Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Kohei Fukuoka, Yonehiro Kanemura, Tomoko Shofuda, Shintaro Fukushima, Satoshi Yamashita, Daichi Narushima, Mamoru Kato, Mai Honda-Kitahara, Hitoshi Ichikawa, Takashi Kohno, Atsushi Sasaki, Junko Hirato, Takanori Hirose, Takashi Komori, Kaishi Satomi, Akihiko Yoshida, Kai Yamasaki, Yoshiko Nakano, Ai Takada, Taishi Nakamura, Hirokazu Takami, Yuko Matsushita, Tomonari Suzuki, Hideo Nakamura, Keishi Makino, Yukihiko Sonoda, Ryuta Saito, Teiji Tominaga, Yasuhiro Matsusaka, Keiichi Kobayashi, Motoo Nagane, Takuya Furuta, Mitsutoshi Nakada, Yoshitaka Narita, Yuichi Hirose, Shigeo Ohba, Akira Wada, Katsuyoshi Shimizu, Kazuhiko Kurozumi, Isao Date, Junya Fukai, Yousuke Miyairi, Naoki Kagawa, Atsufumi Kawamura, Makiko Yoshida, Namiko Nishida, Takafumi Wataya, Masayoshi Yamaoka, Naohiro Tsuyuguchi, Takehiro Uda, Mayu Takahashi, Yoshiteru Nakano, Takuya Akai, Shuichi Izumoto, Masahiro Nonaka, Kazuhisa Yoshifuji, Yoshinori Kodama, Masayuki Mano, Tatsuya Ozawa, Vijay Ramaswamy, Michael D. Taylor, Toshikazu Ushijima, Soichiro Shibui, Mami Yamasaki, Hajime Arai, Hiroaki Sakamoto, Ryo Nishikawa, Koichi Ichimura, on behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG)

ABSTRACT

Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the existence of molecular subgroups. However, the pathogenesis of RELA fusion-negative ependymomas remains elusive. To investigate the molecular pathogenesis of these tumors and validate the molecular classification of ependymal tumors, we conducted thorough molecular analyses of 113 locally diagnosed ependymal tumors from 107 patients in the Japan Pediatric Molecular Neuro-Oncology Group. All tumors were histopathologically reviewed and 12 tumors were re-classified as non-ependymomas. A combination of RT-PCR, FISH, and RNA sequencing identified RELA fusion in 19 of 29 histologically verified ST-EPN cases, whereas another case was diagnosed as ependymoma RELA fusion-positive via the methylation classifier (68.9%). Among the 9 RELA fusion-negative ST-EPN cases, either the YAP1 fusion, BCOR tandem duplication, EP300-BCORL1 fusion, or FOXO1-STK24 fusion was detected in single cases. Methylation classification did not identify a consistent molecular class within this group. Genome-wide methylation profiling successfully sub-classified posterior fossa ependymoma (PF-EPN) into PF-EPN-A (PFA) and PF-EPN-B (PFB). A multivariate analysis using Cox regression confirmed that PFA was the sole molecular marker which was independently associated with patient survival. A clinically applicable pyrosequencing assay was developed to determine the PFB subgroup with 100% specificity using the methylation status of 3 genes, CRIP1, DRD4 and LBX2. Our results emphasized the significance of molecular classification in the diagnosis of ependymomas. RELA fusion-negative ST-EPN appear to be a heterogeneous group of tumors that do not fall into any of the existing molecular subgroups and are unlikely to form a single category. More... »

PAGES

134

References to SciGraph publications

  • 2013-06. Outcome of infants and young children with newly diagnosed ependymoma treated on the “Head Start” III prospective clinical trial in JOURNAL OF NEURO-ONCOLOGY
  • 2013-08. Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma in ACTA NEUROPATHOLOGICA
  • 2016-04. Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer in GASTRIC CANCER
  • 2015-01. Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas in BRAIN TUMOR PATHOLOGY
  • 2013-12. TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas in ACTA NEUROPATHOLOGICA
  • 2018-08. Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas in ACTA NEUROPATHOLOGICA
  • 2012-03. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype in NATURE
  • 2014-02. C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma in NATURE
  • 2014-02. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy in NATURE
  • 2018-08. Heterogeneity within the PF-EPN-B ependymoma subgroup in ACTA NEUROPATHOLOGICA
  • 2015-08. Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney in NATURE GENETICS
  • 2018-03. DNA methylation-based classification of central nervous system tumours in NATURE
  • 2011-12. Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts in JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE
  • 2013-08. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss in ACTA NEUROPATHOLOGICA
  • 2008-02. The prognostic value of histological grading of posterior fossa ependymomas in children: a Children's Oncology Group study and a review of prognostic factors in MODERN PATHOLOGY
  • 2017-11. Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome in ACTA NEUROPATHOLOGICA
  • 2011-08. TopHat-Fusion: an algorithm for discovery of novel fusion transcripts in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40478-018-0630-1

    DOI

    http://dx.doi.org/10.1186/s40478-018-0630-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110371159

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30514397


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Saitama International Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412377.4", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
                "Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuoka", 
            "givenName": "Kohei", 
            "id": "sg:person.0646016572.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646016572.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka National Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416803.8", 
              "name": [
                "Department of Biomedical Research and Innovation, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization|, Osaka, Japan", 
                "Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanemura", 
            "givenName": "Yonehiro", 
            "id": "sg:person.0665013040.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665013040.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka National Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416803.8", 
              "name": [
                "Department of Biomedical Research and Innovation, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization|, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shofuda", 
            "givenName": "Tomoko", 
            "id": "sg:person.01037534556.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037534556.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukushima", 
            "givenName": "Shintaro", 
            "id": "sg:person.0645222335.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645222335.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamashita", 
            "givenName": "Satoshi", 
            "id": "sg:person.01055356417.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055356417.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Bioinformatics, National Cancer Center Research Institute, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Narushima", 
            "givenName": "Daichi", 
            "id": "sg:person.01215604277.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215604277.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Bioinformatics, National Cancer Center Research Institute, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kato", 
            "givenName": "Mamoru", 
            "id": "sg:person.01066626041.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066626041.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Honda-Kitahara", 
            "givenName": "Mai", 
            "id": "sg:person.0655527716.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655527716.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ichikawa", 
            "givenName": "Hitoshi", 
            "id": "sg:person.0631000545.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631000545.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kohno", 
            "givenName": "Takashi", 
            "id": "sg:person.0641101305.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641101305.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Saitama Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410802.f", 
              "name": [
                "Department of Pathology, Saitama Medical University, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sasaki", 
            "givenName": "Atsushi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411887.3", 
              "name": [
                "Department of Pathology, Gunma University Hospital, Maebashi, Gunma, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirato", 
            "givenName": "Junko", 
            "id": "sg:person.01063706261.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063706261.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hyogo Prefectural Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.417755.5", 
              "name": [
                "Department of Diagnostic Pathology, Hyogo Cancer Center, Kobe, Hyogo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirose", 
            "givenName": "Takanori", 
            "id": "sg:person.01145435163.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145435163.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Metropolitan Neurological Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417106.5", 
              "name": [
                "Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Komori", 
            "givenName": "Takashi", 
            "id": "sg:person.0666452416.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666452416.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
                "Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Satomi", 
            "givenName": "Kaishi", 
            "id": "sg:person.01106276524.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106276524.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshida", 
            "givenName": "Akihiko", 
            "id": "sg:person.01160707072.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160707072.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka City General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416948.6", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
                "Department of Pediatric Hematology and Oncology, Osaka City General Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamasaki", 
            "givenName": "Kai", 
            "id": "sg:person.01040300545.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040300545.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka City General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416948.6", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
                "Department of Pediatric Hematology and Oncology, Osaka City General Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakano", 
            "givenName": "Yoshiko", 
            "id": "sg:person.01320051473.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320051473.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka National Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416803.8", 
              "name": [
                "Department of Biomedical Research and Innovation, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization|, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takada", 
            "givenName": "Ai", 
            "id": "sg:person.015353257773.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015353257773.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yokohama City University", 
              "id": "https://www.grid.ac/institutes/grid.268441.d", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
                "Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Fukuura, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamura", 
            "givenName": "Taishi", 
            "id": "sg:person.01077071341.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077071341.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
                "Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takami", 
            "givenName": "Hirokazu", 
            "id": "sg:person.01077606154.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077606154.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan", 
                "Department of Neurosurgery and Neurooncology, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsushita", 
            "givenName": "Yuko", 
            "id": "sg:person.0754605727.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754605727.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Saitama International Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412377.4", 
              "name": [
                "Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Tomonari", 
            "id": "sg:person.0751061011.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751061011.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kurume University", 
              "id": "https://www.grid.ac/institutes/grid.410781.b", 
              "name": [
                "Department of Neurosurgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamura", 
            "givenName": "Hideo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kumamoto University", 
              "id": "https://www.grid.ac/institutes/grid.274841.c", 
              "name": [
                "Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University Graduate School, Kumamoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Makino", 
            "givenName": "Keishi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Neurosurgery, Yamagata University School of Medicine, Yamagata, Japan", 
                "Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sonoda", 
            "givenName": "Yukihiko", 
            "id": "sg:person.01053460006.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053460006.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Ryuta", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tominaga", 
            "givenName": "Teiji", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka City General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416948.6", 
              "name": [
                "Department of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsusaka", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.01052413706.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052413706.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyorin University", 
              "id": "https://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Keiichi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyorin University", 
              "id": "https://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagane", 
            "givenName": "Motoo", 
            "id": "sg:person.0642670565.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642670565.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kurume University", 
              "id": "https://www.grid.ac/institutes/grid.410781.b", 
              "name": [
                "Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan", 
                "Department of Pathology, Kurume University, Kurume, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furuta", 
            "givenName": "Takuya", 
            "id": "sg:person.0630271742.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630271742.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kanazawa University", 
              "id": "https://www.grid.ac/institutes/grid.9707.9", 
              "name": [
                "Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakada", 
            "givenName": "Mitsutoshi", 
            "id": "sg:person.01327521625.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327521625.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Department of Neurosurgery and Neurooncology, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Narita", 
            "givenName": "Yoshitaka", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fujita Health University", 
              "id": "https://www.grid.ac/institutes/grid.256115.4", 
              "name": [
                "Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirose", 
            "givenName": "Yuichi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fujita Health University", 
              "id": "https://www.grid.ac/institutes/grid.256115.4", 
              "name": [
                "Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohba", 
            "givenName": "Shigeo", 
            "id": "sg:person.01006753632.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006753632.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Showa University", 
              "id": "https://www.grid.ac/institutes/grid.410714.7", 
              "name": [
                "Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wada", 
            "givenName": "Akira", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Showa University", 
              "id": "https://www.grid.ac/institutes/grid.410714.7", 
              "name": [
                "Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimizu", 
            "givenName": "Katsuyoshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Okayama University", 
              "id": "https://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Department of Neurological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kurozumi", 
            "givenName": "Kazuhiko", 
            "id": "sg:person.01161013111.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161013111.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Okayama University", 
              "id": "https://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Department of Neurological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Date", 
            "givenName": "Isao", 
            "id": "sg:person.01246002214.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246002214.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wakayama Medical University", 
              "id": "https://www.grid.ac/institutes/grid.412857.d", 
              "name": [
                "Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukai", 
            "givenName": "Junya", 
            "id": "sg:person.0735131615.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735131615.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nagano Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416376.1", 
              "name": [
                "Department of Neurosurgery, Nagano Children\u2019s Hospital, Nagano, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyairi", 
            "givenName": "Yousuke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kagawa", 
            "givenName": "Naoki", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kobe Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415413.6", 
              "name": [
                "Department of Neurosurgery, Hyogo Prefectural Kobe Children\u2019s Hospital, Kobe, Hyogo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kawamura", 
            "givenName": "Atsufumi", 
            "id": "sg:person.01050217454.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050217454.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kobe Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415413.6", 
              "name": [
                "Department of Pathology, Hyogo Prefectural Kobe Children\u2019s Hospital, Kobe, Hyogo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshida", 
            "givenName": "Makiko", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kitano Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415392.8", 
              "name": [
                "Department of Neurosurgery, Tazuke Kofukai Foundation, Medical Research Institute and Kitano Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishida", 
            "givenName": "Namiko", 
            "id": "sg:person.01177075662.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177075662.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shizuoka Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415798.6", 
              "name": [
                "Department of Neurosurgery, Shizuoka Children\u2019s Hospital, Shizuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wataya", 
            "givenName": "Takafumi", 
            "id": "sg:person.01224714316.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224714316.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jikei University", 
              "id": "https://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamaoka", 
            "givenName": "Masayoshi", 
            "id": "sg:person.0773376355.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773376355.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsuyuguchi", 
            "givenName": "Naohiro", 
            "id": "sg:person.0644512571.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644512571.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uda", 
            "givenName": "Takehiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Occupational and Environmental Health Japan", 
              "id": "https://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Mayu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Occupational and Environmental Health Japan", 
              "id": "https://www.grid.ac/institutes/grid.271052.3", 
              "name": [
                "Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakano", 
            "givenName": "Yoshiteru", 
            "id": "sg:person.010576447322.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010576447322.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Toyama University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.452851.f", 
              "name": [
                "Department of Neurosurgery, Kanazawa Medical University, Kanazawa, Japan", 
                "Department of Neurosurgery, Toyama University Hospital, Toyama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akai", 
            "givenName": "Takuya", 
            "id": "sg:person.01005076633.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005076633.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kindai University", 
              "id": "https://www.grid.ac/institutes/grid.258622.9", 
              "name": [
                "Department of Neurosurgery, Faculty of Medicine, Kinki University, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Izumoto", 
            "givenName": "Shuichi", 
            "id": "sg:person.0767232053.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767232053.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kansai Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410783.9", 
              "name": [
                "Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nonaka", 
            "givenName": "Masahiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Neurosurgery, Hokkaido Medical Center for Child Health and Rehabilitation, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshifuji", 
            "givenName": "Kazuhisa", 
            "id": "sg:person.01117226123.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117226123.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka National Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416803.8", 
              "name": [
                "Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan", 
                "Department of Pathology, Osaka National Hospital, National Hospital Organization, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kodama", 
            "givenName": "Yoshinori", 
            "id": "sg:person.01335243744.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335243744.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka National Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416803.8", 
              "name": [
                "Department of Pathology, Osaka National Hospital, National Hospital Organization, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mano", 
            "givenName": "Masayuki", 
            "id": "sg:person.01345445007.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345445007.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ozawa", 
            "givenName": "Tatsuya", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital for Sick Children", 
              "id": "https://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramaswamy", 
            "givenName": "Vijay", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital for Sick Children", 
              "id": "https://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada", 
                "Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taylor", 
            "givenName": "Michael D.", 
            "id": "sg:person.012731463207.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731463207.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ushijima", 
            "givenName": "Toshikazu", 
            "id": "sg:person.01050161671.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050161671.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412305.1", 
              "name": [
                "Department of Neurosurgery, Teikyo University Hospital, Mizonokuchi, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shibui", 
            "givenName": "Soichiro", 
            "id": "sg:person.0770104765.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770104765.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Takatsuki General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416862.f", 
              "name": [
                "Department of Pediatric Neurosurgery, Takatsuki General Hospital, Takatsuki, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamasaki", 
            "givenName": "Mami", 
            "id": "sg:person.01270211556.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270211556.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Juntendo University", 
              "id": "https://www.grid.ac/institutes/grid.258269.2", 
              "name": [
                "Department of Neurosurgery, Juntendo University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arai", 
            "givenName": "Hajime", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka City General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416948.6", 
              "name": [
                "Department of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakamoto", 
            "givenName": "Hiroaki", 
            "id": "sg:person.0672402714.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672402714.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Saitama International Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412377.4", 
              "name": [
                "Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishikawa", 
            "givenName": "Ryo", 
            "id": "sg:person.01024137735.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024137735.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ichimura", 
            "givenName": "Koichi", 
            "id": "sg:person.013545762764.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013545762764.37"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "on behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG)", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1074/jbc.m700246200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000058259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10014-014-0186-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000403235", 
              "https://doi.org/10.1007/s10014-014-0186-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000731655", 
              "https://doi.org/10.1038/ng.3338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002356005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.27.3359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003598231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.29198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004618223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004871541", 
              "https://doi.org/10.1038/nature13108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-8-r72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006381787", 
              "https://doi.org/10.1186/gb-2011-12-8-r72"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nos245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009264853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1124-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009865592", 
              "https://doi.org/10.1007/s00401-013-1124-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010733927", 
              "https://doi.org/10.1038/nature10866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1203-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010767954", 
              "https://doi.org/10.1007/s00401-013-1203-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1141-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014782324", 
              "https://doi.org/10.1007/s00401-013-1141-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.01.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024874051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2012.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025274147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026136199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031794503", 
              "https://doi.org/10.1038/modpathol.3800999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2015.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034457047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-2489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037759400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-5751-10-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038490809", 
              "https://doi.org/10.1186/1477-5751-10-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0360-3016(01)02801-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040090178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.22400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042862319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-013-1111-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043407748", 
              "https://doi.org/10.1007/s11060-013-1111-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.04.2127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043955660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nos213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045678994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(13)70110-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046947199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10120-015-0475-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049852602", 
              "https://doi.org/10.1007/s10120-015-0475-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050781394", 
              "https://doi.org/10.1038/nature13109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/now025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059935190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2015.65.7825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.2012.1564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071512865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nox027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083933773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1752-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090852536", 
              "https://doi.org/10.1007/s00401-017-1752-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1752-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090852536", 
              "https://doi.org/10.1007/s00401-017-1752-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcancer.2017.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092692329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature26000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101533700", 
              "https://doi.org/10.1038/nature26000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature26000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101533700", 
              "https://doi.org/10.1038/nature26000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature26000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101533700", 
              "https://doi.org/10.1038/nature26000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1877-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104694272", 
              "https://doi.org/10.1007/s00401-018-1877-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1888-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105640943", 
              "https://doi.org/10.1007/s00401-018-1888-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1888-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105640943", 
              "https://doi.org/10.1007/s00401-018-1888-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the existence of molecular subgroups. However, the pathogenesis of RELA fusion-negative ependymomas remains elusive. To investigate the molecular pathogenesis of these tumors and validate the molecular classification of ependymal tumors, we conducted thorough molecular analyses of 113 locally diagnosed ependymal tumors from 107 patients in the Japan Pediatric Molecular Neuro-Oncology Group. All tumors were histopathologically reviewed and 12 tumors were re-classified as non-ependymomas. A combination of RT-PCR, FISH, and RNA sequencing identified RELA fusion in 19 of 29 histologically verified ST-EPN cases, whereas another case was diagnosed as ependymoma RELA fusion-positive via the methylation classifier (68.9%). Among the 9 RELA fusion-negative ST-EPN cases, either the YAP1 fusion, BCOR tandem duplication, EP300-BCORL1 fusion, or FOXO1-STK24 fusion was detected in single cases. Methylation classification did not identify a consistent molecular class within this group. Genome-wide methylation profiling successfully sub-classified posterior fossa ependymoma (PF-EPN) into PF-EPN-A (PFA) and PF-EPN-B (PFB). A multivariate analysis using Cox regression confirmed that PFA was the sole molecular marker which was independently associated with patient survival. A clinically applicable pyrosequencing assay was developed to determine the PFB subgroup with 100% specificity using the methylation status of 3 genes, CRIP1, DRD4 and LBX2. Our results emphasized the significance of molecular classification in the diagnosis of ependymomas. RELA fusion-negative ST-EPN appear to be a heterogeneous group of tumors that do not fall into any of the existing molecular subgroups and are unlikely to form a single category.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s40478-018-0630-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5922932", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6841081", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5559245", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1048594", 
            "issn": [
              "2051-5960"
            ], 
            "name": "Acta Neuropathologica Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "name": "Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors", 
        "pagination": "134", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "16a64d3f37bc46b7cddeec9de4d58d5886fce6daf3d3b0196186ec240a29a0d4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30514397"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101610673"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s40478-018-0630-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110371159"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s40478-018-0630-1", 
          "https://app.dimensions.ai/details/publication/pub.1110371159"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99818_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs40478-018-0630-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40478-018-0630-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40478-018-0630-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40478-018-0630-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40478-018-0630-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    774 TRIPLES      21 PREDICATES      66 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s40478-018-0630-1 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Na004724a04aa4c999c64635e5c5f62d8
    4 schema:citation sg:pub.10.1007/s00401-013-1124-7
    5 sg:pub.10.1007/s00401-013-1141-6
    6 sg:pub.10.1007/s00401-013-1203-9
    7 sg:pub.10.1007/s00401-017-1752-4
    8 sg:pub.10.1007/s00401-018-1877-0
    9 sg:pub.10.1007/s00401-018-1888-x
    10 sg:pub.10.1007/s10014-014-0186-0
    11 sg:pub.10.1007/s10120-015-0475-2
    12 sg:pub.10.1007/s11060-013-1111-9
    13 sg:pub.10.1038/modpathol.3800999
    14 sg:pub.10.1038/nature10866
    15 sg:pub.10.1038/nature13108
    16 sg:pub.10.1038/nature13109
    17 sg:pub.10.1038/nature26000
    18 sg:pub.10.1038/ng.3338
    19 sg:pub.10.1186/1477-5751-10-7
    20 sg:pub.10.1186/gb-2011-12-8-r72
    21 https://doi.org/10.1002/cncr.29198
    22 https://doi.org/10.1002/gcc.22400
    23 https://doi.org/10.1016/j.canlet.2012.11.022
    24 https://doi.org/10.1016/j.ccell.2015.04.002
    25 https://doi.org/10.1016/j.ccr.2011.07.007
    26 https://doi.org/10.1016/j.cell.2016.01.015
    27 https://doi.org/10.1016/j.semcancer.2017.11.006
    28 https://doi.org/10.1016/s0360-3016(01)02801-2
    29 https://doi.org/10.1016/s1470-2045(13)70110-4
    30 https://doi.org/10.1074/jbc.m700246200
    31 https://doi.org/10.1093/neuonc/nos213
    32 https://doi.org/10.1093/neuonc/nos245
    33 https://doi.org/10.1093/neuonc/now025
    34 https://doi.org/10.1093/neuonc/nox027
    35 https://doi.org/10.1111/bpa.12050
    36 https://doi.org/10.1158/1078-0432.ccr-11-2489
    37 https://doi.org/10.1200/jco.2005.04.2127
    38 https://doi.org/10.1200/jco.2009.27.3359
    39 https://doi.org/10.1200/jco.2015.65.7825
    40 https://doi.org/10.3892/ijo.2012.1564
    41 schema:datePublished 2018-12
    42 schema:datePublishedReg 2018-12-01
    43 schema:description Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the existence of molecular subgroups. However, the pathogenesis of RELA fusion-negative ependymomas remains elusive. To investigate the molecular pathogenesis of these tumors and validate the molecular classification of ependymal tumors, we conducted thorough molecular analyses of 113 locally diagnosed ependymal tumors from 107 patients in the Japan Pediatric Molecular Neuro-Oncology Group. All tumors were histopathologically reviewed and 12 tumors were re-classified as non-ependymomas. A combination of RT-PCR, FISH, and RNA sequencing identified RELA fusion in 19 of 29 histologically verified ST-EPN cases, whereas another case was diagnosed as ependymoma RELA fusion-positive via the methylation classifier (68.9%). Among the 9 RELA fusion-negative ST-EPN cases, either the YAP1 fusion, BCOR tandem duplication, EP300-BCORL1 fusion, or FOXO1-STK24 fusion was detected in single cases. Methylation classification did not identify a consistent molecular class within this group. Genome-wide methylation profiling successfully sub-classified posterior fossa ependymoma (PF-EPN) into PF-EPN-A (PFA) and PF-EPN-B (PFB). A multivariate analysis using Cox regression confirmed that PFA was the sole molecular marker which was independently associated with patient survival. A clinically applicable pyrosequencing assay was developed to determine the PFB subgroup with 100% specificity using the methylation status of 3 genes, CRIP1, DRD4 and LBX2. Our results emphasized the significance of molecular classification in the diagnosis of ependymomas. RELA fusion-negative ST-EPN appear to be a heterogeneous group of tumors that do not fall into any of the existing molecular subgroups and are unlikely to form a single category.
    44 schema:genre research_article
    45 schema:inLanguage en
    46 schema:isAccessibleForFree true
    47 schema:isPartOf N7ef39b6ec30a454ab451e154e3772139
    48 Nf54f21d226464d64b5858e61332d88c9
    49 sg:journal.1048594
    50 schema:name Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors
    51 schema:pagination 134
    52 schema:productId N17341f60592e41458c3520b03114b48d
    53 N2c9282ae54a24ed8b484c6c7e62a4845
    54 N60ceb2ae9e5e46638db4337484d477d4
    55 Ncf5775d45efa4e93ae0065c8c2143ebc
    56 Ne4771479d0d94cfca2cccd1534b8410c
    57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110371159
    58 https://doi.org/10.1186/s40478-018-0630-1
    59 schema:sdDatePublished 2019-04-11T09:35
    60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    61 schema:sdPublisher N6d61e068b739422cbbf78a892ada772d
    62 schema:url https://link.springer.com/10.1186%2Fs40478-018-0630-1
    63 sgo:license sg:explorer/license/
    64 sgo:sdDataset articles
    65 rdf:type schema:ScholarlyArticle
    66 N05582995a7f5485097f059d14a471c23 rdf:first sg:person.0751061011.67
    67 rdf:rest Nb4a2269af46b41a08464e8a4c38ee7b0
    68 N0723bafc7f1743e8954137af59bffc22 rdf:first N22ee9fbe94844439a1032baa24517c80
    69 rdf:rest N09464de63f87431cb943c9549795606e
    70 N09464de63f87431cb943c9549795606e rdf:first sg:person.01117226123.09
    71 rdf:rest N6824c1eecf0e4058a1b815c3f5ec0623
    72 N0ab503ed90be4e558d27606efc9676ab rdf:first sg:person.01040300545.82
    73 rdf:rest N83de454267d8424c8026d1504f00dafa
    74 N0d1c56d12e054b70becdd02da3b11c85 rdf:first sg:person.0672402714.78
    75 rdf:rest Nbd4efb5b8b6745d286a1a7d8bd8a6914
    76 N0fd106a151744313ad800a3add069920 schema:affiliation https://www.grid.ac/institutes/grid.256115.4
    77 schema:familyName Hirose
    78 schema:givenName Yuichi
    79 rdf:type schema:Person
    80 N137e6f2c9b1841249241384b9087409e rdf:first sg:person.0630271742.11
    81 rdf:rest Nb1b8f6017c4744dd99a5f0637a16a60c
    82 N17341f60592e41458c3520b03114b48d schema:name dimensions_id
    83 schema:value pub.1110371159
    84 rdf:type schema:PropertyValue
    85 N19850b99b79449e8bf64e2c25dc3c56f rdf:first sg:person.01270211556.06
    86 rdf:rest N727626da2e704854bbb75c1070876107
    87 N1ecb60f0c5904ef6a3569aab2ab3ed6a rdf:first sg:person.01006753632.04
    88 rdf:rest Nc9873fdb4ac547fd97db57b0f7091c99
    89 N20a63dc1a99e4066913f12cd6457a54f rdf:first sg:person.01055356417.42
    90 rdf:rest N8e04d1f245ac4f038dfe1fdf54c50621
    91 N22ee9fbe94844439a1032baa24517c80 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
    92 schema:familyName Nonaka
    93 schema:givenName Masahiro
    94 rdf:type schema:Person
    95 N25631a65fad64f3e8cd20d0de68ec28b rdf:first Nfbd86718324048cf8a766daf000cba11
    96 rdf:rest Nd597bc255b12466fba9abb9c62294029
    97 N2603882bd0c5442b9c2b928630f44425 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
    98 schema:familyName Arai
    99 schema:givenName Hajime
    100 rdf:type schema:Person
    101 N2c9282ae54a24ed8b484c6c7e62a4845 schema:name readcube_id
    102 schema:value 16a64d3f37bc46b7cddeec9de4d58d5886fce6daf3d3b0196186ec240a29a0d4
    103 rdf:type schema:PropertyValue
    104 N2dbe632ea764487e80890e73fbecdf10 rdf:first sg:person.0655527716.29
    105 rdf:rest N497cb8d9b0bf4e2aa1c3aafed35a1304
    106 N334259c6951f4e67b233d25202837a5d schema:affiliation https://www.grid.ac/institutes/grid.411205.3
    107 schema:familyName Kobayashi
    108 schema:givenName Keiichi
    109 rdf:type schema:Person
    110 N370aadc06d0d4031b4c2e270c2fad1f3 rdf:first sg:person.0665013040.71
    111 rdf:rest N4d35ee97e55548c3b929cb1c92f596fa
    112 N3a1662e594ca49db87779870910c7fb3 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    113 schema:familyName Uda
    114 schema:givenName Takehiro
    115 rdf:type schema:Person
    116 N3b38f45f1ed446fe97fc031963a371d1 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    117 schema:familyName Tominaga
    118 schema:givenName Teiji
    119 rdf:type schema:Person
    120 N3d83ee49cead4fec836f8a34588ede8c rdf:first sg:person.01246002214.28
    121 rdf:rest N4af585042129434cb27d33f31a90021c
    122 N3e12c6c807744fea9b742e1402ab52f9 schema:affiliation https://www.grid.ac/institutes/grid.410714.7
    123 schema:familyName Shimizu
    124 schema:givenName Katsuyoshi
    125 rdf:type schema:Person
    126 N42e21c46d196498e8009a90b82dec4ef schema:affiliation https://www.grid.ac/institutes/grid.42327.30
    127 schema:familyName Ramaswamy
    128 schema:givenName Vijay
    129 rdf:type schema:Person
    130 N441f9a90d4a54f689f289547d3f27d41 rdf:first sg:person.01077606154.26
    131 rdf:rest N98e5dab3abb54649b8fe4ee4d28f8a25
    132 N496139fc43da437ea2200d12f99e80e8 rdf:first sg:person.0666452416.76
    133 rdf:rest N8689781bd0224c38b682f46bb9748fba
    134 N497cb8d9b0bf4e2aa1c3aafed35a1304 rdf:first sg:person.0631000545.59
    135 rdf:rest Nfac0cd68c0ab471b90028b13358e07a7
    136 N4af585042129434cb27d33f31a90021c rdf:first sg:person.0735131615.03
    137 rdf:rest Nf56ba8651763496586e7becd1c76ddcc
    138 N4d35ee97e55548c3b929cb1c92f596fa rdf:first sg:person.01037534556.22
    139 rdf:rest Nd6bf8d36698d44e5b6d3295541f93af4
    140 N51d9b98e6a3f4148bead50f94a7cce37 schema:affiliation https://www.grid.ac/institutes/grid.271052.3
    141 schema:familyName Takahashi
    142 schema:givenName Mayu
    143 rdf:type schema:Person
    144 N52c51e85911a47dc9986fd31b290df12 rdf:first sg:person.01005076633.76
    145 rdf:rest Nbfaa9c2cbdfe4e0f931c89459ce8e1a1
    146 N60ceb2ae9e5e46638db4337484d477d4 schema:name doi
    147 schema:value 10.1186/s40478-018-0630-1
    148 rdf:type schema:PropertyValue
    149 N64bb12bb9b1e4d3da91cd0ff9ec9cc8c rdf:first Ndd08704817654f068912989fa424f688
    150 rdf:rest Nd147e0f00dc94bbcbad03bfae16896e1
    151 N6787ca065f1642de88d2f932b7ead38d rdf:first Nf9ed4922194c45c5a4b0ce038892dec6
    152 rdf:rest rdf:nil
    153 N6824c1eecf0e4058a1b815c3f5ec0623 rdf:first sg:person.01335243744.91
    154 rdf:rest N850416c4a7a148b2bc218be477a5afff
    155 N6d61e068b739422cbbf78a892ada772d schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 N6e616ac937d240eca44a8fc87be6f0fd rdf:first sg:person.01145435163.00
    158 rdf:rest N496139fc43da437ea2200d12f99e80e8
    159 N727626da2e704854bbb75c1070876107 rdf:first N2603882bd0c5442b9c2b928630f44425
    160 rdf:rest N0d1c56d12e054b70becdd02da3b11c85
    161 N75ac41aa8ba74a9f8c269e97fdfc65b1 rdf:first sg:person.013545762764.37
    162 rdf:rest N6787ca065f1642de88d2f932b7ead38d
    163 N75c658349c204450bd260dd7869b392b rdf:first N334259c6951f4e67b233d25202837a5d
    164 rdf:rest N904e75da1e8a4d82a6d9ff2ccd8fecc6
    165 N77eee8ff9755416f88b7e48920021a51 schema:affiliation https://www.grid.ac/institutes/grid.274841.c
    166 schema:familyName Makino
    167 schema:givenName Keishi
    168 rdf:type schema:Person
    169 N79444edf4bf94d55ac8a6388b32e0588 schema:affiliation https://www.grid.ac/institutes/grid.416376.1
    170 schema:familyName Miyairi
    171 schema:givenName Yousuke
    172 rdf:type schema:Person
    173 N7ef39b6ec30a454ab451e154e3772139 schema:volumeNumber 6
    174 rdf:type schema:PublicationVolume
    175 N838d0bb21d30415a99864282ee9765d8 rdf:first N51d9b98e6a3f4148bead50f94a7cce37
    176 rdf:rest Nb99992c2cea344d8bdf7a01d3d6923a6
    177 N83de454267d8424c8026d1504f00dafa rdf:first sg:person.01320051473.59
    178 rdf:rest Nace9073a75a64c61b6aa4e89619dd73b
    179 N850416c4a7a148b2bc218be477a5afff rdf:first sg:person.01345445007.84
    180 rdf:rest Ndbd81c00b8ee4adeb512447e63605e33
    181 N85d8d43b4363438d8e76b82a56f8ff76 rdf:first sg:person.012731463207.92
    182 rdf:rest Ne32ef8edfc544afc8240955e1395c8e4
    183 N85f0ece87e3d4ba299f1e3b5b7a7a414 schema:affiliation https://www.grid.ac/institutes/grid.410802.f
    184 schema:familyName Sasaki
    185 schema:givenName Atsushi
    186 rdf:type schema:Person
    187 N8689781bd0224c38b682f46bb9748fba rdf:first sg:person.01106276524.16
    188 rdf:rest Nfc0953d00e8e4c48a8347224ddaf562b
    189 N8cac3e6c2a5044f289d60062943f1610 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    190 schema:familyName Ozawa
    191 schema:givenName Tatsuya
    192 rdf:type schema:Person
    193 N8e04d1f245ac4f038dfe1fdf54c50621 rdf:first sg:person.01215604277.31
    194 rdf:rest Nc565f3efe5c940d98fe68198c71e8599
    195 N8fa90f86023e452798d15ce20296cc1b schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    196 schema:familyName Saito
    197 schema:givenName Ryuta
    198 rdf:type schema:Person
    199 N904e75da1e8a4d82a6d9ff2ccd8fecc6 rdf:first sg:person.0642670565.81
    200 rdf:rest N137e6f2c9b1841249241384b9087409e
    201 N98e5dab3abb54649b8fe4ee4d28f8a25 rdf:first sg:person.0754605727.98
    202 rdf:rest N05582995a7f5485097f059d14a471c23
    203 N994f704b843c4dbf91bbb3cd879a6c92 rdf:first sg:person.01161013111.44
    204 rdf:rest N3d83ee49cead4fec836f8a34588ede8c
    205 N9af86e98f20548c4a633824bbd2da9d7 rdf:first N3e12c6c807744fea9b742e1402ab52f9
    206 rdf:rest N994f704b843c4dbf91bbb3cd879a6c92
    207 N9b3378b1141444bab9e4c15ed1e21e12 rdf:first sg:person.01077071341.40
    208 rdf:rest N441f9a90d4a54f689f289547d3f27d41
    209 N9d937d5b620a480bb86fe98277f5f301 rdf:first N8fa90f86023e452798d15ce20296cc1b
    210 rdf:rest Nfda4e2920d904f338312aed482b405da
    211 Na004724a04aa4c999c64635e5c5f62d8 rdf:first sg:person.0646016572.15
    212 rdf:rest N370aadc06d0d4031b4c2e270c2fad1f3
    213 Na49dac65e7a1402bb3d50c7e48e5b5e2 rdf:first N85f0ece87e3d4ba299f1e3b5b7a7a414
    214 rdf:rest Nf0796141a1574ec18b29ee8589431f25
    215 Na70019b270ee4877bded5f22896f5886 rdf:first sg:person.0773376355.83
    216 rdf:rest Ne6c6cb64333d4d8b9ef4d4d8650f540f
    217 Naa8f4703e47144f8809b589e488e1fe7 rdf:first N77eee8ff9755416f88b7e48920021a51
    218 rdf:rest Nb51d6caf3a4b4e508ae48c954dd66de9
    219 Nace9073a75a64c61b6aa4e89619dd73b rdf:first sg:person.015353257773.30
    220 rdf:rest N9b3378b1141444bab9e4c15ed1e21e12
    221 Nb12bd0f6436a4f0b947c940ef95e77dd rdf:first sg:person.01224714316.44
    222 rdf:rest Na70019b270ee4877bded5f22896f5886
    223 Nb1b8f6017c4744dd99a5f0637a16a60c rdf:first sg:person.01327521625.56
    224 rdf:rest N64bb12bb9b1e4d3da91cd0ff9ec9cc8c
    225 Nb4a2269af46b41a08464e8a4c38ee7b0 rdf:first Nfcc66045dee44b08a98883330a59542a
    226 rdf:rest Naa8f4703e47144f8809b589e488e1fe7
    227 Nb51d6caf3a4b4e508ae48c954dd66de9 rdf:first sg:person.01053460006.18
    228 rdf:rest N9d937d5b620a480bb86fe98277f5f301
    229 Nb99992c2cea344d8bdf7a01d3d6923a6 rdf:first sg:person.010576447322.44
    230 rdf:rest N52c51e85911a47dc9986fd31b290df12
    231 Nbd4efb5b8b6745d286a1a7d8bd8a6914 rdf:first sg:person.01024137735.51
    232 rdf:rest N75ac41aa8ba74a9f8c269e97fdfc65b1
    233 Nbf2247f75b614a6cb17a6cc601b2b8ea rdf:first N3a1662e594ca49db87779870910c7fb3
    234 rdf:rest N838d0bb21d30415a99864282ee9765d8
    235 Nbfaa9c2cbdfe4e0f931c89459ce8e1a1 rdf:first sg:person.0767232053.04
    236 rdf:rest N0723bafc7f1743e8954137af59bffc22
    237 Nc565f3efe5c940d98fe68198c71e8599 rdf:first sg:person.01066626041.77
    238 rdf:rest N2dbe632ea764487e80890e73fbecdf10
    239 Nc9873fdb4ac547fd97db57b0f7091c99 rdf:first Ncf6321e007e647c49bc37205a97c94f3
    240 rdf:rest N9af86e98f20548c4a633824bbd2da9d7
    241 Nc9a353defbe4423398c9a15f8a094204 rdf:first Nf3e43aed19cc4ea1a3685939f19914c1
    242 rdf:rest Ncf51b742ec8e47db8b55cc48a026b422
    243 Ncf51b742ec8e47db8b55cc48a026b422 rdf:first sg:person.01177075662.42
    244 rdf:rest Nb12bd0f6436a4f0b947c940ef95e77dd
    245 Ncf5775d45efa4e93ae0065c8c2143ebc schema:name pubmed_id
    246 schema:value 30514397
    247 rdf:type schema:PropertyValue
    248 Ncf6321e007e647c49bc37205a97c94f3 schema:affiliation https://www.grid.ac/institutes/grid.410714.7
    249 schema:familyName Wada
    250 schema:givenName Akira
    251 rdf:type schema:Person
    252 Nd147e0f00dc94bbcbad03bfae16896e1 rdf:first N0fd106a151744313ad800a3add069920
    253 rdf:rest N1ecb60f0c5904ef6a3569aab2ab3ed6a
    254 Nd2de081090d7407ea0d74ea13524eca9 schema:name Department of Neurosurgery, Hokkaido Medical Center for Child Health and Rehabilitation, Sapporo, Japan
    255 rdf:type schema:Organization
    256 Nd597bc255b12466fba9abb9c62294029 rdf:first sg:person.01050217454.06
    257 rdf:rest Nc9a353defbe4423398c9a15f8a094204
    258 Nd6bf8d36698d44e5b6d3295541f93af4 rdf:first sg:person.0645222335.56
    259 rdf:rest N20a63dc1a99e4066913f12cd6457a54f
    260 Ndbd81c00b8ee4adeb512447e63605e33 rdf:first N8cac3e6c2a5044f289d60062943f1610
    261 rdf:rest Nf28fccbfd5e141eb8c276b18a5f59ff2
    262 Ndd08704817654f068912989fa424f688 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    263 schema:familyName Narita
    264 schema:givenName Yoshitaka
    265 rdf:type schema:Person
    266 Ne32ef8edfc544afc8240955e1395c8e4 rdf:first sg:person.01050161671.40
    267 rdf:rest Neeedc5705a8640faa45f40497635d54b
    268 Ne4771479d0d94cfca2cccd1534b8410c schema:name nlm_unique_id
    269 schema:value 101610673
    270 rdf:type schema:PropertyValue
    271 Ne6c6cb64333d4d8b9ef4d4d8650f540f rdf:first sg:person.0644512571.54
    272 rdf:rest Nbf2247f75b614a6cb17a6cc601b2b8ea
    273 Neeedc5705a8640faa45f40497635d54b rdf:first sg:person.0770104765.70
    274 rdf:rest N19850b99b79449e8bf64e2c25dc3c56f
    275 Nf0796141a1574ec18b29ee8589431f25 rdf:first sg:person.01063706261.49
    276 rdf:rest N6e616ac937d240eca44a8fc87be6f0fd
    277 Nf28fccbfd5e141eb8c276b18a5f59ff2 rdf:first N42e21c46d196498e8009a90b82dec4ef
    278 rdf:rest N85d8d43b4363438d8e76b82a56f8ff76
    279 Nf3e43aed19cc4ea1a3685939f19914c1 schema:affiliation https://www.grid.ac/institutes/grid.415413.6
    280 schema:familyName Yoshida
    281 schema:givenName Makiko
    282 rdf:type schema:Person
    283 Nf4f2acb7bae240ee9746337a2d335f5a rdf:first sg:person.01052413706.37
    284 rdf:rest N75c658349c204450bd260dd7869b392b
    285 Nf54f21d226464d64b5858e61332d88c9 schema:issueNumber 1
    286 rdf:type schema:PublicationIssue
    287 Nf56ba8651763496586e7becd1c76ddcc rdf:first N79444edf4bf94d55ac8a6388b32e0588
    288 rdf:rest N25631a65fad64f3e8cd20d0de68ec28b
    289 Nf9ed4922194c45c5a4b0ce038892dec6 schema:familyName on behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG)
    290 rdf:type schema:Person
    291 Nfac0cd68c0ab471b90028b13358e07a7 rdf:first sg:person.0641101305.90
    292 rdf:rest Na49dac65e7a1402bb3d50c7e48e5b5e2
    293 Nfbd86718324048cf8a766daf000cba11 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    294 schema:familyName Kagawa
    295 schema:givenName Naoki
    296 rdf:type schema:Person
    297 Nfc0953d00e8e4c48a8347224ddaf562b rdf:first sg:person.01160707072.32
    298 rdf:rest N0ab503ed90be4e558d27606efc9676ab
    299 Nfcc66045dee44b08a98883330a59542a schema:affiliation https://www.grid.ac/institutes/grid.410781.b
    300 schema:familyName Nakamura
    301 schema:givenName Hideo
    302 rdf:type schema:Person
    303 Nfda4e2920d904f338312aed482b405da rdf:first N3b38f45f1ed446fe97fc031963a371d1
    304 rdf:rest Nf4f2acb7bae240ee9746337a2d335f5a
    305 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    306 schema:name Biological Sciences
    307 rdf:type schema:DefinedTerm
    308 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    309 schema:name Genetics
    310 rdf:type schema:DefinedTerm
    311 sg:grant.5559245 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-018-0630-1
    312 rdf:type schema:MonetaryGrant
    313 sg:grant.5922932 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-018-0630-1
    314 rdf:type schema:MonetaryGrant
    315 sg:grant.6841081 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-018-0630-1
    316 rdf:type schema:MonetaryGrant
    317 sg:journal.1048594 schema:issn 2051-5960
    318 schema:name Acta Neuropathologica Communications
    319 rdf:type schema:Periodical
    320 sg:person.01005076633.76 schema:affiliation https://www.grid.ac/institutes/grid.452851.f
    321 schema:familyName Akai
    322 schema:givenName Takuya
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005076633.76
    324 rdf:type schema:Person
    325 sg:person.01006753632.04 schema:affiliation https://www.grid.ac/institutes/grid.256115.4
    326 schema:familyName Ohba
    327 schema:givenName Shigeo
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006753632.04
    329 rdf:type schema:Person
    330 sg:person.01024137735.51 schema:affiliation https://www.grid.ac/institutes/grid.412377.4
    331 schema:familyName Nishikawa
    332 schema:givenName Ryo
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024137735.51
    334 rdf:type schema:Person
    335 sg:person.01037534556.22 schema:affiliation https://www.grid.ac/institutes/grid.416803.8
    336 schema:familyName Shofuda
    337 schema:givenName Tomoko
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037534556.22
    339 rdf:type schema:Person
    340 sg:person.01040300545.82 schema:affiliation https://www.grid.ac/institutes/grid.416948.6
    341 schema:familyName Yamasaki
    342 schema:givenName Kai
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040300545.82
    344 rdf:type schema:Person
    345 sg:person.01050161671.40 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    346 schema:familyName Ushijima
    347 schema:givenName Toshikazu
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050161671.40
    349 rdf:type schema:Person
    350 sg:person.01050217454.06 schema:affiliation https://www.grid.ac/institutes/grid.415413.6
    351 schema:familyName Kawamura
    352 schema:givenName Atsufumi
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050217454.06
    354 rdf:type schema:Person
    355 sg:person.01052413706.37 schema:affiliation https://www.grid.ac/institutes/grid.416948.6
    356 schema:familyName Matsusaka
    357 schema:givenName Yasuhiro
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052413706.37
    359 rdf:type schema:Person
    360 sg:person.01053460006.18 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    361 schema:familyName Sonoda
    362 schema:givenName Yukihiko
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053460006.18
    364 rdf:type schema:Person
    365 sg:person.01055356417.42 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    366 schema:familyName Yamashita
    367 schema:givenName Satoshi
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055356417.42
    369 rdf:type schema:Person
    370 sg:person.010576447322.44 schema:affiliation https://www.grid.ac/institutes/grid.271052.3
    371 schema:familyName Nakano
    372 schema:givenName Yoshiteru
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010576447322.44
    374 rdf:type schema:Person
    375 sg:person.01063706261.49 schema:affiliation https://www.grid.ac/institutes/grid.411887.3
    376 schema:familyName Hirato
    377 schema:givenName Junko
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063706261.49
    379 rdf:type schema:Person
    380 sg:person.01066626041.77 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    381 schema:familyName Kato
    382 schema:givenName Mamoru
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066626041.77
    384 rdf:type schema:Person
    385 sg:person.01077071341.40 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
    386 schema:familyName Nakamura
    387 schema:givenName Taishi
    388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077071341.40
    389 rdf:type schema:Person
    390 sg:person.01077606154.26 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    391 schema:familyName Takami
    392 schema:givenName Hirokazu
    393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077606154.26
    394 rdf:type schema:Person
    395 sg:person.01106276524.16 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    396 schema:familyName Satomi
    397 schema:givenName Kaishi
    398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106276524.16
    399 rdf:type schema:Person
    400 sg:person.01117226123.09 schema:affiliation Nd2de081090d7407ea0d74ea13524eca9
    401 schema:familyName Yoshifuji
    402 schema:givenName Kazuhisa
    403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117226123.09
    404 rdf:type schema:Person
    405 sg:person.01145435163.00 schema:affiliation https://www.grid.ac/institutes/grid.417755.5
    406 schema:familyName Hirose
    407 schema:givenName Takanori
    408 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145435163.00
    409 rdf:type schema:Person
    410 sg:person.01160707072.32 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    411 schema:familyName Yoshida
    412 schema:givenName Akihiko
    413 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160707072.32
    414 rdf:type schema:Person
    415 sg:person.01161013111.44 schema:affiliation https://www.grid.ac/institutes/grid.261356.5
    416 schema:familyName Kurozumi
    417 schema:givenName Kazuhiko
    418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161013111.44
    419 rdf:type schema:Person
    420 sg:person.01177075662.42 schema:affiliation https://www.grid.ac/institutes/grid.415392.8
    421 schema:familyName Nishida
    422 schema:givenName Namiko
    423 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177075662.42
    424 rdf:type schema:Person
    425 sg:person.01215604277.31 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    426 schema:familyName Narushima
    427 schema:givenName Daichi
    428 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215604277.31
    429 rdf:type schema:Person
    430 sg:person.01224714316.44 schema:affiliation https://www.grid.ac/institutes/grid.415798.6
    431 schema:familyName Wataya
    432 schema:givenName Takafumi
    433 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224714316.44
    434 rdf:type schema:Person
    435 sg:person.01246002214.28 schema:affiliation https://www.grid.ac/institutes/grid.261356.5
    436 schema:familyName Date
    437 schema:givenName Isao
    438 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246002214.28
    439 rdf:type schema:Person
    440 sg:person.01270211556.06 schema:affiliation https://www.grid.ac/institutes/grid.416862.f
    441 schema:familyName Yamasaki
    442 schema:givenName Mami
    443 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270211556.06
    444 rdf:type schema:Person
    445 sg:person.012731463207.92 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
    446 schema:familyName Taylor
    447 schema:givenName Michael D.
    448 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731463207.92
    449 rdf:type schema:Person
    450 sg:person.01320051473.59 schema:affiliation https://www.grid.ac/institutes/grid.416948.6
    451 schema:familyName Nakano
    452 schema:givenName Yoshiko
    453 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320051473.59
    454 rdf:type schema:Person
    455 sg:person.01327521625.56 schema:affiliation https://www.grid.ac/institutes/grid.9707.9
    456 schema:familyName Nakada
    457 schema:givenName Mitsutoshi
    458 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327521625.56
    459 rdf:type schema:Person
    460 sg:person.01335243744.91 schema:affiliation https://www.grid.ac/institutes/grid.416803.8
    461 schema:familyName Kodama
    462 schema:givenName Yoshinori
    463 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335243744.91
    464 rdf:type schema:Person
    465 sg:person.01345445007.84 schema:affiliation https://www.grid.ac/institutes/grid.416803.8
    466 schema:familyName Mano
    467 schema:givenName Masayuki
    468 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345445007.84
    469 rdf:type schema:Person
    470 sg:person.013545762764.37 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    471 schema:familyName Ichimura
    472 schema:givenName Koichi
    473 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013545762764.37
    474 rdf:type schema:Person
    475 sg:person.015353257773.30 schema:affiliation https://www.grid.ac/institutes/grid.416803.8
    476 schema:familyName Takada
    477 schema:givenName Ai
    478 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015353257773.30
    479 rdf:type schema:Person
    480 sg:person.0630271742.11 schema:affiliation https://www.grid.ac/institutes/grid.410781.b
    481 schema:familyName Furuta
    482 schema:givenName Takuya
    483 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630271742.11
    484 rdf:type schema:Person
    485 sg:person.0631000545.59 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    486 schema:familyName Ichikawa
    487 schema:givenName Hitoshi
    488 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631000545.59
    489 rdf:type schema:Person
    490 sg:person.0641101305.90 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    491 schema:familyName Kohno
    492 schema:givenName Takashi
    493 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641101305.90
    494 rdf:type schema:Person
    495 sg:person.0642670565.81 schema:affiliation https://www.grid.ac/institutes/grid.411205.3
    496 schema:familyName Nagane
    497 schema:givenName Motoo
    498 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642670565.81
    499 rdf:type schema:Person
    500 sg:person.0644512571.54 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    501 schema:familyName Tsuyuguchi
    502 schema:givenName Naohiro
    503 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644512571.54
    504 rdf:type schema:Person
    505 sg:person.0645222335.56 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    506 schema:familyName Fukushima
    507 schema:givenName Shintaro
    508 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645222335.56
    509 rdf:type schema:Person
    510 sg:person.0646016572.15 schema:affiliation https://www.grid.ac/institutes/grid.412377.4
    511 schema:familyName Fukuoka
    512 schema:givenName Kohei
    513 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646016572.15
    514 rdf:type schema:Person
    515 sg:person.0655527716.29 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    516 schema:familyName Honda-Kitahara
    517 schema:givenName Mai
    518 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655527716.29
    519 rdf:type schema:Person
    520 sg:person.0665013040.71 schema:affiliation https://www.grid.ac/institutes/grid.416803.8
    521 schema:familyName Kanemura
    522 schema:givenName Yonehiro
    523 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665013040.71
    524 rdf:type schema:Person
    525 sg:person.0666452416.76 schema:affiliation https://www.grid.ac/institutes/grid.417106.5
    526 schema:familyName Komori
    527 schema:givenName Takashi
    528 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666452416.76
    529 rdf:type schema:Person
    530 sg:person.0672402714.78 schema:affiliation https://www.grid.ac/institutes/grid.416948.6
    531 schema:familyName Sakamoto
    532 schema:givenName Hiroaki
    533 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672402714.78
    534 rdf:type schema:Person
    535 sg:person.0735131615.03 schema:affiliation https://www.grid.ac/institutes/grid.412857.d
    536 schema:familyName Fukai
    537 schema:givenName Junya
    538 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735131615.03
    539 rdf:type schema:Person
    540 sg:person.0751061011.67 schema:affiliation https://www.grid.ac/institutes/grid.412377.4
    541 schema:familyName Suzuki
    542 schema:givenName Tomonari
    543 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751061011.67
    544 rdf:type schema:Person
    545 sg:person.0754605727.98 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
    546 schema:familyName Matsushita
    547 schema:givenName Yuko
    548 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754605727.98
    549 rdf:type schema:Person
    550 sg:person.0767232053.04 schema:affiliation https://www.grid.ac/institutes/grid.258622.9
    551 schema:familyName Izumoto
    552 schema:givenName Shuichi
    553 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767232053.04
    554 rdf:type schema:Person
    555 sg:person.0770104765.70 schema:affiliation https://www.grid.ac/institutes/grid.412305.1
    556 schema:familyName Shibui
    557 schema:givenName Soichiro
    558 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770104765.70
    559 rdf:type schema:Person
    560 sg:person.0773376355.83 schema:affiliation https://www.grid.ac/institutes/grid.411898.d
    561 schema:familyName Yamaoka
    562 schema:givenName Masayoshi
    563 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773376355.83
    564 rdf:type schema:Person
    565 sg:pub.10.1007/s00401-013-1124-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009865592
    566 https://doi.org/10.1007/s00401-013-1124-7
    567 rdf:type schema:CreativeWork
    568 sg:pub.10.1007/s00401-013-1141-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014782324
    569 https://doi.org/10.1007/s00401-013-1141-6
    570 rdf:type schema:CreativeWork
    571 sg:pub.10.1007/s00401-013-1203-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010767954
    572 https://doi.org/10.1007/s00401-013-1203-9
    573 rdf:type schema:CreativeWork
    574 sg:pub.10.1007/s00401-017-1752-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090852536
    575 https://doi.org/10.1007/s00401-017-1752-4
    576 rdf:type schema:CreativeWork
    577 sg:pub.10.1007/s00401-018-1877-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104694272
    578 https://doi.org/10.1007/s00401-018-1877-0
    579 rdf:type schema:CreativeWork
    580 sg:pub.10.1007/s00401-018-1888-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1105640943
    581 https://doi.org/10.1007/s00401-018-1888-x
    582 rdf:type schema:CreativeWork
    583 sg:pub.10.1007/s10014-014-0186-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000403235
    584 https://doi.org/10.1007/s10014-014-0186-0
    585 rdf:type schema:CreativeWork
    586 sg:pub.10.1007/s10120-015-0475-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049852602
    587 https://doi.org/10.1007/s10120-015-0475-2
    588 rdf:type schema:CreativeWork
    589 sg:pub.10.1007/s11060-013-1111-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043407748
    590 https://doi.org/10.1007/s11060-013-1111-9
    591 rdf:type schema:CreativeWork
    592 sg:pub.10.1038/modpathol.3800999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031794503
    593 https://doi.org/10.1038/modpathol.3800999
    594 rdf:type schema:CreativeWork
    595 sg:pub.10.1038/nature10866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010733927
    596 https://doi.org/10.1038/nature10866
    597 rdf:type schema:CreativeWork
    598 sg:pub.10.1038/nature13108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004871541
    599 https://doi.org/10.1038/nature13108
    600 rdf:type schema:CreativeWork
    601 sg:pub.10.1038/nature13109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050781394
    602 https://doi.org/10.1038/nature13109
    603 rdf:type schema:CreativeWork
    604 sg:pub.10.1038/nature26000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101533700
    605 https://doi.org/10.1038/nature26000
    606 rdf:type schema:CreativeWork
    607 sg:pub.10.1038/ng.3338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000731655
    608 https://doi.org/10.1038/ng.3338
    609 rdf:type schema:CreativeWork
    610 sg:pub.10.1186/1477-5751-10-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038490809
    611 https://doi.org/10.1186/1477-5751-10-7
    612 rdf:type schema:CreativeWork
    613 sg:pub.10.1186/gb-2011-12-8-r72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006381787
    614 https://doi.org/10.1186/gb-2011-12-8-r72
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1002/cncr.29198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004618223
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1002/gcc.22400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042862319
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1016/j.canlet.2012.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025274147
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1016/j.ccell.2015.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034457047
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1016/j.ccr.2011.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002356005
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1016/j.cell.2016.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024874051
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1016/j.semcancer.2017.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092692329
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1016/s0360-3016(01)02801-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040090178
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1016/s1470-2045(13)70110-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046947199
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1074/jbc.m700246200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000058259
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1093/neuonc/nos213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045678994
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1093/neuonc/nos245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009264853
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1093/neuonc/now025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059935190
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1093/neuonc/nox027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083933773
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1111/bpa.12050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026136199
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1158/1078-0432.ccr-11-2489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037759400
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1200/jco.2005.04.2127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043955660
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1200/jco.2009.27.3359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003598231
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1200/jco.2015.65.7825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204509
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.3892/ijo.2012.1564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071512865
    655 rdf:type schema:CreativeWork
    656 https://www.grid.ac/institutes/grid.136593.b schema:alternateName Osaka University
    657 schema:name Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan
    658 rdf:type schema:Organization
    659 https://www.grid.ac/institutes/grid.256115.4 schema:alternateName Fujita Health University
    660 schema:name Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan
    661 rdf:type schema:Organization
    662 https://www.grid.ac/institutes/grid.258269.2 schema:alternateName Juntendo University
    663 schema:name Department of Neurosurgery, Juntendo University, Tokyo, Japan
    664 rdf:type schema:Organization
    665 https://www.grid.ac/institutes/grid.258622.9 schema:alternateName Kindai University
    666 schema:name Department of Neurosurgery, Faculty of Medicine, Kinki University, Osaka, Japan
    667 rdf:type schema:Organization
    668 https://www.grid.ac/institutes/grid.261356.5 schema:alternateName Okayama University
    669 schema:name Department of Neurological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
    670 rdf:type schema:Organization
    671 https://www.grid.ac/institutes/grid.268441.d schema:alternateName Yokohama City University
    672 schema:name Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Fukuura, Kanagawa, Japan
    673 Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    674 rdf:type schema:Organization
    675 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
    676 schema:name Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    677 Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    678 rdf:type schema:Organization
    679 https://www.grid.ac/institutes/grid.271052.3 schema:alternateName University of Occupational and Environmental Health Japan
    680 schema:name Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    681 rdf:type schema:Organization
    682 https://www.grid.ac/institutes/grid.272242.3 schema:alternateName National Cancer Centre
    683 schema:name Department of Bioinformatics, National Cancer Center Research Institute, Tokyo, Japan
    684 Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan
    685 Department of Neurosurgery and Neurooncology, National Cancer Center Hospital, Tokyo, Japan
    686 Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    687 Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    688 Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan
    689 Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan
    690 rdf:type schema:Organization
    691 https://www.grid.ac/institutes/grid.274841.c schema:alternateName Kumamoto University
    692 schema:name Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University Graduate School, Kumamoto, Japan
    693 rdf:type schema:Organization
    694 https://www.grid.ac/institutes/grid.410714.7 schema:alternateName Showa University
    695 schema:name Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan
    696 rdf:type schema:Organization
    697 https://www.grid.ac/institutes/grid.410781.b schema:alternateName Kurume University
    698 schema:name Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
    699 Department of Neurosurgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    700 Department of Pathology, Kurume University, Kurume, Fukuoka, Japan
    701 rdf:type schema:Organization
    702 https://www.grid.ac/institutes/grid.410783.9 schema:alternateName Kansai Medical University
    703 schema:name Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka, Japan
    704 rdf:type schema:Organization
    705 https://www.grid.ac/institutes/grid.410802.f schema:alternateName Saitama Medical University
    706 schema:name Department of Pathology, Saitama Medical University, Saitama, Japan
    707 rdf:type schema:Organization
    708 https://www.grid.ac/institutes/grid.411205.3 schema:alternateName Kyorin University
    709 schema:name Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan
    710 rdf:type schema:Organization
    711 https://www.grid.ac/institutes/grid.411887.3 schema:alternateName Gunma University Hospital
    712 schema:name Department of Pathology, Gunma University Hospital, Maebashi, Gunma, Japan
    713 rdf:type schema:Organization
    714 https://www.grid.ac/institutes/grid.411898.d schema:alternateName Jikei University
    715 schema:name Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan
    716 rdf:type schema:Organization
    717 https://www.grid.ac/institutes/grid.412305.1 schema:alternateName Teikyo University Hospital
    718 schema:name Department of Neurosurgery, Teikyo University Hospital, Mizonokuchi, Kanagawa, Japan
    719 rdf:type schema:Organization
    720 https://www.grid.ac/institutes/grid.412377.4 schema:alternateName Saitama International Medical Center
    721 schema:name Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan
    722 Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    723 rdf:type schema:Organization
    724 https://www.grid.ac/institutes/grid.412857.d schema:alternateName Wakayama Medical University
    725 schema:name Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan
    726 rdf:type schema:Organization
    727 https://www.grid.ac/institutes/grid.415392.8 schema:alternateName Kitano Hospital
    728 schema:name Department of Neurosurgery, Tazuke Kofukai Foundation, Medical Research Institute and Kitano Hospital, Osaka, Japan
    729 rdf:type schema:Organization
    730 https://www.grid.ac/institutes/grid.415413.6 schema:alternateName Kobe Children's Hospital
    731 schema:name Department of Neurosurgery, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Hyogo, Japan
    732 Department of Pathology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Hyogo, Japan
    733 rdf:type schema:Organization
    734 https://www.grid.ac/institutes/grid.415798.6 schema:alternateName Shizuoka Children's Hospital
    735 schema:name Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka, Japan
    736 rdf:type schema:Organization
    737 https://www.grid.ac/institutes/grid.416376.1 schema:alternateName Nagano Children's Hospital
    738 schema:name Department of Neurosurgery, Nagano Children’s Hospital, Nagano, Japan
    739 rdf:type schema:Organization
    740 https://www.grid.ac/institutes/grid.416803.8 schema:alternateName Osaka National Hospital
    741 schema:name Department of Biomedical Research and Innovation, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization|, Osaka, Japan
    742 Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka, Japan
    743 Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    744 Department of Pathology, Osaka National Hospital, National Hospital Organization, Osaka, Japan
    745 rdf:type schema:Organization
    746 https://www.grid.ac/institutes/grid.416862.f schema:alternateName Takatsuki General Hospital
    747 schema:name Department of Pediatric Neurosurgery, Takatsuki General Hospital, Takatsuki, Osaka, Japan
    748 rdf:type schema:Organization
    749 https://www.grid.ac/institutes/grid.416948.6 schema:alternateName Osaka City General Hospital
    750 schema:name Department of Pediatric Hematology and Oncology, Osaka City General Hospital, Osaka, Japan
    751 Department of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan
    752 Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    753 rdf:type schema:Organization
    754 https://www.grid.ac/institutes/grid.417106.5 schema:alternateName Tokyo Metropolitan Neurological Hospital
    755 schema:name Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
    756 rdf:type schema:Organization
    757 https://www.grid.ac/institutes/grid.417755.5 schema:alternateName Hyogo Prefectural Cancer Center
    758 schema:name Department of Diagnostic Pathology, Hyogo Cancer Center, Kobe, Hyogo, Japan
    759 rdf:type schema:Organization
    760 https://www.grid.ac/institutes/grid.42327.30 schema:alternateName Hospital for Sick Children
    761 schema:name Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
    762 Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada
    763 rdf:type schema:Organization
    764 https://www.grid.ac/institutes/grid.452851.f schema:alternateName Toyama University Hospital
    765 schema:name Department of Neurosurgery, Kanazawa Medical University, Kanazawa, Japan
    766 Department of Neurosurgery, Toyama University Hospital, Toyama, Japan
    767 rdf:type schema:Organization
    768 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
    769 schema:name Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    770 Department of Neurosurgery, Yamagata University School of Medicine, Yamagata, Japan
    771 rdf:type schema:Organization
    772 https://www.grid.ac/institutes/grid.9707.9 schema:alternateName Kanazawa University
    773 schema:name Department of Neurosurgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
    774 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...