Designer nanoparticle: nanobiotechnology tool for cell biology View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Deepak B. Thimiri Govinda Raj, Niamat Ali Khan

ABSTRACT

This article discusses the use of nanotechnology for subcellular compartment isolation and its application towards subcellular omics. This technology review significantly contributes to our understanding on use of nanotechnology for subcellular systems biology. Here we elaborate nanobiotechnology approach of using superparamagnetic nanoparticles (SPMNPs) optimized with different surface coatings for subcellular organelle isolation. Using pulse-chase approach, we review that SPMNPs interacted differently with the cell depending on its surface functionalization. The article focuses on the use of functionalized-SPMNPs as a nanobiotechnology tool to isolate high quality (both purity and yield) plasma membranes and endosomes or lysosomes. Such nanobiotechnology tool can be applied in generating subcellular compartment inventories. As a future perspective, this strategy could be applied in areas such as immunology, cancer and stem cell research. More... »

PAGES

22

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  • Journal

    TITLE

    Nano Convergence

    ISSUE

    1

    VOLUME

    3

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40580-016-0082-x

    DOI

    http://dx.doi.org/10.1186/s40580-016-0082-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005313892

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28191432


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