Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Sarabjot Pabla, Jeffrey M. Conroy, Mary K. Nesline, Sean T. Glenn, Antonios Papanicolau-Sengos, Blake Burgher, Jacob Hagen, Vincent Giamo, Jonathan Andreas, Felicia L. Lenzo, Wang Yirong, Grace K. Dy, Edwin Yau, Amy Early, Hongbin Chen, Wiam Bshara, Katherine G. Madden, Keisuke Shirai, Konstantin Dragnev, Laura J. Tafe, Daniele Marin, Jason Zhu, Jeff Clarke, Matthew Labriola, Shannon McCall, Tian Zhang, Matthew Zibelman, Pooja Ghatalia, Isabel Araujo-Fernandez, Arun Singavi, Ben George, Andrew Craig MacKinnon, Jonathan Thompson, Rajbir Singh, Robin Jacob, Lynn Dressler, Mark Steciuk, Oliver Binns, Deepa Kasuganti, Neel Shah, Marc Ernstoff, Kunle Odunsi, Razelle Kurzrock, Mark Gardner, Lorenzo Galluzzi, Carl Morrison

ABSTRACT

BACKGROUND: Resistance to immune checkpoint inhibitors (ICIs) has been linked to local immunosuppression independent of major ICI targets (e.g., PD-1). Clinical experience with response prediction based on PD-L1 expression suggests that other factors influence sensitivity to ICIs in non-small cell lung cancer (NSCLC) patients. METHODS: Tumor specimens from 120 NSCLC patients from 10 institutions were evaluated for PD-L1 expression by immunohistochemistry, and global proliferative profile by targeted RNA-seq. RESULTS: Cell proliferation, derived from the mean expression of 10 proliferation-associated genes (namely BUB1, CCNB2, CDK1, CDKN3, FOXM1, KIAA0101, MAD2L1, MELK, MKI67, and TOP2A), was identified as a marker of response to ICIs in NSCLC. Poorly, moderately, and highly proliferative tumors were somewhat equally represented in NSCLC, with tumors with the highest PD-L1 expression being more frequently moderately proliferative as compared to lesser levels of PD-L1 expression. Proliferation status had an impact on survival in patients with both PD-L1 positive and negative tumors. There was a significant survival advantage for moderately proliferative tumors compared to their combined highly/poorly counterparts (p = 0.021). Moderately proliferative PD-L1 positive tumors had a median survival of 14.6 months that was almost twice that of PD-L1 negative highly/poorly proliferative at 7.6 months (p = 0.028). Median survival in moderately proliferative PD-L1 negative tumors at 12.6 months was comparable to that of highly/poorly proliferative PD-L1 positive tumors at 11.5 months, but in both instances less than that of moderately proliferative PD-L1 positive tumors. Similar to survival, proliferation status has impact on disease control (DC) in patients with both PD-L1 positive and negative tumors. Patients with moderately versus those with poorly or highly proliferative tumors have a superior DC rate when combined with any classification schema used to score PD-L1 as a positive result (i.e., TPS ≥ 50% or ≥ 1%), and best displayed by a DC rate for moderately proliferative tumors of no less than 40% for any classification of PD-L1 as a negative result. While there is an over representation of moderately proliferative tumors as PD-L1 expression increases this does not account for the improved survival or higher disease control rates seen in PD-L1 negative tumors. CONCLUSIONS: Cell proliferation is potentially a new biomarker of response to ICIs in NSCLC and is applicable to PD-L1 negative tumors. More... »

PAGES

27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-019-0506-3

DOI

http://dx.doi.org/10.1186/s40425-019-0506-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111834442

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30709424


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pabla", 
        "givenName": "Sarabjot", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA", 
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conroy", 
        "givenName": "Jeffrey M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nesline", 
        "givenName": "Mary K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA", 
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Glenn", 
        "givenName": "Sean T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papanicolau-Sengos", 
        "givenName": "Antonios", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burgher", 
        "givenName": "Blake", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagen", 
        "givenName": "Jacob", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giamo", 
        "givenName": "Vincent", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andreas", 
        "givenName": "Jonathan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lenzo", 
        "givenName": "Felicia L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yirong", 
        "givenName": "Wang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dy", 
        "givenName": "Grace K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yau", 
        "givenName": "Edwin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Early", 
        "givenName": "Amy", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Hongbin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bshara", 
        "givenName": "Wiam", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dartmouth\u2013Hitchcock Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413480.a", 
          "name": [
            "Dartmouth-Hitchcock Medical Center, 03756, Lebanon, NH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madden", 
        "givenName": "Katherine G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dartmouth\u2013Hitchcock Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413480.a", 
          "name": [
            "Dartmouth-Hitchcock Medical Center, 03756, Lebanon, NH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shirai", 
        "givenName": "Keisuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dartmouth\u2013Hitchcock Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413480.a", 
          "name": [
            "Dartmouth-Hitchcock Medical Center, 03756, Lebanon, NH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dragnev", 
        "givenName": "Konstantin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dartmouth\u2013Hitchcock Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413480.a", 
          "name": [
            "Dartmouth-Hitchcock Medical Center, 03756, Lebanon, NH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tafe", 
        "givenName": "Laura J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke University, 27708, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marin", 
        "givenName": "Daniele", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke University, 27708, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Jason", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke University, 27708, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clarke", 
        "givenName": "Jeff", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke University, 27708, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Labriola", 
        "givenName": "Matthew", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke University, 27708, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCall", 
        "givenName": "Shannon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke University, 27708, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Tian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University Health System", 
          "id": "https://www.grid.ac/institutes/grid.412530.1", 
          "name": [
            "Fox Chase Cancer Center, 19111, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zibelman", 
        "givenName": "Matthew", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University Health System", 
          "id": "https://www.grid.ac/institutes/grid.412530.1", 
          "name": [
            "Fox Chase Cancer Center, 19111, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghatalia", 
        "givenName": "Pooja", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Virgen Macarena", 
          "id": "https://www.grid.ac/institutes/grid.411375.5", 
          "name": [
            "Hospital Universitario Virgen Macarena, 41009, Sevilla, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Araujo-Fernandez", 
        "givenName": "Isabel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Medical College of Wisconsin, 53226, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singavi", 
        "givenName": "Arun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Medical College of Wisconsin, 53226, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "George", 
        "givenName": "Ben", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Medical College of Wisconsin, 53226, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MacKinnon", 
        "givenName": "Andrew Craig", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Medical College of Wisconsin, 53226, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Jonathan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Meharry Medical College", 
          "id": "https://www.grid.ac/institutes/grid.259870.1", 
          "name": [
            "Meharry Medical College, 37208, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singh", 
        "givenName": "Rajbir", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Meharry Medical College", 
          "id": "https://www.grid.ac/institutes/grid.259870.1", 
          "name": [
            "Meharry Medical College, 37208, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacob", 
        "givenName": "Robin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Mission Health System, 28801, Asheville, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dressler", 
        "givenName": "Lynn", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Mission Health System, 28801, Asheville, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steciuk", 
        "givenName": "Mark", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Mission Health System, 28801, Asheville, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Binns", 
        "givenName": "Oliver", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Community Hospital, 46321, Munster, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kasuganti", 
        "givenName": "Deepa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Community Hospital, 46321, Munster, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Neel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ernstoff", 
        "givenName": "Marc", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Odunsi", 
        "givenName": "Kunle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Personalized Cancer Therapy, Moores Cancer Center, 92093, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurzrock", 
        "givenName": "Razelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gardner", 
        "givenName": "Mark", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "Department of Radiation Oncology, Weill Cornell Medical College, 10065, New York, NY, USA", 
            "Sandra and Edward Meyer Cancer Center, 10065, New York, NY, USA", 
            "Universit\u00e9 Paris Descartes/Paris V, 75006, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galluzzi", 
        "givenName": "Lorenzo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA", 
            "Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morrison", 
        "givenName": "Carl", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1507643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000663586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)00587-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006558153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2015-0498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017863613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.13691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024263540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1501824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031881319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lungcan.2012.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049838318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21037/tlcr.2016.10.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068835190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079151271", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079203013", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.16961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084637464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2017.88", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086289497", 
          "https://doi.org/10.1038/nrclinonc.2017.88"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/2162402x.2017.1373237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091406353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.74.7642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092312928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmoldx.2017.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092331992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1701830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092593266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2018.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103168559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2018.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103168559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2018.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103168559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40425-018-0344-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103905747", 
          "https://doi.org/10.1186/s40425-018-0344-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40425-018-0344-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103905747", 
          "https://doi.org/10.1186/s40425-018-0344-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21873/anticanres.12670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105346673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-05032-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106026156", 
          "https://doi.org/10.1038/s41467-018-05032-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-05032-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106026156", 
          "https://doi.org/10.1038/s41467-018-05032-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aat7807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107110876"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Resistance to immune checkpoint inhibitors (ICIs) has been linked to local immunosuppression independent of major ICI targets (e.g., PD-1). Clinical experience with response prediction based on PD-L1 expression suggests that other factors influence sensitivity to ICIs in non-small cell lung cancer (NSCLC) patients.\nMETHODS: Tumor specimens from 120 NSCLC patients from 10 institutions were evaluated for PD-L1 expression by immunohistochemistry, and global proliferative profile by targeted RNA-seq.\nRESULTS: Cell proliferation, derived from the mean expression of 10 proliferation-associated genes (namely BUB1, CCNB2, CDK1, CDKN3, FOXM1, KIAA0101, MAD2L1, MELK, MKI67, and TOP2A), was identified as a marker of response to ICIs in NSCLC. Poorly, moderately, and highly proliferative tumors were somewhat equally represented in NSCLC, with tumors with the highest PD-L1 expression being more frequently moderately proliferative as compared to lesser levels of PD-L1 expression. Proliferation status had an impact on survival in patients with both PD-L1 positive and negative tumors. There was a significant survival advantage for moderately proliferative tumors compared to their combined highly/poorly counterparts (p\u2009=\u20090.021). Moderately proliferative PD-L1 positive tumors had a median survival of 14.6\u2009months that was almost twice that of PD-L1 negative highly/poorly proliferative at 7.6\u2009months (p\u2009=\u20090.028). Median survival in moderately proliferative PD-L1 negative tumors at 12.6\u2009months was comparable to that of highly/poorly proliferative PD-L1 positive tumors at 11.5\u2009months, but in both instances less than that of moderately proliferative PD-L1 positive tumors. Similar to survival, proliferation status has impact on disease control (DC) in patients with both PD-L1 positive and negative tumors. Patients with moderately versus those with poorly or highly proliferative tumors have a superior DC rate when combined with any classification schema used to score PD-L1 as a positive result (i.e., TPS\u2009\u2265\u200950% or\u2009\u2265\u20091%), and best displayed by a DC rate for moderately proliferative tumors of no less than 40% for any classification of PD-L1 as a negative result. While there is an over representation of moderately proliferative tumors as PD-L1 expression increases this does not account for the improved survival or higher disease control rates seen in PD-L1 negative tumors.\nCONCLUSIONS: Cell proliferation is potentially a new biomarker of response to ICIs in NSCLC and is applicable to PD-L1 negative tumors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40425-019-0506-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients", 
    "pagination": "27", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2f2b18779f9e374db10c96070e9d32cdd2b16b1501c2abde659820a00b4ae112"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30709424"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40425-019-0506-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111834442"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40425-019-0506-3", 
      "https://app.dimensions.ai/details/publication/pub.1111834442"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000331_0000000331/records_105406_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40425-019-0506-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0506-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0506-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0506-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0506-3'


 

This table displays all metadata directly associated to this object as RDF triples.

473 TRIPLES      21 PREDICATES      49 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40425-019-0506-3 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Na1b70d0f0ee64eaeb32f7c3fb9495441
4 schema:citation sg:pub.10.1038/nrclinonc.2017.88
5 sg:pub.10.1038/s41467-018-05032-8
6 sg:pub.10.1186/s40425-018-0344-8
7 https://app.dimensions.ai/details/publication/pub.1079151271
8 https://app.dimensions.ai/details/publication/pub.1079203013
9 https://doi.org/10.1016/j.immuni.2018.03.023
10 https://doi.org/10.1016/j.jmoldx.2017.10.001
11 https://doi.org/10.1016/j.lungcan.2012.10.008
12 https://doi.org/10.1016/s0140-6736(16)00587-0
13 https://doi.org/10.1056/nejmoa1501824
14 https://doi.org/10.1056/nejmoa1507643
15 https://doi.org/10.1056/nejmoa1701830
16 https://doi.org/10.1080/2162402x.2017.1373237
17 https://doi.org/10.1126/scitranslmed.aat7807
18 https://doi.org/10.1200/jco.2017.74.7642
19 https://doi.org/10.1634/theoncologist.2015-0498
20 https://doi.org/10.18632/oncotarget.13691
21 https://doi.org/10.18632/oncotarget.16961
22 https://doi.org/10.21037/tlcr.2016.10.11
23 https://doi.org/10.21873/anticanres.12670
24 schema:datePublished 2019-12
25 schema:datePublishedReg 2019-12-01
26 schema:description BACKGROUND: Resistance to immune checkpoint inhibitors (ICIs) has been linked to local immunosuppression independent of major ICI targets (e.g., PD-1). Clinical experience with response prediction based on PD-L1 expression suggests that other factors influence sensitivity to ICIs in non-small cell lung cancer (NSCLC) patients. METHODS: Tumor specimens from 120 NSCLC patients from 10 institutions were evaluated for PD-L1 expression by immunohistochemistry, and global proliferative profile by targeted RNA-seq. RESULTS: Cell proliferation, derived from the mean expression of 10 proliferation-associated genes (namely BUB1, CCNB2, CDK1, CDKN3, FOXM1, KIAA0101, MAD2L1, MELK, MKI67, and TOP2A), was identified as a marker of response to ICIs in NSCLC. Poorly, moderately, and highly proliferative tumors were somewhat equally represented in NSCLC, with tumors with the highest PD-L1 expression being more frequently moderately proliferative as compared to lesser levels of PD-L1 expression. Proliferation status had an impact on survival in patients with both PD-L1 positive and negative tumors. There was a significant survival advantage for moderately proliferative tumors compared to their combined highly/poorly counterparts (p = 0.021). Moderately proliferative PD-L1 positive tumors had a median survival of 14.6 months that was almost twice that of PD-L1 negative highly/poorly proliferative at 7.6 months (p = 0.028). Median survival in moderately proliferative PD-L1 negative tumors at 12.6 months was comparable to that of highly/poorly proliferative PD-L1 positive tumors at 11.5 months, but in both instances less than that of moderately proliferative PD-L1 positive tumors. Similar to survival, proliferation status has impact on disease control (DC) in patients with both PD-L1 positive and negative tumors. Patients with moderately versus those with poorly or highly proliferative tumors have a superior DC rate when combined with any classification schema used to score PD-L1 as a positive result (i.e., TPS ≥ 50% or ≥ 1%), and best displayed by a DC rate for moderately proliferative tumors of no less than 40% for any classification of PD-L1 as a negative result. While there is an over representation of moderately proliferative tumors as PD-L1 expression increases this does not account for the improved survival or higher disease control rates seen in PD-L1 negative tumors. CONCLUSIONS: Cell proliferation is potentially a new biomarker of response to ICIs in NSCLC and is applicable to PD-L1 negative tumors.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N1d414d5a144d4eeab45d6cc9fb89e9e1
31 Na5699d48db154602b26da49d9a84ec10
32 sg:journal.1049249
33 schema:name Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients
34 schema:pagination 27
35 schema:productId N3a0d136c91ca451aa6eb8f561f31cfd9
36 N42e97747d7b64605a0fe6b94400510ca
37 N740eaf57eb094e4d85ed907e0ebbc8e6
38 N9fcb7b5063584ed7856833aa6e7921bb
39 Ne901b7d13b154aedb5a8352c97aa79fe
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111834442
41 https://doi.org/10.1186/s40425-019-0506-3
42 schema:sdDatePublished 2019-04-11T09:02
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher N376fb645e68349f9906d84d17f0a43be
45 schema:url https://link.springer.com/10.1186%2Fs40425-019-0506-3
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N03dba9c601a3468bbf08669c8ea54aeb schema:affiliation N7552c88a0c574530b9e1d654b9144d0d
50 schema:familyName Kasuganti
51 schema:givenName Deepa
52 rdf:type schema:Person
53 N0875ea185ac540c4b113a5f8f1133ea3 schema:affiliation Nc7b023df434040bc870f7d0b419c8cf8
54 schema:familyName Dy
55 schema:givenName Grace K.
56 rdf:type schema:Person
57 N08805558432e420ea16525eb7856f0e3 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
58 schema:familyName Zhu
59 schema:givenName Jason
60 rdf:type schema:Person
61 N0d9184da59d94d2b82fd6bcc2765c32d schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
62 rdf:type schema:Organization
63 N0daa579845624943b974ec04913a0c7b rdf:first Nde3951dcd1a441798a6ecffab6972a01
64 rdf:rest N0fb4e0fc9ec14e108bc9ed9f71aa3061
65 N0df62e0a07b345a0af3c6515d64de1b3 schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
66 rdf:type schema:Organization
67 N0ef6a5e634f64bb885fbfd23e50f4e8c rdf:first Nfc4cdff59d0b49e3bc9cf84e27d46f12
68 rdf:rest Nd8cfdd751d9d4bf3ae6e43f6c79f0c0c
69 N0fb4e0fc9ec14e108bc9ed9f71aa3061 rdf:first Nb6c6681b21a6496f835e9fa2bdc9567a
70 rdf:rest N1beb25660db24518923e06c2c6f02161
71 N10e0b8469eff42f7845507509818aba4 schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
72 rdf:type schema:Organization
73 N136b7110929942d392e5d950c79f69b2 schema:affiliation https://www.grid.ac/institutes/grid.259870.1
74 schema:familyName Singh
75 schema:givenName Rajbir
76 rdf:type schema:Person
77 N169518e9d7974616a4aec3125fe95d9b rdf:first N1953bc20011946658c2f8e59a942bd38
78 rdf:rest N2b6e0e7e03744f36a15e48617681c998
79 N1953bc20011946658c2f8e59a942bd38 schema:affiliation N82605773496e48b7a542908e19366f46
80 schema:familyName Papanicolau-Sengos
81 schema:givenName Antonios
82 rdf:type schema:Person
83 N1beb25660db24518923e06c2c6f02161 rdf:first N3210885f1ed64b7f99dd9dd6e77f6b34
84 rdf:rest Ne0a6c3ce5f4942a88e6ba24b3eadad6d
85 N1d414d5a144d4eeab45d6cc9fb89e9e1 schema:volumeNumber 7
86 rdf:type schema:PublicationVolume
87 N1f2d4884ef5f4f47a9d7af217091ce4f rdf:first Nb8bda6e33244449fbebb951bd26ee433
88 rdf:rest N66006923f857469f8a1cb6a464a242f8
89 N2669fa6e5021433b98126443ed3f46d8 rdf:first Na74168dd3a0844e9b740e0f107a77b35
90 rdf:rest Neab5d0972d0b428da6b43bba941c6a55
91 N272e2b5ce27344daaecf99e03a0af96a schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
92 rdf:type schema:Organization
93 N28701acca50140a38e35dde2b2803480 rdf:first N03dba9c601a3468bbf08669c8ea54aeb
94 rdf:rest N31efac479cb14331b974b95115a197ad
95 N299a29f8cc9d44108070e1d90381498e schema:name Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
96 rdf:type schema:Organization
97 N2b6e0e7e03744f36a15e48617681c998 rdf:first N79c76d86f0554bfc83dabebb491e6549
98 rdf:rest N9ebd5bd8d86d4be3bbb4ae994d415aed
99 N2d53e018f5154ea7bbb43124c369ec2a schema:affiliation https://www.grid.ac/institutes/grid.411375.5
100 schema:familyName Araujo-Fernandez
101 schema:givenName Isabel
102 rdf:type schema:Person
103 N2d722ab9396544778057ef6e1a751597 rdf:first N9e1d973c810e473ba1b8729ba3371faa
104 rdf:rest N7bca2434a7974f04b2e12f43e8a66c62
105 N31efac479cb14331b974b95115a197ad rdf:first N41d7155971b84b5eaace8142daa67956
106 rdf:rest Nca397ea08b02452ba8d6a03dbac07e85
107 N3210885f1ed64b7f99dd9dd6e77f6b34 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
108 schema:familyName MacKinnon
109 schema:givenName Andrew Craig
110 rdf:type schema:Person
111 N376fb645e68349f9906d84d17f0a43be schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N3a0d136c91ca451aa6eb8f561f31cfd9 schema:name nlm_unique_id
114 schema:value 101620585
115 rdf:type schema:PropertyValue
116 N413d48f645754b76b906b4dc985e2d65 schema:affiliation Nf3789c6cc9ca4722ad015e72a3ea0d9c
117 schema:familyName Glenn
118 schema:givenName Sean T.
119 rdf:type schema:Person
120 N41d7155971b84b5eaace8142daa67956 schema:affiliation N69e957f9111f44af92f8859c53c179c0
121 schema:familyName Shah
122 schema:givenName Neel
123 rdf:type schema:Person
124 N42e97747d7b64605a0fe6b94400510ca schema:name readcube_id
125 schema:value 2f2b18779f9e374db10c96070e9d32cdd2b16b1501c2abde659820a00b4ae112
126 rdf:type schema:PropertyValue
127 N490ac10c155e47829b14a77364ba3f9a schema:affiliation N272e2b5ce27344daaecf99e03a0af96a
128 schema:familyName Gardner
129 schema:givenName Mark
130 rdf:type schema:Person
131 N4c894fc2e4bc4c258e89b18602d3a816 rdf:first Nfe4b686f7cec49c6a908ac6cb52e4e1b
132 rdf:rest Nb655996976ab4adfb0107ea41352623f
133 N4d36d86bd8d548ed9b88d2ca94fe8889 rdf:first N08805558432e420ea16525eb7856f0e3
134 rdf:rest Nfcf8ba7dba8946799f8c5eab744e00c3
135 N4fb0c8ba99444d4ebe2460ff7a4dc6ec rdf:first Ndbb9060c58d743ce964ade29b61e16da
136 rdf:rest N90f2376d99bc499188461e2743a0bf8a
137 N5e4dbfe97ea84ebc8515196b2b1c9316 schema:affiliation Ne7582de1703e4e8ebbf81fae6b2bb760
138 schema:familyName Steciuk
139 schema:givenName Mark
140 rdf:type schema:Person
141 N66006923f857469f8a1cb6a464a242f8 rdf:first Nb7d2535619034afd823000b36027c3a5
142 rdf:rest Nd04571792a044a1fbd004a06774d8f25
143 N676e110e51b149cb9fbbc741bb32f6ae schema:affiliation https://www.grid.ac/institutes/grid.30760.32
144 schema:familyName Thompson
145 schema:givenName Jonathan
146 rdf:type schema:Person
147 N6997da7002384819b50d9f3c8bf172d4 rdf:first Nffb3fd112452487dba4290ab5f0fba1c
148 rdf:rest N2d722ab9396544778057ef6e1a751597
149 N69e957f9111f44af92f8859c53c179c0 schema:name Community Hospital, 46321, Munster, IN, USA
150 rdf:type schema:Organization
151 N6c38667a1cda43788b530ae22adacb02 rdf:first N490ac10c155e47829b14a77364ba3f9a
152 rdf:rest Nba53afee2cd9464bb6362dfac54a3201
153 N6d0aff371ef845ccb621f695d875664b schema:affiliation Na45a77b81ca841a58e06dc569358ddf2
154 schema:familyName Chen
155 schema:givenName Hongbin
156 rdf:type schema:Person
157 N6d1ddd4640774385bf50e9d8031038cc rdf:first N0875ea185ac540c4b113a5f8f1133ea3
158 rdf:rest N4c894fc2e4bc4c258e89b18602d3a816
159 N6e428ae85ce445bebcbfc739c2d348c4 schema:affiliation Nc1e1dabf47c2467f9e53a3c27ff2044c
160 schema:familyName Hagen
161 schema:givenName Jacob
162 rdf:type schema:Person
163 N6f637d60c7bd4c53994b48fffe1a1d90 schema:name Mission Health System, 28801, Asheville, NC, USA
164 rdf:type schema:Organization
165 N71d80ab3f3ee4b59ab2a727480743274 schema:affiliation N10e0b8469eff42f7845507509818aba4
166 schema:familyName Andreas
167 schema:givenName Jonathan
168 rdf:type schema:Person
169 N740eaf57eb094e4d85ed907e0ebbc8e6 schema:name pubmed_id
170 schema:value 30709424
171 rdf:type schema:PropertyValue
172 N7552c88a0c574530b9e1d654b9144d0d schema:name Community Hospital, 46321, Munster, IN, USA
173 rdf:type schema:Organization
174 N75cf888e20254e4ca31dcb57e43a4d11 schema:affiliation Naf224ca3c70a450ca8e2222f86ee0f63
175 schema:familyName Conroy
176 schema:givenName Jeffrey M.
177 rdf:type schema:Person
178 N79c76d86f0554bfc83dabebb491e6549 schema:affiliation Nf1e118b3e3c949be817db26a0c31d44a
179 schema:familyName Burgher
180 schema:givenName Blake
181 rdf:type schema:Person
182 N7bca2434a7974f04b2e12f43e8a66c62 rdf:first Naf157cc5bfb44eb1b540984f85b7b14a
183 rdf:rest N8faed5b01d454a54bd2ae343d1778ff1
184 N7c49988cd2144a7e9aa3333d00ae78e8 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
185 schema:familyName Galluzzi
186 schema:givenName Lorenzo
187 rdf:type schema:Person
188 N7e8a8799b1964fdeb455b4392a8c9204 schema:name Center for Personalized Cancer Therapy, Moores Cancer Center, 92093, La Jolla, CA, USA
189 rdf:type schema:Organization
190 N7fff3a9625a043368c43fb1e47382339 schema:affiliation N9898da2e11124d3db04665e06867b85f
191 schema:familyName Early
192 schema:givenName Amy
193 rdf:type schema:Person
194 N80fe5fcdf2f8430eb2abc7859c40cedd schema:affiliation Nda125010c43e4ef9ae8ad61e370bd0ff
195 schema:familyName Lenzo
196 schema:givenName Felicia L.
197 rdf:type schema:Person
198 N816e6e1e32374cf29894cb9e000ace49 schema:name Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
199 rdf:type schema:Organization
200 N8190ff24a1ef4c8b9dce0bf08fa5b472 rdf:first Nda1b891c013943ffbcb16168c89cd2a7
201 rdf:rest N4d36d86bd8d548ed9b88d2ca94fe8889
202 N82605773496e48b7a542908e19366f46 schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
203 rdf:type schema:Organization
204 N85d57262835a408fa2f7e2f3b0523924 rdf:first N6d0aff371ef845ccb621f695d875664b
205 rdf:rest Ne122523090ae4843a094795d13da9f71
206 N89563a33ec92475581a3e9d14660b0af schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
207 schema:familyName Labriola
208 schema:givenName Matthew
209 rdf:type schema:Person
210 N8b3c5c344d484c80829582214b725a0a rdf:first N75cf888e20254e4ca31dcb57e43a4d11
211 rdf:rest N0ef6a5e634f64bb885fbfd23e50f4e8c
212 N8bd2bce1391247428051adcaef072ec1 schema:affiliation N6f637d60c7bd4c53994b48fffe1a1d90
213 schema:familyName Dressler
214 schema:givenName Lynn
215 rdf:type schema:Person
216 N8be5b788f90343a6beac6e0b4c55b6c4 schema:affiliation N0d9184da59d94d2b82fd6bcc2765c32d
217 schema:familyName Yirong
218 schema:givenName Wang
219 rdf:type schema:Person
220 N8faed5b01d454a54bd2ae343d1778ff1 rdf:first Nc3ecd03e4f394b19be6ef10a60ca30e9
221 rdf:rest N8190ff24a1ef4c8b9dce0bf08fa5b472
222 N90f2376d99bc499188461e2743a0bf8a rdf:first N71d80ab3f3ee4b59ab2a727480743274
223 rdf:rest Nae17b5b5cc9b44bea8125660ee360151
224 N9898da2e11124d3db04665e06867b85f schema:name Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
225 rdf:type schema:Organization
226 N9e1d973c810e473ba1b8729ba3371faa schema:affiliation https://www.grid.ac/institutes/grid.413480.a
227 schema:familyName Shirai
228 schema:givenName Keisuke
229 rdf:type schema:Person
230 N9ebd5bd8d86d4be3bbb4ae994d415aed rdf:first N6e428ae85ce445bebcbfc739c2d348c4
231 rdf:rest N4fb0c8ba99444d4ebe2460ff7a4dc6ec
232 N9ef7127b82d5486dbb6c0a749416fff6 rdf:first N5e4dbfe97ea84ebc8515196b2b1c9316
233 rdf:rest Neba0a2bc417d4252bb522e74ec7f11a9
234 N9fcb7b5063584ed7856833aa6e7921bb schema:name doi
235 schema:value 10.1186/s40425-019-0506-3
236 rdf:type schema:PropertyValue
237 Na1b70d0f0ee64eaeb32f7c3fb9495441 rdf:first Nab0b930218eb481391f5357de307e44b
238 rdf:rest N8b3c5c344d484c80829582214b725a0a
239 Na45a77b81ca841a58e06dc569358ddf2 schema:name Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
240 rdf:type schema:Organization
241 Na5699d48db154602b26da49d9a84ec10 schema:issueNumber 1
242 rdf:type schema:PublicationIssue
243 Na74168dd3a0844e9b740e0f107a77b35 schema:affiliation N816e6e1e32374cf29894cb9e000ace49
244 schema:familyName Odunsi
245 schema:givenName Kunle
246 rdf:type schema:Person
247 Na9195cfe38b140a7995f7eae8920499d schema:affiliation https://www.grid.ac/institutes/grid.412530.1
248 schema:familyName Ghatalia
249 schema:givenName Pooja
250 rdf:type schema:Person
251 Nab0b930218eb481391f5357de307e44b schema:affiliation Nbb77b92d0d3c4ed9a56f0e728ec2bbaa
252 schema:familyName Pabla
253 schema:givenName Sarabjot
254 rdf:type schema:Person
255 Nac0424dfb7754a8fb91957e8d9ad290b rdf:first N8bd2bce1391247428051adcaef072ec1
256 rdf:rest N9ef7127b82d5486dbb6c0a749416fff6
257 Nae17b5b5cc9b44bea8125660ee360151 rdf:first N80fe5fcdf2f8430eb2abc7859c40cedd
258 rdf:rest Ncd2613f573bb4f3895cf33f2455714a9
259 Naed2f7065d4d41cd9b19310b7dd4da1a rdf:first Nf6285294853944dfa298ca70cd541ba4
260 rdf:rest rdf:nil
261 Naf157cc5bfb44eb1b540984f85b7b14a schema:affiliation https://www.grid.ac/institutes/grid.413480.a
262 schema:familyName Dragnev
263 schema:givenName Konstantin
264 rdf:type schema:Person
265 Naf224ca3c70a450ca8e2222f86ee0f63 schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
266 Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
267 rdf:type schema:Organization
268 Nb655996976ab4adfb0107ea41352623f rdf:first N7fff3a9625a043368c43fb1e47382339
269 rdf:rest N85d57262835a408fa2f7e2f3b0523924
270 Nb6c6681b21a6496f835e9fa2bdc9567a schema:affiliation https://www.grid.ac/institutes/grid.30760.32
271 schema:familyName George
272 schema:givenName Ben
273 rdf:type schema:Person
274 Nb7d2535619034afd823000b36027c3a5 schema:affiliation https://www.grid.ac/institutes/grid.412530.1
275 schema:familyName Zibelman
276 schema:givenName Matthew
277 rdf:type schema:Person
278 Nb8bda6e33244449fbebb951bd26ee433 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
279 schema:familyName Zhang
280 schema:givenName Tian
281 rdf:type schema:Person
282 Nb8c711ac8f9e480fa38c0075d020a7d5 schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
283 Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
284 rdf:type schema:Organization
285 Nba53afee2cd9464bb6362dfac54a3201 rdf:first N7c49988cd2144a7e9aa3333d00ae78e8
286 rdf:rest Naed2f7065d4d41cd9b19310b7dd4da1a
287 Nbb77b92d0d3c4ed9a56f0e728ec2bbaa schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
288 rdf:type schema:Organization
289 Nbcd1645110284967b1d4eac1d04a88b1 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
290 schema:familyName McCall
291 schema:givenName Shannon
292 rdf:type schema:Person
293 Nc1d30033e944496eb00d80d58b43a7d4 rdf:first N136b7110929942d392e5d950c79f69b2
294 rdf:rest Ne7e982e4c52d4358bddd56b618bcae36
295 Nc1e1dabf47c2467f9e53a3c27ff2044c schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
296 rdf:type schema:Organization
297 Nc3ecd03e4f394b19be6ef10a60ca30e9 schema:affiliation https://www.grid.ac/institutes/grid.413480.a
298 schema:familyName Tafe
299 schema:givenName Laura J.
300 rdf:type schema:Person
301 Nc41ec44ccb0b4cf69438e7cda74141f4 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
302 schema:familyName Clarke
303 schema:givenName Jeff
304 rdf:type schema:Person
305 Nc7b023df434040bc870f7d0b419c8cf8 schema:name Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
306 rdf:type schema:Organization
307 Nca397ea08b02452ba8d6a03dbac07e85 rdf:first Nd15e7e4b7748424d886e066d1253a79f
308 rdf:rest N2669fa6e5021433b98126443ed3f46d8
309 Ncd2613f573bb4f3895cf33f2455714a9 rdf:first N8be5b788f90343a6beac6e0b4c55b6c4
310 rdf:rest N6d1ddd4640774385bf50e9d8031038cc
311 Nd04571792a044a1fbd004a06774d8f25 rdf:first Na9195cfe38b140a7995f7eae8920499d
312 rdf:rest Nfaa176e1bc1d4e72ad950b8ef6c0473c
313 Nd15e7e4b7748424d886e066d1253a79f schema:affiliation N299a29f8cc9d44108070e1d90381498e
314 schema:familyName Ernstoff
315 schema:givenName Marc
316 rdf:type schema:Person
317 Nd64254fbad6d4fea848c7fbf733c5ff4 schema:name Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
318 rdf:type schema:Organization
319 Nd7a8f2f8a1674b34be5fa0998bc43e9a schema:affiliation N7e8a8799b1964fdeb455b4392a8c9204
320 schema:familyName Kurzrock
321 schema:givenName Razelle
322 rdf:type schema:Person
323 Nd8cfdd751d9d4bf3ae6e43f6c79f0c0c rdf:first N413d48f645754b76b906b4dc985e2d65
324 rdf:rest N169518e9d7974616a4aec3125fe95d9b
325 Nda125010c43e4ef9ae8ad61e370bd0ff schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
326 rdf:type schema:Organization
327 Nda1b891c013943ffbcb16168c89cd2a7 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
328 schema:familyName Marin
329 schema:givenName Daniele
330 rdf:type schema:Person
331 Ndbb9060c58d743ce964ade29b61e16da schema:affiliation N0df62e0a07b345a0af3c6515d64de1b3
332 schema:familyName Giamo
333 schema:givenName Vincent
334 rdf:type schema:Person
335 Ndd07016c0a5c4155ac93cebbcae6d5b0 schema:name Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
336 rdf:type schema:Organization
337 Nde3951dcd1a441798a6ecffab6972a01 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
338 schema:familyName Singavi
339 schema:givenName Arun
340 rdf:type schema:Person
341 Ne0a6c3ce5f4942a88e6ba24b3eadad6d rdf:first N676e110e51b149cb9fbbc741bb32f6ae
342 rdf:rest Nc1d30033e944496eb00d80d58b43a7d4
343 Ne122523090ae4843a094795d13da9f71 rdf:first Nf3ec1ad0a6954b87a1e101f68bca7b1b
344 rdf:rest N6997da7002384819b50d9f3c8bf172d4
345 Ne5f9acee5c9248f9ab7707453ccbaf99 schema:affiliation https://www.grid.ac/institutes/grid.259870.1
346 schema:familyName Jacob
347 schema:givenName Robin
348 rdf:type schema:Person
349 Ne7582de1703e4e8ebbf81fae6b2bb760 schema:name Mission Health System, 28801, Asheville, NC, USA
350 rdf:type schema:Organization
351 Ne79cb050ec2f419c846d9bbc12129d4a schema:name Mission Health System, 28801, Asheville, NC, USA
352 rdf:type schema:Organization
353 Ne7b74b6021ca46ab9172fbb99bf956e7 schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
354 rdf:type schema:Organization
355 Ne7e982e4c52d4358bddd56b618bcae36 rdf:first Ne5f9acee5c9248f9ab7707453ccbaf99
356 rdf:rest Nac0424dfb7754a8fb91957e8d9ad290b
357 Ne901b7d13b154aedb5a8352c97aa79fe schema:name dimensions_id
358 schema:value pub.1111834442
359 rdf:type schema:PropertyValue
360 Ne97140013a4f4ba785fc1144931c3aae rdf:first N89563a33ec92475581a3e9d14660b0af
361 rdf:rest Neafef973496543c19c3756259b9be6a7
362 Neab5d0972d0b428da6b43bba941c6a55 rdf:first Nd7a8f2f8a1674b34be5fa0998bc43e9a
363 rdf:rest N6c38667a1cda43788b530ae22adacb02
364 Neafef973496543c19c3756259b9be6a7 rdf:first Nbcd1645110284967b1d4eac1d04a88b1
365 rdf:rest N1f2d4884ef5f4f47a9d7af217091ce4f
366 Neba0a2bc417d4252bb522e74ec7f11a9 rdf:first Nf7620f1e052d42d79de55399c25da082
367 rdf:rest N28701acca50140a38e35dde2b2803480
368 Nf1e118b3e3c949be817db26a0c31d44a schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
369 rdf:type schema:Organization
370 Nf3789c6cc9ca4722ad015e72a3ea0d9c schema:name OmniSeq, Inc., 700 Ellicott Street, 14203, Buffalo, NY, USA
371 Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, 14206, Buffalo, NY, USA
372 rdf:type schema:Organization
373 Nf3ec1ad0a6954b87a1e101f68bca7b1b schema:affiliation Nd64254fbad6d4fea848c7fbf733c5ff4
374 schema:familyName Bshara
375 schema:givenName Wiam
376 rdf:type schema:Person
377 Nf6285294853944dfa298ca70cd541ba4 schema:affiliation Nb8c711ac8f9e480fa38c0075d020a7d5
378 schema:familyName Morrison
379 schema:givenName Carl
380 rdf:type schema:Person
381 Nf7620f1e052d42d79de55399c25da082 schema:affiliation Ne79cb050ec2f419c846d9bbc12129d4a
382 schema:familyName Binns
383 schema:givenName Oliver
384 rdf:type schema:Person
385 Nfaa176e1bc1d4e72ad950b8ef6c0473c rdf:first N2d53e018f5154ea7bbb43124c369ec2a
386 rdf:rest N0daa579845624943b974ec04913a0c7b
387 Nfc4cdff59d0b49e3bc9cf84e27d46f12 schema:affiliation Ne7b74b6021ca46ab9172fbb99bf956e7
388 schema:familyName Nesline
389 schema:givenName Mary K.
390 rdf:type schema:Person
391 Nfcf8ba7dba8946799f8c5eab744e00c3 rdf:first Nc41ec44ccb0b4cf69438e7cda74141f4
392 rdf:rest Ne97140013a4f4ba785fc1144931c3aae
393 Nfe4b686f7cec49c6a908ac6cb52e4e1b schema:affiliation Ndd07016c0a5c4155ac93cebbcae6d5b0
394 schema:familyName Yau
395 schema:givenName Edwin
396 rdf:type schema:Person
397 Nffb3fd112452487dba4290ab5f0fba1c schema:affiliation https://www.grid.ac/institutes/grid.413480.a
398 schema:familyName Madden
399 schema:givenName Katherine G.
400 rdf:type schema:Person
401 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
402 schema:name Medical and Health Sciences
403 rdf:type schema:DefinedTerm
404 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
405 schema:name Oncology and Carcinogenesis
406 rdf:type schema:DefinedTerm
407 sg:journal.1049249 schema:issn 2051-1426
408 schema:name Journal for ImmunoTherapy of Cancer
409 rdf:type schema:Periodical
410 sg:pub.10.1038/nrclinonc.2017.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086289497
411 https://doi.org/10.1038/nrclinonc.2017.88
412 rdf:type schema:CreativeWork
413 sg:pub.10.1038/s41467-018-05032-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106026156
414 https://doi.org/10.1038/s41467-018-05032-8
415 rdf:type schema:CreativeWork
416 sg:pub.10.1186/s40425-018-0344-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103905747
417 https://doi.org/10.1186/s40425-018-0344-8
418 rdf:type schema:CreativeWork
419 https://app.dimensions.ai/details/publication/pub.1079151271 schema:CreativeWork
420 https://app.dimensions.ai/details/publication/pub.1079203013 schema:CreativeWork
421 https://doi.org/10.1016/j.immuni.2018.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103168559
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1016/j.jmoldx.2017.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092331992
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1016/j.lungcan.2012.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049838318
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1016/s0140-6736(16)00587-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006558153
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1056/nejmoa1501824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031881319
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1056/nejmoa1507643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000663586
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1056/nejmoa1701830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092593266
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1080/2162402x.2017.1373237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091406353
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1126/scitranslmed.aat7807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107110876
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1200/jco.2017.74.7642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092312928
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1634/theoncologist.2015-0498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017863613
442 rdf:type schema:CreativeWork
443 https://doi.org/10.18632/oncotarget.13691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024263540
444 rdf:type schema:CreativeWork
445 https://doi.org/10.18632/oncotarget.16961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084637464
446 rdf:type schema:CreativeWork
447 https://doi.org/10.21037/tlcr.2016.10.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068835190
448 rdf:type schema:CreativeWork
449 https://doi.org/10.21873/anticanres.12670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105346673
450 rdf:type schema:CreativeWork
451 https://www.grid.ac/institutes/grid.10992.33 schema:alternateName Paris Descartes University
452 schema:name Department of Radiation Oncology, Weill Cornell Medical College, 10065, New York, NY, USA
453 Sandra and Edward Meyer Cancer Center, 10065, New York, NY, USA
454 Université Paris Descartes/Paris V, 75006, Paris, France
455 rdf:type schema:Organization
456 https://www.grid.ac/institutes/grid.259870.1 schema:alternateName Meharry Medical College
457 schema:name Meharry Medical College, 37208, Nashville, TN, USA
458 rdf:type schema:Organization
459 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
460 schema:name Duke University, 27708, Durham, NC, USA
461 rdf:type schema:Organization
462 https://www.grid.ac/institutes/grid.30760.32 schema:alternateName Medical College of Wisconsin
463 schema:name Medical College of Wisconsin, 53226, Milwaukee, WI, USA
464 rdf:type schema:Organization
465 https://www.grid.ac/institutes/grid.411375.5 schema:alternateName Hospital Universitario Virgen Macarena
466 schema:name Hospital Universitario Virgen Macarena, 41009, Sevilla, Spain
467 rdf:type schema:Organization
468 https://www.grid.ac/institutes/grid.412530.1 schema:alternateName Temple University Health System
469 schema:name Fox Chase Cancer Center, 19111, Philadelphia, PA, USA
470 rdf:type schema:Organization
471 https://www.grid.ac/institutes/grid.413480.a schema:alternateName Dartmouth–Hitchcock Medical Center
472 schema:name Dartmouth-Hitchcock Medical Center, 03756, Lebanon, NH, USA
473 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...