Is polymyxin B-immobilized fiber column ineffective for septic shock? A discussion on the press release for EUPHRATES trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-03

AUTHORS

Toshiaki Iba, Lucy Fowler

ABSTRACT

The efficacy of polymyxin B-immobilized (PMX) fiber column on septic shock is still under debate. Recently, the result from “Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock (EUPHRATES)” trial has been announced as a press release. According to that report, less than a 5% mortality difference was recognized in the “per protocol population” (n = 244, 31.9 vs. 36.9%) and the decrease was not statistically significant. However, among the patients in refractory shock with a multiple organ dysfunction score of more than 9 and an EAA between 0.6 and 0.9, a 10.7% reduction in 28-day mortality was recognized (p = 0.0474) when they received two sessions of hemoperfusion using the PMX fiber column. Since this favorable effect was obtained from “post hoc” analysis, further study is expected. More... »

PAGES

40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40560-017-0236-x

DOI

http://dx.doi.org/10.1186/s40560-017-0236-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090335829

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28690852


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