In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Shannon F. Rudy, J. Chad Brenner, Jennifer L. Harris, Jun Liu, Jianwei Che, Megan V. Scott, John Henry Owen, Christine M. Komarck, Martin P. Graham, Emily L. Bellile, Carol R. Bradford, Mark EP Prince, Thomas E. Carey

ABSTRACT

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic agent. METHODS: We tested anti-metastatic effects of a WNT pathway inhibitor, WNT974 (also known as LGK974), which targets porcupine (PORCN) the palmityl-transferase that is essential for secretion of Wnt proteins. CAM assays were performed with 8 HNSCC cell lines: UM-SCC-1, UM-SCC-10A, UM-SCC-10B, UM-SCC-11A, UM-SCC-14A UM-SCC-17A, UM-SCC-17B, UM-SCC-25, and UM-SCC-34. RESULTS: UM-SCC-1 (University of Michigan Squamous Cell Carcinoma cell line) CAM xenografts contain CD44+ and ALDH+ cancer stem cell (CSC) proportions similar to UM-SCC-1 mouse xenografts supporting the applicability of the CAM assay for study of CSCs. Inhibition of WNT signaling by the PORCN inhibitor WNT974 reduced metastatic spread of UM-SCC cells, especially in UM-SCCs with Notch1 deficiency. CONCLUSIONS: Our data demonstrate decreased tumor growth and metastases in tumors from cell lines that showed in vitro responses to WNT974, providing evidence that this agent may have a role in future HNSCC therapy. More... »

PAGES

26

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40463-016-0140-8

DOI

http://dx.doi.org/10.1186/s40463-016-0140-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030094066

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27117272


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chick Embryo", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chorioallantoic Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head and Neck Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Notch1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Squamous Cell Carcinoma of Head and Neck", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Signaling Pathway", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA", 
            "Department of Otolaryngology/Head Neck Surgery, Stanford University, 94305, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rudy", 
        "givenName": "Shannon F.", 
        "id": "sg:person.0611470541.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611470541.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA", 
            "Comprehensive Cancer Center, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brenner", 
        "givenName": "J. Chad", 
        "id": "sg:person.07711361637.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07711361637.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harris", 
        "givenName": "Jennifer L.", 
        "id": "sg:person.0646666743.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646666743.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jun", 
        "id": "sg:person.01266125726.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266125726.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Che", 
        "givenName": "Jianwei", 
        "id": "sg:person.01275406763.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275406763.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wayne State University", 
          "id": "https://www.grid.ac/institutes/grid.254444.7", 
          "name": [
            "Comprehensive Cancer Center, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA", 
            "Wayne State University School of Medicine, 48201, Detroit, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scott", 
        "givenName": "Megan V.", 
        "id": "sg:person.01110260741.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110260741.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Owen", 
        "givenName": "John Henry", 
        "id": "sg:person.0662500235.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662500235.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komarck", 
        "givenName": "Christine M.", 
        "id": "sg:person.014756243577.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014756243577.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P. Graham", 
        "givenName": "Martin", 
        "id": "sg:person.0730613435.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730613435.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Cancer Center Biostatistics Core, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L. Bellile", 
        "givenName": "Emily", 
        "id": "sg:person.0677227034.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677227034.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA", 
            "Comprehensive Cancer Center, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bradford", 
        "givenName": "Carol R.", 
        "id": "sg:person.0703050524.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703050524.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA", 
            "Comprehensive Cancer Center, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prince", 
        "givenName": "Mark EP", 
        "id": "sg:person.01360341424.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360341424.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA", 
            "Comprehensive Cancer Center, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carey", 
        "givenName": "Thomas E.", 
        "id": "sg:person.01102623101.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102623101.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrc3419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003577201", 
          "https://doi.org/10.1038/nrc3419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.1535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004110786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1314239110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005087863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005670808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007760258", 
          "https://doi.org/10.1038/nrc3452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008443664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008443664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011682275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.23869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014399057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.21198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016133683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.21198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016133683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2006.03.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017919092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028228628", 
          "https://doi.org/10.1038/nrc2389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028859186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766632", 
          "https://doi.org/10.1038/nature03319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766632", 
          "https://doi.org/10.1038/nature03319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.10152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032174222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1208130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038068253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1208130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038068253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040091914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041697410", 
          "https://doi.org/10.1038/ng1099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041697410", 
          "https://doi.org/10.1038/ng1099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2005.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045826744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408622102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048544695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-2927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050440398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.20.010403.113126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051113440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms13089959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051325972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.23202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051368643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1071549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062446527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1206923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1206923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/org.4.2.5851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072306840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074457939", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic agent.\nMETHODS: We tested anti-metastatic effects of a WNT pathway inhibitor, WNT974 (also known as LGK974), which targets porcupine (PORCN) the palmityl-transferase that is essential for secretion of Wnt proteins. CAM assays were performed with 8 HNSCC cell lines: UM-SCC-1, UM-SCC-10A, UM-SCC-10B, UM-SCC-11A, UM-SCC-14A UM-SCC-17A, UM-SCC-17B, UM-SCC-25, and UM-SCC-34.\nRESULTS: UM-SCC-1 (University of Michigan Squamous Cell Carcinoma cell line) CAM xenografts contain CD44+ and ALDH+ cancer stem cell (CSC) proportions similar to UM-SCC-1 mouse xenografts supporting the applicability of the CAM assay for study of CSCs. Inhibition of WNT signaling by the PORCN inhibitor WNT974 reduced metastatic spread of UM-SCC cells, especially in UM-SCCs with Notch1 deficiency.\nCONCLUSIONS: Our data demonstrate decreased tumor growth and metastases in tumors from cell lines that showed in vitro responses to WNT974, providing evidence that this agent may have a role in future HNSCC therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40463-016-0140-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4103851", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438933", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682982", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440191", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2491269", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295041", 
        "issn": [
          "1916-0208", 
          "1916-0216"
        ], 
        "name": "Journal of Otolaryngology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "name": "In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model", 
    "pagination": "26", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8f5d9b1a5d1c7481c31dc087d697ab8ac5e45be926ec0df729fbb7890524d69a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27117272"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101479544"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40463-016-0140-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030094066"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40463-016-0140-8", 
      "https://app.dimensions.ai/details/publication/pub.1030094066"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113661_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40463-016-0140-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40463-016-0140-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40463-016-0140-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40463-016-0140-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40463-016-0140-8'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      74 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40463-016-0140-8 schema:about N02733c30dfcd465f83e4f757723afa87
2 N2c50f7d9fe054d60a8916337a31a3eb2
3 N48ea9e69838d4b0f8907da97f5d87133
4 N51287b972c9148b0be3d0d061896b1f8
5 N554ed701e95a46ee860cc5cf239e3170
6 N67b95a5c59854fd7bf444bc170a5d3a0
7 N6f80f1996bfe4e2483abe69bdeae7741
8 N7621216a900e4eeebe3a23bcde049b94
9 N94667b559c334166ad1335a280ac4a26
10 N976fcb5dacb8442f9d85f098eeba2c43
11 N97ca2a049420489dbf428844f1a30485
12 Nadeeaf3b4b8b40d5a16ad1516c413b8e
13 Ndcc901d0ab7240278d1a1e7f6dacf0b4
14 Ndd4ff89e3f174e9a8568bcb63614ed72
15 Nde997ea767d2424e8c4f3dcc095b8b8e
16 Ne269001c484e437a964d5adba981eb8b
17 Neb3ac0bfddc643998c7815c2a3e446ff
18 Necbe227b745c4a2f989a149298a213f7
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N0fd3fb37e9754973b05b8ce8f4a528a7
22 schema:citation sg:pub.10.1038/nature03319
23 sg:pub.10.1038/ng1099
24 sg:pub.10.1038/nrc2389
25 sg:pub.10.1038/nrc3419
26 sg:pub.10.1038/nrc3452
27 https://app.dimensions.ai/details/publication/pub.1074457939
28 https://doi.org/10.1002/hed.21198
29 https://doi.org/10.1002/hed.23202
30 https://doi.org/10.1002/hed.23869
31 https://doi.org/10.1002/ijc.1535
32 https://doi.org/10.1002/ijc.25516
33 https://doi.org/10.1002/jbm.10152
34 https://doi.org/10.1016/j.ccr.2011.04.010
35 https://doi.org/10.1016/j.cell.2012.05.012
36 https://doi.org/10.1016/j.cellsig.2005.06.015
37 https://doi.org/10.1016/j.febslet.2006.03.024
38 https://doi.org/10.1073/pnas.0408622102
39 https://doi.org/10.1073/pnas.1314239110
40 https://doi.org/10.1126/science.1071549
41 https://doi.org/10.1126/science.1206923
42 https://doi.org/10.1126/science.1208130
43 https://doi.org/10.1146/annurev.cellbio.20.010403.113126
44 https://doi.org/10.1158/1078-0432.ccr-12-2927
45 https://doi.org/10.1158/2159-8290.cd-12-0537
46 https://doi.org/10.3322/caac.21254
47 https://doi.org/10.3390/ijms13089959
48 https://doi.org/10.4161/org.4.2.5851
49 schema:datePublished 2016-12
50 schema:datePublishedReg 2016-12-01
51 schema:description BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic agent. METHODS: We tested anti-metastatic effects of a WNT pathway inhibitor, WNT974 (also known as LGK974), which targets porcupine (PORCN) the palmityl-transferase that is essential for secretion of Wnt proteins. CAM assays were performed with 8 HNSCC cell lines: UM-SCC-1, UM-SCC-10A, UM-SCC-10B, UM-SCC-11A, UM-SCC-14A UM-SCC-17A, UM-SCC-17B, UM-SCC-25, and UM-SCC-34. RESULTS: UM-SCC-1 (University of Michigan Squamous Cell Carcinoma cell line) CAM xenografts contain CD44+ and ALDH+ cancer stem cell (CSC) proportions similar to UM-SCC-1 mouse xenografts supporting the applicability of the CAM assay for study of CSCs. Inhibition of WNT signaling by the PORCN inhibitor WNT974 reduced metastatic spread of UM-SCC cells, especially in UM-SCCs with Notch1 deficiency. CONCLUSIONS: Our data demonstrate decreased tumor growth and metastases in tumors from cell lines that showed in vitro responses to WNT974, providing evidence that this agent may have a role in future HNSCC therapy.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf N1e644795429444148a6f2ec3bea1ee31
56 N546fbca8d3084eebb91e54cf27d5ea6b
57 sg:journal.1295041
58 schema:name In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model
59 schema:pagination 26
60 schema:productId N0e98bf9280c6408fb473d5a1766677f6
61 N10da9d53d43648968dee2e3ab8b728ce
62 N55b054ae41624826adcc382b805821b9
63 N7dde957e79924397884835f38ad76d03
64 Nef17a061427a4495aca8eb300a946eea
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030094066
66 https://doi.org/10.1186/s40463-016-0140-8
67 schema:sdDatePublished 2019-04-11T10:33
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nf640e88e9ab04f0398f99d99b7993e8a
70 schema:url https://link.springer.com/10.1186%2Fs40463-016-0140-8
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N02733c30dfcd465f83e4f757723afa87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Mice
76 rdf:type schema:DefinedTerm
77 N0e98bf9280c6408fb473d5a1766677f6 schema:name doi
78 schema:value 10.1186/s40463-016-0140-8
79 rdf:type schema:PropertyValue
80 N0fd3fb37e9754973b05b8ce8f4a528a7 rdf:first sg:person.0611470541.19
81 rdf:rest Ne7d740bd1dcd44d78bdfafdde30d8c98
82 N10da9d53d43648968dee2e3ab8b728ce schema:name nlm_unique_id
83 schema:value 101479544
84 rdf:type schema:PropertyValue
85 N1e644795429444148a6f2ec3bea1ee31 schema:issueNumber 1
86 rdf:type schema:PublicationIssue
87 N2a7156ded02c41faa9525e9900b9ab49 rdf:first sg:person.0662500235.22
88 rdf:rest Nd1c67b06a14f48dc88531930d8cec239
89 N2c50f7d9fe054d60a8916337a31a3eb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Animals
91 rdf:type schema:DefinedTerm
92 N37cf83221e094227a1994eee4aad8ed7 rdf:first sg:person.01110260741.00
93 rdf:rest N2a7156ded02c41faa9525e9900b9ab49
94 N446b83c287de488d972637587c041791 rdf:first sg:person.0677227034.14
95 rdf:rest Ned2ee18e02fe45b0a2f37f87f7f4326d
96 N48ea9e69838d4b0f8907da97f5d87133 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Wnt Proteins
98 rdf:type schema:DefinedTerm
99 N4e23fc17d2b24ba4a6a6477586b2c5c5 rdf:first sg:person.0730613435.11
100 rdf:rest N446b83c287de488d972637587c041791
101 N51287b972c9148b0be3d0d061896b1f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mutation
103 rdf:type schema:DefinedTerm
104 N546fbca8d3084eebb91e54cf27d5ea6b schema:volumeNumber 45
105 rdf:type schema:PublicationVolume
106 N554ed701e95a46ee860cc5cf239e3170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cell Line, Tumor
108 rdf:type schema:DefinedTerm
109 N55b054ae41624826adcc382b805821b9 schema:name readcube_id
110 schema:value 8f5d9b1a5d1c7481c31dc087d697ab8ac5e45be926ec0df729fbb7890524d69a
111 rdf:type schema:PropertyValue
112 N6052df7c2c7d4667a5e5190fea02fe67 rdf:first sg:person.01360341424.85
113 rdf:rest Nd197e7a998a149c6ab05be10183bd731
114 N67b95a5c59854fd7bf444bc170a5d3a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name DNA
116 rdf:type schema:DefinedTerm
117 N6f80f1996bfe4e2483abe69bdeae7741 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Receptor, Notch1
119 rdf:type schema:DefinedTerm
120 N7621216a900e4eeebe3a23bcde049b94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Squamous Cell Carcinoma of Head and Neck
122 rdf:type schema:DefinedTerm
123 N7a5b3c294cf04727a4cd9d4890449880 rdf:first sg:person.0646666743.90
124 rdf:rest Nbf2a440bca3f4111827b80f611f338b7
125 N7dde957e79924397884835f38ad76d03 schema:name pubmed_id
126 schema:value 27117272
127 rdf:type schema:PropertyValue
128 N9231a9ea7a3f415aafc6dc78b0c6fa24 rdf:first sg:person.01275406763.99
129 rdf:rest N37cf83221e094227a1994eee4aad8ed7
130 N94667b559c334166ad1335a280ac4a26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Neoplasms, Experimental
132 rdf:type schema:DefinedTerm
133 N976fcb5dacb8442f9d85f098eeba2c43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N97ca2a049420489dbf428844f1a30485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name DNA Mutational Analysis
138 rdf:type schema:DefinedTerm
139 Nadeeaf3b4b8b40d5a16ad1516c413b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Chick Embryo
141 rdf:type schema:DefinedTerm
142 Nbf2a440bca3f4111827b80f611f338b7 rdf:first sg:person.01266125726.78
143 rdf:rest N9231a9ea7a3f415aafc6dc78b0c6fa24
144 Nd197e7a998a149c6ab05be10183bd731 rdf:first sg:person.01102623101.19
145 rdf:rest rdf:nil
146 Nd1c67b06a14f48dc88531930d8cec239 rdf:first sg:person.014756243577.69
147 rdf:rest N4e23fc17d2b24ba4a6a6477586b2c5c5
148 Ndcc901d0ab7240278d1a1e7f6dacf0b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Wnt Signaling Pathway
150 rdf:type schema:DefinedTerm
151 Ndd4ff89e3f174e9a8568bcb63614ed72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Neoplasm Metastasis
153 rdf:type schema:DefinedTerm
154 Nde997ea767d2424e8c4f3dcc095b8b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Polymerase Chain Reaction
156 rdf:type schema:DefinedTerm
157 Ne269001c484e437a964d5adba981eb8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Chorioallantoic Membrane
159 rdf:type schema:DefinedTerm
160 Ne7d740bd1dcd44d78bdfafdde30d8c98 rdf:first sg:person.07711361637.13
161 rdf:rest N7a5b3c294cf04727a4cd9d4890449880
162 Neb3ac0bfddc643998c7815c2a3e446ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Head and Neck Neoplasms
164 rdf:type schema:DefinedTerm
165 Necbe227b745c4a2f989a149298a213f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Carcinoma, Squamous Cell
167 rdf:type schema:DefinedTerm
168 Ned2ee18e02fe45b0a2f37f87f7f4326d rdf:first sg:person.0703050524.31
169 rdf:rest N6052df7c2c7d4667a5e5190fea02fe67
170 Nef17a061427a4495aca8eb300a946eea schema:name dimensions_id
171 schema:value pub.1030094066
172 rdf:type schema:PropertyValue
173 Nf640e88e9ab04f0398f99d99b7993e8a schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
179 schema:name Oncology and Carcinogenesis
180 rdf:type schema:DefinedTerm
181 sg:grant.2438933 http://pending.schema.org/fundedItem sg:pub.10.1186/s40463-016-0140-8
182 rdf:type schema:MonetaryGrant
183 sg:grant.2440191 http://pending.schema.org/fundedItem sg:pub.10.1186/s40463-016-0140-8
184 rdf:type schema:MonetaryGrant
185 sg:grant.2491269 http://pending.schema.org/fundedItem sg:pub.10.1186/s40463-016-0140-8
186 rdf:type schema:MonetaryGrant
187 sg:grant.2682982 http://pending.schema.org/fundedItem sg:pub.10.1186/s40463-016-0140-8
188 rdf:type schema:MonetaryGrant
189 sg:grant.4103851 http://pending.schema.org/fundedItem sg:pub.10.1186/s40463-016-0140-8
190 rdf:type schema:MonetaryGrant
191 sg:journal.1295041 schema:issn 1916-0208
192 1916-0216
193 schema:name Journal of Otolaryngology
194 rdf:type schema:Periodical
195 sg:person.01102623101.19 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
196 schema:familyName Carey
197 schema:givenName Thomas E.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102623101.19
199 rdf:type schema:Person
200 sg:person.01110260741.00 schema:affiliation https://www.grid.ac/institutes/grid.254444.7
201 schema:familyName Scott
202 schema:givenName Megan V.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110260741.00
204 rdf:type schema:Person
205 sg:person.01266125726.78 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
206 schema:familyName Liu
207 schema:givenName Jun
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266125726.78
209 rdf:type schema:Person
210 sg:person.01275406763.99 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
211 schema:familyName Che
212 schema:givenName Jianwei
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275406763.99
214 rdf:type schema:Person
215 sg:person.01360341424.85 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
216 schema:familyName Prince
217 schema:givenName Mark EP
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360341424.85
219 rdf:type schema:Person
220 sg:person.014756243577.69 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
221 schema:familyName Komarck
222 schema:givenName Christine M.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014756243577.69
224 rdf:type schema:Person
225 sg:person.0611470541.19 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
226 schema:familyName Rudy
227 schema:givenName Shannon F.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611470541.19
229 rdf:type schema:Person
230 sg:person.0646666743.90 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
231 schema:familyName Harris
232 schema:givenName Jennifer L.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646666743.90
234 rdf:type schema:Person
235 sg:person.0662500235.22 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
236 schema:familyName Owen
237 schema:givenName John Henry
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662500235.22
239 rdf:type schema:Person
240 sg:person.0677227034.14 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
241 schema:familyName L. Bellile
242 schema:givenName Emily
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677227034.14
244 rdf:type schema:Person
245 sg:person.0703050524.31 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
246 schema:familyName Bradford
247 schema:givenName Carol R.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703050524.31
249 rdf:type schema:Person
250 sg:person.0730613435.11 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
251 schema:familyName P. Graham
252 schema:givenName Martin
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730613435.11
254 rdf:type schema:Person
255 sg:person.07711361637.13 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
256 schema:familyName Brenner
257 schema:givenName J. Chad
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07711361637.13
259 rdf:type schema:Person
260 sg:pub.10.1038/nature03319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766632
261 https://doi.org/10.1038/nature03319
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/ng1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041697410
264 https://doi.org/10.1038/ng1099
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nrc2389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028228628
267 https://doi.org/10.1038/nrc2389
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nrc3419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003577201
270 https://doi.org/10.1038/nrc3419
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nrc3452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007760258
273 https://doi.org/10.1038/nrc3452
274 rdf:type schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1074457939 schema:CreativeWork
276 https://doi.org/10.1002/hed.21198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016133683
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/hed.23202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051368643
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/hed.23869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014399057
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/ijc.1535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004110786
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/ijc.25516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008443664
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/jbm.10152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032174222
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.ccr.2011.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040091914
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.cell.2012.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005670808
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.cellsig.2005.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045826744
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.febslet.2006.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017919092
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1073/pnas.0408622102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048544695
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.1314239110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005087863
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/science.1071549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446527
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1126/science.1206923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464764
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1126/science.1208130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038068253
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1146/annurev.cellbio.20.010403.113126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051113440
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1158/1078-0432.ccr-12-2927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050440398
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1158/2159-8290.cd-12-0537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028859186
311 rdf:type schema:CreativeWork
312 https://doi.org/10.3322/caac.21254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011682275
313 rdf:type schema:CreativeWork
314 https://doi.org/10.3390/ijms13089959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051325972
315 rdf:type schema:CreativeWork
316 https://doi.org/10.4161/org.4.2.5851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306840
317 rdf:type schema:CreativeWork
318 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
319 schema:name Department of Otolaryngology/Head Neck Surgery, Stanford University, 94305, Stanford, CA, USA
320 Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
323 schema:name Cancer Center Biostatistics Core, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA
324 Comprehensive Cancer Center, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA
325 Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.254444.7 schema:alternateName Wayne State University
328 schema:name Comprehensive Cancer Center, University of Michigan School of Medicine, 48109-5616, Ann Arbor, MI, USA
329 Wayne State University School of Medicine, 48201, Detroit, MI, USA
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.418185.1 schema:alternateName Genomics Institute of the Novartis Research Foundation
332 schema:name Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, 92121, San Diego, CA, USA
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...