Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Jérôme Chapuis, Mohammed Moudjou, Fabienne Reine, Laetitia Herzog, Emilie Jaumain, Céline Chapuis, Isabelle Quadrio, Jacques Boulliat, Armand Perret-Liaudet, Michel Dron, Hubert Laude, Human Rezaei, Vincent Béringue

ABSTRACT

INTRODUCTION: Mammalian prions are proteinaceous pathogens responsible for a broad range of fatal neurodegenerative diseases in humans and animals. These diseases can occur spontaneously, such as Creutzfeldt-Jakob disease (CJD) in humans, or be acquired or inherited. Prions are primarily formed of macromolecular assemblies of the disease-associated prion protein PrP(Sc), a misfolded isoform of the host-encoded prion protein PrP(C). Within defined host-species, prions can exist as conformational variants or strains. Based on both the M/V polymorphism at codon 129 of PrP and the electrophoretic signature of PrP(Sc) in the brain, sporadic CJD is classified in different subtypes, which may encode different strains. A transmission barrier, the mechanism of which remains unknown, limits prion cross-species propagation. To adapt to the new host, prions have the capacity to 'mutate' conformationally, leading to the emergence of a variant with new biological properties. Here, we transmitted experimentally one rare subtype of human CJD, designated cortical MM2 (129 MM with type 2 PrP(Sc)), to transgenic mice overexpressing either human or the VRQ allele of ovine PrP(C). RESULTS: In marked contrast with the reported absence of transmission to knock-in mice expressing physiological levels of human PrP, this subtype transmitted faithfully to mice overexpressing human PrP, and exhibited unique strain features. Onto the ovine PrP sequence, the cortical MM2 subtype abruptly evolved on second passage, thereby allowing emergence of a pair of strain variants with distinct PrP(Sc) biochemical characteristics and differing tropism for the central and lymphoid tissues. These two strain components exhibited remarkably distinct replicative properties in cell-free amplification assay, allowing the 'physical' cloning of the minor, lymphotropic component, and subsequent isolation in ovine PrP mice and RK13 cells. CONCLUSIONS: Here, we provide in-depth assessment of the transmissibility and evolution of one rare subtype of sporadic CJD upon homologous and heterologous transmission. The notion that the environment or matrix where replication is occurring is key to the selection and preferential amplification of prion substrain components raises new questions on the determinants of prion replication within and between species. These data also further interrogate on the interplay between animal and human prions. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40478-016-0284-9

DOI

http://dx.doi.org/10.1186/s40478-016-0284-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012571478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26847207


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Transformed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Creutzfeldt-Jakob Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Folding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sheep", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spleen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chapuis", 
        "givenName": "J\u00e9r\u00f4me", 
        "id": "sg:person.01235452335.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235452335.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moudjou", 
        "givenName": "Mohammed", 
        "id": "sg:person.01315157731.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315157731.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reine", 
        "givenName": "Fabienne", 
        "id": "sg:person.0726502407.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726502407.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herzog", 
        "givenName": "Laetitia", 
        "id": "sg:person.0760125155.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760125155.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jaumain", 
        "givenName": "Emilie", 
        "id": "sg:person.01337777323.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337777323.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chapuis", 
        "givenName": "C\u00e9line", 
        "id": "sg:person.0736075727.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736075727.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lyon Neuroscience Research Center", 
          "id": "https://www.grid.ac/institutes/grid.461862.f", 
          "name": [
            "Neurobiology Laboratory, Biochemistry and Molecular Biology Department, H\u00f4pitaux de Lyon, Lyon, France", 
            "University of Lyon 1, CNRS UMR5292, INSERM U1028, BioRan, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quadrio", 
        "givenName": "Isabelle", 
        "id": "sg:person.01274331655.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274331655.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Neurology Department, Centre Hospitalo-Universitaire, Bourg en Bresse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boulliat", 
        "givenName": "Jacques", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lyon Neuroscience Research Center", 
          "id": "https://www.grid.ac/institutes/grid.461862.f", 
          "name": [
            "Neurobiology Laboratory, Biochemistry and Molecular Biology Department, H\u00f4pitaux de Lyon, Lyon, France", 
            "University of Lyon 1, CNRS UMR5292, INSERM U1028, BioRan, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perret-Liaudet", 
        "givenName": "Armand", 
        "id": "sg:person.01371355100.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371355100.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dron", 
        "givenName": "Michel", 
        "id": "sg:person.0642211573.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642211573.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laude", 
        "givenName": "Hubert", 
        "id": "sg:person.01010636435.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010636435.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rezaei", 
        "givenName": "Human", 
        "id": "sg:person.01122076506.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122076506.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Mol\u00e9culaires, F-78350, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e9ringue", 
        "givenName": "Vincent", 
        "id": "sg:person.01271513565.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271513565.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1531-8249(199908)46:2<224::aid-ana12>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000020394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awp196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001056335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bmb/66.1.255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003665731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m407006200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004564118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2012.00572.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004770478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.18.10248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006395623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006621160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35081095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007025374", 
          "https://doi.org/10.1038/35081095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35081095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007025374", 
          "https://doi.org/10.1038/35081095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35081095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007025374", 
          "https://doi.org/10.1038/35081095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.00829-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007459728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01855-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008410898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1013014108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008846397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0368-1742(61)80013-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009986609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410110406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011612357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01118-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012663005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014193079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0693-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015672362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016387498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.198465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016740510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018058270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019868700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00243-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023969691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024268166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.1994.0036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025248911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/embor.2011.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027657846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.13.5977-5984.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029475102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.041490898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030850580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1004688107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032870732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.061337998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035021747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-6148-2-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035095535", 
          "https://doi.org/10.1186/1746-6148-2-19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035750714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035750714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-1-74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035846648", 
          "https://doi.org/10.1186/2051-5960-1-74"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bmb/66.1.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035861295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037079750", 
          "https://doi.org/10.1038/39057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037079750", 
          "https://doi.org/10.1038/39057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1138718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038670498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2010.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038728253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1001285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039446344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awg125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041381633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2011.09.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042451812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042856736", 
          "https://doi.org/10.1038/ncomms6821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410350504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044321395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046826220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/embor.2011.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047380503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.78.082907.145410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047949038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(05)70225-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049384747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(05)70225-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049384747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.24.1.519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049805862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0502296102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050394401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0502296102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050394401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.23.13363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050742662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1812.120342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051282321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep11573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051294499", 
          "https://doi.org/10.1038/srep11573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1412.080941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053448160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1051/vetres:2008024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057072359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-70-8-2017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060357233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.83344-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060401660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1183218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062461322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1187107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062461574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1187107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062461574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1215659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062465772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.9.2173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.9.2173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.9.2173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075768844", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080722638", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0034-5288(18)34525-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080722638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0034-5288(18)34525-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080722638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.bmb.a072649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082668179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083020924", 
          "https://doi.org/10.1007/bf03401656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083173514", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "INTRODUCTION: Mammalian prions are proteinaceous pathogens responsible for a broad range of fatal neurodegenerative diseases in humans and animals. These diseases can occur spontaneously, such as Creutzfeldt-Jakob disease (CJD) in humans, or be acquired or inherited. Prions are primarily formed of macromolecular assemblies of the disease-associated prion protein PrP(Sc), a misfolded isoform of the host-encoded prion protein PrP(C). Within defined host-species, prions can exist as conformational variants or strains. Based on both the M/V polymorphism at codon 129 of PrP and the electrophoretic signature of PrP(Sc) in the brain, sporadic CJD is classified in different subtypes, which may encode different strains. A transmission barrier, the mechanism of which remains unknown, limits prion cross-species propagation. To adapt to the new host, prions have the capacity to 'mutate' conformationally, leading to the emergence of a variant with new biological properties. Here, we transmitted experimentally one rare subtype of human CJD, designated cortical MM2\u00a0(129 MM with type 2 PrP(Sc)), to transgenic mice overexpressing either human or the VRQ allele of ovine PrP(C).\nRESULTS: In marked contrast with the reported absence of transmission to knock-in mice expressing physiological levels of human PrP, this subtype transmitted faithfully to mice overexpressing human PrP, and exhibited unique strain features. Onto the ovine PrP sequence, the cortical MM2 subtype abruptly evolved on second passage, thereby allowing emergence of a pair of strain variants with distinct PrP(Sc) biochemical characteristics and differing tropism for the central and lymphoid tissues. These two strain components exhibited remarkably distinct replicative properties in cell-free amplification assay, allowing the 'physical' cloning of the minor, lymphotropic component, and subsequent isolation in ovine PrP mice and RK13 cells.\nCONCLUSIONS: Here, we provide in-depth assessment of the transmissibility and evolution of one rare subtype of sporadic CJD upon homologous and heterologous transmission. The notion that the environment or matrix where replication is occurring is key to the selection and preferential amplification of prion substrain components raises new questions on the determinants of prion replication within and between species. These data also further interrogate on the interplay between animal and human prions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40478-016-0284-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1048594", 
        "issn": [
          "2051-5960"
        ], 
        "name": "Acta Neuropathologica Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions", 
    "pagination": "10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3be49735089f5724bcd92db26fa29e30e41ac1c347fbb363ac7d14f6919281ed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26847207"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101610673"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40478-016-0284-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012571478"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40478-016-0284-9", 
      "https://app.dimensions.ai/details/publication/pub.1012571478"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89789_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40478-016-0284-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40478-016-0284-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40478-016-0284-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40478-016-0284-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40478-016-0284-9'


 

This table displays all metadata directly associated to this object as RDF triples.

422 TRIPLES      21 PREDICATES      110 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40478-016-0284-9 schema:about N1b26e4b066184eefa1a99bdf8c3837cb
2 N2bc0e3b88e424c2bb0d654c3534d04cd
3 N2bed66010af5444ca73d84fe69e08283
4 N5d9d23203b6743d28a7553c9de60e9f5
5 N67e06bde911d4628b32164d5b0ceef30
6 N6c3fe0acdd77428a978b45faa7545368
7 N7b88095789b94edab3f06c76285bf3ef
8 N7c2e9592dc584519af1576b58ce7f0f4
9 N7e3678ac5de140c780a18e9f1a4516fe
10 N86e82a724b774bb4ba58655bc9ed59cb
11 N9d8855bbd9da41f1953e5b50bbf22171
12 Na632c09514954332b3c9bab3f2b0a074
13 Nba0ba9e43345433092512989778d620b
14 Nc0a3ab7d0cf2448da1d84e583013e5b3
15 Nc763c194bd6e4b928533e9991b9ae41b
16 Ne950641b54bf4eb3b21622667fe4620a
17 Nf93b6d0a06024e3ea478d93a7d7f458f
18 Nfea5e10ca22b479bbe8e7d15918a7876
19 anzsrc-for:11
20 anzsrc-for:1108
21 schema:author Nef8525abf13e47d59203cf749bd26b33
22 schema:citation sg:pub.10.1007/bf03401656
23 sg:pub.10.1038/35081095
24 sg:pub.10.1038/39057
25 sg:pub.10.1038/ncomms6821
26 sg:pub.10.1038/srep11573
27 sg:pub.10.1186/1746-6148-2-19
28 sg:pub.10.1186/2051-5960-1-74
29 https://app.dimensions.ai/details/publication/pub.1075768844
30 https://app.dimensions.ai/details/publication/pub.1080722638
31 https://app.dimensions.ai/details/publication/pub.1083173514
32 https://doi.org/10.1002/1531-8249(199908)46:2<224::aid-ana12>3.0.co;2-w
33 https://doi.org/10.1002/ana.410110406
34 https://doi.org/10.1002/ana.410350504
35 https://doi.org/10.1016/j.cell.2008.07.030
36 https://doi.org/10.1016/j.nbd.2010.09.010
37 https://doi.org/10.1016/j.virusres.2011.09.018
38 https://doi.org/10.1016/s0034-5288(18)34525-9
39 https://doi.org/10.1016/s0368-1742(61)80013-1
40 https://doi.org/10.1016/s1474-4422(05)70225-8
41 https://doi.org/10.1038/embor.2011.191
42 https://doi.org/10.1038/embor.2011.192
43 https://doi.org/10.1051/vetres:2008024
44 https://doi.org/10.1073/pnas.041490898
45 https://doi.org/10.1073/pnas.0502296102
46 https://doi.org/10.1073/pnas.061337998
47 https://doi.org/10.1073/pnas.1004688107
48 https://doi.org/10.1073/pnas.1013014108
49 https://doi.org/10.1073/pnas.95.23.13363
50 https://doi.org/10.1073/pnas.97.18.10248
51 https://doi.org/10.1074/jbc.m110.198465
52 https://doi.org/10.1074/jbc.m407006200
53 https://doi.org/10.1093/bmb/66.1.255
54 https://doi.org/10.1093/bmb/66.1.99
55 https://doi.org/10.1093/brain/awg125
56 https://doi.org/10.1093/brain/awp196
57 https://doi.org/10.1093/oxfordjournals.bmb.a072649
58 https://doi.org/10.1098/rstb.1994.0036
59 https://doi.org/10.1099/0022-1317-70-8-2017
60 https://doi.org/10.1099/vir.0.83344-0
61 https://doi.org/10.1111/j.1750-3639.2012.00572.x
62 https://doi.org/10.1126/science.1138718
63 https://doi.org/10.1126/science.1183218
64 https://doi.org/10.1126/science.1187107
65 https://doi.org/10.1126/science.1215659
66 https://doi.org/10.1128/jvi.00243-10
67 https://doi.org/10.1128/jvi.01118-14
68 https://doi.org/10.1128/jvi.01855-09
69 https://doi.org/10.1128/jvi.75.13.5977-5984.2001
70 https://doi.org/10.1128/mbio.00829-13
71 https://doi.org/10.1146/annurev.biochem.78.082907.145410
72 https://doi.org/10.1146/annurev.neuro.24.1.519
73 https://doi.org/10.1212/wnl.53.9.2173
74 https://doi.org/10.1371/journal.pmed.0030014
75 https://doi.org/10.1371/journal.pone.0001419
76 https://doi.org/10.1371/journal.ppat.1000029
77 https://doi.org/10.1371/journal.ppat.1000139
78 https://doi.org/10.1371/journal.ppat.1000859
79 https://doi.org/10.1371/journal.ppat.1001285
80 https://doi.org/10.1371/journal.ppat.1002582
81 https://doi.org/10.1371/journal.ppat.1003702
82 https://doi.org/10.1523/jneurosci.0693-07.2007
83 https://doi.org/10.3201/eid1412.080941
84 https://doi.org/10.3201/eid1812.120342
85 schema:datePublished 2016-12
86 schema:datePublishedReg 2016-12-01
87 schema:description INTRODUCTION: Mammalian prions are proteinaceous pathogens responsible for a broad range of fatal neurodegenerative diseases in humans and animals. These diseases can occur spontaneously, such as Creutzfeldt-Jakob disease (CJD) in humans, or be acquired or inherited. Prions are primarily formed of macromolecular assemblies of the disease-associated prion protein PrP(Sc), a misfolded isoform of the host-encoded prion protein PrP(C). Within defined host-species, prions can exist as conformational variants or strains. Based on both the M/V polymorphism at codon 129 of PrP and the electrophoretic signature of PrP(Sc) in the brain, sporadic CJD is classified in different subtypes, which may encode different strains. A transmission barrier, the mechanism of which remains unknown, limits prion cross-species propagation. To adapt to the new host, prions have the capacity to 'mutate' conformationally, leading to the emergence of a variant with new biological properties. Here, we transmitted experimentally one rare subtype of human CJD, designated cortical MM2 (129 MM with type 2 PrP(Sc)), to transgenic mice overexpressing either human or the VRQ allele of ovine PrP(C). RESULTS: In marked contrast with the reported absence of transmission to knock-in mice expressing physiological levels of human PrP, this subtype transmitted faithfully to mice overexpressing human PrP, and exhibited unique strain features. Onto the ovine PrP sequence, the cortical MM2 subtype abruptly evolved on second passage, thereby allowing emergence of a pair of strain variants with distinct PrP(Sc) biochemical characteristics and differing tropism for the central and lymphoid tissues. These two strain components exhibited remarkably distinct replicative properties in cell-free amplification assay, allowing the 'physical' cloning of the minor, lymphotropic component, and subsequent isolation in ovine PrP mice and RK13 cells. CONCLUSIONS: Here, we provide in-depth assessment of the transmissibility and evolution of one rare subtype of sporadic CJD upon homologous and heterologous transmission. The notion that the environment or matrix where replication is occurring is key to the selection and preferential amplification of prion substrain components raises new questions on the determinants of prion replication within and between species. These data also further interrogate on the interplay between animal and human prions.
88 schema:genre research_article
89 schema:inLanguage en
90 schema:isAccessibleForFree true
91 schema:isPartOf N8fbe5aac180f4037a94ec2cbe6e1f323
92 Ne6c953d54803471b82abd88ad49f069a
93 sg:journal.1048594
94 schema:name Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions
95 schema:pagination 10
96 schema:productId N2572950353c8452fa8376dcbe1ce6f72
97 N314928a803e449fb9c016a506fa65df4
98 N4739d9cb5b0f40afae02a62a7abf8414
99 N6f152a7a1eef429793090a60fa065a3c
100 N96c612c7d2a24e0396e7f38b36789fc7
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012571478
102 https://doi.org/10.1186/s40478-016-0284-9
103 schema:sdDatePublished 2019-04-11T09:51
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher Nc07b67e6c11f4f718f5a68aabea41d67
106 schema:url https://link.springer.com/10.1186%2Fs40478-016-0284-9
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N0844a24b3ac24536880327756edf069c schema:affiliation Ncd8db85854e44d0e8ce1395f4a574b4c
111 schema:familyName Boulliat
112 schema:givenName Jacques
113 rdf:type schema:Person
114 N0f4a724a4a324945968a619492cdb9e0 rdf:first sg:person.01315157731.24
115 rdf:rest N368c92b62d144d93adffa760bf12e0b4
116 N119ee3c1bdae415b8a603f223384017f rdf:first sg:person.01122076506.03
117 rdf:rest Ndb05a13c3eed471ca9144ba23381cbf9
118 N1995275e236845ffa059d5149d476eb7 rdf:first sg:person.0760125155.14
119 rdf:rest Nc20531e18efa499999ed776a93d0a1ee
120 N1b26e4b066184eefa1a99bdf8c3837cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Disease Models, Animal
122 rdf:type schema:DefinedTerm
123 N2572950353c8452fa8376dcbe1ce6f72 schema:name nlm_unique_id
124 schema:value 101610673
125 rdf:type schema:PropertyValue
126 N2bc0e3b88e424c2bb0d654c3534d04cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 N2bed66010af5444ca73d84fe69e08283 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice, Transgenic
131 rdf:type schema:DefinedTerm
132 N2e0cb8c9bbe546f29bc1297a686f63e4 rdf:first N0844a24b3ac24536880327756edf069c
133 rdf:rest Nca2eb11c9187487593f4d6038367ad1a
134 N314928a803e449fb9c016a506fa65df4 schema:name readcube_id
135 schema:value 3be49735089f5724bcd92db26fa29e30e41ac1c347fbb363ac7d14f6919281ed
136 rdf:type schema:PropertyValue
137 N368c92b62d144d93adffa760bf12e0b4 rdf:first sg:person.0726502407.48
138 rdf:rest N1995275e236845ffa059d5149d476eb7
139 N39d49072b6e9494a93a024c14aa3eb73 rdf:first sg:person.0736075727.96
140 rdf:rest Nfe898a0d9cfb4d3eaa1e5220e2819a88
141 N4739d9cb5b0f40afae02a62a7abf8414 schema:name pubmed_id
142 schema:value 26847207
143 rdf:type schema:PropertyValue
144 N50a6deb23d69492dab468b7f005a3161 rdf:first sg:person.01010636435.20
145 rdf:rest N119ee3c1bdae415b8a603f223384017f
146 N5d9d23203b6743d28a7553c9de60e9f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 N67e06bde911d4628b32164d5b0ceef30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Prions
151 rdf:type schema:DefinedTerm
152 N6c3fe0acdd77428a978b45faa7545368 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Polymorphism, Genetic
154 rdf:type schema:DefinedTerm
155 N6f152a7a1eef429793090a60fa065a3c schema:name dimensions_id
156 schema:value pub.1012571478
157 rdf:type schema:PropertyValue
158 N7b88095789b94edab3f06c76285bf3ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Male
160 rdf:type schema:DefinedTerm
161 N7c2e9592dc584519af1576b58ce7f0f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Swine
163 rdf:type schema:DefinedTerm
164 N7e3678ac5de140c780a18e9f1a4516fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cell Line, Transformed
166 rdf:type schema:DefinedTerm
167 N86e82a724b774bb4ba58655bc9ed59cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Protein Folding
169 rdf:type schema:DefinedTerm
170 N8fbe5aac180f4037a94ec2cbe6e1f323 schema:volumeNumber 4
171 rdf:type schema:PublicationVolume
172 N96c612c7d2a24e0396e7f38b36789fc7 schema:name doi
173 schema:value 10.1186/s40478-016-0284-9
174 rdf:type schema:PropertyValue
175 N9d8855bbd9da41f1953e5b50bbf22171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Mice
177 rdf:type schema:DefinedTerm
178 Na366b0e2d97d49278e42f9f56d018df6 rdf:first sg:person.0642211573.79
179 rdf:rest N50a6deb23d69492dab468b7f005a3161
180 Na632c09514954332b3c9bab3f2b0a074 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Sheep
182 rdf:type schema:DefinedTerm
183 Nba0ba9e43345433092512989778d620b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Transfection
185 rdf:type schema:DefinedTerm
186 Nc07b67e6c11f4f718f5a68aabea41d67 schema:name Springer Nature - SN SciGraph project
187 rdf:type schema:Organization
188 Nc0a3ab7d0cf2448da1d84e583013e5b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Spleen
190 rdf:type schema:DefinedTerm
191 Nc20531e18efa499999ed776a93d0a1ee rdf:first sg:person.01337777323.65
192 rdf:rest N39d49072b6e9494a93a024c14aa3eb73
193 Nc763c194bd6e4b928533e9991b9ae41b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Gene Expression Regulation
195 rdf:type schema:DefinedTerm
196 Nca2eb11c9187487593f4d6038367ad1a rdf:first sg:person.01371355100.80
197 rdf:rest Na366b0e2d97d49278e42f9f56d018df6
198 Ncd8db85854e44d0e8ce1395f4a574b4c schema:name Neurology Department, Centre Hospitalo-Universitaire, Bourg en Bresse, France
199 rdf:type schema:Organization
200 Ndb05a13c3eed471ca9144ba23381cbf9 rdf:first sg:person.01271513565.84
201 rdf:rest rdf:nil
202 Ne6c953d54803471b82abd88ad49f069a schema:issueNumber 1
203 rdf:type schema:PublicationIssue
204 Ne950641b54bf4eb3b21622667fe4620a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Humans
206 rdf:type schema:DefinedTerm
207 Nef8525abf13e47d59203cf749bd26b33 rdf:first sg:person.01235452335.80
208 rdf:rest N0f4a724a4a324945968a619492cdb9e0
209 Nf93b6d0a06024e3ea478d93a7d7f458f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Creutzfeldt-Jakob Syndrome
211 rdf:type schema:DefinedTerm
212 Nfe898a0d9cfb4d3eaa1e5220e2819a88 rdf:first sg:person.01274331655.24
213 rdf:rest N2e0cb8c9bbe546f29bc1297a686f63e4
214 Nfea5e10ca22b479bbe8e7d15918a7876 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Cerebral Cortex
216 rdf:type schema:DefinedTerm
217 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
218 schema:name Medical and Health Sciences
219 rdf:type schema:DefinedTerm
220 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
221 schema:name Medical Microbiology
222 rdf:type schema:DefinedTerm
223 sg:journal.1048594 schema:issn 2051-5960
224 schema:name Acta Neuropathologica Communications
225 rdf:type schema:Periodical
226 sg:person.01010636435.20 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
227 schema:familyName Laude
228 schema:givenName Hubert
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010636435.20
230 rdf:type schema:Person
231 sg:person.01122076506.03 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
232 schema:familyName Rezaei
233 schema:givenName Human
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122076506.03
235 rdf:type schema:Person
236 sg:person.01235452335.80 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
237 schema:familyName Chapuis
238 schema:givenName Jérôme
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235452335.80
240 rdf:type schema:Person
241 sg:person.01271513565.84 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
242 schema:familyName Béringue
243 schema:givenName Vincent
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271513565.84
245 rdf:type schema:Person
246 sg:person.01274331655.24 schema:affiliation https://www.grid.ac/institutes/grid.461862.f
247 schema:familyName Quadrio
248 schema:givenName Isabelle
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274331655.24
250 rdf:type schema:Person
251 sg:person.01315157731.24 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
252 schema:familyName Moudjou
253 schema:givenName Mohammed
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315157731.24
255 rdf:type schema:Person
256 sg:person.01337777323.65 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
257 schema:familyName Jaumain
258 schema:givenName Emilie
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337777323.65
260 rdf:type schema:Person
261 sg:person.01371355100.80 schema:affiliation https://www.grid.ac/institutes/grid.461862.f
262 schema:familyName Perret-Liaudet
263 schema:givenName Armand
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371355100.80
265 rdf:type schema:Person
266 sg:person.0642211573.79 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
267 schema:familyName Dron
268 schema:givenName Michel
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642211573.79
270 rdf:type schema:Person
271 sg:person.0726502407.48 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
272 schema:familyName Reine
273 schema:givenName Fabienne
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726502407.48
275 rdf:type schema:Person
276 sg:person.0736075727.96 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
277 schema:familyName Chapuis
278 schema:givenName Céline
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736075727.96
280 rdf:type schema:Person
281 sg:person.0760125155.14 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
282 schema:familyName Herzog
283 schema:givenName Laetitia
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760125155.14
285 rdf:type schema:Person
286 sg:pub.10.1007/bf03401656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083020924
287 https://doi.org/10.1007/bf03401656
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/35081095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007025374
290 https://doi.org/10.1038/35081095
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/39057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037079750
293 https://doi.org/10.1038/39057
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/ncomms6821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042856736
296 https://doi.org/10.1038/ncomms6821
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/srep11573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051294499
299 https://doi.org/10.1038/srep11573
300 rdf:type schema:CreativeWork
301 sg:pub.10.1186/1746-6148-2-19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035095535
302 https://doi.org/10.1186/1746-6148-2-19
303 rdf:type schema:CreativeWork
304 sg:pub.10.1186/2051-5960-1-74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035846648
305 https://doi.org/10.1186/2051-5960-1-74
306 rdf:type schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1075768844 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1080722638 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1083173514 schema:CreativeWork
310 https://doi.org/10.1002/1531-8249(199908)46:2<224::aid-ana12>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1000020394
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/ana.410110406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011612357
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1002/ana.410350504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044321395
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.cell.2008.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019868700
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.nbd.2010.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038728253
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.virusres.2011.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042451812
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s0034-5288(18)34525-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080722638
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0368-1742(61)80013-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009986609
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s1474-4422(05)70225-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049384747
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1038/embor.2011.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047380503
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1038/embor.2011.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027657846
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1051/vetres:2008024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057072359
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1073/pnas.041490898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030850580
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1073/pnas.0502296102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050394401
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1073/pnas.061337998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035021747
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1073/pnas.1004688107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032870732
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1073/pnas.1013014108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008846397
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1073/pnas.95.23.13363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050742662
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1073/pnas.97.18.10248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006395623
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1074/jbc.m110.198465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016740510
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1074/jbc.m407006200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004564118
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1093/bmb/66.1.255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003665731
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1093/bmb/66.1.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035861295
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1093/brain/awg125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041381633
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1093/brain/awp196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001056335
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1093/oxfordjournals.bmb.a072649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082668179
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1098/rstb.1994.0036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025248911
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1099/0022-1317-70-8-2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060357233
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1099/vir.0.83344-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060401660
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1111/j.1750-3639.2012.00572.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004770478
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1126/science.1138718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038670498
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1126/science.1183218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062461322
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1126/science.1187107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062461574
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1126/science.1215659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062465772
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1128/jvi.00243-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023969691
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1128/jvi.01118-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012663005
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1128/jvi.01855-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008410898
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1128/jvi.75.13.5977-5984.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029475102
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1128/mbio.00829-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007459728
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1146/annurev.biochem.78.082907.145410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047949038
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1146/annurev.neuro.24.1.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049805862
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1212/wnl.53.9.2173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064378038
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1371/journal.pmed.0030014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035750714
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1371/journal.pone.0001419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046826220
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1371/journal.ppat.1000029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006621160
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1371/journal.ppat.1000139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024268166
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1371/journal.ppat.1000859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016387498
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1371/journal.ppat.1001285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039446344
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1371/journal.ppat.1002582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018058270
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1371/journal.ppat.1003702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014193079
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1523/jneurosci.0693-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015672362
411 rdf:type schema:CreativeWork
412 https://doi.org/10.3201/eid1412.080941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053448160
413 rdf:type schema:CreativeWork
414 https://doi.org/10.3201/eid1812.120342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051282321
415 rdf:type schema:CreativeWork
416 https://www.grid.ac/institutes/grid.417961.c schema:alternateName Centre de Recherches de Jouy-en-Josas
417 schema:name INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Moléculaires, F-78350, Jouy-en-Josas, France
418 rdf:type schema:Organization
419 https://www.grid.ac/institutes/grid.461862.f schema:alternateName Lyon Neuroscience Research Center
420 schema:name Neurobiology Laboratory, Biochemistry and Molecular Biology Department, Hôpitaux de Lyon, Lyon, France
421 University of Lyon 1, CNRS UMR5292, INSERM U1028, BioRan, Lyon, France
422 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...