The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Yann Fichou, Youssra K. Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O. Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée, Isabelle Landrieu

ABSTRACT

Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer's and Pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to up-date our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research - diagnosis and therapeutics. More... »

PAGES

31

References to SciGraph publications

  • 2016-02. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau in ACTA NEUROPATHOLOGICA
  • 2017-12. Atypical, non-standard functions of the microtubule associated Tau protein in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2018-12. Different tau species lead to heterogeneous tau pathology propagation and misfolding in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2018-02. High performance plasma amyloid-β biomarkers for Alzheimer’s disease in NATURE
  • 2016-05. Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2015-09. Structure of the toxic core of α-synuclein from invisible crystals in NATURE
  • 2019-12. A walk through tau therapeutic strategies in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2001-09. A genomic sequence analysis of the mouse and human microtubule-associated protein tau in MAMMALIAN GENOME
  • 2017-12. Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau in NATURE COMMUNICATIONS
  • 2018-12. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex in NATURE COMMUNICATIONS
  • 2017-12. Propagation of Tau aggregates in MOLECULAR BRAIN
  • 2016-07-04. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model in NATURE COMMUNICATIONS
  • 2018-09. Structures of filaments from Pick’s disease reveal a novel tau protein fold in NATURE
  • 2017-12. Signature of an aggregation-prone conformation of tau in SCIENTIFIC REPORTS
  • 2018-12. Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein in SCIENTIFIC REPORTS
  • 2018-12. Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges in SCIENTIFIC REPORTS
  • 2017-12. Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes in NATURE COMMUNICATIONS
  • 2014-12. Alpha-synuclein and tau: teammates in neurodegeneration? in MOLECULAR NEURODEGENERATION
  • 2018-02. Structure-based inhibitors of tau aggregation in NATURE CHEMISTRY
  • 2017-12. EuroTau: towing scientists to tau without tautology in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 1996-07. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules in NATURE MEDICINE
  • 2017-12. Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates in SCIENTIFIC REPORTS
  • 1994-08. Mechanism of neurofibrillary degeneration in Alzheimer's disease in MOLECULAR NEUROBIOLOGY
  • 2017-07. Cryo-EM structures of tau filaments from Alzheimer’s disease in NATURE
  • 2007-05. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau in ACTA NEUROPATHOLOGICA
  • 1995-01. Monitoring pathological assembly of tau and β-amyloid proteins in Alzheimer's disease in ACTA NEUROPATHOLOGICA
  • 2017-12. Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain in ALZHEIMER'S RESEARCH & THERAPY
  • 2011-11. Are Tangles as Toxic as They Look? in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2017-12. Tau passive immunization inhibits not only tau but also Aβ pathology in ALZHEIMER'S RESEARCH & THERAPY
  • 2007-05-24. Atomic structures of amyloid cross-β spines reveal varied steric zippers in NATURE
  • 2014-11. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease in NATURE MEDICINE
  • 2015-08. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice in NATURE NEUROSCIENCE
  • 1996-10. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans in NATURE
  • 1998-10. RNA sequestration to pathological lesions of neurodegenerative diseases in ACTA NEUROPATHOLOGICA
  • 2018-11. Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold in ACTA NEUROPATHOLOGICA
  • 1996-06. Comparison of the neurofibrillary pathology in Alzheimer’s disease and familial presenile dementia with tangles in ACTA NEUROPATHOLOGICA
  • 2017. Neurotoxicity of Zinc in NEUROTOXICITY OF METALS
  • 2010-04. Caspase activation precedes and leads to tangles in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40478-019-0682-x

    DOI

    http://dx.doi.org/10.1186/s40478-019-0682-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112469408

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30823892


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of California, Santa Barbara", 
              "id": "https://www.grid.ac/institutes/grid.133342.4", 
              "name": [
                "Department of chemistry and biochemistry, University of California Santa Barbara, 93106, Santa Barbara, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fichou", 
            "givenName": "Yann", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Al-Mustansiriya University", 
              "id": "https://www.grid.ac/institutes/grid.411309.e", 
              "name": [
                "Dementia Research group, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, E Sussex, UK", 
                "Chemistry Department, Science College, Mustansiriyah University, Baghdad, Iraq"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Al-Hilaly", 
            "givenName": "Youssra K.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aix-Marseille University", 
              "id": "https://www.grid.ac/institutes/grid.5399.6", 
              "name": [
                "Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, Fac Pharm, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Devred", 
            "givenName": "Fran\u00e7ois", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lille 1 University", 
              "id": "https://www.grid.ac/institutes/grid.4461.7", 
              "name": [
                "University of Lille, CNRS, UMR8576, 59000, Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smet-Nocca", 
            "givenName": "Caroline", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aix-Marseille University", 
              "id": "https://www.grid.ac/institutes/grid.5399.6", 
              "name": [
                "Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, Fac Pharm, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsvetkov", 
            "givenName": "Philipp O.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Functional Biology, KU Leuven, Kasteelpark Arenberg 31, Box 2433, 3001, Heverlee, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Verelst", 
            "givenName": "Joke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Functional Biology, KU Leuven, Kasteelpark Arenberg 31, Box 2433, 3001, Heverlee, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winderickx", 
            "givenName": "Joris", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Pharmabs, KU Leuven, Herestraat 49, box 820, B 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geukens", 
            "givenName": "Nick", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ADx NeuroSciences NV, Technologiepark Zwijnaarde 94, 9052, Ghent, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vanmechelen", 
            "givenName": "Eugeen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Life Molecular Imaging, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perrotin", 
            "givenName": "Audrey", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Sussex", 
              "id": "https://www.grid.ac/institutes/grid.12082.39", 
              "name": [
                "Dementia Research group, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, E Sussex, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serpell", 
            "givenName": "Louise", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cliniques Universitaires Saint-Luc", 
              "id": "https://www.grid.ac/institutes/grid.48769.34", 
              "name": [
                "Neurology Department, Cliniques Universitaires Saint-Luc, 10 Avenue Hippocrate, 1200 Brussels, Belgium", 
                "Gordon Center for Medical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hanseeuw", 
            "givenName": "Bernard J", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "CIBERNED (Network Center for Biomedical Research in Neurodegenerative Diseases), Madrid, Spain", 
                "CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Medina", 
            "givenName": "Miguel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lille 1 University", 
              "id": "https://www.grid.ac/institutes/grid.4461.7", 
              "name": [
                "University of Lille, Inserm, CHU-Lille, UMRS1172, 59000, Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bu\u00e9e", 
            "givenName": "Luc", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lille 1 University", 
              "id": "https://www.grid.ac/institutes/grid.4461.7", 
              "name": [
                "University of Lille, CNRS, UMR8576, 59000, Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Landrieu", 
            "givenName": "Isabelle", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0400348101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001373405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12031-011-9566-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001895385", 
              "https://doi.org/10.1007/s12031-011-9566-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.51.32789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002057838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroimage.2015.03.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003517578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.9.4.1381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004623729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.24988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005431861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010050923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005505668", 
              "https://doi.org/10.1007/s004010050923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m115.641902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005882612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m116.715557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006237188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1504081112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007367617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.627919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007472055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/biom6020021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007600030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2003.01879.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008022820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m805300200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008139879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1503-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008581766", 
              "https://doi.org/10.1007/s00401-015-1503-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1503-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008581766", 
              "https://doi.org/10.1007/s00401-015-1503-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008694534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008694534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008757821", 
              "https://doi.org/10.1038/nature05695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja305470p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008801729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2006.05226.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009810297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fphar.2014.00227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010083744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.10.5129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010163892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2016.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011459568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1998.71062465.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012342023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013022767", 
              "https://doi.org/10.1038/nature15368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(89)90210-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013144390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.611368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013295585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010050487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013833108", 
              "https://doi.org/10.1007/s004010050487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awp099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014418232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awp099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014418232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2007.05555.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015091088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015127175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2011.11.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015501052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1001080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015620170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00294259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016021239", 
              "https://doi.org/10.1007/bf00294259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.3194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016142352", 
              "https://doi.org/10.1038/nsmb.3194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.12.4506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016689265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jproteome.5b01001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017508856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0357006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017863140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0357006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017863140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0401911101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017961633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2004.04.098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018445032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(97)00056-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018951481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms12082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019311148", 
              "https://doi.org/10.1038/ncomms12082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20120015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020373206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20120015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020373206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.72.5.1858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020607127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.380642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021058311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201501898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(86)90495-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022342684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-4580(95)00027-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022928700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2009.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023128700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201105493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023462552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0796-783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023642547", 
              "https://doi.org/10.1038/nm0796-783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1530287100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023923464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2012.07911.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024281237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0207-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024620200", 
              "https://doi.org/10.1007/s00401-007-0207-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0207-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024620200", 
              "https://doi.org/10.1007/s00401-007-0207-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja303498q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024957362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025095211", 
              "https://doi.org/10.1038/nm.3700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1789.2008.00916.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025579521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00335-001-2044-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025669938", 
              "https://doi.org/10.1007/s00335-001-2044-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1567-1364.2010.00662.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026310189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1567-1364.2010.00662.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026310189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.058883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026348813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2015.1285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026618324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.415935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027046299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-4580(95)00021-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027172018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2014.01.161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027203461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1630428100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028428842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000003246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028554691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000003246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028554691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.13.5842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029178020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.13.4884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029272999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.12.5562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029496056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/nen.0b013e31825018f7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029938501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.13.4913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030184264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2013.03.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030372162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13195-016-0227-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032120237", 
              "https://doi.org/10.1186/s13195-016-0227-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13195-016-0227-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032120237", 
              "https://doi.org/10.1186/s13195-016-0227-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2015.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032169228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2005.11.077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035326234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.121119298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036209363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.73.11.4070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036876132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036907252", 
              "https://doi.org/10.1038/nature08890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036907252", 
              "https://doi.org/10.1038/nature08890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/aww027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039511982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4061/2011/971021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039780709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.06.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039980474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000095257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040609531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.21867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041665887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0076523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042116638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0076523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042116638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0076523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042116638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2016.09.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042416233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383550a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042539440", 
              "https://doi.org/10.1038/383550a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biochi.2011.09.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043153140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.364067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047171870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047328174", 
              "https://doi.org/10.1038/nn.4067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4137/jen.s12202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048178402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1750-1326-9-43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049166689", 
              "https://doi.org/10.1186/1750-1326-9-43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050357746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02816111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051138575", 
              "https://doi.org/10.1007/bf02816111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02816111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051138575", 
              "https://doi.org/10.1007/bf02816111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2010.10.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053548017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.analchem.5b04509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055079439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi5014613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055206719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi981874p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055216568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi981874p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055216568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja504864m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055856546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja7100517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055857311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja7100517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055857311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m115.700914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058214297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/aww334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059445324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1151839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062457243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3122323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062592538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000003050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064353764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000003050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064353764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000003050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064353764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-160227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071127259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074713230", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1991.tb07820.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077836672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-130032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078715779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-130098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078772125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079547073", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05665.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082463016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084007938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep44739", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084132616", 
              "https://doi.org/10.1038/srep44739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13195-017-0253-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252361", 
              "https://doi.org/10.1186/s13195-017-0253-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13195-017-0253-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252361", 
              "https://doi.org/10.1186/s13195-017-0253-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13041-017-0298-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085704994", 
              "https://doi.org/10.1186/s13041-017-0298-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13041-017-0298-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085704994", 
              "https://doi.org/10.1186/s13041-017-0298-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/07391102.2017.1343684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086132537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature23002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090348371", 
              "https://doi.org/10.1038/nature23002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature23002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090348371", 
              "https://doi.org/10.1038/nature23002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2017.06.2266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090806044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-07215-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090883002", 
              "https://doi.org/10.1038/s41598-017-07215-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-07215-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090883002", 
              "https://doi.org/10.1038/s41598-017-07215-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/febs.14185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090920704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1708448114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091089394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-00480-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091119425", 
              "https://doi.org/10.1038/s41467-017-00480-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-60189-2_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091580493", 
              "https://doi.org/10.1007/978-3-319-60189-2_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2017.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091818537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2017.07.426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092312379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2017.06.2556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092327467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-01575-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092730294", 
              "https://doi.org/10.1038/s41467-017-01575-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092795271", 
              "https://doi.org/10.1038/nchem.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092795271", 
              "https://doi.org/10.1038/nchem.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092795271", 
              "https://doi.org/10.1038/nchem.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-017-0491-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093037510", 
              "https://doi.org/10.1186/s40478-017-0491-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-017-0491-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093037510", 
              "https://doi.org/10.1186/s40478-017-0491-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-017-0491-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093037510", 
              "https://doi.org/10.1186/s40478-017-0491-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-017-0489-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093074652", 
              "https://doi.org/10.1186/s40478-017-0489-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.27271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100074192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000004860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100087912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000004860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100087912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000004860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100087912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0000000000004860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100087912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.ra118.001784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100714238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100715012", 
              "https://doi.org/10.1038/nature25456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100715012", 
              "https://doi.org/10.1038/nature25456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.aca.2018.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101080359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/embj.201798049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101166200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awy059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101192536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awy065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101270769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/bmc-2018-0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101410232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/bmc-2018-0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101410232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/bmc-2018-0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101410232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101673165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101673165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101673165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101673165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-170840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101829956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.ra117.000490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103204959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c8cc01355a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103205764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-24276-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103361101", 
              "https://doi.org/10.1038/s41598-018-24276-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aat1780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103933900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aat1780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103933900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-179942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104291827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-179942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104291827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-180151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104541577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-180151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104541577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm-2018-0147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105179382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.36584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105413195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.36584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105413195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-180404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105676653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-180404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105676653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0201182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105703226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2018.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106186455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0454-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106388788", 
              "https://doi.org/10.1038/s41586-018-0454-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0454-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106388788", 
              "https://doi.org/10.1038/s41586-018-0454-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0454-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106388788", 
              "https://doi.org/10.1038/s41586-018-0454-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0454-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106388788", 
              "https://doi.org/10.1038/s41586-018-0454-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0454-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106388788", 
              "https://doi.org/10.1038/s41586-018-0454-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.07.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106624290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.07.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106624290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-32096-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106921303", 
              "https://doi.org/10.1038/s41598-018-32096-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.ra118.005316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107123731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.ra118.005316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107123731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.ra118.005316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107123731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1914-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107347554", 
              "https://doi.org/10.1007/s00401-018-1914-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1914-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107347554", 
              "https://doi.org/10.1007/s00401-018-1914-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gky929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107415659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gky929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107415659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2018.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107538759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2018.00595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107644435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2018.06.2287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107759635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-06880-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107849703", 
              "https://doi.org/10.1038/s41467-018-06880-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-018-0637-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110272102", 
              "https://doi.org/10.1186/s40478-018-0637-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-018-0637-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110272102", 
              "https://doi.org/10.1186/s40478-018-0637-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-018-0637-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110272102", 
              "https://doi.org/10.1186/s40478-018-0637-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-018-0637-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110272102", 
              "https://doi.org/10.1186/s40478-018-0637-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2018.3692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110344100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2018.3692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110344100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2018.3692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110344100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaneurol.2018.3692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110344100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2018.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110422860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2018.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110422860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2018.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110422860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1810058115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110538248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1810058115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110538248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1810058115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110538248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1810058115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110538248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnmol.2018.00459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110603467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnmol.2018.00459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110603467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnmol.2018.00459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110603467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnmol.2018.00459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110603467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2018.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110813009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2018.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110813009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.25406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110995776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.25406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110995776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.25406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110995776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.25406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110995776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.25406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110995776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0210864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111606017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sciadv.aau3333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111632681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sciadv.aau3333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111632681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.43584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111920482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.43584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111920482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.43584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111920482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-019-0664-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112168870", 
              "https://doi.org/10.1186/s40478-019-0664-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-019-0664-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112168870", 
              "https://doi.org/10.1186/s40478-019-0664-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-019-0664-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112168870", 
              "https://doi.org/10.1186/s40478-019-0664-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-019-0664-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112168870", 
              "https://doi.org/10.1186/s40478-019-0664-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer's and Pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to up-date our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research - diagnosis and therapeutics.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s40478-019-0682-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1048594", 
            "issn": [
              "2051-5960"
            ], 
            "name": "Acta Neuropathologica Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?", 
        "pagination": "31", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "572f5edca335fcedc8eda89615f99431023a0cedbeecf02eefa3079ec782d8aa"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30823892"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101610673"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s40478-019-0682-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112469408"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s40478-019-0682-x", 
          "https://app.dimensions.ai/details/publication/pub.1112469408"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78959_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs40478-019-0682-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0682-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0682-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0682-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0682-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    733 TRIPLES      21 PREDICATES      201 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s40478-019-0682-x schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N8d65f21cf02b489e9bd871346ca8ea03
    4 schema:citation sg:pub.10.1007/978-3-319-60189-2_15
    5 sg:pub.10.1007/bf00294259
    6 sg:pub.10.1007/bf02816111
    7 sg:pub.10.1007/s00335-001-2044-8
    8 sg:pub.10.1007/s00401-007-0207-8
    9 sg:pub.10.1007/s00401-015-1503-3
    10 sg:pub.10.1007/s00401-018-1914-z
    11 sg:pub.10.1007/s004010050487
    12 sg:pub.10.1007/s004010050923
    13 sg:pub.10.1007/s12031-011-9566-7
    14 sg:pub.10.1038/383550a0
    15 sg:pub.10.1038/nature05695
    16 sg:pub.10.1038/nature08890
    17 sg:pub.10.1038/nature15368
    18 sg:pub.10.1038/nature23002
    19 sg:pub.10.1038/nature25456
    20 sg:pub.10.1038/nchem.2889
    21 sg:pub.10.1038/ncomms12082
    22 sg:pub.10.1038/nm.3700
    23 sg:pub.10.1038/nm0796-783
    24 sg:pub.10.1038/nn.4067
    25 sg:pub.10.1038/nsmb.3194
    26 sg:pub.10.1038/s41467-017-00480-0
    27 sg:pub.10.1038/s41467-017-01575-4
    28 sg:pub.10.1038/s41467-018-06880-0
    29 sg:pub.10.1038/s41586-018-0454-y
    30 sg:pub.10.1038/s41598-017-07215-7
    31 sg:pub.10.1038/s41598-018-24276-4
    32 sg:pub.10.1038/s41598-018-32096-9
    33 sg:pub.10.1038/srep44739
    34 sg:pub.10.1186/1750-1326-9-43
    35 sg:pub.10.1186/s13041-017-0298-7
    36 sg:pub.10.1186/s13195-016-0227-5
    37 sg:pub.10.1186/s13195-017-0253-y
    38 sg:pub.10.1186/s40478-017-0489-6
    39 sg:pub.10.1186/s40478-017-0491-z
    40 sg:pub.10.1186/s40478-018-0637-7
    41 sg:pub.10.1186/s40478-019-0664-z
    42 https://app.dimensions.ai/details/publication/pub.1074713230
    43 https://app.dimensions.ai/details/publication/pub.1079547073
    44 https://doi.org/10.1001/jamaneurol.2015.1285
    45 https://doi.org/10.1001/jamaneurol.2018.3692
    46 https://doi.org/10.1002/ana.24517
    47 https://doi.org/10.1002/ana.24546
    48 https://doi.org/10.1002/ana.24910
    49 https://doi.org/10.1002/ana.25406
    50 https://doi.org/10.1002/anie.201105493
    51 https://doi.org/10.1002/anie.201501898
    52 https://doi.org/10.1002/cne.21867
    53 https://doi.org/10.1002/j.1460-2075.1991.tb07820.x
    54 https://doi.org/10.1002/j.1460-2075.1993.tb05665.x
    55 https://doi.org/10.1002/mds.27271
    56 https://doi.org/10.1002/prot.24988
    57 https://doi.org/10.1016/0197-4580(95)00021-6
    58 https://doi.org/10.1016/0197-4580(95)00027-c
    59 https://doi.org/10.1016/0896-6273(89)90210-9
    60 https://doi.org/10.1016/j.aca.2018.02.011
    61 https://doi.org/10.1016/j.ajpath.2010.10.034
    62 https://doi.org/10.1016/j.bbadis.2016.11.022
    63 https://doi.org/10.1016/j.bbrc.2014.01.161
    64 https://doi.org/10.1016/j.biochi.2011.09.011
    65 https://doi.org/10.1016/j.celrep.2014.06.047
    66 https://doi.org/10.1016/j.expneurol.2015.06.003
    67 https://doi.org/10.1016/j.febslet.2004.04.098
    68 https://doi.org/10.1016/j.febslet.2005.11.077
    69 https://doi.org/10.1016/j.jalz.2017.06.2266
    70 https://doi.org/10.1016/j.jalz.2017.06.2556
    71 https://doi.org/10.1016/j.jalz.2017.07.426
    72 https://doi.org/10.1016/j.jalz.2018.06.2287
    73 https://doi.org/10.1016/j.jmb.2017.09.007
    74 https://doi.org/10.1016/j.jmb.2018.08.010
    75 https://doi.org/10.1016/j.jmb.2018.12.008
    76 https://doi.org/10.1016/j.mcn.2018.12.001
    77 https://doi.org/10.1016/j.neurobiolaging.2013.03.015
    78 https://doi.org/10.1016/j.neuroimage.2015.03.069
    79 https://doi.org/10.1016/j.neuron.2011.11.033
    80 https://doi.org/10.1016/j.neuron.2016.09.055
    81 https://doi.org/10.1016/j.neuron.2018.02.015
    82 https://doi.org/10.1016/j.neuron.2018.07.039
    83 https://doi.org/10.1016/j.sbi.2009.04.003
    84 https://doi.org/10.1016/j.str.2018.08.012
    85 https://doi.org/10.1016/s0140-6736(86)90495-2
    86 https://doi.org/10.1016/s0197-4580(97)00056-0
    87 https://doi.org/10.1021/acs.analchem.5b04509
    88 https://doi.org/10.1021/acs.jproteome.5b01001
    89 https://doi.org/10.1021/bi0357006
    90 https://doi.org/10.1021/bi5014613
    91 https://doi.org/10.1021/bi981874p
    92 https://doi.org/10.1021/ja303498q
    93 https://doi.org/10.1021/ja305470p
    94 https://doi.org/10.1021/ja504864m
    95 https://doi.org/10.1021/ja7100517
    96 https://doi.org/10.1039/c8cc01355a
    97 https://doi.org/10.1042/bst20120015
    98 https://doi.org/10.1046/j.1471-4159.1998.71062465.x
    99 https://doi.org/10.1046/j.1471-4159.2003.01879.x
    100 https://doi.org/10.1073/pnas.0400348101
    101 https://doi.org/10.1073/pnas.0401911101
    102 https://doi.org/10.1073/pnas.121119298
    103 https://doi.org/10.1073/pnas.1504081112
    104 https://doi.org/10.1073/pnas.1530287100
    105 https://doi.org/10.1073/pnas.1630428100
    106 https://doi.org/10.1073/pnas.1708448114
    107 https://doi.org/10.1073/pnas.1810058115
    108 https://doi.org/10.1073/pnas.72.5.1858
    109 https://doi.org/10.1073/pnas.73.11.4070
    110 https://doi.org/10.1073/pnas.83.13.4913
    111 https://doi.org/10.1073/pnas.85.12.4506
    112 https://doi.org/10.1073/pnas.85.13.4884
    113 https://doi.org/10.1073/pnas.88.13.5842
    114 https://doi.org/10.1073/pnas.91.12.5562
    115 https://doi.org/10.1073/pnas.97.10.5129
    116 https://doi.org/10.1074/jbc.271.51.32789
    117 https://doi.org/10.1074/jbc.m109.058883
    118 https://doi.org/10.1074/jbc.m112.364067
    119 https://doi.org/10.1074/jbc.m112.380642
    120 https://doi.org/10.1074/jbc.m112.415935
    121 https://doi.org/10.1074/jbc.m114.611368
    122 https://doi.org/10.1074/jbc.m114.627919
    123 https://doi.org/10.1074/jbc.m115.641902
    124 https://doi.org/10.1074/jbc.m115.700914
    125 https://doi.org/10.1074/jbc.m116.715557
    126 https://doi.org/10.1074/jbc.m805300200
    127 https://doi.org/10.1074/jbc.ra117.000490
    128 https://doi.org/10.1074/jbc.ra118.001784
    129 https://doi.org/10.1074/jbc.ra118.005316
    130 https://doi.org/10.1080/07391102.2017.1343684
    131 https://doi.org/10.1093/bioinformatics/btt278
    132 https://doi.org/10.1093/brain/awp099
    133 https://doi.org/10.1093/brain/aww027
    134 https://doi.org/10.1093/brain/aww334
    135 https://doi.org/10.1093/brain/awy059
    136 https://doi.org/10.1093/brain/awy065
    137 https://doi.org/10.1093/nar/gky929
    138 https://doi.org/10.1097/nen.0b013e31825018f7
    139 https://doi.org/10.1111/febs.14185
    140 https://doi.org/10.1111/j.1440-1789.2008.00916.x
    141 https://doi.org/10.1111/j.1460-9568.2006.05226.x
    142 https://doi.org/10.1111/j.1460-9568.2007.05555.x
    143 https://doi.org/10.1111/j.1471-4159.2012.07911.x
    144 https://doi.org/10.1111/j.1567-1364.2010.00662.x
    145 https://doi.org/10.1126/sciadv.aau3333
    146 https://doi.org/10.1126/science.1151839
    147 https://doi.org/10.1126/science.3122323
    148 https://doi.org/10.1126/science.aat1780
    149 https://doi.org/10.1128/mcb.9.4.1381
    150 https://doi.org/10.1159/000095257
    151 https://doi.org/10.1212/wnl.0000000000003050
    152 https://doi.org/10.1212/wnl.0000000000003246
    153 https://doi.org/10.1212/wnl.0000000000004860
    154 https://doi.org/10.1371/journal.pbio.1001080
    155 https://doi.org/10.1371/journal.pone.0076523
    156 https://doi.org/10.1371/journal.pone.0201182
    157 https://doi.org/10.1371/journal.pone.0210864
    158 https://doi.org/10.1515/bmc-2018-0001
    159 https://doi.org/10.1515/cclm-2018-0147
    160 https://doi.org/10.15252/embj.201798049
    161 https://doi.org/10.3233/jad-130032
    162 https://doi.org/10.3233/jad-130098
    163 https://doi.org/10.3233/jad-160227
    164 https://doi.org/10.3233/jad-170840
    165 https://doi.org/10.3233/jad-179942
    166 https://doi.org/10.3233/jad-180151
    167 https://doi.org/10.3233/jad-180404
    168 https://doi.org/10.3389/fendo.2018.00595
    169 https://doi.org/10.3389/fnmol.2018.00459
    170 https://doi.org/10.3389/fphar.2014.00227
    171 https://doi.org/10.3390/biom6020021
    172 https://doi.org/10.4061/2011/971021
    173 https://doi.org/10.4137/jen.s12202
    174 https://doi.org/10.7554/elife.36584
    175 https://doi.org/10.7554/elife.43584
    176 schema:datePublished 2019-12
    177 schema:datePublishedReg 2019-12-01
    178 schema:description Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer's and Pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to up-date our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research - diagnosis and therapeutics.
    179 schema:genre research_article
    180 schema:inLanguage en
    181 schema:isAccessibleForFree true
    182 schema:isPartOf N062224d3dc41424094646bb122eb2d44
    183 N3571ea5ec9f34d3f818b01a23b0528d4
    184 sg:journal.1048594
    185 schema:name The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?
    186 schema:pagination 31
    187 schema:productId N4e768357948740d68e7073228c8c6922
    188 N582ceab1922d4de7b7dea39d879c1393
    189 N666a966d393d4c598f5d24472b7dc703
    190 Nc12d4256e94e4e95902066b83e2f2339
    191 Ne9d81c9c989e43ce8cab9fe0ccdcb192
    192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112469408
    193 https://doi.org/10.1186/s40478-019-0682-x
    194 schema:sdDatePublished 2019-04-11T13:19
    195 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    196 schema:sdPublisher N482b0feb958543e2b43d3fde2e6bc907
    197 schema:url https://link.springer.com/10.1186%2Fs40478-019-0682-x
    198 sgo:license sg:explorer/license/
    199 sgo:sdDataset articles
    200 rdf:type schema:ScholarlyArticle
    201 N062224d3dc41424094646bb122eb2d44 schema:issueNumber 1
    202 rdf:type schema:PublicationIssue
    203 N18b24c31890640aeb87561febc77061a schema:name ADx NeuroSciences NV, Technologiepark Zwijnaarde 94, 9052, Ghent, Belgium
    204 rdf:type schema:Organization
    205 N1a60919d01b348d0a1b5aa763ef958fd schema:name Life Molecular Imaging, Berlin, Germany
    206 rdf:type schema:Organization
    207 N2fb7b781938e4fefb31bcfb18f3bf793 schema:affiliation https://www.grid.ac/institutes/grid.411309.e
    208 schema:familyName Al-Hilaly
    209 schema:givenName Youssra K.
    210 rdf:type schema:Person
    211 N3571ea5ec9f34d3f818b01a23b0528d4 schema:volumeNumber 7
    212 rdf:type schema:PublicationVolume
    213 N4008d372621449de93fe962db355a080 rdf:first Nb225d41aafe34a0186b2a1a3abffce91
    214 rdf:rest N444bdddd370d4f51b029b127965dc8b9
    215 N40d4216c5cb14bdc94df1b772644d223 rdf:first Ne148f1dbfa2b45f39ce9d1986cbdb20d
    216 rdf:rest Na42fe5b9dff04779bb8bb0f4d9192c5e
    217 N43e9127c7aba420dad88b02808e7ec48 schema:affiliation N1a60919d01b348d0a1b5aa763ef958fd
    218 schema:familyName Perrotin
    219 schema:givenName Audrey
    220 rdf:type schema:Person
    221 N444bdddd370d4f51b029b127965dc8b9 rdf:first Nd1d824a7161b48298b047228775f4520
    222 rdf:rest N90f0750b7ac34f2b9b6e9f22d5b24fa8
    223 N482b0feb958543e2b43d3fde2e6bc907 schema:name Springer Nature - SN SciGraph project
    224 rdf:type schema:Organization
    225 N4ccd4259e66241aa995de3803706888e rdf:first N43e9127c7aba420dad88b02808e7ec48
    226 rdf:rest N6d5773dde52e4dcaaa56e9e5c9e93148
    227 N4e768357948740d68e7073228c8c6922 schema:name pubmed_id
    228 schema:value 30823892
    229 rdf:type schema:PropertyValue
    230 N582ceab1922d4de7b7dea39d879c1393 schema:name readcube_id
    231 schema:value 572f5edca335fcedc8eda89615f99431023a0cedbeecf02eefa3079ec782d8aa
    232 rdf:type schema:PropertyValue
    233 N666a966d393d4c598f5d24472b7dc703 schema:name dimensions_id
    234 schema:value pub.1112469408
    235 rdf:type schema:PropertyValue
    236 N6a6cf680624d4ee8911a7496a419bde5 rdf:first Ne361304366a8410bb3e0251a564fc54f
    237 rdf:rest Nf9f34b1cc2514393821b1c115e6e9994
    238 N6b263d8f829545298425892ed9002a15 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
    239 schema:familyName Devred
    240 schema:givenName François
    241 rdf:type schema:Person
    242 N6d5773dde52e4dcaaa56e9e5c9e93148 rdf:first N6f5ab1e6aa8d4626ae078df7e29ef75f
    243 rdf:rest Nc56b8c7bab0c4588acd27e71ed26e645
    244 N6f5ab1e6aa8d4626ae078df7e29ef75f schema:affiliation https://www.grid.ac/institutes/grid.12082.39
    245 schema:familyName Serpell
    246 schema:givenName Louise
    247 rdf:type schema:Person
    248 N714236f4d1c74ab4a5b78d1b0ecba877 schema:affiliation https://www.grid.ac/institutes/grid.133342.4
    249 schema:familyName Fichou
    250 schema:givenName Yann
    251 rdf:type schema:Person
    252 N72a88cc1aeb74d93864a0e080cb3e86f rdf:first Nda811b67bd2f43b58428a0e4d883ed22
    253 rdf:rest N6a6cf680624d4ee8911a7496a419bde5
    254 N82a08ff965ef4c4493480f514abe3818 rdf:first N6b263d8f829545298425892ed9002a15
    255 rdf:rest N40d4216c5cb14bdc94df1b772644d223
    256 N875e2cf5a2374c328746e19a67e2037b schema:affiliation https://www.grid.ac/institutes/grid.5399.6
    257 schema:familyName Tsvetkov
    258 schema:givenName Philipp O.
    259 rdf:type schema:Person
    260 N8d65f21cf02b489e9bd871346ca8ea03 rdf:first N714236f4d1c74ab4a5b78d1b0ecba877
    261 rdf:rest Na62527fe3bb946ee815c5df8cff9af03
    262 N90f0750b7ac34f2b9b6e9f22d5b24fa8 rdf:first Nfab1b1b9cd2841d18e2169de23e7305f
    263 rdf:rest rdf:nil
    264 Na42fe5b9dff04779bb8bb0f4d9192c5e rdf:first N875e2cf5a2374c328746e19a67e2037b
    265 rdf:rest N72a88cc1aeb74d93864a0e080cb3e86f
    266 Na62527fe3bb946ee815c5df8cff9af03 rdf:first N2fb7b781938e4fefb31bcfb18f3bf793
    267 rdf:rest N82a08ff965ef4c4493480f514abe3818
    268 Nb225d41aafe34a0186b2a1a3abffce91 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    269 schema:familyName Medina
    270 schema:givenName Miguel
    271 rdf:type schema:Person
    272 Nc12d4256e94e4e95902066b83e2f2339 schema:name doi
    273 schema:value 10.1186/s40478-019-0682-x
    274 rdf:type schema:PropertyValue
    275 Nc56b8c7bab0c4588acd27e71ed26e645 rdf:first Nfd64a4b019eb4133806cb33fa0cf7451
    276 rdf:rest N4008d372621449de93fe962db355a080
    277 Nd0e5e4c254e54610a3575654ca9a1d8f schema:affiliation N18b24c31890640aeb87561febc77061a
    278 schema:familyName Vanmechelen
    279 schema:givenName Eugeen
    280 rdf:type schema:Person
    281 Nd1d824a7161b48298b047228775f4520 schema:affiliation https://www.grid.ac/institutes/grid.4461.7
    282 schema:familyName Buée
    283 schema:givenName Luc
    284 rdf:type schema:Person
    285 Nd9c818d7c93440b1b68b6634c3ef0f9c schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    286 schema:familyName Geukens
    287 schema:givenName Nick
    288 rdf:type schema:Person
    289 Nda811b67bd2f43b58428a0e4d883ed22 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    290 schema:familyName Verelst
    291 schema:givenName Joke
    292 rdf:type schema:Person
    293 Ne148f1dbfa2b45f39ce9d1986cbdb20d schema:affiliation https://www.grid.ac/institutes/grid.4461.7
    294 schema:familyName Smet-Nocca
    295 schema:givenName Caroline
    296 rdf:type schema:Person
    297 Ne361304366a8410bb3e0251a564fc54f schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    298 schema:familyName Winderickx
    299 schema:givenName Joris
    300 rdf:type schema:Person
    301 Ne74c927bd82040b794c4c5f9ff89ab52 rdf:first Nd0e5e4c254e54610a3575654ca9a1d8f
    302 rdf:rest N4ccd4259e66241aa995de3803706888e
    303 Ne9d81c9c989e43ce8cab9fe0ccdcb192 schema:name nlm_unique_id
    304 schema:value 101610673
    305 rdf:type schema:PropertyValue
    306 Nf9f34b1cc2514393821b1c115e6e9994 rdf:first Nd9c818d7c93440b1b68b6634c3ef0f9c
    307 rdf:rest Ne74c927bd82040b794c4c5f9ff89ab52
    308 Nfab1b1b9cd2841d18e2169de23e7305f schema:affiliation https://www.grid.ac/institutes/grid.4461.7
    309 schema:familyName Landrieu
    310 schema:givenName Isabelle
    311 rdf:type schema:Person
    312 Nfd64a4b019eb4133806cb33fa0cf7451 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
    313 schema:familyName Hanseeuw
    314 schema:givenName Bernard J
    315 rdf:type schema:Person
    316 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    317 schema:name Biological Sciences
    318 rdf:type schema:DefinedTerm
    319 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    320 schema:name Biochemistry and Cell Biology
    321 rdf:type schema:DefinedTerm
    322 sg:journal.1048594 schema:issn 2051-5960
    323 schema:name Acta Neuropathologica Communications
    324 rdf:type schema:Periodical
    325 sg:pub.10.1007/978-3-319-60189-2_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091580493
    326 https://doi.org/10.1007/978-3-319-60189-2_15
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1007/bf00294259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016021239
    329 https://doi.org/10.1007/bf00294259
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1007/bf02816111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051138575
    332 https://doi.org/10.1007/bf02816111
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1007/s00335-001-2044-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025669938
    335 https://doi.org/10.1007/s00335-001-2044-8
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1007/s00401-007-0207-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024620200
    338 https://doi.org/10.1007/s00401-007-0207-8
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1007/s00401-015-1503-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008581766
    341 https://doi.org/10.1007/s00401-015-1503-3
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1007/s00401-018-1914-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1107347554
    344 https://doi.org/10.1007/s00401-018-1914-z
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1007/s004010050487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013833108
    347 https://doi.org/10.1007/s004010050487
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1007/s004010050923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005505668
    350 https://doi.org/10.1007/s004010050923
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1007/s12031-011-9566-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001895385
    353 https://doi.org/10.1007/s12031-011-9566-7
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/383550a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042539440
    356 https://doi.org/10.1038/383550a0
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/nature05695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008757821
    359 https://doi.org/10.1038/nature05695
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/nature08890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036907252
    362 https://doi.org/10.1038/nature08890
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/nature15368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013022767
    365 https://doi.org/10.1038/nature15368
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/nature23002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090348371
    368 https://doi.org/10.1038/nature23002
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/nature25456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100715012
    371 https://doi.org/10.1038/nature25456
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/nchem.2889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092795271
    374 https://doi.org/10.1038/nchem.2889
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/ncomms12082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019311148
    377 https://doi.org/10.1038/ncomms12082
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/nm.3700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025095211
    380 https://doi.org/10.1038/nm.3700
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/nm0796-783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023642547
    383 https://doi.org/10.1038/nm0796-783
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/nn.4067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047328174
    386 https://doi.org/10.1038/nn.4067
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/nsmb.3194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016142352
    389 https://doi.org/10.1038/nsmb.3194
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/s41467-017-00480-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091119425
    392 https://doi.org/10.1038/s41467-017-00480-0
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/s41467-017-01575-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092730294
    395 https://doi.org/10.1038/s41467-017-01575-4
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/s41467-018-06880-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107849703
    398 https://doi.org/10.1038/s41467-018-06880-0
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/s41586-018-0454-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1106388788
    401 https://doi.org/10.1038/s41586-018-0454-y
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/s41598-017-07215-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090883002
    404 https://doi.org/10.1038/s41598-017-07215-7
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/s41598-018-24276-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103361101
    407 https://doi.org/10.1038/s41598-018-24276-4
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/s41598-018-32096-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106921303
    410 https://doi.org/10.1038/s41598-018-32096-9
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/srep44739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084132616
    413 https://doi.org/10.1038/srep44739
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1186/1750-1326-9-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049166689
    416 https://doi.org/10.1186/1750-1326-9-43
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1186/s13041-017-0298-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085704994
    419 https://doi.org/10.1186/s13041-017-0298-7
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1186/s13195-016-0227-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032120237
    422 https://doi.org/10.1186/s13195-016-0227-5
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1186/s13195-017-0253-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252361
    425 https://doi.org/10.1186/s13195-017-0253-y
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1186/s40478-017-0489-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093074652
    428 https://doi.org/10.1186/s40478-017-0489-6
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1186/s40478-017-0491-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1093037510
    431 https://doi.org/10.1186/s40478-017-0491-z
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1186/s40478-018-0637-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110272102
    434 https://doi.org/10.1186/s40478-018-0637-7
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1186/s40478-019-0664-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1112168870
    437 https://doi.org/10.1186/s40478-019-0664-z
    438 rdf:type schema:CreativeWork
    439 https://app.dimensions.ai/details/publication/pub.1074713230 schema:CreativeWork
    440 https://app.dimensions.ai/details/publication/pub.1079547073 schema:CreativeWork
    441 https://doi.org/10.1001/jamaneurol.2015.1285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026618324
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1001/jamaneurol.2018.3692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110344100
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1002/ana.24517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050357746
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1002/ana.24546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015127175
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1002/ana.24910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084007938
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1002/ana.25406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110995776
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1002/anie.201105493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023462552
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1002/anie.201501898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812501
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1002/cne.21867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041665887
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1002/j.1460-2075.1991.tb07820.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077836672
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1002/j.1460-2075.1993.tb05665.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082463016
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1002/mds.27271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100074192
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1002/prot.24988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005431861
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/0197-4580(95)00021-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027172018
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/0197-4580(95)00027-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1022928700
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/0896-6273(89)90210-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013144390
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/j.aca.2018.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101080359
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/j.ajpath.2010.10.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053548017
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/j.bbadis.2016.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011459568
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/j.bbrc.2014.01.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027203461
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1016/j.biochi.2011.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043153140
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1016/j.celrep.2014.06.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039980474
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1016/j.expneurol.2015.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032169228
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1016/j.febslet.2004.04.098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018445032
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1016/j.febslet.2005.11.077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035326234
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1016/j.jalz.2017.06.2266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090806044
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1016/j.jalz.2017.06.2556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092327467
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1016/j.jalz.2017.07.426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092312379
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1016/j.jalz.2018.06.2287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107759635
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1016/j.jmb.2017.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091818537
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1016/j.jmb.2018.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106186455
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1016/j.jmb.2018.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110813009
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1016/j.mcn.2018.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110422860
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1016/j.neurobiolaging.2013.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030372162
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1016/j.neuroimage.2015.03.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003517578
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1016/j.neuron.2011.11.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015501052
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1016/j.neuron.2016.09.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042416233
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1016/j.neuron.2018.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101673165
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1016/j.neuron.2018.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106624290
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1016/j.sbi.2009.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023128700
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1016/j.str.2018.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107538759
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1016/s0140-6736(86)90495-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022342684
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1016/s0197-4580(97)00056-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018951481
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1021/acs.analchem.5b04509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055079439
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1021/acs.jproteome.5b01001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017508856
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1021/bi0357006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017863140
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1021/bi5014613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055206719
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1021/bi981874p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055216568
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1021/ja303498q schema:sameAs https://app.dimensions.ai/details/publication/pub.1024957362
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1021/ja305470p schema:sameAs https://app.dimensions.ai/details/publication/pub.1008801729
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1021/ja504864m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055856546
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1021/ja7100517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055857311
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1039/c8cc01355a schema:sameAs https://app.dimensions.ai/details/publication/pub.1103205764
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1042/bst20120015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020373206
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1046/j.1471-4159.1998.71062465.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012342023
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1046/j.1471-4159.2003.01879.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008022820
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1073/pnas.0400348101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001373405
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1073/pnas.0401911101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017961633
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1073/pnas.121119298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036209363
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1073/pnas.1504081112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007367617
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1073/pnas.1530287100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023923464
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1073/pnas.1630428100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028428842
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1073/pnas.1708448114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091089394
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1073/pnas.1810058115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110538248
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1073/pnas.72.5.1858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020607127
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1073/pnas.73.11.4070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036876132
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1073/pnas.83.13.4913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030184264
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1073/pnas.85.12.4506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016689265
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1073/pnas.85.13.4884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029272999
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1073/pnas.88.13.5842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029178020
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1073/pnas.91.12.5562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029496056
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1073/pnas.97.10.5129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010163892
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1074/jbc.271.51.32789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002057838
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1074/jbc.m109.058883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026348813
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1074/jbc.m112.364067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047171870
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1074/jbc.m112.380642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021058311
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1074/jbc.m112.415935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027046299
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1074/jbc.m114.611368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013295585
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1074/jbc.m114.627919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007472055
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1074/jbc.m115.641902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005882612
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1074/jbc.m115.700914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058214297
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1074/jbc.m116.715557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006237188
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1074/jbc.m805300200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008139879
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1074/jbc.ra117.000490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103204959
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1074/jbc.ra118.001784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100714238
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1074/jbc.ra118.005316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107123731
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1080/07391102.2017.1343684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086132537
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1093/bioinformatics/btt278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008694534
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1093/brain/awp099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014418232
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1093/brain/aww027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039511982
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1093/brain/aww334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059445324
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1093/brain/awy059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101192536
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1093/brain/awy065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101270769
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1093/nar/gky929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107415659
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1097/nen.0b013e31825018f7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029938501
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1111/febs.14185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090920704
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1111/j.1440-1789.2008.00916.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025579521
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1111/j.1460-9568.2006.05226.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009810297
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1111/j.1460-9568.2007.05555.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015091088
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1111/j.1471-4159.2012.07911.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024281237
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1111/j.1567-1364.2010.00662.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026310189
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1126/sciadv.aau3333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111632681
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1126/science.1151839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457243
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1126/science.3122323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062592538
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1126/science.aat1780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103933900
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1128/mcb.9.4.1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004623729
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1159/000095257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040609531
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1212/wnl.0000000000003050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064353764
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1212/wnl.0000000000003246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028554691
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1212/wnl.0000000000004860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100087912
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1371/journal.pbio.1001080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015620170
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1371/journal.pone.0076523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042116638
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1371/journal.pone.0201182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105703226
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1371/journal.pone.0210864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111606017
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1515/bmc-2018-0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101410232
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1515/cclm-2018-0147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105179382
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.15252/embj.201798049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101166200
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.3233/jad-130032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078715779
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.3233/jad-130098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078772125
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.3233/jad-160227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071127259
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.3233/jad-170840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101829956
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.3233/jad-179942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104291827
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.3233/jad-180151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104541577
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.3233/jad-180404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105676653
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.3389/fendo.2018.00595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107644435
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.3389/fnmol.2018.00459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110603467
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.3389/fphar.2014.00227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010083744
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.3390/biom6020021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007600030
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.4061/2011/971021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039780709
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.4137/jen.s12202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048178402
    700 rdf:type schema:CreativeWork
    701 https://doi.org/10.7554/elife.36584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105413195
    702 rdf:type schema:CreativeWork
    703 https://doi.org/10.7554/elife.43584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111920482
    704 rdf:type schema:CreativeWork
    705 https://www.grid.ac/institutes/grid.12082.39 schema:alternateName University of Sussex
    706 schema:name Dementia Research group, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, E Sussex, UK
    707 rdf:type schema:Organization
    708 https://www.grid.ac/institutes/grid.133342.4 schema:alternateName University of California, Santa Barbara
    709 schema:name Department of chemistry and biochemistry, University of California Santa Barbara, 93106, Santa Barbara, CA, USA
    710 rdf:type schema:Organization
    711 https://www.grid.ac/institutes/grid.411309.e schema:alternateName Al-Mustansiriya University
    712 schema:name Chemistry Department, Science College, Mustansiriyah University, Baghdad, Iraq
    713 Dementia Research group, School of Life Sciences, University of Sussex, Falmer, BN1 9QG, E Sussex, UK
    714 rdf:type schema:Organization
    715 https://www.grid.ac/institutes/grid.413448.e schema:alternateName Instituto de Salud Carlos III
    716 schema:name CIBERNED (Network Center for Biomedical Research in Neurodegenerative Diseases), Madrid, Spain
    717 CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain
    718 rdf:type schema:Organization
    719 https://www.grid.ac/institutes/grid.4461.7 schema:alternateName Lille 1 University
    720 schema:name University of Lille, CNRS, UMR8576, 59000, Lille, France
    721 University of Lille, Inserm, CHU-Lille, UMRS1172, 59000, Lille, France
    722 rdf:type schema:Organization
    723 https://www.grid.ac/institutes/grid.48769.34 schema:alternateName Cliniques Universitaires Saint-Luc
    724 schema:name Gordon Center for Medical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    725 Neurology Department, Cliniques Universitaires Saint-Luc, 10 Avenue Hippocrate, 1200 Brussels, Belgium
    726 rdf:type schema:Organization
    727 https://www.grid.ac/institutes/grid.5399.6 schema:alternateName Aix-Marseille University
    728 schema:name Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, Fac Pharm, Marseille, France
    729 rdf:type schema:Organization
    730 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
    731 schema:name Functional Biology, KU Leuven, Kasteelpark Arenberg 31, Box 2433, 3001, Heverlee, Belgium
    732 Pharmabs, KU Leuven, Herestraat 49, box 820, B 3000, Leuven, Belgium
    733 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...