The clinical practice guideline for the management of ARDS in Japan View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-25

AUTHORS

Satoru Hashimoto, Masamitsu Sanui, Moritoki Egi, Shinichiro Ohshimo, Junji Shiotsuka, Ryutaro Seo, Ryoma Tanaka, Yu Tanaka, Yasuhiro Norisue, Yoshiro Hayashi, Eishu Nango, ARDS clinical practice guideline committee from the Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine

ABSTRACT

BackgroundThe Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine provide here a clinical practice guideline for the management of adult patients with ARDS in the ICU.MethodThe guideline was developed applying the GRADE system for performing robust systematic reviews with plausible recommendations. The guideline consists of 13 clinical questions mainly regarding ventilator settings and drug therapies (the last question includes 11 medications that are not approved for clinical use in Japan).ResultsThe recommendations for adult patients with ARDS include: we suggest against early tracheostomy (GRADE 2C), we suggest using NPPV for early respiratory management (GRADE 2C), we recommend the use of low tidal volumes at 6-8 mL/kg (GRADE 1B), we suggest setting the plateau pressure at 30cmH20 or less (GRADE2B), we suggest using PEEP within the range of plateau pressures less than or equal to 30cmH2O, without compromising hemodynamics (Grade 2B), and using higher PEEP levels in patients with moderate to severe ARDS (Grade 2B), we suggest using protocolized methods for liberation from mechanical ventilation (Grade 2D), we suggest prone positioning especially in patients with moderate to severe respiratory dysfunction (GRADE 2C), we suggest against the use of high frequency oscillation (GRADE 2C), we suggest the use of neuromuscular blocking agents in patients requiring mechanical ventilation under certain circumstances (GRADE 2B), we suggest fluid restriction in the management of ARDS (GRADE 2A), we do not suggest the use of neutrophil elastase inhibitors (GRADE 2D), we suggest the administration of steroids, equivalent to methylprednisolone 1-2mg/kg/ day (GRADE 2A), and we do not recommend other medications for the treatment of adult patients with ARDS (GRADE1B; inhaled/intravenous β2 stimulants, prostaglandin E1, activated protein C, ketoconazole, and lisofylline, GRADE 1C; inhaled nitric oxide, GRADE 1D; surfactant, GRADE 2B; granulocyte macrophage colony-stimulating factor, N-acetylcysteine, GRADE 2C; Statin.)ConclusionsThis article was translated from the Japanese version originally published as the ARDS clinical practice guidelines 2016 by the committee of ARDS clinical practice guideline (Tokyo, 2016, 293p, available from http://www.jsicm.org/ARDSGL/ARDSGL2016.pdf). The original article, written for Japanese healthcare providers, provides points of view that are different from those in other countries. More... »

PAGES

50

References to SciGraph publications

  • 2002-04-09. Prone position as prevention of lung injury in comatose patients: a prospective, randomized, controlled study in INTENSIVE CARE MEDICINE
  • 2005-06-21. High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669] in CRITICAL CARE
  • 2015-01-21. Effectiveness of treatment based on PiCCO parameters in critically ill patients with septic shock and/or acute respiratory distress syndrome: a randomized controlled trial in INTENSIVE CARE MEDICINE
  • 2014-05-28. The effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta-analysis of randomized controlled trials in CRITICAL CARE
  • 2009-02-24. Efficacy of positive end-expiratory pressure titration after the alveolar recruitment manoeuvre in patients with acute respiratory distress syndrome in CRITICAL CARE
  • 1998-04. The American-European consensus conference on ARDS, Part 2 in INTENSIVE CARE MEDICINE
  • 2008-06-25. A randomised, controlled trial of conventional versus automated weaning from mechanical ventilation using SmartCare™/PS in INTENSIVE CARE MEDICINE
  • 2001-10. A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome in INTENSIVE CARE MEDICINE
  • 2006-11-03. Causes of death and determinants of outcome in critically ill patients in CRITICAL CARE
  • 2005-01-11. Extravascular lung water in patients with severe sepsis: a prospective cohort study in CRITICAL CARE
  • 2014-01-16. Extravascular lung water and pulmonary arterial wedge pressure for fluid management in patients with acute respiratory distress syndrome in MULTIDISCIPLINARY RESPIRATORY MEDICINE
  • 2008-04-22. Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial in INTENSIVE CARE MEDICINE
  • 2003-07-02. ICU Cornerstone: High frequency ventilation is here to stay in CRITICAL CARE
  • 2007-11-14. Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature in INTENSIVE CARE MEDICINE
  • 1986-11. Beta-2-adrenoceptor agonists as inhibitors of lung vascular permeability to radiolabelled transferrin in the adult respiratory distress syndrome in man in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2011-09-19. Respiratory failure in patients undergoing allogeneic hematopoietic SCT—a randomized trial on early non-invasive ventilation based on standard care hematology wards in BONE MARROW TRANSPLANTATION
  • 2014-05-10. Helmet CPAP vs. oxygen therapy in severe hypoxemic respiratory failure due to pneumonia in INTENSIVE CARE MEDICINE
  • 2008-07-01. Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients in INTENSIVE CARE MEDICINE
  • 2002-05-17. Aerosolized β2-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure in INTENSIVE CARE MEDICINE
  • 2014-10-29. A randomized clinical trial for the timing of tracheotomy in critically ill patients: factors precluding inclusion in a single center study in CRITICAL CARE
  • 2014-10-28. The Japanese guidelines for the management of sepsis in JOURNAL OF INTENSIVE CARE
  • 2014-09-30. Mechanisms of the effects of prone positioning in acute respiratory distress syndrome in INTENSIVE CARE MEDICINE
  • 2010-06-09. Early CPAP prevents evolution of acute lung injury in patients with hematologic malignancy in INTENSIVE CARE MEDICINE
  • 2007-03-22. The effect of exogenous surfactant in patients with lung contusions and acute lung injury in INTENSIVE CARE MEDICINE
  • 2012-02-10. Early tracheostomy decreases ventilation time but has no impact on mortality of intensive care patients: a randomized study in LANGENBECK'S ARCHIVES OF SURGERY
  • 2014-01-17. Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis in INTENSIVE CARE MEDICINE
  • 2001-10-16. Complication profiles of adult asthmatics requiring paralysis during mechanical ventilation in INTENSIVE CARE MEDICINE
  • 2016-01-13. Clinical and investigative critical care medicine in Japan in INTENSIVE CARE MEDICINE
  • 2009-06-26. Comparison of automated protocol-based versus non-protocol-based physician-directed weaning from mechanical ventilation in INTENSIVMEDIZIN UND NOTFALLMEDIZIN
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40560-017-0222-3

    DOI

    http://dx.doi.org/10.1186/s40560-017-0222-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090893019

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28770093


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272458.e", 
              "name": [
                "Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hashimoto", 
            "givenName": "Satoru", 
            "id": "sg:person.01360236023.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360236023.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415020.2", 
              "name": [
                "Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sanui", 
            "givenName": "Masamitsu", 
            "id": "sg:person.01017443232.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017443232.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of anesthesiology, Kobe University Hospital, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411102.7", 
              "name": [
                "Department of anesthesiology, Kobe University Hospital, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Egi", 
            "givenName": "Moritoki", 
            "id": "sg:person.01330665462.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330665462.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Emergency and Critical Care Medicine, Hiroshima University, Hiroshima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.257022.0", 
              "name": [
                "Department of Emergency and Critical Care Medicine, Hiroshima University, Hiroshima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohshimo", 
            "givenName": "Shinichiro", 
            "id": "sg:person.01336546542.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336546542.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Critical Care Medicine, Okinawa Chubu Hospital, Okinawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416827.e", 
              "name": [
                "Division of Critical Care Medicine, Okinawa Chubu Hospital, Okinawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiotsuka", 
            "givenName": "Junji", 
            "id": "sg:person.01173356225.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173356225.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Emergency Medicine, Kobe City Medical Center General Hospital, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410843.a", 
              "name": [
                "Department of Emergency Medicine, Kobe City Medical Center General Hospital, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seo", 
            "givenName": "Ryutaro", 
            "id": "sg:person.0743040560.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743040560.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pulmonary & Critical Care Medicine, LDS Hospital, Salt Lake City, USA", 
              "id": "http://www.grid.ac/institutes/grid.410473.5", 
              "name": [
                "Pulmonary & Critical Care Medicine, LDS Hospital, Salt Lake City, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Ryoma", 
            "id": "sg:person.0621140604.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621140604.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology, Nara Medical University, Nara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410814.8", 
              "name": [
                "Department of Anesthesiology, Nara Medical University, Nara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Yu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Emergency and Critical Care Medicine, Tokyo Bay Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Emergency and Critical Care Medicine, Tokyo Bay Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Norisue", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.010503101601.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010503101601.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Intensive Care Medicine, Kameda Medical Center, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414927.d", 
              "name": [
                "Department of Intensive Care Medicine, Kameda Medical Center, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hayashi", 
            "givenName": "Yoshiro", 
            "id": "sg:person.0667654041.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667654041.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Medicine, Tokyo kita Social Insurance Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.440146.3", 
              "name": [
                "Department of General Medicine, Tokyo kita Social Insurance Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nango", 
            "givenName": "Eishu", 
            "id": "sg:person.01003264005.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003264005.42"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "ARDS clinical practice guideline committee from the Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s001340050585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050107199", 
              "https://doi.org/10.1007/s001340050585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2011.160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021452054", 
              "https://doi.org/10.1038/bmt.2011.160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc13896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018772929", 
              "https://doi.org/10.1186/cc13896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-014-3638-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005847538", 
              "https://doi.org/10.1007/s00134-014-3638-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc5086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003867350", 
              "https://doi.org/10.1186/cc5086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-6958-9-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003535881", 
              "https://doi.org/10.1186/2049-6958-9-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00252194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046667501", 
              "https://doi.org/10.1007/bf00252194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-002-1282-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051591599", 
              "https://doi.org/10.1007/s00134-002-1282-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1179-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037174318", 
              "https://doi.org/10.1007/s00134-008-1179-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-007-0933-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037461607", 
              "https://doi.org/10.1007/s00134-007-0933-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-014-3325-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001690734", 
              "https://doi.org/10.1007/s00134-014-3325-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-001-1112-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053425479", 
              "https://doi.org/10.1007/s00134-001-1112-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-011-0873-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043379108", 
              "https://doi.org/10.1007/s00423-011-0873-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-014-0585-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047433547", 
              "https://doi.org/10.1186/s13054-014-0585-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1195-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016228534", 
              "https://doi.org/10.1007/s00134-008-1195-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-014-3500-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037284908", 
              "https://doi.org/10.1007/s00134-014-3500-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc3737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037165657", 
              "https://doi.org/10.1186/cc3737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001340101077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028540144", 
              "https://doi.org/10.1007/s001340101077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1119-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004448236", 
              "https://doi.org/10.1007/s00134-008-1119-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-4165-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048491421", 
              "https://doi.org/10.1007/s00134-015-4165-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc7725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040777231", 
              "https://doi.org/10.1186/cc7725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc3025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033187760", 
              "https://doi.org/10.1186/cc3025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00390-009-0061-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038740761", 
              "https://doi.org/10.1007/s00390-009-0061-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-002-1266-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000414091", 
              "https://doi.org/10.1007/s00134-002-1266-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc2327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010933366", 
              "https://doi.org/10.1186/cc2327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-007-0597-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037973868", 
              "https://doi.org/10.1007/s00134-007-0597-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-010-1934-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003342055", 
              "https://doi.org/10.1007/s00134-010-1934-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-3194-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021815253", 
              "https://doi.org/10.1007/s00134-013-3194-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40560-014-0055-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051842416", 
              "https://doi.org/10.1186/s40560-014-0055-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-07-25", 
        "datePublishedReg": "2017-07-25", 
        "description": "BackgroundThe Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine provide here a clinical practice guideline for the management of adult patients with ARDS in the ICU.MethodThe guideline was developed applying the GRADE system for performing robust systematic reviews with plausible recommendations. The guideline consists of 13 clinical questions mainly regarding ventilator settings and drug therapies (the last question includes 11 medications that are not approved for clinical use in Japan).ResultsThe recommendations for adult patients with ARDS include: we suggest against early tracheostomy (GRADE 2C), we suggest using NPPV for early respiratory management (GRADE 2C), we recommend the use of low tidal volumes at 6-8 mL/kg (GRADE 1B), we suggest setting the plateau pressure at 30cmH20 or less (GRADE2B), we suggest using PEEP within the range of plateau pressures less than or equal to 30cmH2O, without compromising hemodynamics (Grade 2B), and using higher PEEP levels in patients with moderate to severe ARDS (Grade 2B), we suggest using protocolized methods for liberation from mechanical ventilation (Grade 2D), we suggest prone positioning especially in patients with moderate to severe respiratory dysfunction (GRADE 2C), we suggest against the use of high frequency oscillation (GRADE 2C), we suggest the use of neuromuscular blocking agents in patients requiring mechanical ventilation under certain circumstances (GRADE 2B), we suggest fluid restriction in the management of ARDS (GRADE 2A), we do not suggest the use of neutrophil elastase inhibitors (GRADE 2D), we suggest the administration of steroids, equivalent to methylprednisolone 1-2mg/kg/ day (GRADE 2A), and we do not recommend other medications for the treatment of adult patients with ARDS (GRADE1B; inhaled/intravenous \u03b22 stimulants, prostaglandin E1, activated protein C, ketoconazole, and lisofylline, GRADE 1C; inhaled nitric oxide, GRADE 1D; surfactant, GRADE 2B; granulocyte macrophage colony-stimulating factor, N-acetylcysteine, GRADE 2C; Statin.)ConclusionsThis article was translated from the Japanese version originally published as the ARDS clinical practice guidelines 2016 by the committee of ARDS clinical practice guideline (Tokyo, 2016, 293p, available from http://www.jsicm.org/ARDSGL/ARDSGL2016.pdf). The original article, written for Japanese healthcare providers, provides points of view that are different from those in other countries.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s40560-017-0222-3", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6137001", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6827479", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1049769", 
            "issn": [
              "2052-0492"
            ], 
            "name": "Journal of Intensive Care", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "keywords": [
          "clinical practice guidelines", 
          "management of ARDS", 
          "adult patients", 
          "practice guidelines", 
          "mechanical ventilation", 
          "care medicine", 
          "early respiratory management", 
          "administration of steroids", 
          "higher PEEP levels", 
          "severe respiratory dysfunction", 
          "low tidal volume", 
          "robust systematic review", 
          "granulocyte-macrophage colony-stimulating factor", 
          "intensive care medicine", 
          "neutrophil elastase inhibitor", 
          "macrophage colony-stimulating factor", 
          "colony-stimulating factor", 
          "early tracheostomy", 
          "\u03b22 stimulants", 
          "grade 2c", 
          "severe ARDS", 
          "respiratory management", 
          "prone positioning", 
          "fluid restriction", 
          "PEEP levels", 
          "respiratory dysfunction", 
          "ventilator settings", 
          "drug therapy", 
          "grade 2b", 
          "kg/ day", 
          "ARDS", 
          "tidal volume", 
          "clinical questions", 
          "prostaglandin E1", 
          "patients", 
          "GRADE system", 
          "healthcare providers", 
          "systematic review", 
          "N-acetylcysteine", 
          "nitric oxide", 
          "plateau pressure", 
          "elastase inhibitor", 
          "protein C", 
          "Japanese Society", 
          "mL/", 
          "Japanese version", 
          "original articles", 
          "ventilation", 
          "guidelines", 
          "ConclusionsThis article", 
          "high-frequency oscillations", 
          "medicine", 
          "tracheostomy", 
          "ICU", 
          "NPPV", 
          "medications", 
          "statins", 
          "management", 
          "dysfunction", 
          "hemodynamics", 
          "lisofylline", 
          "therapy", 
          "PEEP", 
          "steroids", 
          "administration", 
          "ketoconazole", 
          "stimulants", 
          "treatment", 
          "recommendations", 
          "inhibitors", 
          "use", 
          "days", 
          "plausible recommendations", 
          "review", 
          "providers", 
          "pressure", 
          "agents", 
          "E1", 
          "setting", 
          "certain circumstances", 
          "levels", 
          "factors", 
          "Committee", 
          "frequency oscillations", 
          "volume", 
          "restriction", 
          "countries", 
          "Japan", 
          "article", 
          "society", 
          "circumstances", 
          "positioning", 
          "questions", 
          "method", 
          "point", 
          "liberation", 
          "view", 
          "oxide", 
          "version", 
          "system", 
          "range", 
          "point of view", 
          "oscillations", 
          "surfactants"
        ], 
        "name": "The clinical practice guideline for the management of ARDS in Japan", 
        "pagination": "50", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1090893019"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s40560-017-0222-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28770093"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s40560-017-0222-3", 
          "https://app.dimensions.ai/details/publication/pub.1090893019"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_726.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s40560-017-0222-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40560-017-0222-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40560-017-0222-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40560-017-0222-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40560-017-0222-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    387 TRIPLES      21 PREDICATES      157 URIs      120 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s40560-017-0222-3 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author N61ec40453cab474b888bdb7a2cb7dc94
    4 schema:citation sg:pub.10.1007/bf00252194
    5 sg:pub.10.1007/s00134-001-1112-6
    6 sg:pub.10.1007/s00134-002-1266-x
    7 sg:pub.10.1007/s00134-002-1282-x
    8 sg:pub.10.1007/s00134-007-0597-z
    9 sg:pub.10.1007/s00134-007-0933-3
    10 sg:pub.10.1007/s00134-008-1119-3
    11 sg:pub.10.1007/s00134-008-1179-4
    12 sg:pub.10.1007/s00134-008-1195-4
    13 sg:pub.10.1007/s00134-010-1934-1
    14 sg:pub.10.1007/s00134-013-3194-3
    15 sg:pub.10.1007/s00134-014-3325-5
    16 sg:pub.10.1007/s00134-014-3500-8
    17 sg:pub.10.1007/s00134-014-3638-4
    18 sg:pub.10.1007/s00134-015-4165-7
    19 sg:pub.10.1007/s001340050585
    20 sg:pub.10.1007/s001340101077
    21 sg:pub.10.1007/s00390-009-0061-0
    22 sg:pub.10.1007/s00423-011-0873-9
    23 sg:pub.10.1038/bmt.2011.160
    24 sg:pub.10.1186/2049-6958-9-3
    25 sg:pub.10.1186/cc13896
    26 sg:pub.10.1186/cc2327
    27 sg:pub.10.1186/cc3025
    28 sg:pub.10.1186/cc3737
    29 sg:pub.10.1186/cc5086
    30 sg:pub.10.1186/cc7725
    31 sg:pub.10.1186/s13054-014-0585-y
    32 sg:pub.10.1186/s40560-014-0055-2
    33 schema:datePublished 2017-07-25
    34 schema:datePublishedReg 2017-07-25
    35 schema:description BackgroundThe Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine provide here a clinical practice guideline for the management of adult patients with ARDS in the ICU.MethodThe guideline was developed applying the GRADE system for performing robust systematic reviews with plausible recommendations. The guideline consists of 13 clinical questions mainly regarding ventilator settings and drug therapies (the last question includes 11 medications that are not approved for clinical use in Japan).ResultsThe recommendations for adult patients with ARDS include: we suggest against early tracheostomy (GRADE 2C), we suggest using NPPV for early respiratory management (GRADE 2C), we recommend the use of low tidal volumes at 6-8 mL/kg (GRADE 1B), we suggest setting the plateau pressure at 30cmH20 or less (GRADE2B), we suggest using PEEP within the range of plateau pressures less than or equal to 30cmH2O, without compromising hemodynamics (Grade 2B), and using higher PEEP levels in patients with moderate to severe ARDS (Grade 2B), we suggest using protocolized methods for liberation from mechanical ventilation (Grade 2D), we suggest prone positioning especially in patients with moderate to severe respiratory dysfunction (GRADE 2C), we suggest against the use of high frequency oscillation (GRADE 2C), we suggest the use of neuromuscular blocking agents in patients requiring mechanical ventilation under certain circumstances (GRADE 2B), we suggest fluid restriction in the management of ARDS (GRADE 2A), we do not suggest the use of neutrophil elastase inhibitors (GRADE 2D), we suggest the administration of steroids, equivalent to methylprednisolone 1-2mg/kg/ day (GRADE 2A), and we do not recommend other medications for the treatment of adult patients with ARDS (GRADE1B; inhaled/intravenous β2 stimulants, prostaglandin E1, activated protein C, ketoconazole, and lisofylline, GRADE 1C; inhaled nitric oxide, GRADE 1D; surfactant, GRADE 2B; granulocyte macrophage colony-stimulating factor, N-acetylcysteine, GRADE 2C; Statin.)ConclusionsThis article was translated from the Japanese version originally published as the ARDS clinical practice guidelines 2016 by the committee of ARDS clinical practice guideline (Tokyo, 2016, 293p, available from http://www.jsicm.org/ARDSGL/ARDSGL2016.pdf). The original article, written for Japanese healthcare providers, provides points of view that are different from those in other countries.
    36 schema:genre article
    37 schema:isAccessibleForFree true
    38 schema:isPartOf N3a444bb94e10472aa4037da13df17d4d
    39 N820a80b7653e4d6dadcae43aa29ad2b1
    40 sg:journal.1049769
    41 schema:keywords ARDS
    42 Committee
    43 ConclusionsThis article
    44 E1
    45 GRADE system
    46 ICU
    47 Japan
    48 Japanese Society
    49 Japanese version
    50 N-acetylcysteine
    51 NPPV
    52 PEEP
    53 PEEP levels
    54 administration
    55 administration of steroids
    56 adult patients
    57 agents
    58 article
    59 care medicine
    60 certain circumstances
    61 circumstances
    62 clinical practice guidelines
    63 clinical questions
    64 colony-stimulating factor
    65 countries
    66 days
    67 drug therapy
    68 dysfunction
    69 early respiratory management
    70 early tracheostomy
    71 elastase inhibitor
    72 factors
    73 fluid restriction
    74 frequency oscillations
    75 grade 2b
    76 grade 2c
    77 granulocyte-macrophage colony-stimulating factor
    78 guidelines
    79 healthcare providers
    80 hemodynamics
    81 high-frequency oscillations
    82 higher PEEP levels
    83 inhibitors
    84 intensive care medicine
    85 ketoconazole
    86 kg/ day
    87 levels
    88 liberation
    89 lisofylline
    90 low tidal volume
    91 mL/
    92 macrophage colony-stimulating factor
    93 management
    94 management of ARDS
    95 mechanical ventilation
    96 medications
    97 medicine
    98 method
    99 neutrophil elastase inhibitor
    100 nitric oxide
    101 original articles
    102 oscillations
    103 oxide
    104 patients
    105 plateau pressure
    106 plausible recommendations
    107 point
    108 point of view
    109 positioning
    110 practice guidelines
    111 pressure
    112 prone positioning
    113 prostaglandin E1
    114 protein C
    115 providers
    116 questions
    117 range
    118 recommendations
    119 respiratory dysfunction
    120 respiratory management
    121 restriction
    122 review
    123 robust systematic review
    124 setting
    125 severe ARDS
    126 severe respiratory dysfunction
    127 society
    128 statins
    129 steroids
    130 stimulants
    131 surfactants
    132 system
    133 systematic review
    134 therapy
    135 tidal volume
    136 tracheostomy
    137 treatment
    138 use
    139 ventilation
    140 ventilator settings
    141 version
    142 view
    143 volume
    144 β2 stimulants
    145 schema:name The clinical practice guideline for the management of ARDS in Japan
    146 schema:pagination 50
    147 schema:productId N0b00703f7fed4f99a4639b45a8ba22d8
    148 N63b4192b8b954a2d9328436cf620abc0
    149 Ne23f4bdc3050466fa1e09434d9033910
    150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090893019
    151 https://doi.org/10.1186/s40560-017-0222-3
    152 schema:sdDatePublished 2022-12-01T06:36
    153 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    154 schema:sdPublisher N1d1a5679392049259416183dc048fc09
    155 schema:url https://doi.org/10.1186/s40560-017-0222-3
    156 sgo:license sg:explorer/license/
    157 sgo:sdDataset articles
    158 rdf:type schema:ScholarlyArticle
    159 N0b00703f7fed4f99a4639b45a8ba22d8 schema:name doi
    160 schema:value 10.1186/s40560-017-0222-3
    161 rdf:type schema:PropertyValue
    162 N0c713cf527724c25a47d5bc7720b1cb3 rdf:first sg:person.01003264005.42
    163 rdf:rest N40b7d5c9631a45daaea668a82e29c2d5
    164 N1d1a5679392049259416183dc048fc09 schema:name Springer Nature - SN SciGraph project
    165 rdf:type schema:Organization
    166 N3447f24d5334418bbee43f4e52d98ea6 rdf:first Nb33183a53727410b88fa2b43f45654fc
    167 rdf:rest Nd18fe843a3ee4962b157f3b8b59f023e
    168 N3a444bb94e10472aa4037da13df17d4d schema:volumeNumber 5
    169 rdf:type schema:PublicationVolume
    170 N40b7d5c9631a45daaea668a82e29c2d5 rdf:first Nc1588c83d6724ea5a84feaf9d301fdb4
    171 rdf:rest rdf:nil
    172 N4a264e16a0ff482a82de18b8c36b76a0 rdf:first sg:person.01017443232.14
    173 rdf:rest Nb4c1ebbb519e43d482e53a995a3df902
    174 N61ec40453cab474b888bdb7a2cb7dc94 rdf:first sg:person.01360236023.62
    175 rdf:rest N4a264e16a0ff482a82de18b8c36b76a0
    176 N63b4192b8b954a2d9328436cf620abc0 schema:name pubmed_id
    177 schema:value 28770093
    178 rdf:type schema:PropertyValue
    179 N820a80b7653e4d6dadcae43aa29ad2b1 schema:issueNumber 1
    180 rdf:type schema:PublicationIssue
    181 Nb1242f44b2724c7d90ac6d037f61e27c rdf:first sg:person.0743040560.05
    182 rdf:rest Ne01ef89cf68e4183be35110fadbba3ff
    183 Nb33183a53727410b88fa2b43f45654fc schema:affiliation grid-institutes:grid.410814.8
    184 schema:familyName Tanaka
    185 schema:givenName Yu
    186 rdf:type schema:Person
    187 Nb4c1ebbb519e43d482e53a995a3df902 rdf:first sg:person.01330665462.89
    188 rdf:rest Ndfad6a2331ac4f2cb105ef5d36a0d0cc
    189 Nbeaf7935eb554ceaab9a0e6f6e23304b rdf:first sg:person.0667654041.00
    190 rdf:rest N0c713cf527724c25a47d5bc7720b1cb3
    191 Nc1588c83d6724ea5a84feaf9d301fdb4 schema:familyName ARDS clinical practice guideline committee from the Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine
    192 rdf:type schema:Person
    193 Nd18fe843a3ee4962b157f3b8b59f023e rdf:first sg:person.010503101601.23
    194 rdf:rest Nbeaf7935eb554ceaab9a0e6f6e23304b
    195 Ndd4bba0a626d49e998fb5a9d1773dd2b rdf:first sg:person.01173356225.48
    196 rdf:rest Nb1242f44b2724c7d90ac6d037f61e27c
    197 Ndfad6a2331ac4f2cb105ef5d36a0d0cc rdf:first sg:person.01336546542.65
    198 rdf:rest Ndd4bba0a626d49e998fb5a9d1773dd2b
    199 Ne01ef89cf68e4183be35110fadbba3ff rdf:first sg:person.0621140604.82
    200 rdf:rest N3447f24d5334418bbee43f4e52d98ea6
    201 Ne23f4bdc3050466fa1e09434d9033910 schema:name dimensions_id
    202 schema:value pub.1090893019
    203 rdf:type schema:PropertyValue
    204 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    205 schema:name Medical and Health Sciences
    206 rdf:type schema:DefinedTerm
    207 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Clinical Sciences
    209 rdf:type schema:DefinedTerm
    210 sg:grant.6137001 http://pending.schema.org/fundedItem sg:pub.10.1186/s40560-017-0222-3
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.6827479 http://pending.schema.org/fundedItem sg:pub.10.1186/s40560-017-0222-3
    213 rdf:type schema:MonetaryGrant
    214 sg:journal.1049769 schema:issn 2052-0492
    215 schema:name Journal of Intensive Care
    216 schema:publisher Springer Nature
    217 rdf:type schema:Periodical
    218 sg:person.01003264005.42 schema:affiliation grid-institutes:grid.440146.3
    219 schema:familyName Nango
    220 schema:givenName Eishu
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003264005.42
    222 rdf:type schema:Person
    223 sg:person.01017443232.14 schema:affiliation grid-institutes:grid.415020.2
    224 schema:familyName Sanui
    225 schema:givenName Masamitsu
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017443232.14
    227 rdf:type schema:Person
    228 sg:person.010503101601.23 schema:affiliation grid-institutes:None
    229 schema:familyName Norisue
    230 schema:givenName Yasuhiro
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010503101601.23
    232 rdf:type schema:Person
    233 sg:person.01173356225.48 schema:affiliation grid-institutes:grid.416827.e
    234 schema:familyName Shiotsuka
    235 schema:givenName Junji
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173356225.48
    237 rdf:type schema:Person
    238 sg:person.01330665462.89 schema:affiliation grid-institutes:grid.411102.7
    239 schema:familyName Egi
    240 schema:givenName Moritoki
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330665462.89
    242 rdf:type schema:Person
    243 sg:person.01336546542.65 schema:affiliation grid-institutes:grid.257022.0
    244 schema:familyName Ohshimo
    245 schema:givenName Shinichiro
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336546542.65
    247 rdf:type schema:Person
    248 sg:person.01360236023.62 schema:affiliation grid-institutes:grid.272458.e
    249 schema:familyName Hashimoto
    250 schema:givenName Satoru
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360236023.62
    252 rdf:type schema:Person
    253 sg:person.0621140604.82 schema:affiliation grid-institutes:grid.410473.5
    254 schema:familyName Tanaka
    255 schema:givenName Ryoma
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621140604.82
    257 rdf:type schema:Person
    258 sg:person.0667654041.00 schema:affiliation grid-institutes:grid.414927.d
    259 schema:familyName Hayashi
    260 schema:givenName Yoshiro
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667654041.00
    262 rdf:type schema:Person
    263 sg:person.0743040560.05 schema:affiliation grid-institutes:grid.410843.a
    264 schema:familyName Seo
    265 schema:givenName Ryutaro
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743040560.05
    267 rdf:type schema:Person
    268 sg:pub.10.1007/bf00252194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046667501
    269 https://doi.org/10.1007/bf00252194
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/s00134-001-1112-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053425479
    272 https://doi.org/10.1007/s00134-001-1112-6
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/s00134-002-1266-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000414091
    275 https://doi.org/10.1007/s00134-002-1266-x
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/s00134-002-1282-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051591599
    278 https://doi.org/10.1007/s00134-002-1282-x
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/s00134-007-0597-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037973868
    281 https://doi.org/10.1007/s00134-007-0597-z
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/s00134-007-0933-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037461607
    284 https://doi.org/10.1007/s00134-007-0933-3
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/s00134-008-1119-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004448236
    287 https://doi.org/10.1007/s00134-008-1119-3
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s00134-008-1179-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037174318
    290 https://doi.org/10.1007/s00134-008-1179-4
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s00134-008-1195-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016228534
    293 https://doi.org/10.1007/s00134-008-1195-4
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s00134-010-1934-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003342055
    296 https://doi.org/10.1007/s00134-010-1934-1
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s00134-013-3194-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021815253
    299 https://doi.org/10.1007/s00134-013-3194-3
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s00134-014-3325-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001690734
    302 https://doi.org/10.1007/s00134-014-3325-5
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s00134-014-3500-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037284908
    305 https://doi.org/10.1007/s00134-014-3500-8
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s00134-014-3638-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005847538
    308 https://doi.org/10.1007/s00134-014-3638-4
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s00134-015-4165-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048491421
    311 https://doi.org/10.1007/s00134-015-4165-7
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s001340050585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050107199
    314 https://doi.org/10.1007/s001340050585
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s001340101077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028540144
    317 https://doi.org/10.1007/s001340101077
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1007/s00390-009-0061-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038740761
    320 https://doi.org/10.1007/s00390-009-0061-0
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1007/s00423-011-0873-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043379108
    323 https://doi.org/10.1007/s00423-011-0873-9
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/bmt.2011.160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021452054
    326 https://doi.org/10.1038/bmt.2011.160
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1186/2049-6958-9-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003535881
    329 https://doi.org/10.1186/2049-6958-9-3
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1186/cc13896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018772929
    332 https://doi.org/10.1186/cc13896
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1186/cc2327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010933366
    335 https://doi.org/10.1186/cc2327
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1186/cc3025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033187760
    338 https://doi.org/10.1186/cc3025
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1186/cc3737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037165657
    341 https://doi.org/10.1186/cc3737
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1186/cc5086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003867350
    344 https://doi.org/10.1186/cc5086
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1186/cc7725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040777231
    347 https://doi.org/10.1186/cc7725
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1186/s13054-014-0585-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047433547
    350 https://doi.org/10.1186/s13054-014-0585-y
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1186/s40560-014-0055-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051842416
    353 https://doi.org/10.1186/s40560-014-0055-2
    354 rdf:type schema:CreativeWork
    355 grid-institutes:None schema:alternateName Department of Emergency and Critical Care Medicine, Tokyo Bay Medical Center, Tokyo, Japan
    356 schema:name Department of Emergency and Critical Care Medicine, Tokyo Bay Medical Center, Tokyo, Japan
    357 rdf:type schema:Organization
    358 grid-institutes:grid.257022.0 schema:alternateName Department of Emergency and Critical Care Medicine, Hiroshima University, Hiroshima, Japan
    359 schema:name Department of Emergency and Critical Care Medicine, Hiroshima University, Hiroshima, Japan
    360 rdf:type schema:Organization
    361 grid-institutes:grid.272458.e schema:alternateName Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto, Japan
    362 schema:name Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, Kyoto, Japan
    363 rdf:type schema:Organization
    364 grid-institutes:grid.410473.5 schema:alternateName Pulmonary & Critical Care Medicine, LDS Hospital, Salt Lake City, USA
    365 schema:name Pulmonary & Critical Care Medicine, LDS Hospital, Salt Lake City, USA
    366 rdf:type schema:Organization
    367 grid-institutes:grid.410814.8 schema:alternateName Department of Anesthesiology, Nara Medical University, Nara, Japan
    368 schema:name Department of Anesthesiology, Nara Medical University, Nara, Japan
    369 rdf:type schema:Organization
    370 grid-institutes:grid.410843.a schema:alternateName Department of Emergency Medicine, Kobe City Medical Center General Hospital, Kobe, Japan
    371 schema:name Department of Emergency Medicine, Kobe City Medical Center General Hospital, Kobe, Japan
    372 rdf:type schema:Organization
    373 grid-institutes:grid.411102.7 schema:alternateName Department of anesthesiology, Kobe University Hospital, Kobe, Japan
    374 schema:name Department of anesthesiology, Kobe University Hospital, Kobe, Japan
    375 rdf:type schema:Organization
    376 grid-institutes:grid.414927.d schema:alternateName Department of Intensive Care Medicine, Kameda Medical Center, Chiba, Japan
    377 schema:name Department of Intensive Care Medicine, Kameda Medical Center, Chiba, Japan
    378 rdf:type schema:Organization
    379 grid-institutes:grid.415020.2 schema:alternateName Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan
    380 schema:name Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan
    381 rdf:type schema:Organization
    382 grid-institutes:grid.416827.e schema:alternateName Division of Critical Care Medicine, Okinawa Chubu Hospital, Okinawa, Japan
    383 schema:name Division of Critical Care Medicine, Okinawa Chubu Hospital, Okinawa, Japan
    384 rdf:type schema:Organization
    385 grid-institutes:grid.440146.3 schema:alternateName Department of General Medicine, Tokyo kita Social Insurance Hospital, Tokyo, Japan
    386 schema:name Department of General Medicine, Tokyo kita Social Insurance Hospital, Tokyo, Japan
    387 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...