Two roads for oncolytic immunotherapy development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Howard L. Kaufman, Praveen K. Bommareddy

ABSTRACT

Oncolytic viruses are an emerging class of immunotherapy agents for cancer treatment. In this issue of JITC, Machiels et al. reports early phase data from an oncolytic adenovirus given by intravenous (IV) administration. While this may allow easy access to metastatic lesions, there is limited data supporting the therapeutic effectiveness of this approach. Further studies should include assessment of viral replication in tumor tissue and consider comparative trials using IV and intratumoral delivery to fully optimize oncolytic immunotherapy. More... »

PAGES

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-019-0515-2

DOI

http://dx.doi.org/10.1186/s40425-019-0515-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111834722

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30709365


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street, Warren 401, 02114, Boston, MA, USA", 
            "Replimune, Inc., Woburn, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaufman", 
        "givenName": "Howard L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Rutgers Graduate School of Biomedical Sciences, New Brunswick, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bommareddy", 
        "givenName": "Praveen K.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-1706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005617183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mt.2015.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009508041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024265520", 
          "https://doi.org/10.1038/sj.gt.3301424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024265520", 
          "https://doi.org/10.1038/sj.gt.3301424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.58.3377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032993053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mt.2016.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033370010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.09.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0000000000000234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074229094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0000000000000234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074229094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-16-3232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090395572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-16-3232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090395572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40425-017-0277-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091472881", 
          "https://doi.org/10.1186/s40425-017-0277-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091503595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.73.7379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092106958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aam7577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100162645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aam7577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100162645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aam7577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100162645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41577-018-0014-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103884843", 
          "https://doi.org/10.1038/s41577-018-0014-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.2018.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107119731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.2018.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107119731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.2018.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107119731"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Oncolytic viruses are an emerging class of immunotherapy agents for cancer treatment. In this issue of JITC, Machiels et al. reports early phase data from an oncolytic adenovirus given by intravenous (IV) administration. While this may allow easy access to metastatic lesions, there is limited data supporting the therapeutic effectiveness of this approach. Further studies should include assessment of viral replication in tumor tissue and consider comparative trials using IV and intratumoral delivery to fully optimize oncolytic immunotherapy.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1186/s40425-019-0515-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Two roads for oncolytic immunotherapy development", 
    "pagination": "26", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3677896eadad0a1870350d143fc363b0669a2a50ab71419fb3477ef9ab46c396"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30709365"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40425-019-0515-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111834722"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40425-019-0515-2", 
      "https://app.dimensions.ai/details/publication/pub.1111834722"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000331_0000000331/records_105418_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40425-019-0515-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0515-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0515-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0515-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0515-2'


 

This table displays all metadata directly associated to this object as RDF triples.

121 TRIPLES      21 PREDICATES      43 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40425-019-0515-2 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N5453829a6a4f4bf0ad33696f63272ca5
4 schema:citation sg:pub.10.1038/s41577-018-0014-6
5 sg:pub.10.1038/sj.gt.3301424
6 sg:pub.10.1186/s40425-017-0277-7
7 https://doi.org/10.1016/j.cell.2017.08.027
8 https://doi.org/10.1038/mt.2015.109
9 https://doi.org/10.1038/mt.2016.101
10 https://doi.org/10.1089/hum.2018.107
11 https://doi.org/10.1097/ppo.0000000000000234
12 https://doi.org/10.1126/scitranslmed.aam7577
13 https://doi.org/10.1158/1078-0432.ccr-10-1706
14 https://doi.org/10.1158/1078-0432.ccr-16-3232
15 https://doi.org/10.1200/jco.2003.09.114
16 https://doi.org/10.1200/jco.2014.58.3377
17 https://doi.org/10.1200/jco.2017.73.7379
18 schema:datePublished 2019-12
19 schema:datePublishedReg 2019-12-01
20 schema:description Oncolytic viruses are an emerging class of immunotherapy agents for cancer treatment. In this issue of JITC, Machiels et al. reports early phase data from an oncolytic adenovirus given by intravenous (IV) administration. While this may allow easy access to metastatic lesions, there is limited data supporting the therapeutic effectiveness of this approach. Further studies should include assessment of viral replication in tumor tissue and consider comparative trials using IV and intratumoral delivery to fully optimize oncolytic immunotherapy.
21 schema:genre non_research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N035537d2e0e9475799ee1aa39e81bd74
25 Ndbadb68a9fc246f9bbf959bb4166e880
26 sg:journal.1049249
27 schema:name Two roads for oncolytic immunotherapy development
28 schema:pagination 26
29 schema:productId N2e5a406a96f04b9f9f2151eb9b949197
30 N7bda58cfa2054cedb53a866daf42c253
31 Nb56d9c87e7e54d89997b777b2b74a44c
32 Nee1b25c69bd84b84b8ce63ed9df141a8
33 Nfd090a43abd4470dad235deaae0d4fa2
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111834722
35 https://doi.org/10.1186/s40425-019-0515-2
36 schema:sdDatePublished 2019-04-11T09:02
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher Ncb8a24d40dc847b58f52ab83cf599790
39 schema:url https://link.springer.com/10.1186%2Fs40425-019-0515-2
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N035537d2e0e9475799ee1aa39e81bd74 schema:volumeNumber 7
44 rdf:type schema:PublicationVolume
45 N106b36a1d00947738eeaeca1f057a915 schema:name Rutgers Graduate School of Biomedical Sciences, New Brunswick, NJ, USA
46 rdf:type schema:Organization
47 N2e5a406a96f04b9f9f2151eb9b949197 schema:name pubmed_id
48 schema:value 30709365
49 rdf:type schema:PropertyValue
50 N5453829a6a4f4bf0ad33696f63272ca5 rdf:first N82a30482d2b749cea1efc54730a9212c
51 rdf:rest Nf0dc2d2837ad4bdb9b3d1e3e2afe28ac
52 N7bda58cfa2054cedb53a866daf42c253 schema:name dimensions_id
53 schema:value pub.1111834722
54 rdf:type schema:PropertyValue
55 N82a30482d2b749cea1efc54730a9212c schema:affiliation https://www.grid.ac/institutes/grid.32224.35
56 schema:familyName Kaufman
57 schema:givenName Howard L.
58 rdf:type schema:Person
59 Nb56d9c87e7e54d89997b777b2b74a44c schema:name readcube_id
60 schema:value 3677896eadad0a1870350d143fc363b0669a2a50ab71419fb3477ef9ab46c396
61 rdf:type schema:PropertyValue
62 Ncb8a24d40dc847b58f52ab83cf599790 schema:name Springer Nature - SN SciGraph project
63 rdf:type schema:Organization
64 Ndbadb68a9fc246f9bbf959bb4166e880 schema:issueNumber 1
65 rdf:type schema:PublicationIssue
66 Ne0e29d7e30044014babc073260e02678 schema:affiliation N106b36a1d00947738eeaeca1f057a915
67 schema:familyName Bommareddy
68 schema:givenName Praveen K.
69 rdf:type schema:Person
70 Nee1b25c69bd84b84b8ce63ed9df141a8 schema:name doi
71 schema:value 10.1186/s40425-019-0515-2
72 rdf:type schema:PropertyValue
73 Nf0dc2d2837ad4bdb9b3d1e3e2afe28ac rdf:first Ne0e29d7e30044014babc073260e02678
74 rdf:rest rdf:nil
75 Nfd090a43abd4470dad235deaae0d4fa2 schema:name nlm_unique_id
76 schema:value 101620585
77 rdf:type schema:PropertyValue
78 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
79 schema:name Medical and Health Sciences
80 rdf:type schema:DefinedTerm
81 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
82 schema:name Oncology and Carcinogenesis
83 rdf:type schema:DefinedTerm
84 sg:journal.1049249 schema:issn 2051-1426
85 schema:name Journal for ImmunoTherapy of Cancer
86 rdf:type schema:Periodical
87 sg:pub.10.1038/s41577-018-0014-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103884843
88 https://doi.org/10.1038/s41577-018-0014-6
89 rdf:type schema:CreativeWork
90 sg:pub.10.1038/sj.gt.3301424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024265520
91 https://doi.org/10.1038/sj.gt.3301424
92 rdf:type schema:CreativeWork
93 sg:pub.10.1186/s40425-017-0277-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091472881
94 https://doi.org/10.1186/s40425-017-0277-7
95 rdf:type schema:CreativeWork
96 https://doi.org/10.1016/j.cell.2017.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091503595
97 rdf:type schema:CreativeWork
98 https://doi.org/10.1038/mt.2015.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009508041
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1038/mt.2016.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033370010
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1089/hum.2018.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107119731
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1097/ppo.0000000000000234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074229094
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1126/scitranslmed.aam7577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100162645
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1158/1078-0432.ccr-10-1706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005617183
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1158/1078-0432.ccr-16-3232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090395572
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1200/jco.2003.09.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203860
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1200/jco.2014.58.3377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032993053
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1200/jco.2017.73.7379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092106958
117 rdf:type schema:CreativeWork
118 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
119 schema:name Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street, Warren 401, 02114, Boston, MA, USA
120 Replimune, Inc., Woburn, MA, USA
121 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...