Albumin-based drug delivery: harnessing nature to cure disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Maja Thim Larsen, Matthias Kuhlmann, Michael Lykke Hvam, Kenneth A. Howard

ABSTRACT

The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform. More... »

PAGES

3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40591-016-0048-8

DOI

http://dx.doi.org/10.1186/s40591-016-0048-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046156327

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26925240


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