism underlying the functional consequences of TCF7L2 on obesity and type 2 diabetes across the life course. More... »

PAGES

26

References to SciGraph publications

  • 2012-12. Bayesian refinement of association signals for 14 loci in 3 common diseases in NATURE GENETICS
  • 2016-12. Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans in BMC GENETICS
  • 2015-12. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci in NATURE GENETICS
  • 2016-12. Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico in BMC GENETICS
  • 2007-01. TCF7L2: the biggest story in diabetes genetics since HLA? in DIABETOLOGIA
  • 2015-01. Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2 in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2017-06. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci in HUMAN GENETICS
  • 2007-02. A genome-wide association study identifies novel risk loci for type 2 diabetes in NATURE
  • 2014-02. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico in NATURE
  • 2014-03. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility in NATURE GENETICS
  • 2010-03. A map of open chromatin in human pancreatic islets in NATURE GENETICS
  • 2007-02. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution in NATURE GENETICS
  • 1998-08. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 in NATURE GENETICS
  • 2015-02. Genetic studies of body mass index yield new insights for obesity biology in NATURE
  • 2006-03. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40608-018-0200-x

    DOI

    http://dx.doi.org/10.1186/s40608-018-0200-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105158602

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30305909


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