Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Kazuhiro Kurosawa, Tatsuro Misu, Yoshiki Takai, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Yoichiro Abe, Hiroko Iwanari, Ryo Ogawa, Ichiro Nakashima, Kazuo Fujihara, Takao Hamakubo, Masato Yasui, Masashi Aoki

ABSTRACT

INTRODUCTION: Neuromyelitis optica (NMO), an autoimmune astrocytopathic disease associated with anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions preferentially involving the optic nerves and spinal cord. However, previous in-vivo experimental models injecting human anti-AQP4 antibodies only resulted in mild spinal cord lesions compared to NMO autopsied cases. Here, we investigated whether the formation of severe NMO-like lesions occurs in Lewis rats in the context of experimental autoimmune encephalomyelitis (EAE), intraperitoneally injecting incremental doses of purified human immunoglobulin-G from a NMO patient (hIgGNMO) or a high affinity anti-AQP4 monoclonal antibody (E5415A), recognizing extracellular domain of AQP4 made by baculovirus display method. RESULTS: NMO-like lesions were observed in the spinal cord, brainstem, and optic chiasm of EAE-rats with injection of pathogenic IgG (hIgGNMO and E5415A), but not in control EAE. Only in higher dose E5415A rats, there were acute and significantly severer clinical exacerbations (tetraparesis or moribund) compared with controls, within half day after the injection of pathogenic IgG. Loss of AQP4 was observed both in EAE rats receiving hIgGNMO and E5415A in a dose dependent manner, but the ratio of AQP4 loss in spinal sections became significantly larger in those receiving high dose E5415A up to about 50 % than those receiving low-dose E5415A or hIgGNMO less than 3 %. These lesions were also characterized by extensive loss of glial fibrillary acidic protein but relatively preserved myelin sheaths with perivascular deposition of IgG and C5b-9, which is compatible with post mortem NMO pathology. In high dose E5415A rats, massive neutrophil infiltration was observed especially at the lesion edge, and such lesions were highly vacuolated with partial demyelination and axonal damage. In contrast, such changes were absent in EAE rats receiving low-dose E5415A and hIgGNMO. CONCLUSIONS: In the present study, we established a severe experimental NMO rat model with highly clinical exacerbation and extensive tissue destructive lesions typically observed in NMO patients, which has not adequately been realized in in-vivo rodent models. Our data suggest that the pathogenic antibodies could induce immune mediated astrocytopathy with mobilized neutrophils, resulted in early lesion expansion of NMO lesion with vacuolation and other tissue damages. (350/350). More... »

PAGES

82

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40478-015-0259-2

DOI

http://dx.doi.org/10.1186/s40478-015-0259-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030741293

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26637322


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Affinity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aquaporin 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Astrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement C9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microfilament Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuromyelitis Optica", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophil Infiltration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Lew", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vacuoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurosawa", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.0616222770.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616222770.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
            "Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Misu", 
        "givenName": "Tatsuro", 
        "id": "sg:person.01163274307.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163274307.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takai", 
        "givenName": "Yoshiki", 
        "id": "sg:person.0633727560.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633727560.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pontifical Catholic University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.412519.a", 
          "name": [
            "Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan", 
            "Department of Neurology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil", 
            "Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Douglas Kazutoshi", 
        "id": "sg:person.01153514255.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153514255.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
            "Department of Neurology, Yonezawa National Hospital, Yamagata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Toshiyuki", 
        "id": "sg:person.012460423164.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012460423164.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Keio Advanced Research Center for Water Biology and Medicine, Keio University, Tokyo, Japan", 
            "Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abe", 
        "givenName": "Yoichiro", 
        "id": "sg:person.01325123440.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325123440.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwanari", 
        "givenName": "Hiroko", 
        "id": "sg:person.0667121234.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667121234.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogawa", 
        "givenName": "Ryo", 
        "id": "sg:person.01317504517.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317504517.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakashima", 
        "givenName": "Ichiro", 
        "id": "sg:person.0761450707.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761450707.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujihara", 
        "givenName": "Kazuo", 
        "id": "sg:person.0720177674.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720177674.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamakubo", 
        "givenName": "Takao", 
        "id": "sg:person.01041036543.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041036543.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Keio Advanced Research Center for Water Biology and Medicine, Keio University, Tokyo, Japan", 
            "Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yasui", 
        "givenName": "Masato", 
        "id": "sg:person.01213275756.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213275756.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "Masashi", 
        "id": "sg:person.01121427064.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121427064.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/archneur.63.7.964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001067105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0027412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001201237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awp309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001487793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-1-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003315524", 
          "https://doi.org/10.1186/2051-5960-1-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-1-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003315524", 
          "https://doi.org/10.1186/2051-5960-1-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-11-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004410354", 
          "https://doi.org/10.1186/1742-2094-11-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004576417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nyas.12794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007324742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471142735.im1502s85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010223615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471142735.im1502s85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010223615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.21802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010854142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.21802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010854142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcn.2013.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011373878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2011.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011388295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2013.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012181699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-2-48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013619469", 
          "https://doi.org/10.1186/2051-5960-2-48"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-2-48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013619469", 
          "https://doi.org/10.1186/2051-5960-2-48"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ncl.2004.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015404575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2014.12.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016038526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awm047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016879161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-1-85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017867931", 
          "https://doi.org/10.1186/2051-5960-1-85"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2006.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021758131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(12)70133-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022431208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.344325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022582094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jim.2007.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024277011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458510379247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024461006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458510379247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024461006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458510379247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024461006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1017385108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028738307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.msard.2012.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029843611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000001729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030826316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000001729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030826316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1620/tjem.209.269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031103007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2014.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031267244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-1019130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032530340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.msard.2015.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034633042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.63.3.390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036354125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410070212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037231079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038393413", 
          "https://doi.org/10.1038/ni.1923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038393413", 
          "https://doi.org/10.1038/ni.1923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp-2011-300403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038423158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.06.085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039026210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.02.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039032785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1220-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039124051", 
          "https://doi.org/10.1007/s00401-013-1220-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2009.04.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041691051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2007.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042491825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(94)00463-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043747288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awm062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044889277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bpa.12098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045761647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458512440060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045981497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458512440060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045981497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458512440060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045981497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.146.5.1323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046327327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(13)70076-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047190631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-004-0271-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047478324", 
          "https://doi.org/10.1007/s00415-004-0271-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bph.13340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047880099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0341-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048473419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awf151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050485749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000216139.44259.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051204711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000216139.44259.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051204711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)17551-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051436972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.21837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051623452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.21837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051623452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1116-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053660374", 
          "https://doi.org/10.1007/s00401-013-1116-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1116-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053660374", 
          "https://doi.org/10.1007/s00401-013-1116-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/mab.2013.0007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059296854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000289761.64862.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000289761.64862.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000289761.64862.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000183151.19351.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000183151.19351.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000183151.19351.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181e2414b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064355335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181e2414b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064355335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181e2414b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064355335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.5.1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064377773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.5.1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064377773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.5.1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064377773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082228680", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082444096", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "INTRODUCTION: Neuromyelitis optica (NMO), an autoimmune astrocytopathic disease associated with anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions preferentially involving the optic nerves and spinal cord. However, previous in-vivo experimental models injecting human anti-AQP4 antibodies only resulted in mild spinal cord lesions compared to NMO autopsied cases. Here, we investigated whether the formation of severe NMO-like lesions occurs in Lewis rats in the context of experimental autoimmune encephalomyelitis (EAE), intraperitoneally injecting incremental doses of purified human immunoglobulin-G from a NMO patient (hIgGNMO) or a high affinity anti-AQP4 monoclonal antibody (E5415A), recognizing extracellular domain of AQP4 made by baculovirus display method.\nRESULTS: NMO-like lesions were observed in the spinal cord, brainstem, and optic chiasm of EAE-rats with injection of pathogenic IgG (hIgGNMO and E5415A), but not in control EAE. Only in higher dose E5415A rats, there were acute and significantly severer clinical exacerbations (tetraparesis or moribund) compared with controls, within half day after the injection of pathogenic IgG. Loss of AQP4 was observed both in EAE rats receiving hIgGNMO and E5415A in a dose dependent manner, but the ratio of AQP4 loss in spinal sections became significantly larger in those receiving high dose E5415A up to about 50\u00a0% than those receiving low-dose E5415A or hIgGNMO less than 3\u00a0%. These lesions were also characterized by extensive loss of glial fibrillary acidic protein but relatively preserved myelin sheaths with perivascular deposition of IgG and C5b-9, which is compatible with post mortem NMO pathology. In high dose E5415A rats, massive neutrophil infiltration was observed especially at the lesion edge, and such lesions were highly vacuolated with partial demyelination and axonal damage. In contrast, such changes were absent in EAE rats receiving low-dose E5415A and hIgGNMO.\nCONCLUSIONS: In the present study, we established a severe experimental NMO rat model with highly clinical exacerbation and extensive tissue destructive lesions typically observed in NMO patients, which has not adequately been realized in in-vivo rodent models. Our data suggest that the pathogenic antibodies could induce immune mediated astrocytopathy with mobilized neutrophils, resulted in early lesion expansion of NMO lesion with vacuolation and other tissue damages. (350/350).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40478-015-0259-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6034910", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6139734", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6091441", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6038557", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5654171", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6109425", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5872850", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5880441", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5882032", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6077192", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1048594", 
        "issn": [
          "2051-5960"
        ], 
        "name": "Acta Neuropathologica Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody", 
    "pagination": "82", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9272710cdabaa7f7905792dc42dd696e05a2641f96b538e295f7ddc9d31f1f6d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26637322"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101610673"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40478-015-0259-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030741293"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40478-015-0259-2", 
      "https://app.dimensions.ai/details/publication/pub.1030741293"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs40478-015-0259-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40478-015-0259-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40478-015-0259-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40478-015-0259-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40478-015-0259-2'


 

This table displays all metadata directly associated to this object as RDF triples.

449 TRIPLES      21 PREDICATES      108 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40478-015-0259-2 schema:about N1956bd440573422585474f49f5fd4e69
2 N1d98b8cdb4d04c9fa69cf42a7b1092da
3 N448a0be5306749bf881261fed60f965b
4 N492de14698bd47f1b36d3e42b58fcc27
5 N4ba373eb65f347dfb452ecff25b003de
6 N63e26865de5f47b29725f7fda3a840b9
7 N6418a347e0564200bd7d48e514b81f50
8 N682efedd24e94e3eaaebe80933a15313
9 N890fab0f4387471d91c2dfdf27e4aef7
10 N8dbd9bd5287844b8a385bcda9fd3a5b4
11 N8fc8e056893d44b2aafae3ff7984aa56
12 Na5a460ea896a4a6baa50bad648cd965e
13 Nb5305704e70b49449fe0219205a564f7
14 Nbb1d25d4ee45463eaaa615d04683bfdd
15 Nc6b860fb709a4ab580bf2a85e430c4fc
16 Nd7ddab2c26d0458783cdee1cf0a51476
17 Ndda5f25523bb442a810d310ff18a4310
18 Ne5713918067e49478ba73456eb7ab824
19 Nf52ca2184c174bdf8711ca8ccd572492
20 Nfd32fbb6db8d414982d95f647fb6c783
21 anzsrc-for:11
22 anzsrc-for:1109
23 schema:author N3051f8cad99b497da27d64f387df6c61
24 schema:citation sg:pub.10.1007/s00401-013-1116-7
25 sg:pub.10.1007/s00401-013-1220-8
26 sg:pub.10.1007/s00415-004-0271-0
27 sg:pub.10.1038/ni.1923
28 sg:pub.10.1186/1742-2094-11-16
29 sg:pub.10.1186/2051-5960-1-5
30 sg:pub.10.1186/2051-5960-1-85
31 sg:pub.10.1186/2051-5960-2-48
32 https://app.dimensions.ai/details/publication/pub.1082228680
33 https://app.dimensions.ai/details/publication/pub.1082444096
34 https://doi.org/10.1001/archneur.63.3.390
35 https://doi.org/10.1001/archneur.63.7.964
36 https://doi.org/10.1002/0471142735.im1502s85
37 https://doi.org/10.1002/ana.21802
38 https://doi.org/10.1002/ana.21837
39 https://doi.org/10.1002/ana.22686
40 https://doi.org/10.1002/ana.410070212
41 https://doi.org/10.1016/0014-5793(94)00463-3
42 https://doi.org/10.1016/j.bbrc.2009.06.085
43 https://doi.org/10.1016/j.bbrc.2010.02.157
44 https://doi.org/10.1016/j.expneurol.2014.12.015
45 https://doi.org/10.1016/j.jaut.2014.02.011
46 https://doi.org/10.1016/j.jim.2007.02.005
47 https://doi.org/10.1016/j.jneuroim.2011.03.007
48 https://doi.org/10.1016/j.jneuroim.2013.03.003
49 https://doi.org/10.1016/j.mcn.2013.02.002
50 https://doi.org/10.1016/j.molimm.2009.04.027
51 https://doi.org/10.1016/j.msard.2012.06.003
52 https://doi.org/10.1016/j.msard.2015.06.003
53 https://doi.org/10.1016/j.ncl.2004.09.002
54 https://doi.org/10.1016/j.tins.2006.08.004
55 https://doi.org/10.1016/j.tins.2007.11.003
56 https://doi.org/10.1016/s0140-6736(04)17551-x
57 https://doi.org/10.1016/s1474-4422(12)70133-3
58 https://doi.org/10.1016/s1474-4422(13)70076-0
59 https://doi.org/10.1055/s-2007-1019130
60 https://doi.org/10.1073/pnas.1017385108
61 https://doi.org/10.1074/jbc.m112.344325
62 https://doi.org/10.1084/jem.146.5.1323
63 https://doi.org/10.1089/mab.2013.0007
64 https://doi.org/10.1093/brain/awf151
65 https://doi.org/10.1093/brain/awm047
66 https://doi.org/10.1093/brain/awm062
67 https://doi.org/10.1093/brain/awp309
68 https://doi.org/10.1111/bpa.12098
69 https://doi.org/10.1111/bph.13340
70 https://doi.org/10.1111/nyas.12794
71 https://doi.org/10.1136/jnnp-2011-300403
72 https://doi.org/10.1177/1352458510379247
73 https://doi.org/10.1177/1352458512440060
74 https://doi.org/10.1212/01.wnl.0000183151.19351.82
75 https://doi.org/10.1212/01.wnl.0000216139.44259.74
76 https://doi.org/10.1212/01.wnl.0000289761.64862.ce
77 https://doi.org/10.1212/wnl.0000000000001729
78 https://doi.org/10.1212/wnl.0b013e3181e2414b
79 https://doi.org/10.1212/wnl.53.5.1107
80 https://doi.org/10.1371/journal.pone.0027412
81 https://doi.org/10.1523/jneurosci.0341-09.2009
82 https://doi.org/10.1620/tjem.209.269
83 schema:datePublished 2015-12
84 schema:datePublishedReg 2015-12-01
85 schema:description INTRODUCTION: Neuromyelitis optica (NMO), an autoimmune astrocytopathic disease associated with anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions preferentially involving the optic nerves and spinal cord. However, previous in-vivo experimental models injecting human anti-AQP4 antibodies only resulted in mild spinal cord lesions compared to NMO autopsied cases. Here, we investigated whether the formation of severe NMO-like lesions occurs in Lewis rats in the context of experimental autoimmune encephalomyelitis (EAE), intraperitoneally injecting incremental doses of purified human immunoglobulin-G from a NMO patient (hIgGNMO) or a high affinity anti-AQP4 monoclonal antibody (E5415A), recognizing extracellular domain of AQP4 made by baculovirus display method. RESULTS: NMO-like lesions were observed in the spinal cord, brainstem, and optic chiasm of EAE-rats with injection of pathogenic IgG (hIgGNMO and E5415A), but not in control EAE. Only in higher dose E5415A rats, there were acute and significantly severer clinical exacerbations (tetraparesis or moribund) compared with controls, within half day after the injection of pathogenic IgG. Loss of AQP4 was observed both in EAE rats receiving hIgGNMO and E5415A in a dose dependent manner, but the ratio of AQP4 loss in spinal sections became significantly larger in those receiving high dose E5415A up to about 50 % than those receiving low-dose E5415A or hIgGNMO less than 3 %. These lesions were also characterized by extensive loss of glial fibrillary acidic protein but relatively preserved myelin sheaths with perivascular deposition of IgG and C5b-9, which is compatible with post mortem NMO pathology. In high dose E5415A rats, massive neutrophil infiltration was observed especially at the lesion edge, and such lesions were highly vacuolated with partial demyelination and axonal damage. In contrast, such changes were absent in EAE rats receiving low-dose E5415A and hIgGNMO. CONCLUSIONS: In the present study, we established a severe experimental NMO rat model with highly clinical exacerbation and extensive tissue destructive lesions typically observed in NMO patients, which has not adequately been realized in in-vivo rodent models. Our data suggest that the pathogenic antibodies could induce immune mediated astrocytopathy with mobilized neutrophils, resulted in early lesion expansion of NMO lesion with vacuolation and other tissue damages. (350/350).
86 schema:genre research_article
87 schema:inLanguage en
88 schema:isAccessibleForFree true
89 schema:isPartOf N27ad5ae5c44e451aa4c4eefb36daf090
90 N730b91bbd4a94f9cbba4dcbe515cd732
91 sg:journal.1048594
92 schema:name Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody
93 schema:pagination 82
94 schema:productId N0ab8088b2f1e46e692f162cc596e2117
95 N34e4992799f046d590cb257384300e96
96 N5d8497d9ed854c3097d0a0c98c79a571
97 N733231361d23458e81d692fc15a9b828
98 Ne44f3820076247af9d9012a9cb98973e
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030741293
100 https://doi.org/10.1186/s40478-015-0259-2
101 schema:sdDatePublished 2019-04-10T16:44
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher Nd886cc3559cc412ab52828a2053478f3
104 schema:url http://link.springer.com/10.1186%2Fs40478-015-0259-2
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N08c777855dd04597ad90ffea8c445db1 rdf:first sg:person.01213275756.66
109 rdf:rest Nbc8a5dded713401880f402ca2d7e05b2
110 N0ab8088b2f1e46e692f162cc596e2117 schema:name readcube_id
111 schema:value 9272710cdabaa7f7905792dc42dd696e05a2641f96b538e295f7ddc9d31f1f6d
112 rdf:type schema:PropertyValue
113 N1956bd440573422585474f49f5fd4e69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Aquaporin 4
115 rdf:type schema:DefinedTerm
116 N1d98b8cdb4d04c9fa69cf42a7b1092da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Female
118 rdf:type schema:DefinedTerm
119 N1facfdc931fc4cc59f8acccd3a08e6bc rdf:first sg:person.0633727560.70
120 rdf:rest Ne3ffff60b52e40dbb98ad8a76cc31c4e
121 N27ad5ae5c44e451aa4c4eefb36daf090 schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N3051f8cad99b497da27d64f387df6c61 rdf:first sg:person.0616222770.24
124 rdf:rest N39312efbf6984de5a3734518f4e5fd6e
125 N34e4992799f046d590cb257384300e96 schema:name dimensions_id
126 schema:value pub.1030741293
127 rdf:type schema:PropertyValue
128 N39312efbf6984de5a3734518f4e5fd6e rdf:first sg:person.01163274307.92
129 rdf:rest N1facfdc931fc4cc59f8acccd3a08e6bc
130 N448a0be5306749bf881261fed60f965b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Neutrophil Infiltration
132 rdf:type schema:DefinedTerm
133 N492de14698bd47f1b36d3e42b58fcc27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N4ba373eb65f347dfb452ecff25b003de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Time Factors
138 rdf:type schema:DefinedTerm
139 N5c8b61c00e824b7dba687dccd446116b rdf:first sg:person.01041036543.19
140 rdf:rest N08c777855dd04597ad90ffea8c445db1
141 N5d8497d9ed854c3097d0a0c98c79a571 schema:name pubmed_id
142 schema:value 26637322
143 rdf:type schema:PropertyValue
144 N63e26865de5f47b29725f7fda3a840b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Nerve Tissue Proteins
146 rdf:type schema:DefinedTerm
147 N6418a347e0564200bd7d48e514b81f50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Vacuoles
149 rdf:type schema:DefinedTerm
150 N682efedd24e94e3eaaebe80933a15313 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Neuromyelitis Optica
152 rdf:type schema:DefinedTerm
153 N6b9ade2403324705b9a8af42d21f5dc5 rdf:first sg:person.0761450707.25
154 rdf:rest Nb4626be95e964c8b8e295bc186bd211d
155 N730b91bbd4a94f9cbba4dcbe515cd732 schema:volumeNumber 3
156 rdf:type schema:PublicationVolume
157 N733231361d23458e81d692fc15a9b828 schema:name doi
158 schema:value 10.1186/s40478-015-0259-2
159 rdf:type schema:PropertyValue
160 N85c5b55518904d3c9c14867e4d46228a rdf:first sg:person.012460423164.65
161 rdf:rest N9823df25505d45b18c421d916b934117
162 N890fab0f4387471d91c2dfdf27e4aef7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Rats
164 rdf:type schema:DefinedTerm
165 N8dbd9bd5287844b8a385bcda9fd3a5b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 N8fc8e056893d44b2aafae3ff7984aa56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Aged
170 rdf:type schema:DefinedTerm
171 N9823df25505d45b18c421d916b934117 rdf:first sg:person.01325123440.16
172 rdf:rest Na505e94d5b354bd390e056e23436d86f
173 Na505e94d5b354bd390e056e23436d86f rdf:first sg:person.0667121234.06
174 rdf:rest Nbc32f75c5ffb48028b72dd95e9e6b0e0
175 Na5a460ea896a4a6baa50bad648cd965e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Calcium-Binding Proteins
177 rdf:type schema:DefinedTerm
178 Nb4626be95e964c8b8e295bc186bd211d rdf:first sg:person.0720177674.05
179 rdf:rest N5c8b61c00e824b7dba687dccd446116b
180 Nb5305704e70b49449fe0219205a564f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Microfilament Proteins
182 rdf:type schema:DefinedTerm
183 Nbb1d25d4ee45463eaaa615d04683bfdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Dose-Response Relationship, Drug
185 rdf:type schema:DefinedTerm
186 Nbc32f75c5ffb48028b72dd95e9e6b0e0 rdf:first sg:person.01317504517.29
187 rdf:rest N6b9ade2403324705b9a8af42d21f5dc5
188 Nbc8a5dded713401880f402ca2d7e05b2 rdf:first sg:person.01121427064.04
189 rdf:rest rdf:nil
190 Nc6b860fb709a4ab580bf2a85e430c4fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Immunoglobulin G
192 rdf:type schema:DefinedTerm
193 Nd7ddab2c26d0458783cdee1cf0a51476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Antibody Affinity
195 rdf:type schema:DefinedTerm
196 Nd886cc3559cc412ab52828a2053478f3 schema:name Springer Nature - SN SciGraph project
197 rdf:type schema:Organization
198 Ndda5f25523bb442a810d310ff18a4310 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Rats, Inbred Lew
200 rdf:type schema:DefinedTerm
201 Ne3ffff60b52e40dbb98ad8a76cc31c4e rdf:first sg:person.01153514255.96
202 rdf:rest N85c5b55518904d3c9c14867e4d46228a
203 Ne44f3820076247af9d9012a9cb98973e schema:name nlm_unique_id
204 schema:value 101610673
205 rdf:type schema:PropertyValue
206 Ne5713918067e49478ba73456eb7ab824 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Complement C9
208 rdf:type schema:DefinedTerm
209 Nf52ca2184c174bdf8711ca8ccd572492 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Disease Models, Animal
211 rdf:type schema:DefinedTerm
212 Nfd32fbb6db8d414982d95f647fb6c783 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Astrocytes
214 rdf:type schema:DefinedTerm
215 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
216 schema:name Medical and Health Sciences
217 rdf:type schema:DefinedTerm
218 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
219 schema:name Neurosciences
220 rdf:type schema:DefinedTerm
221 sg:grant.5654171 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
222 rdf:type schema:MonetaryGrant
223 sg:grant.5872850 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
224 rdf:type schema:MonetaryGrant
225 sg:grant.5880441 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
226 rdf:type schema:MonetaryGrant
227 sg:grant.5882032 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
228 rdf:type schema:MonetaryGrant
229 sg:grant.6034910 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
230 rdf:type schema:MonetaryGrant
231 sg:grant.6038557 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
232 rdf:type schema:MonetaryGrant
233 sg:grant.6077192 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
234 rdf:type schema:MonetaryGrant
235 sg:grant.6091441 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
236 rdf:type schema:MonetaryGrant
237 sg:grant.6109425 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
238 rdf:type schema:MonetaryGrant
239 sg:grant.6139734 http://pending.schema.org/fundedItem sg:pub.10.1186/s40478-015-0259-2
240 rdf:type schema:MonetaryGrant
241 sg:journal.1048594 schema:issn 2051-5960
242 schema:name Acta Neuropathologica Communications
243 rdf:type schema:Periodical
244 sg:person.01041036543.19 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
245 schema:familyName Hamakubo
246 schema:givenName Takao
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041036543.19
248 rdf:type schema:Person
249 sg:person.01121427064.04 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
250 schema:familyName Aoki
251 schema:givenName Masashi
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121427064.04
253 rdf:type schema:Person
254 sg:person.01153514255.96 schema:affiliation https://www.grid.ac/institutes/grid.412519.a
255 schema:familyName Sato
256 schema:givenName Douglas Kazutoshi
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153514255.96
258 rdf:type schema:Person
259 sg:person.01163274307.92 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
260 schema:familyName Misu
261 schema:givenName Tatsuro
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163274307.92
263 rdf:type schema:Person
264 sg:person.01213275756.66 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
265 schema:familyName Yasui
266 schema:givenName Masato
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213275756.66
268 rdf:type schema:Person
269 sg:person.012460423164.65 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
270 schema:familyName Takahashi
271 schema:givenName Toshiyuki
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012460423164.65
273 rdf:type schema:Person
274 sg:person.01317504517.29 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
275 schema:familyName Ogawa
276 schema:givenName Ryo
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317504517.29
278 rdf:type schema:Person
279 sg:person.01325123440.16 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
280 schema:familyName Abe
281 schema:givenName Yoichiro
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325123440.16
283 rdf:type schema:Person
284 sg:person.0616222770.24 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
285 schema:familyName Kurosawa
286 schema:givenName Kazuhiro
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616222770.24
288 rdf:type schema:Person
289 sg:person.0633727560.70 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
290 schema:familyName Takai
291 schema:givenName Yoshiki
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633727560.70
293 rdf:type schema:Person
294 sg:person.0667121234.06 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
295 schema:familyName Iwanari
296 schema:givenName Hiroko
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667121234.06
298 rdf:type schema:Person
299 sg:person.0720177674.05 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
300 schema:familyName Fujihara
301 schema:givenName Kazuo
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720177674.05
303 rdf:type schema:Person
304 sg:person.0761450707.25 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
305 schema:familyName Nakashima
306 schema:givenName Ichiro
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761450707.25
308 rdf:type schema:Person
309 sg:pub.10.1007/s00401-013-1116-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053660374
310 https://doi.org/10.1007/s00401-013-1116-7
311 rdf:type schema:CreativeWork
312 sg:pub.10.1007/s00401-013-1220-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039124051
313 https://doi.org/10.1007/s00401-013-1220-8
314 rdf:type schema:CreativeWork
315 sg:pub.10.1007/s00415-004-0271-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047478324
316 https://doi.org/10.1007/s00415-004-0271-0
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/ni.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038393413
319 https://doi.org/10.1038/ni.1923
320 rdf:type schema:CreativeWork
321 sg:pub.10.1186/1742-2094-11-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004410354
322 https://doi.org/10.1186/1742-2094-11-16
323 rdf:type schema:CreativeWork
324 sg:pub.10.1186/2051-5960-1-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003315524
325 https://doi.org/10.1186/2051-5960-1-5
326 rdf:type schema:CreativeWork
327 sg:pub.10.1186/2051-5960-1-85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017867931
328 https://doi.org/10.1186/2051-5960-1-85
329 rdf:type schema:CreativeWork
330 sg:pub.10.1186/2051-5960-2-48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013619469
331 https://doi.org/10.1186/2051-5960-2-48
332 rdf:type schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1082228680 schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1082444096 schema:CreativeWork
335 https://doi.org/10.1001/archneur.63.3.390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036354125
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1001/archneur.63.7.964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001067105
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1002/0471142735.im1502s85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010223615
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1002/ana.21802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010854142
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1002/ana.21837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051623452
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1002/ana.22686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004576417
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1002/ana.410070212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037231079
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/0014-5793(94)00463-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043747288
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/j.bbrc.2009.06.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039026210
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/j.bbrc.2010.02.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039032785
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/j.expneurol.2014.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016038526
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/j.jaut.2014.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031267244
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/j.jim.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024277011
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/j.jneuroim.2011.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011388295
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/j.jneuroim.2013.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012181699
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1016/j.mcn.2013.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011373878
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/j.molimm.2009.04.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041691051
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/j.msard.2012.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029843611
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/j.msard.2015.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034633042
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1016/j.ncl.2004.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015404575
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1016/j.tins.2006.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021758131
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1016/j.tins.2007.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042491825
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1016/s0140-6736(04)17551-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051436972
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1016/s1474-4422(12)70133-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022431208
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1016/s1474-4422(13)70076-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047190631
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1055/s-2007-1019130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032530340
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1073/pnas.1017385108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028738307
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1074/jbc.m112.344325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022582094
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1084/jem.146.5.1323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046327327
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1089/mab.2013.0007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059296854
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1093/brain/awf151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050485749
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1093/brain/awm047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016879161
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1093/brain/awm062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044889277
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1093/brain/awp309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001487793
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1111/bpa.12098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045761647
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1111/bph.13340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047880099
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1111/nyas.12794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007324742
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1136/jnnp-2011-300403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038423158
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1177/1352458510379247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024461006
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1177/1352458512440060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045981497
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1212/01.wnl.0000183151.19351.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347563
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1212/01.wnl.0000216139.44259.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051204711
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1212/01.wnl.0000289761.64862.ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347221
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1212/wnl.0000000000001729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030826316
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1212/wnl.0b013e3181e2414b schema:sameAs https://app.dimensions.ai/details/publication/pub.1064355335
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1212/wnl.53.5.1107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064377773
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1371/journal.pone.0027412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001201237
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1523/jneurosci.0341-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048473419
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1620/tjem.209.269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031103007
432 rdf:type schema:CreativeWork
433 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
434 schema:name Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan
435 Keio Advanced Research Center for Water Biology and Medicine, Keio University, Tokyo, Japan
436 rdf:type schema:Organization
437 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
438 schema:name Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
439 rdf:type schema:Organization
440 https://www.grid.ac/institutes/grid.412519.a schema:alternateName Pontifical Catholic University of Rio Grande do Sul
441 schema:name Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil
442 Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan
443 Department of Neurology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
444 rdf:type schema:Organization
445 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
446 schema:name Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan
447 Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
448 Department of Neurology, Yonezawa National Hospital, Yamagata, Japan
449 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...