The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the ... View Full Text


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Article Info

DATE

2019-12

AUTHORS

Laura Pinton, Elena Masetto, Marina Vettore, Samantha Solito, Sara Magri, Marta D’Andolfi, Paola Del Bianco, Giovanna Lollo, Jean-Pierre Benoit, Hideho Okada, Aaron Diaz, Alessandro Della Puppa, Susanna Mandruzzato

ABSTRACT

BACKGROUND: Systemic and local immune suppression plays a significant role in glioma progression. Glioma microenvironment contains both brain-resident microglial cells (MG) and bone marrow-derived macrophages (BMDM), but the study of their functional and immune regulatory activity has been hampered until now by the lack of markers allowing a proper identification and isolation to collect pure populations. METHODS: Myeloid and lymphoid infiltrate were characterized in grade II, III and IV gliomas by multicolor flow cytometry, along with the composition of the cell subsets of circulating myeloid cells. Macrophages were sorted and tested for their immunosuppressive ability. Moreover, following preoperative administration of 5-aminolevulinic acid to patients, distinct areas of tumor lesion were surgically removed and analyzed, based on protoporphyrin IX fluorescence emission. RESULTS: The immune microenvironment of grade II to grade IV gliomas contains a large proportion of myeloid cells and a small proportion of lymphocytes expressing markers of dysfunctional activity. BMDM and resident MG cells were characterized through a combination of markers, thus permitting their geographical identification in the lesions, their sorting and subsequent analysis of the functional characteristics. The infiltration by BMDM reached the highest percentages in grade IV gliomas, and it increased from the periphery to the center of the lesion, where it exerted a strong immunosuppression that was, instead, absent in the marginal area. By contrast, MG showed little or no suppression. Functional differences, such as iron metabolism and phagocytosis, characterized resident versus blood-derived macrophages. Significant alterations in circulating monocytes were present in grade IV patients, correlating with accumulation of tumor macrophages. CONCLUSIONS: Grade IV gliomas have an alteration in both circulating and tumor-associated myeloid cells and, differently from grade II and III gliomas, show a significant presence of blood-derived, immune suppressive macrophages. BMDM and MG have different functional properties. More... »

PAGES

58

References to SciGraph publications

  • 2012-12. Hypoxic Cell Waves Around Necrotic Cores in Glioblastoma: A Biomathematical Model and Its Therapeutic Implications in BULLETIN OF MATHEMATICAL BIOLOGY
  • 2019-01. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial in NATURE
  • 2017-01-16. The movers and shapers in immune privilege of the CNS in NATURE IMMUNOLOGY
  • 2017-12. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment in GENOME BIOLOGY
  • 2014-02. Phenotypic and functional characterization of Glioblastoma cancer stem cells identified trough 5-aminolevulinic acid-assisted surgery in JOURNAL OF NEURO-ONCOLOGY
  • 1988-05. Mononuclear cell infiltrate and HLA-DR expression in low grade astrocytomas in ACTA NEUROPATHOLOGICA
  • 2014-12. Expression of Tumor-Associated Macrophage in Progression of Human Glioma in CELL BIOCHEMISTRY AND BIOPHYSICS
  • 2018-12-19. Actively personalized vaccination trial for newly diagnosed glioblastoma in NATURE
  • 2017-11-20. Microglia and macrophages in brain homeostasis and disease in NATURE REVIEWS IMMUNOLOGY
  • 2017-12. Single-cell RNA-seq study determines the ontogeny of macrophages in glioblastomas in GENOME BIOLOGY
  • 2011-08. Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy in JOURNAL OF NEURO-ONCOLOGY
  • 2015-07. Structural and functional features of central nervous system lymphatic vessels in NATURE
  • 1996-08. Distribution and characterization of microglia/macrophages in human brain tumors in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40425-019-0536-x

    DOI

    http://dx.doi.org/10.1186/s40425-019-0536-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112433914

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30813960


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