Interaction of host immunity with HER2-targeted treatment and tumor heterogeneity in HER2-positive breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Gaia Griguolo, Tomás Pascual, Maria Vittoria Dieci, Valentina Guarneri, Aleix Prat

ABSTRACT

Growing evidence suggests a clear role of the host immune system in HER2+ breast cancer. In addition, HER2+ breast cancer is generally considered more immunogenic than hormone receptor-positive (HR+)/HER2-, and specific molecular HER2+ subgroups (e.g. HER2-enriched disease) are more immunogenic than others (e.g. Luminal A or B). From a clinical perspective, the immune system plays a relevant prognostic role in HER2+ breast cancer and contributes to the therapeutic effects of trastuzumab. However, as more HER2-targeted agents become available, a better understanding of the role played by the immune system in modulating therapy response to different agents will be needed. Furthermore, the recent introduction in oncology of immune checkpoint inhibitors capable of unleashing anti-tumor immune response opens new possibilities for therapeutic combinations in HER2+ breast cancer. Here, we review the current pre-clinical and clinical data on the interplay between the immune system and HER2+ breast cancer, focusing on different HER2-targeted treatments and the biological heterogeneity that exists within HER2+ disease. Finally, we discuss new therapeutic approaches exploiting the immune system to increase activity or revert resistance to HER2-targeted agents. More... »

PAGES

90

References to SciGraph publications

  • 2015-12. Anti-HER2 CD4+ T-helper type 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2-positive breast cancer in BREAST CANCER RESEARCH
  • 2010-09. Anti-HER2 vaccines: new prospects for breast cancer therapy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2016-11. NK cell-mediated antibody-dependent cellular cytotoxicity is enhanced by tamoxifen in HER2/neu non-amplified, but not HER2/neu-amplified, breast cancer cells in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2007-06. Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells in ONCOGENE
  • 2017-02. Prognostic value of tumor infiltrating lymphocyte subsets in breast cancer depends on hormone receptor status in BREAST CANCER RESEARCH AND TREATMENT
  • 2000-08. Molecular portraits of human breast tumours in NATURE
  • 2017-06. Tumor-infiltrating lymphocytes and molecular response after neoadjuvant therapy for HR+/HER2− breast cancer: results from two prospective trials in BREAST CANCER RESEARCH AND TREATMENT
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2018-12. Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2004-07. Immmunotherapy of cancer: from vision to standard clinical practice in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2017-08. CDK4/6 inhibition triggers anti-tumour immunity in NATURE
  • 2018-12. Immune characterization of breast cancer metastases: prognostic implications in BREAST CANCER RESEARCH
  • 2013-09. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers in NATURE GENETICS
  • 2016-04. Clinical relevance of host immunity in breast cancer: from TILs to the clinic in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2009-02. Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity in ONCOGENE
  • 2016-10. Immunoglobulin G fragment C receptor polymorphisms and efficacy of preoperative chemotherapy plus trastuzumab and lapatinib in HER2-positive breast cancer in THE PHARMACOGENOMICS JOURNAL
  • 2014-09. The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40425-019-0548-6

    DOI

    http://dx.doi.org/10.1186/s40425-019-0548-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113063223

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30922362


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