Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Roshan Fatima, Vijay Suresh Akhade, Debosree Pal, Satyanarayana MR Rao

ABSTRACT

Long noncoding RNAs are emerging as key players in various fundamental biological processes. We highlight the varied molecular mechanisms by which lncRNAs modulate gene expression in diverse cellular contexts and their role in early mammalian development in this review. Furthermore, it is being increasingly recognized that altered expression of lncRNAs is specifically associated with tumorigenesis, tumor progression and metastasis. We discuss various lncRNAs implicated in different cancer types with a focus on their clinical applications as potential biomarkers and therapeutic targets in the pathology of diverse cancers. More... »

PAGES

5

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40591-015-0042-6

    DOI

    http://dx.doi.org/10.1186/s40591-015-0042-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027148306

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26082843


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