Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Benoît Souchet, Mickael Audrain, Jean Marie Billard, Julien Dairou, Romain Fol, Nicola Salvatore Orefice, Satoru Tada, Yuchen Gu, Gaelle Dufayet-Chaffaud, Emmanuelle Limanton, François Carreaux, Jean-Pierre Bazureau, Sandro Alves, Laurent Meijer, Nathalie Janel, Jérôme Braudeau, Nathalie Cartier

ABSTRACT

Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer's disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus without consequences on its kinase activity. Resulting truncated forms accumulate in astrocytes and exhibit increased affinity towards STAT3ɑ, a regulator of inflammatory process. These findings were confirmed in APP/PS1 mice, an amyloid model of AD, suggesting that this DYRK1A cleavage is a consequence of the amyloid pathology. We identified in vitro the Leucettine L41 as a compound able to prevent DYRK1A proteolysis in both human and mouse protein extracts. We then showed that intraperitoneal injections of L41 in aged APP/PS1 mice inhibit STAT3ɑ phosphorylation and reduce pro-inflammatory cytokines levels (IL1- β, TNF-ɑ and IL-12) associated to an increased microglial recruitment around amyloid plaques and decreased amyloid-β plaque burden. Importantly, L41 treatment improved synaptic plasticity and rescued memory functions in APP/PS1 mice. Collectively, our results suggest that DYRK1A may contribute to AD pathology through its proteolytic process, reducing its kinase specificity. Further evaluation of inhibitors of DYRK1A truncation promises a new therapeutic approach for AD. More... »

PAGES

46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40478-019-0678-6

DOI

http://dx.doi.org/10.1186/s40478-019-0678-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112857010

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30885273


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Paris-Saclay", 
          "id": "https://www.grid.ac/institutes/grid.460789.4", 
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France", 
            "Universit\u00e9 Paris Saclay, Saclay, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Souchet", 
        "givenName": "Beno\u00eet", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Audrain", 
        "givenName": "Mickael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "INSERM UMR894, Centre de Psychiatrie et Neurosciences, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Billard", 
        "givenName": "Jean Marie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques", 
          "id": "https://www.grid.ac/institutes/grid.463887.6", 
          "name": [
            "UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universit\u00e9 Paris Descartes-Sorbonne Paris Cit\u00e9, 75270, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dairou", 
        "givenName": "Julien", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fol", 
        "givenName": "Romain", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orefice", 
        "givenName": "Nicola Salvatore", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tada", 
        "givenName": "Satoru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "INSERM UMR894, Centre de Psychiatrie et Neurosciences, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gu", 
        "givenName": "Yuchen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dufayet-Chaffaud", 
        "givenName": "Gaelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Sciences Chimiques de Rennes", 
          "id": "https://www.grid.ac/institutes/grid.461889.a", 
          "name": [
            "Laboratoire Sciences Chimique de Rennes, UMR CNRS 6226, Groupe ICMV, Universit\u00e9 de Rennes 1, 35042, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Limanton", 
        "givenName": "Emmanuelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Sciences Chimiques de Rennes", 
          "id": "https://www.grid.ac/institutes/grid.461889.a", 
          "name": [
            "Laboratoire Sciences Chimique de Rennes, UMR CNRS 6226, Groupe ICMV, Universit\u00e9 de Rennes 1, 35042, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carreaux", 
        "givenName": "Fran\u00e7ois", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Sciences Chimiques de Rennes", 
          "id": "https://www.grid.ac/institutes/grid.461889.a", 
          "name": [
            "Laboratoire Sciences Chimique de Rennes, UMR CNRS 6226, Groupe ICMV, Universit\u00e9 de Rennes 1, 35042, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bazureau", 
        "givenName": "Jean-Pierre", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alves", 
        "givenName": "Sandro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ManRos Therapeutics (France)", 
          "id": "https://www.grid.ac/institutes/grid.429403.8", 
          "name": [
            "ManRos Therapeutics, H\u00f4tel de Recherche, Centre de Perharidy, 29680, Roscoff, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meijer", 
        "givenName": "Laurent", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Sorbonne Paris Cit\u00e9, Adaptive Functional Biology, Universit\u00e9 Paris-Diderot, UMR CNRS, 8251, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janel", 
        "givenName": "Nathalie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CEA Fontenay-Aux-Roses", 
          "id": "https://www.grid.ac/institutes/grid.457349.8", 
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France", 
            "CEA, DRF Institut Fran\u00e7ois Jacob, MIRCen, 92265, Fontenay-aux-Roses, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braudeau", 
        "givenName": "J\u00e9r\u00f4me", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University", 
          "id": "https://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "INSERM UMR1169, 92265, Fontenay-aux-Roses, France", 
            "Universit\u00e9 Paris Saclay, Saclay, France", 
            "Institute for Brain and Spine (ICM) H\u00f4pital Piti\u00e9 \u2013Salp\u00eatri\u00e8re, Universit\u00e9 Paris Sorbonne, 47 boulevard de l\u2019H\u00f4pital 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cartier", 
        "givenName": "Nathalie", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1523/jneurosci.0616-08.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003145749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2008.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004348941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2007.05075.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004814148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m707358200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004955097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2006.01.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006192059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.11-181297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006942840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35012636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007843170", 
          "https://doi.org/10.1038/35012636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35012636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007843170", 
          "https://doi.org/10.1038/35012636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(96)10031-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012388451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858413504466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013090464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858413504466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013090464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ab.2013.12.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013135358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013900805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(15)70016-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015473099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016351608", 
          "https://doi.org/10.1038/nature04678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016351608", 
          "https://doi.org/10.1038/nature04678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016351608", 
          "https://doi.org/10.1038/nature04678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci34254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017136487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181b6bb95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017671254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181b6bb95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017671254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.17.9354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018075333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019447518", 
          "https://doi.org/10.1038/nrm2203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2013.03.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019616040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2008.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019685908", 
          "https://doi.org/10.1038/mp.2008.105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0519-10.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019899960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-015-1498-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020214627", 
          "https://doi.org/10.1007/s00401-015-1498-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1211851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020273582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1211851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020273582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3550609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021636971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3550609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021636971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022933218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature21029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024342012", 
          "https://doi.org/10.1038/nature21029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000356529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026601032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m307556200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031423851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.7.3488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032089356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.74.9.1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033700714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2009.07346.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033972959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10799899909036638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036070511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.07-104539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038320592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/lm.850808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040730636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2005.03.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040961404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2010.06769.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041543791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2010.06769.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041543791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/embr.201540374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044163336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2013.12.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051681631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m115.645507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052464844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052597019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cn300094k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053939512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200274d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200274d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm301034u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/15665240113139990076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069185070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1567205012666151020114607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069188329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000472398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082629675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-017-1737-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085991635", 
          "https://doi.org/10.1007/s00401-017-1737-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-017-1737-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085991635", 
          "https://doi.org/10.1007/s00401-017-1737-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13543776.2017.1360285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090950228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/acel.12648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091051201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2018.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101375460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2018.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101375460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2018.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101375460"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer's disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus without consequences on its kinase activity. Resulting truncated forms accumulate in astrocytes and exhibit increased affinity towards STAT3\u0251, a regulator of inflammatory process. These findings were confirmed in APP/PS1 mice, an amyloid model of AD, suggesting that this DYRK1A cleavage is a consequence of the amyloid pathology. We identified in vitro the Leucettine L41 as a compound able to prevent DYRK1A proteolysis in both human and mouse protein extracts. We then showed that intraperitoneal injections of L41 in aged APP/PS1 mice inhibit STAT3\u0251 phosphorylation and reduce pro-inflammatory cytokines levels (IL1- \u03b2, TNF-\u0251 and IL-12) associated to an increased microglial recruitment around amyloid plaques and decreased amyloid-\u03b2 plaque burden. Importantly, L41 treatment improved synaptic plasticity and rescued memory functions in APP/PS1 mice. Collectively, our results suggest that DYRK1A may contribute to AD pathology through its proteolytic process, reducing its kinase specificity. Further evaluation of inhibitors of DYRK1A truncation promises a new therapeutic approach for AD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40478-019-0678-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1048594", 
        "issn": [
          "2051-5960"
        ], 
        "name": "Acta Neuropathologica Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice", 
    "pagination": "46", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c64d34af65a4b88e9e04da4ae560ba428d20c3b82d3e2420a78ed43d415b3c89"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30885273"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101610673"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40478-019-0678-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112857010"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40478-019-0678-6", 
      "https://app.dimensions.ai/details/publication/pub.1112857010"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78938_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40478-019-0678-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0678-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0678-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0678-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40478-019-0678-6'


 

This table displays all metadata directly associated to this object as RDF triples.

354 TRIPLES      21 PREDICATES      78 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40478-019-0678-6 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nfbf0e0a672ac4c6a800e978e2770813e
4 schema:citation sg:pub.10.1007/s00401-015-1498-9
5 sg:pub.10.1007/s00401-017-1737-3
6 sg:pub.10.1038/35012636
7 sg:pub.10.1038/mp.2008.105
8 sg:pub.10.1038/nature04678
9 sg:pub.10.1038/nature21029
10 sg:pub.10.1038/nrm2203
11 https://doi.org/10.1016/j.ab.2013.12.024
12 https://doi.org/10.1016/j.ajpath.2012.04.020
13 https://doi.org/10.1016/j.nbd.2005.03.020
14 https://doi.org/10.1016/j.neurobiolaging.2013.03.034
15 https://doi.org/10.1016/j.neuron.2006.01.022
16 https://doi.org/10.1016/j.neuron.2013.12.034
17 https://doi.org/10.1016/j.neuron.2018.01.031
18 https://doi.org/10.1016/j.tips.2008.06.005
19 https://doi.org/10.1016/s0968-0004(96)10031-1
20 https://doi.org/10.1016/s1474-4422(15)70016-5
21 https://doi.org/10.1021/cn300094k
22 https://doi.org/10.1021/jm200274d
23 https://doi.org/10.1021/jm301034u
24 https://doi.org/10.1042/bj3550609
25 https://doi.org/10.1056/nejmoa1211851
26 https://doi.org/10.1073/pnas.94.17.9354
27 https://doi.org/10.1074/jbc.271.7.3488
28 https://doi.org/10.1074/jbc.m115.645507
29 https://doi.org/10.1074/jbc.m307556200
30 https://doi.org/10.1074/jbc.m707358200
31 https://doi.org/10.1080/13543776.2017.1360285
32 https://doi.org/10.1093/hmg/ddh019
33 https://doi.org/10.1096/fj.07-104539
34 https://doi.org/10.1096/fj.11-181297
35 https://doi.org/10.1101/lm.850808
36 https://doi.org/10.1111/acel.12648
37 https://doi.org/10.1111/j.1471-4159.2007.05075.x
38 https://doi.org/10.1111/j.1471-4159.2010.06769.x
39 https://doi.org/10.1111/j.1742-4658.2009.07346.x
40 https://doi.org/10.1126/science.1072994
41 https://doi.org/10.1136/jnnp.74.9.1200
42 https://doi.org/10.1159/000356529
43 https://doi.org/10.1159/000472398
44 https://doi.org/10.1172/jci34254
45 https://doi.org/10.1177/1073858413504466
46 https://doi.org/10.1212/wnl.0b013e3181b6bb95
47 https://doi.org/10.1523/jneurosci.0519-10.2010
48 https://doi.org/10.1523/jneurosci.0616-08.2008
49 https://doi.org/10.15252/embr.201540374
50 https://doi.org/10.2174/15665240113139990076
51 https://doi.org/10.2174/1567205012666151020114607
52 https://doi.org/10.3109/10799899909036638
53 schema:datePublished 2019-12
54 schema:datePublishedReg 2019-12-01
55 schema:description Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer's disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus without consequences on its kinase activity. Resulting truncated forms accumulate in astrocytes and exhibit increased affinity towards STAT3ɑ, a regulator of inflammatory process. These findings were confirmed in APP/PS1 mice, an amyloid model of AD, suggesting that this DYRK1A cleavage is a consequence of the amyloid pathology. We identified in vitro the Leucettine L41 as a compound able to prevent DYRK1A proteolysis in both human and mouse protein extracts. We then showed that intraperitoneal injections of L41 in aged APP/PS1 mice inhibit STAT3ɑ phosphorylation and reduce pro-inflammatory cytokines levels (IL1- β, TNF-ɑ and IL-12) associated to an increased microglial recruitment around amyloid plaques and decreased amyloid-β plaque burden. Importantly, L41 treatment improved synaptic plasticity and rescued memory functions in APP/PS1 mice. Collectively, our results suggest that DYRK1A may contribute to AD pathology through its proteolytic process, reducing its kinase specificity. Further evaluation of inhibitors of DYRK1A truncation promises a new therapeutic approach for AD.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf Naf9b76c6363a4496a2f83748a2c4ed13
60 Nbaf1bf6271214fa9a188798a7ed774ef
61 sg:journal.1048594
62 schema:name Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice
63 schema:pagination 46
64 schema:productId N4198cd8def21472b84d0d5440fd35847
65 N463bec11a7cd49739f1c7a87b9bf5da4
66 N5e3b1aaecb344a7ab741376e8a500573
67 Nc15f2a992ffa41e596a0a5029493f20e
68 Nddafebddea984937a841b9384e328988
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112857010
70 https://doi.org/10.1186/s40478-019-0678-6
71 schema:sdDatePublished 2019-04-11T13:18
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N7d3e96792cf1447c80fac9fc79c29b67
74 schema:url https://link.springer.com/10.1186%2Fs40478-019-0678-6
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N006ac84818d84a7a9cb8412992d3791f schema:affiliation https://www.grid.ac/institutes/grid.457349.8
79 schema:familyName Braudeau
80 schema:givenName Jérôme
81 rdf:type schema:Person
82 N0485be79dd5343bcafe7c66b556f32d8 rdf:first N8f526660752f4de0aa5beaa0c35fe55c
83 rdf:rest N32e6816747124231a3503ed40c2a31bb
84 N0e72db9ab261426ea7265bd467e1ba19 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
85 schema:familyName Billard
86 schema:givenName Jean Marie
87 rdf:type schema:Person
88 N11736e56ce7a4c51bd5a78b877c353c8 rdf:first N006ac84818d84a7a9cb8412992d3791f
89 rdf:rest Nc926484a2f054ba1b2cb0c82cef40ffd
90 N13c11bd808314d58bfc31045538522f3 rdf:first N0e72db9ab261426ea7265bd467e1ba19
91 rdf:rest N55eb4dc6461b49e89cd75408d023b711
92 N2216c002a2c54b37831bcb41f5e5ea79 rdf:first Nbc5fe739dfdc496d813702526b4fc58a
93 rdf:rest N80fa0667e2e64227ba6438dbbef475d4
94 N24eee0c74d5c474a8b83a6b2daeaebca schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
95 rdf:type schema:Organization
96 N3274a729776c4fc2a70eb5d14b013792 schema:affiliation N40152a1d004842a4bf7f8a2331e0e254
97 schema:familyName Audrain
98 schema:givenName Mickael
99 rdf:type schema:Person
100 N32e6816747124231a3503ed40c2a31bb rdf:first N4475bf22601c4bc58d4cb11d69f8794d
101 rdf:rest N795f91089006495990c9801adb670c91
102 N369febbcb28242d4b6175c5bc6bf4983 rdf:first Nbd7d3193e6f942208e2c37b542b5b34a
103 rdf:rest N8e5ed674898c4aa4bcb83622ea239907
104 N3b84c5f6516a4ee584d5fa024c444609 schema:affiliation N88f2e732ca4d4363889fac88deb43d25
105 schema:familyName Dufayet-Chaffaud
106 schema:givenName Gaelle
107 rdf:type schema:Person
108 N40152a1d004842a4bf7f8a2331e0e254 schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
109 rdf:type schema:Organization
110 N4198cd8def21472b84d0d5440fd35847 schema:name pubmed_id
111 schema:value 30885273
112 rdf:type schema:PropertyValue
113 N4475bf22601c4bc58d4cb11d69f8794d schema:affiliation N62fdef8b5f904bcca71d49e3b7054759
114 schema:familyName Tada
115 schema:givenName Satoru
116 rdf:type schema:Person
117 N463bec11a7cd49739f1c7a87b9bf5da4 schema:name doi
118 schema:value 10.1186/s40478-019-0678-6
119 rdf:type schema:PropertyValue
120 N49bb795c355549a3b609290bcef0314a schema:affiliation https://www.grid.ac/institutes/grid.463887.6
121 schema:familyName Dairou
122 schema:givenName Julien
123 rdf:type schema:Person
124 N55eb4dc6461b49e89cd75408d023b711 rdf:first N49bb795c355549a3b609290bcef0314a
125 rdf:rest Nd28a81c3f94e44bab5a126fec050e585
126 N5e3b1aaecb344a7ab741376e8a500573 schema:name dimensions_id
127 schema:value pub.1112857010
128 rdf:type schema:PropertyValue
129 N61457e1c74de4f8c89082e89894c7bba schema:affiliation https://www.grid.ac/institutes/grid.7452.4
130 schema:familyName Janel
131 schema:givenName Nathalie
132 rdf:type schema:Person
133 N62fdef8b5f904bcca71d49e3b7054759 schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
134 rdf:type schema:Organization
135 N6acaaced51164b889256b984afd61422 schema:affiliation N24eee0c74d5c474a8b83a6b2daeaebca
136 schema:familyName Fol
137 schema:givenName Romain
138 rdf:type schema:Person
139 N75e4c565171e4c769fb58e75f772ee30 schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
140 rdf:type schema:Organization
141 N795f91089006495990c9801adb670c91 rdf:first Nf0d630b5579743d796ccf4538335a1a8
142 rdf:rest Nc8527fb80f0b44ffb125560bd65d27f5
143 N7d3e96792cf1447c80fac9fc79c29b67 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 N80fa0667e2e64227ba6438dbbef475d4 rdf:first N61457e1c74de4f8c89082e89894c7bba
146 rdf:rest N11736e56ce7a4c51bd5a78b877c353c8
147 N82178df85bfb42b18c608053c95d8ac6 schema:affiliation https://www.grid.ac/institutes/grid.461889.a
148 schema:familyName Carreaux
149 schema:givenName François
150 rdf:type schema:Person
151 N85b17fb640a6471eb8f19d38faf36960 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
152 schema:familyName Cartier
153 schema:givenName Nathalie
154 rdf:type schema:Person
155 N88f2e732ca4d4363889fac88deb43d25 schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
156 rdf:type schema:Organization
157 N8e5ed674898c4aa4bcb83622ea239907 rdf:first Naa617122738649e2b0ad8db65312d461
158 rdf:rest N2216c002a2c54b37831bcb41f5e5ea79
159 N8eb93b7f87814213a3e615913e907048 schema:affiliation https://www.grid.ac/institutes/grid.460789.4
160 schema:familyName Souchet
161 schema:givenName Benoît
162 rdf:type schema:Person
163 N8f526660752f4de0aa5beaa0c35fe55c schema:affiliation N75e4c565171e4c769fb58e75f772ee30
164 schema:familyName Orefice
165 schema:givenName Nicola Salvatore
166 rdf:type schema:Person
167 N99fb6b1866a049d994b9053b62c4461b rdf:first N82178df85bfb42b18c608053c95d8ac6
168 rdf:rest N369febbcb28242d4b6175c5bc6bf4983
169 Naa617122738649e2b0ad8db65312d461 schema:affiliation Ned96ae70f39241e1a49d20cfb894e4b6
170 schema:familyName Alves
171 schema:givenName Sandro
172 rdf:type schema:Person
173 Naf9b76c6363a4496a2f83748a2c4ed13 schema:issueNumber 1
174 rdf:type schema:PublicationIssue
175 Nbaf1bf6271214fa9a188798a7ed774ef schema:volumeNumber 7
176 rdf:type schema:PublicationVolume
177 Nbc5fe739dfdc496d813702526b4fc58a schema:affiliation https://www.grid.ac/institutes/grid.429403.8
178 schema:familyName Meijer
179 schema:givenName Laurent
180 rdf:type schema:Person
181 Nbd7d3193e6f942208e2c37b542b5b34a schema:affiliation https://www.grid.ac/institutes/grid.461889.a
182 schema:familyName Bazureau
183 schema:givenName Jean-Pierre
184 rdf:type schema:Person
185 Nc15f2a992ffa41e596a0a5029493f20e schema:name readcube_id
186 schema:value c64d34af65a4b88e9e04da4ae560ba428d20c3b82d3e2420a78ed43d415b3c89
187 rdf:type schema:PropertyValue
188 Nc671aaad63d94858a32d272fc19118e6 rdf:first N3274a729776c4fc2a70eb5d14b013792
189 rdf:rest N13c11bd808314d58bfc31045538522f3
190 Nc8527fb80f0b44ffb125560bd65d27f5 rdf:first N3b84c5f6516a4ee584d5fa024c444609
191 rdf:rest Nd63697009dad40dc8296ceb752b9e32f
192 Nc926484a2f054ba1b2cb0c82cef40ffd rdf:first N85b17fb640a6471eb8f19d38faf36960
193 rdf:rest rdf:nil
194 Nd28a81c3f94e44bab5a126fec050e585 rdf:first N6acaaced51164b889256b984afd61422
195 rdf:rest N0485be79dd5343bcafe7c66b556f32d8
196 Nd63697009dad40dc8296ceb752b9e32f rdf:first Nf64668a47f9b4f8bb856846f314f10d1
197 rdf:rest N99fb6b1866a049d994b9053b62c4461b
198 Nddafebddea984937a841b9384e328988 schema:name nlm_unique_id
199 schema:value 101610673
200 rdf:type schema:PropertyValue
201 Ned96ae70f39241e1a49d20cfb894e4b6 schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
202 rdf:type schema:Organization
203 Nf0d630b5579743d796ccf4538335a1a8 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
204 schema:familyName Gu
205 schema:givenName Yuchen
206 rdf:type schema:Person
207 Nf64668a47f9b4f8bb856846f314f10d1 schema:affiliation https://www.grid.ac/institutes/grid.461889.a
208 schema:familyName Limanton
209 schema:givenName Emmanuelle
210 rdf:type schema:Person
211 Nfbf0e0a672ac4c6a800e978e2770813e rdf:first N8eb93b7f87814213a3e615913e907048
212 rdf:rest Nc671aaad63d94858a32d272fc19118e6
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
217 schema:name Neurosciences
218 rdf:type schema:DefinedTerm
219 sg:journal.1048594 schema:issn 2051-5960
220 schema:name Acta Neuropathologica Communications
221 rdf:type schema:Periodical
222 sg:pub.10.1007/s00401-015-1498-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020214627
223 https://doi.org/10.1007/s00401-015-1498-9
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s00401-017-1737-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085991635
226 https://doi.org/10.1007/s00401-017-1737-3
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/35012636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007843170
229 https://doi.org/10.1038/35012636
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/mp.2008.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019685908
232 https://doi.org/10.1038/mp.2008.105
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nature04678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016351608
235 https://doi.org/10.1038/nature04678
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nature21029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024342012
238 https://doi.org/10.1038/nature21029
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nrm2203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019447518
241 https://doi.org/10.1038/nrm2203
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.ab.2013.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013135358
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.ajpath.2012.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013900805
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.nbd.2005.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040961404
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.neurobiolaging.2013.03.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019616040
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.neuron.2006.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006192059
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.neuron.2013.12.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051681631
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.neuron.2018.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101375460
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.tips.2008.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004348941
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0968-0004(96)10031-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012388451
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s1474-4422(15)70016-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015473099
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1021/cn300094k schema:sameAs https://app.dimensions.ai/details/publication/pub.1053939512
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1021/jm200274d schema:sameAs https://app.dimensions.ai/details/publication/pub.1055952253
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1021/jm301034u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953268
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1042/bj3550609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021636971
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1056/nejmoa1211851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020273582
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1073/pnas.94.17.9354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018075333
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1074/jbc.271.7.3488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032089356
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1074/jbc.m115.645507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052464844
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1074/jbc.m307556200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031423851
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1074/jbc.m707358200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004955097
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1080/13543776.2017.1360285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090950228
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1093/hmg/ddh019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022933218
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1096/fj.07-104539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038320592
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1096/fj.11-181297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006942840
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1101/lm.850808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040730636
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1111/acel.12648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091051201
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1111/j.1471-4159.2007.05075.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004814148
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1471-4159.2010.06769.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041543791
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1111/j.1742-4658.2009.07346.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033972959
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.1072994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052597019
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1136/jnnp.74.9.1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033700714
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1159/000356529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026601032
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1159/000472398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082629675
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1172/jci34254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017136487
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1177/1073858413504466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013090464
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1212/wnl.0b013e3181b6bb95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017671254
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1523/jneurosci.0519-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019899960
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1523/jneurosci.0616-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003145749
318 rdf:type schema:CreativeWork
319 https://doi.org/10.15252/embr.201540374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044163336
320 rdf:type schema:CreativeWork
321 https://doi.org/10.2174/15665240113139990076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069185070
322 rdf:type schema:CreativeWork
323 https://doi.org/10.2174/1567205012666151020114607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069188329
324 rdf:type schema:CreativeWork
325 https://doi.org/10.3109/10799899909036638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036070511
326 rdf:type schema:CreativeWork
327 https://www.grid.ac/institutes/grid.10992.33 schema:alternateName Paris Descartes University
328 schema:name INSERM UMR894, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.429403.8 schema:alternateName ManRos Therapeutics (France)
331 schema:name ManRos Therapeutics, Hôtel de Recherche, Centre de Perharidy, 29680, Roscoff, France
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.457349.8 schema:alternateName CEA Fontenay-Aux-Roses
334 schema:name CEA, DRF Institut François Jacob, MIRCen, 92265, Fontenay-aux-Roses, France
335 INSERM UMR1169, 92265, Fontenay-aux-Roses, France
336 rdf:type schema:Organization
337 https://www.grid.ac/institutes/grid.460789.4 schema:alternateName University of Paris-Saclay
338 schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
339 Université Paris Saclay, Saclay, France
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.461889.a schema:alternateName Institut des Sciences Chimiques de Rennes
342 schema:name Laboratoire Sciences Chimique de Rennes, UMR CNRS 6226, Groupe ICMV, Université de Rennes 1, 35042, Rennes, France
343 rdf:type schema:Organization
344 https://www.grid.ac/institutes/grid.462844.8 schema:alternateName Sorbonne University
345 schema:name INSERM UMR1169, 92265, Fontenay-aux-Roses, France
346 Institute for Brain and Spine (ICM) Hôpital Pitié –Salpêtrière, Université Paris Sorbonne, 47 boulevard de l’Hôpital 75013, Paris, France
347 Université Paris Saclay, Saclay, France
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.463887.6 schema:alternateName Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
350 schema:name UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes-Sorbonne Paris Cité, 75270, Paris, France
351 rdf:type schema:Organization
352 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
353 schema:name Sorbonne Paris Cité, Adaptive Functional Biology, Université Paris-Diderot, UMR CNRS, 8251, Paris, France
354 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...