Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Clara Chong Hui Ong, Aye Aye Thike, Wei Hseun Yeap, Yi Yang, Ansel Yi Herh Lim, Timothy Kwang Yong Tay, Jin Liu, Siew-Cheng Wong, Jinmiao Chen, Elaine Hsuen Lim, Jabed Iqbal, Rebecca Dent, Evan W. Newell, Puay Hoon Tan

ABSTRACT

The role of programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) in triple negative breast cancer (TNBC) remains to be fully understood. In this study, we investigated the role of PD-1 as a prognostic marker for TNBC in an Asian cohort (n = 269). Samples from patients with TNBC were labeled with antibodies against PD-L1 and PD-1, and subjected to NanoString assays to measure the expression of immune-related genes. Associations between disease-free survival (DFS), overall survival (OS) and biomarker expression were investigated. Multivariate analysis showed that tumors with high PD-1+ immune infiltrates harbored significantly increased DFS, and this increase was significant even after controlling for clinicopathological parameters (HR 0.95; P = 0.030). In addition, the density of cells expressing both CD8 and PD-1, but not the density of CD8-PD-1+ immune infiltrates, was associated with improved DFS. Notably, this prognostic significance was independent of clinicopathological parameters and the densities of total CD8+ cell (HR 0.43, P = 0.011). At the transcriptional level, high expression of PDCD1 within the tumor was significantly associated with improved DFS (HR 0.38; P = 0.027). In line with these findings, high expression of IFNG (HR 0.38; P = 0.001) and IFN signaling genes (HR 0.46; p = 0.027) was also associated with favorable DFS. Inclusion of PD-1 immune infiltrates and PDCD1 gene expression added significant prognostic value for DFS (ΔLRχ2 = 6.35; P = 0.041) and OS (ΔLRχ2 = 9.53; P = 0.008), beyond that provided by classical clinicopathological variables. Thus, PD-1 mRNA and protein expression status represent a promising, independent indicator of prognosis in TNBC. More... »

PAGES

34

References to SciGraph publications

  • 2016-12. PD-L1 expression and CD274 gene alteration in triple-negative breast cancer: implication for prognostic biomarker in SPRINGERPLUS
  • 2018-08. Homologous recombination deficiency and host anti-tumor immunity in triple-negative breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2018-05. Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates in NATURE
  • 2013-04. Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis in GENOME BIOLOGY
  • 2008-03. Direct multiplexed measurement of gene expression with color-coded probe pairs in NATURE BIOTECHNOLOGY
  • 2017-11-02. Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers in ONCOGENE
  • 2015-06. T-cell exhaustion in the tumor microenvironment in CELL DEATH & DISEASE
  • 2002-11. Cancer immunoediting: from immunosurveillance to tumor escape in NATURE IMMUNOLOGY
  • 2015-09. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis in NATURE MEDICINE
  • 2005-06. Interferon-γ and cancer immunoediting in IMMUNOLOGIC RESEARCH
  • 2010-01. Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer in MODERN PATHOLOGY
  • 2016-04. Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2016-12. COX-2 modulates mammary tumor progression in response to collagen density in BREAST CANCER RESEARCH
  • 2017-10. Immunotherapy in Breast Cancer: the Emerging Role of PD-1 and PD-L1 in CURRENT ONCOLOGY REPORTS
  • 2012-04. The blockade of immune checkpoints in cancer immunotherapy in NATURE REVIEWS CANCER
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2014-03. Loss of androgen receptor expression predicts early recurrence in triple-negative and basal-like breast cancer in MODERN PATHOLOGY
  • 2012-06. The clonal and mutational evolution spectrum of primary triple-negative breast cancers in NATURE
  • 2016-02. HER2 FISH classification of equivocal HER2 IHC breast cancers with use of the 2013 ASCO/CAP practice guideline in BREAST CANCER RESEARCH AND TREATMENT
  • 2017-05. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity in NATURE
  • 2012-04. CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer in BREAST CANCER RESEARCH
  • 2012-07. Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance in NATURE MEDICINE
  • 2016-12. An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers in BREAST CANCER RESEARCH
  • 2017-12. Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer in SCIENTIFIC REPORTS
  • 2016-12. Expression of PD-L1 in triple-negative breast cancer based on different immunohistochemical antibodies in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2015-08. Molecular and cellular insights into T cell exhaustion in NATURE REVIEWS IMMUNOLOGY
  • 2017-12. Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer in SCIENTIFIC REPORTS
  • 2016-05-10. The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes in NATURE COMMUNICATIONS
  • 2009-04. T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers in BREAST CANCER RESEARCH
  • 2017-02. PD-L1 expression and tumor infiltrating PD-1+ lymphocytes associated with outcome in HER2+ breast cancer patients in BREAST CANCER RESEARCH AND TREATMENT
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40425-019-0499-y

    DOI

    http://dx.doi.org/10.1186/s40425-019-0499-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111954631

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30728081


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Singapore Immunology Network", 
              "id": "https://www.grid.ac/institutes/grid.430276.4", 
              "name": [
                "Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore", 
                "Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 8A, Biomedical Grove, Immunos, 138648, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yeong", 
            "givenName": "Joe", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.163555.1", 
              "name": [
                "Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Jeffrey Chun Tatt", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore Immunology Network", 
              "id": "https://www.grid.ac/institutes/grid.430276.4", 
              "name": [
                "Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 8A, Biomedical Grove, Immunos, 138648, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Bernett", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.163555.1", 
              "name": [
                "Division of Medicine, Singapore General Hospital, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Huihua", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.163555.1", 
              "name": [
                "Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ong", 
            "givenName": "Clara Chong Hui", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke NUS Graduate Medical School", 
              "id": "https://www.grid.ac/institutes/grid.428397.3", 
              "name": [
                "Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore", 
                "Duke-NUS Medical School, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thike", 
            "givenName": "Aye Aye", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore Immunology Network", 
              "id": "https://www.grid.ac/institutes/grid.430276.4", 
              "name": [
                "Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 8A, Biomedical Grove, Immunos, 138648, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yeap", 
            "givenName": "Wei Hseun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shanghai University of Finance and Economics", 
              "id": "https://www.grid.ac/institutes/grid.443531.4", 
              "name": [
                "Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore", 
                "Shanghai University of Finance and Economics, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Yi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Ansel Yi Herh", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.163555.1", 
              "name": [
                "Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tay", 
            "givenName": "Timothy Kwang Yong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke NUS Graduate Medical School", 
              "id": "https://www.grid.ac/institutes/grid.428397.3", 
              "name": [
                "Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Jin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore Immunology Network", 
              "id": "https://www.grid.ac/institutes/grid.430276.4", 
              "name": [
                "Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 8A, Biomedical Grove, Immunos, 138648, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wong", 
            "givenName": "Siew-Cheng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore Immunology Network", 
              "id": "https://www.grid.ac/institutes/grid.430276.4", 
              "name": [
                "Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 8A, Biomedical Grove, Immunos, 138648, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Jinmiao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre Singapore", 
              "id": "https://www.grid.ac/institutes/grid.410724.4", 
              "name": [
                "National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Elaine Hsuen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke NUS Graduate Medical School", 
              "id": "https://www.grid.ac/institutes/grid.428397.3", 
              "name": [
                "Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore", 
                "Duke-NUS Medical School, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iqbal", 
            "givenName": "Jabed", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Centre Singapore", 
              "id": "https://www.grid.ac/institutes/grid.410724.4", 
              "name": [
                "National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dent", 
            "givenName": "Rebecca", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore Immunology Network", 
              "id": "https://www.grid.ac/institutes/grid.430276.4", 
              "name": [
                "Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 8A, Biomedical Grove, Immunos, 138648, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Newell", 
            "givenName": "Evan W.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke NUS Graduate Medical School", 
              "id": "https://www.grid.ac/institutes/grid.428397.3", 
              "name": [
                "Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore", 
                "Duke-NUS Medical School, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tan", 
            "givenName": "Puay Hoon", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1056/nejmoa1507643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000663586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2014.08.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002944887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2014.08.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002944887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13058-016-0695-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004125643", 
              "https://doi.org/10.1186/s13058-016-0695-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3816/cbc.2009.n.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006637826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.58.1967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006980479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.22.012703.104803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007787378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472-can-04-3913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011326721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011831914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(01)00038-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012007571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/2162402x.2015.1104448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012554752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.05733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013230338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-016-3743-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013411374", 
              "https://doi.org/10.1007/s10549-016-3743-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.aad6352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013700027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013709887", 
              "https://doi.org/10.1038/ni1102-991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013709887", 
              "https://doi.org/10.1038/ni1102-991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1603702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014027039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014237989", 
              "https://doi.org/10.1186/bcr3148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/ir:32:1-3:231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015039980", 
              "https://doi.org/10.1385/ir:32:1-3:231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0045831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015410342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1229620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015967817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.05.9584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016311334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1005177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018062329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acschembio.5b00577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018476151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci65416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018481946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018567687", 
              "https://doi.org/10.1038/nm.3902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-016-0925-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018850062", 
              "https://doi.org/10.1186/s12967-016-0925-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-016-0925-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018850062", 
              "https://doi.org/10.1186/s12967-016-0925-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2014.17322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018973821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019011944", 
              "https://doi.org/10.1038/nri3862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2015-310814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019647047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/tbj.12753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019793378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-016-4095-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021178743", 
              "https://doi.org/10.1007/s10549-016-4095-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-016-4095-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021178743", 
              "https://doi.org/10.1007/s10549-016-4095-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.41.0902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021750149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-016-3717-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021839209", 
              "https://doi.org/10.1007/s10549-016-3717-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5858/arpa.2013-0953-sa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023063099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djp090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023191704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.55.0491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023387220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e3181fad2b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023692192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e3181fad2b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023692192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e3181fad2b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023692192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e3181fad2b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023692192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2015.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023772516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2015.162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023955040", 
              "https://doi.org/10.1038/cddis.2015.162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-1849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024765690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942368", 
              "https://doi.org/10.1038/nature11412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1001389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025958385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026488299", 
              "https://doi.org/10.1038/modpathol.2009.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027457561", 
              "https://doi.org/10.1038/nature10933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/jca.14549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027905230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.50.9984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028197158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.14698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028622486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jclinpath-2012-200734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029710694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2014.01.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030577661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-12-195792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031554317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000453569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031972888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1004251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032936139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.10290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033302383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2004088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033807182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-4-r34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034169227", 
              "https://doi.org/10.1186/gb-2013-14-4-r34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-13-0286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034201112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035269256", 
              "https://doi.org/10.1186/bcr2234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.25746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036042314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1002042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037027991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1606774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037631694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20142237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038520844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32835b651e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038549508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32835b651e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038549508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.00409-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038927474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-14-0133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039800119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2015.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040675165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2014.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041557628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci80445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041643808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13058-016-0783-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042514267", 
              "https://doi.org/10.1186/s13058-016-0783-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13058-016-0783-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042514267", 
              "https://doi.org/10.1186/s13058-016-0783-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/2162402x.2016.1257452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043695252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/tlo.13256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043778485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.10.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043947020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.12150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045368491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0082870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045482066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40064-016-2513-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046340888", 
              "https://doi.org/10.1186/s40064-016-2513-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40064-016-2513-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046340888", 
              "https://doi.org/10.1186/s40064-016-2513-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci73639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046634997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.30552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046810495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jclinpath-2012-201428", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047143747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047946992", 
              "https://doi.org/10.1038/nrc3239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-3045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048367977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2013.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049562019", 
              "https://doi.org/10.1038/modpathol.2013.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050455938", 
              "https://doi.org/10.1038/ncomms11479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050783607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050979495", 
              "https://doi.org/10.1038/nm.2795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdw217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052148972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.5583", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052440002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052864697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053259870", 
              "https://doi.org/10.1038/nbt1385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1758834012475152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054045483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1758834012475152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054045483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcp/aqw134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059380698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2015.64.8931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.5.2756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075112145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1502635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079244591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081897289", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083780777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083780777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms18020459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083860742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.15532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083919401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep42929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084131191", 
              "https://doi.org/10.1038/srep42929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000464353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084233584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085425411", 
              "https://doi.org/10.1038/nature22396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085425411", 
              "https://doi.org/10.1038/nature22396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085425411", 
              "https://doi.org/10.1038/nature22396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci91190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086257148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2017.00760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090275502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2017.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090575369", 
              "https://doi.org/10.1038/onc.2017.209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci.insight.93652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090809969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci.insight.93652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090809969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jclinpath-2017-204495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090879742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11912-017-0627-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091143231", 
              "https://doi.org/10.1007/s11912-017-0627-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11912-017-0627-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091143231", 
              "https://doi.org/10.1007/s11912-017-0627-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-08479-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091144067", 
              "https://doi.org/10.1038/s41598-017-08479-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-08479-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091144067", 
              "https://doi.org/10.1038/s41598-017-08479-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/2162402x.2017.1364828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091307941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-16-3167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091691929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-16-2684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092343393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pathol.2017.11.087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100913388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.21037/cco.2018.04.01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103718205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-018-4807-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103851740", 
              "https://doi.org/10.1007/s10549-018-4807-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-018-4807-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103851740", 
              "https://doi.org/10.1007/s10549-018-4807-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0130-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103975533", 
              "https://doi.org/10.1038/s41586-018-0130-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2018.01209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104292641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.34.15_suppl.1009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106840881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.35.15_suppl.1008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106845569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.35.15_suppl.3062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106846296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.35.15_suppl.556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106846836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.35.15_suppl.e15609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106848319"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "The role of programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) in triple negative breast cancer (TNBC) remains to be fully understood. In this study, we investigated the role of PD-1 as a prognostic marker for TNBC in an Asian cohort (n\u2009=\u2009269). Samples from patients with TNBC were labeled with antibodies against PD-L1 and PD-1, and subjected to NanoString assays to measure the expression of immune-related genes. Associations between disease-free survival (DFS), overall survival (OS) and biomarker expression were investigated. Multivariate analysis showed that tumors with high PD-1+ immune infiltrates harbored significantly increased DFS, and this increase was significant even after controlling for clinicopathological parameters (HR 0.95; P\u2009=\u20090.030). In addition, the density of cells expressing both CD8 and PD-1, but not the density of CD8-PD-1+ immune infiltrates, was associated with improved DFS. Notably, this prognostic significance was independent of clinicopathological parameters and the densities of total CD8+ cell (HR 0.43, P\u2009=\u20090.011). At the transcriptional level, high expression of PDCD1 within the tumor was significantly associated with improved DFS (HR 0.38; P\u2009=\u20090.027). In line with these findings, high expression of IFNG (HR 0.38; P\u2009=\u20090.001) and IFN signaling genes (HR 0.46; p\u2009=\u20090.027) was also associated with favorable DFS. Inclusion of PD-1 immune infiltrates and PDCD1 gene expression added significant prognostic value for DFS (\u0394LR\u03c72\u2009=\u20096.35; P\u2009=\u20090.041) and OS (\u0394LR\u03c72\u2009=\u20099.53; P\u2009=\u20090.008), beyond that provided by classical clinicopathological variables. Thus, PD-1 mRNA and protein expression status represent a promising, independent indicator of prognosis in TNBC.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s40425-019-0499-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1049249", 
            "issn": [
              "2051-1426"
            ], 
            "name": "Journal for ImmunoTherapy of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer", 
        "pagination": "34", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f0aca6972b139eb2431ee8b8fc029036fb66d3ca61a774d30fdd672e81379bb0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30728081"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101620585"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s40425-019-0499-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111954631"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s40425-019-0499-y", 
          "https://app.dimensions.ai/details/publication/pub.1111954631"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47957_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs40425-019-0499-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0499-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0499-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0499-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-019-0499-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    575 TRIPLES      21 PREDICATES      148 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s40425-019-0499-y schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author Nd710f06ad82944d3acbca0cc3c2e32b7
    4 schema:citation sg:pub.10.1007/s10549-016-3717-z
    5 sg:pub.10.1007/s10549-016-3743-x
    6 sg:pub.10.1007/s10549-016-4095-2
    7 sg:pub.10.1007/s10549-018-4807-x
    8 sg:pub.10.1007/s11912-017-0627-0
    9 sg:pub.10.1038/cddis.2015.162
    10 sg:pub.10.1038/modpathol.2009.145
    11 sg:pub.10.1038/modpathol.2013.145
    12 sg:pub.10.1038/nature10933
    13 sg:pub.10.1038/nature11412
    14 sg:pub.10.1038/nature22396
    15 sg:pub.10.1038/nbt1385
    16 sg:pub.10.1038/ncomms11479
    17 sg:pub.10.1038/ni1102-991
    18 sg:pub.10.1038/nm.2795
    19 sg:pub.10.1038/nm.3902
    20 sg:pub.10.1038/nrc3239
    21 sg:pub.10.1038/nri3862
    22 sg:pub.10.1038/onc.2017.209
    23 sg:pub.10.1038/s41586-018-0130-2
    24 sg:pub.10.1038/s41598-017-08479-9
    25 sg:pub.10.1038/srep42929
    26 sg:pub.10.1186/bcr2234
    27 sg:pub.10.1186/bcr3148
    28 sg:pub.10.1186/gb-2013-14-4-r34
    29 sg:pub.10.1186/s12967-016-0925-6
    30 sg:pub.10.1186/s13058-016-0695-3
    31 sg:pub.10.1186/s13058-016-0783-4
    32 sg:pub.10.1186/s40064-016-2513-x
    33 sg:pub.10.1385/ir:32:1-3:231
    34 https://app.dimensions.ai/details/publication/pub.1081897289
    35 https://doi.org/10.1001/jama.2014.17322
    36 https://doi.org/10.1002/cncr.25746
    37 https://doi.org/10.1002/ijc.30552
    38 https://doi.org/10.1002/jcp.10290
    39 https://doi.org/10.1016/j.cell.2011.02.013
    40 https://doi.org/10.1016/j.cell.2015.10.054
    41 https://doi.org/10.1016/j.coi.2014.01.004
    42 https://doi.org/10.1016/j.coi.2015.12.007
    43 https://doi.org/10.1016/j.humpath.2014.01.008
    44 https://doi.org/10.1016/j.humpath.2015.09.006
    45 https://doi.org/10.1016/j.pathol.2017.11.087
    46 https://doi.org/10.1016/j.ymeth.2014.08.016
    47 https://doi.org/10.1016/s1359-6101(01)00038-7
    48 https://doi.org/10.1021/acschembio.5b00577
    49 https://doi.org/10.1056/nejmoa1507643
    50 https://doi.org/10.1056/nejmoa1603702
    51 https://doi.org/10.1056/nejmoa1606774
    52 https://doi.org/10.1056/nejmra1001389
    53 https://doi.org/10.1080/2162402x.2015.1104448
    54 https://doi.org/10.1080/2162402x.2016.1257452
    55 https://doi.org/10.1080/2162402x.2017.1364828
    56 https://doi.org/10.1084/jem.20142237
    57 https://doi.org/10.1093/ajcp/aqw134
    58 https://doi.org/10.1093/annonc/mdw217
    59 https://doi.org/10.1093/jnci/djp090
    60 https://doi.org/10.1097/cco.0b013e32835b651e
    61 https://doi.org/10.1097/cji.0b013e3181fad2b0
    62 https://doi.org/10.1097/pas.0000000000000780
    63 https://doi.org/10.1111/his.12904
    64 https://doi.org/10.1111/tbj.12753
    65 https://doi.org/10.1126/science.1229620
    66 https://doi.org/10.1126/scisignal.2004088
    67 https://doi.org/10.1126/scitranslmed.aad6352
    68 https://doi.org/10.1128/jvi.00409-07
    69 https://doi.org/10.1136/gutjnl-2015-310814
    70 https://doi.org/10.1136/jclinpath-2012-200734
    71 https://doi.org/10.1136/jclinpath-2012-201428
    72 https://doi.org/10.1136/jclinpath-2017-204495
    73 https://doi.org/10.1146/annurev.immunol.22.012703.104803
    74 https://doi.org/10.1158/0008-5472-can-04-3913
    75 https://doi.org/10.1158/0008-5472.can-16-2684
    76 https://doi.org/10.1158/0008-5472.can-16-3167
    77 https://doi.org/10.1158/1078-0432.ccr-06-3045
    78 https://doi.org/10.1158/1078-0432.ccr-15-1849
    79 https://doi.org/10.1158/2159-8290.cd-12-0095
    80 https://doi.org/10.1158/2159-8290.cd-13-0286
    81 https://doi.org/10.1158/2326-6066.cir-13-0127
    82 https://doi.org/10.1158/2326-6066.cir-14-0133
    83 https://doi.org/10.1159/000453569
    84 https://doi.org/10.1159/000464353
    85 https://doi.org/10.1172/jci.insight.93652
    86 https://doi.org/10.1172/jci65416
    87 https://doi.org/10.1172/jci73639
    88 https://doi.org/10.1172/jci80445
    89 https://doi.org/10.1172/jci91190
    90 https://doi.org/10.1177/1758834012475152
    91 https://doi.org/10.1182/blood-2008-12-195792
    92 https://doi.org/10.1200/jco.2006.05.9584
    93 https://doi.org/10.1200/jco.2011.41.0902
    94 https://doi.org/10.1200/jco.2013.50.9984
    95 https://doi.org/10.1200/jco.2013.55.0491
    96 https://doi.org/10.1200/jco.2014.58.1967
    97 https://doi.org/10.1200/jco.2015.64.8931
    98 https://doi.org/10.1200/jco.2016.34.15_suppl.1009
    99 https://doi.org/10.1200/jco.2017.35.15_suppl.1008
    100 https://doi.org/10.1200/jco.2017.35.15_suppl.3062
    101 https://doi.org/10.1200/jco.2017.35.15_suppl.556
    102 https://doi.org/10.1200/jco.2017.35.15_suppl.e15609
    103 https://doi.org/10.1371/journal.pone.0045831
    104 https://doi.org/10.1371/journal.pone.0082870
    105 https://doi.org/10.1371/journal.ppat.1004251
    106 https://doi.org/10.1371/journal.ppat.1005177
    107 https://doi.org/10.1593/neo.05733
    108 https://doi.org/10.1593/tlo.13256
    109 https://doi.org/10.18632/oncotarget.12150
    110 https://doi.org/10.18632/oncotarget.14698
    111 https://doi.org/10.18632/oncotarget.15532
    112 https://doi.org/10.18632/oncotarget.5583
    113 https://doi.org/10.21037/cco.2018.04.01
    114 https://doi.org/10.3389/fimmu.2017.00760
    115 https://doi.org/10.3389/fimmu.2018.01209
    116 https://doi.org/10.3390/ijms18020459
    117 https://doi.org/10.3816/cbc.2009.n.005
    118 https://doi.org/10.4049/jimmunol.1002042
    119 https://doi.org/10.4049/jimmunol.1502635
    120 https://doi.org/10.4049/jimmunol.169.5.2756
    121 https://doi.org/10.5858/arpa.2013-0953-sa
    122 https://doi.org/10.7150/jca.14549
    123 schema:datePublished 2019-12
    124 schema:datePublishedReg 2019-12-01
    125 schema:description The role of programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) in triple negative breast cancer (TNBC) remains to be fully understood. In this study, we investigated the role of PD-1 as a prognostic marker for TNBC in an Asian cohort (n = 269). Samples from patients with TNBC were labeled with antibodies against PD-L1 and PD-1, and subjected to NanoString assays to measure the expression of immune-related genes. Associations between disease-free survival (DFS), overall survival (OS) and biomarker expression were investigated. Multivariate analysis showed that tumors with high PD-1<sup>+</sup> immune infiltrates harbored significantly increased DFS, and this increase was significant even after controlling for clinicopathological parameters (HR 0.95; P = 0.030). In addition, the density of cells expressing both CD8 and PD-1, but not the density of CD8<sup>-</sup>PD-1<sup>+</sup> immune infiltrates, was associated with improved DFS. Notably, this prognostic significance was independent of clinicopathological parameters and the densities of total CD8<sup>+</sup> cell (HR 0.43, P = 0.011). At the transcriptional level, high expression of PDCD1 within the tumor was significantly associated with improved DFS (HR 0.38; P = 0.027). In line with these findings, high expression of IFNG (HR 0.38; P = 0.001) and IFN signaling genes (HR 0.46; p = 0.027) was also associated with favorable DFS. Inclusion of PD-1 immune infiltrates and PDCD1 gene expression added significant prognostic value for DFS (ΔLRχ<sup>2</sup> = 6.35; P = 0.041) and OS (ΔLRχ<sup>2</sup> = 9.53; P = 0.008), beyond that provided by classical clinicopathological variables. Thus, PD-1 mRNA and protein expression status represent a promising, independent indicator of prognosis in TNBC.
    126 schema:genre research_article
    127 schema:inLanguage en
    128 schema:isAccessibleForFree true
    129 schema:isPartOf N0c303954aeab4f81982c5a9ac5cd4a07
    130 Nbb5f6a8c4c0749e6ac0287f586f140d7
    131 sg:journal.1049249
    132 schema:name Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer
    133 schema:pagination 34
    134 schema:productId N023880eadf174fde834f1741adede6b5
    135 N05d727cd526b429ea989029d7b2b3223
    136 N154003af1c534cb78427d3def599d2ce
    137 N8526b16611ef467aa680bbb9d484c40b
    138 Nd4af0f8b4d0e47d586bad64d839a03c2
    139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111954631
    140 https://doi.org/10.1186/s40425-019-0499-y
    141 schema:sdDatePublished 2019-04-11T09:08
    142 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    143 schema:sdPublisher Ne73cc3ea02594a83b920aca800598901
    144 schema:url https://link.springer.com/10.1186%2Fs40425-019-0499-y
    145 sgo:license sg:explorer/license/
    146 sgo:sdDataset articles
    147 rdf:type schema:ScholarlyArticle
    148 N023880eadf174fde834f1741adede6b5 schema:name dimensions_id
    149 schema:value pub.1111954631
    150 rdf:type schema:PropertyValue
    151 N05d727cd526b429ea989029d7b2b3223 schema:name doi
    152 schema:value 10.1186/s40425-019-0499-y
    153 rdf:type schema:PropertyValue
    154 N068904e2ff524421af7e22ea472457ed rdf:first Nef0239593efe480886479e862efe9b22
    155 rdf:rest N78290e9398e240b998bc0039e35ff053
    156 N08cc84a4c656448c8f47b4b021103ed8 schema:affiliation https://www.grid.ac/institutes/grid.430276.4
    157 schema:familyName Chen
    158 schema:givenName Jinmiao
    159 rdf:type schema:Person
    160 N0c303954aeab4f81982c5a9ac5cd4a07 schema:issueNumber 1
    161 rdf:type schema:PublicationIssue
    162 N154003af1c534cb78427d3def599d2ce schema:name readcube_id
    163 schema:value f0aca6972b139eb2431ee8b8fc029036fb66d3ca61a774d30fdd672e81379bb0
    164 rdf:type schema:PropertyValue
    165 N178336a6abeb4272b543b749ced32f78 schema:affiliation https://www.grid.ac/institutes/grid.430276.4
    166 schema:familyName Newell
    167 schema:givenName Evan W.
    168 rdf:type schema:Person
    169 N1b87239f17164544ba4a1cf0c063bc96 rdf:first Ne9bd6e931ae5468aad26831b55ecbc61
    170 rdf:rest Ne952e1728bb04eb39a7e9c2e600a5d71
    171 N1e2ba98cab5f4587b4ee718dcaf1605a schema:affiliation https://www.grid.ac/institutes/grid.430276.4
    172 schema:familyName Yeong
    173 schema:givenName Joe
    174 rdf:type schema:Person
    175 N2554bcaaad6249a1ab555548b5a49074 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
    176 schema:familyName Ong
    177 schema:givenName Clara Chong Hui
    178 rdf:type schema:Person
    179 N31565202cff6433dac30417d496cf44a rdf:first Nedb6cfce9ff1443393f1372919d7267e
    180 rdf:rest Na92f13c8f0dc4ea2a0df2db13e3e760b
    181 N321569123dc445648e45dfe64f78be47 rdf:first Nbf95bab29a2f421785c917e97fb7e8c1
    182 rdf:rest N3fd0a8cb68aa4dea986d566ab1e4ac81
    183 N344928101c58405fb5c0684f3af27c5c rdf:first N444f75bbc848459ab4698b48b2caac28
    184 rdf:rest N9ddb2d1de82f4798976eba08801f8363
    185 N3fd0a8cb68aa4dea986d566ab1e4ac81 rdf:first N2554bcaaad6249a1ab555548b5a49074
    186 rdf:rest Na90eb01694dd4e3db7a006d4096f5449
    187 N41c8eb999f3b4757bbe5934d019ad97d schema:affiliation https://www.grid.ac/institutes/grid.430276.4
    188 schema:familyName Lee
    189 schema:givenName Bernett
    190 rdf:type schema:Person
    191 N444f75bbc848459ab4698b48b2caac28 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
    192 schema:familyName Liu
    193 schema:givenName Jin
    194 rdf:type schema:Person
    195 N5118f6d260c442969758193b8ca131af rdf:first N08cc84a4c656448c8f47b4b021103ed8
    196 rdf:rest N1b87239f17164544ba4a1cf0c063bc96
    197 N51e95e846b1b48ad89a6d369e9952229 rdf:first N178336a6abeb4272b543b749ced32f78
    198 rdf:rest N6544e8549b254af0a731eb0f2a52c426
    199 N650f4531375c41fd91462d576be5fdcf schema:affiliation https://www.grid.ac/institutes/grid.430276.4
    200 schema:familyName Yeap
    201 schema:givenName Wei Hseun
    202 rdf:type schema:Person
    203 N6544e8549b254af0a731eb0f2a52c426 rdf:first Nf9c12636dec3425c8d5165d6822d8995
    204 rdf:rest rdf:nil
    205 N78290e9398e240b998bc0039e35ff053 rdf:first Ned64c801f0cf4a0792e3f112e590331c
    206 rdf:rest N344928101c58405fb5c0684f3af27c5c
    207 N7c5621aa2c25443da97c01e7a041ae8c schema:affiliation https://www.grid.ac/institutes/grid.443531.4
    208 schema:familyName Yang
    209 schema:givenName Yi
    210 rdf:type schema:Person
    211 N8526b16611ef467aa680bbb9d484c40b schema:name nlm_unique_id
    212 schema:value 101620585
    213 rdf:type schema:PropertyValue
    214 N92d0f7a21c254968b0ae50e391d0fad8 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
    215 schema:familyName Thike
    216 schema:givenName Aye Aye
    217 rdf:type schema:Person
    218 N9657098f9dca4e9a9fb621f3358595ff rdf:first N650f4531375c41fd91462d576be5fdcf
    219 rdf:rest N9729ac7564dc40bd984f72cad7d850cd
    220 N9729ac7564dc40bd984f72cad7d850cd rdf:first N7c5621aa2c25443da97c01e7a041ae8c
    221 rdf:rest N068904e2ff524421af7e22ea472457ed
    222 N9a8a0b8ced4745bd98f7f999a7000d97 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
    223 schema:familyName Iqbal
    224 schema:givenName Jabed
    225 rdf:type schema:Person
    226 N9ddb2d1de82f4798976eba08801f8363 rdf:first Nea5f34afe3dc439bb995c387a8cd4597
    227 rdf:rest N5118f6d260c442969758193b8ca131af
    228 Na90eb01694dd4e3db7a006d4096f5449 rdf:first N92d0f7a21c254968b0ae50e391d0fad8
    229 rdf:rest N9657098f9dca4e9a9fb621f3358595ff
    230 Na92f13c8f0dc4ea2a0df2db13e3e760b rdf:first N41c8eb999f3b4757bbe5934d019ad97d
    231 rdf:rest N321569123dc445648e45dfe64f78be47
    232 Nbb5f6a8c4c0749e6ac0287f586f140d7 schema:volumeNumber 7
    233 rdf:type schema:PublicationVolume
    234 Nbf95bab29a2f421785c917e97fb7e8c1 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
    235 schema:familyName Li
    236 schema:givenName Huihua
    237 rdf:type schema:Person
    238 Nd4af0f8b4d0e47d586bad64d839a03c2 schema:name pubmed_id
    239 schema:value 30728081
    240 rdf:type schema:PropertyValue
    241 Nd710f06ad82944d3acbca0cc3c2e32b7 rdf:first N1e2ba98cab5f4587b4ee718dcaf1605a
    242 rdf:rest N31565202cff6433dac30417d496cf44a
    243 Nd86ca653a1434592a5eb20e726e9f60c schema:affiliation https://www.grid.ac/institutes/grid.410724.4
    244 schema:familyName Dent
    245 schema:givenName Rebecca
    246 rdf:type schema:Person
    247 Ndee694809d2a425e833e7e73a28f8704 rdf:first Nd86ca653a1434592a5eb20e726e9f60c
    248 rdf:rest N51e95e846b1b48ad89a6d369e9952229
    249 Ne73cc3ea02594a83b920aca800598901 schema:name Springer Nature - SN SciGraph project
    250 rdf:type schema:Organization
    251 Ne952e1728bb04eb39a7e9c2e600a5d71 rdf:first N9a8a0b8ced4745bd98f7f999a7000d97
    252 rdf:rest Ndee694809d2a425e833e7e73a28f8704
    253 Ne9bd6e931ae5468aad26831b55ecbc61 schema:affiliation https://www.grid.ac/institutes/grid.410724.4
    254 schema:familyName Lim
    255 schema:givenName Elaine Hsuen
    256 rdf:type schema:Person
    257 Nea5f34afe3dc439bb995c387a8cd4597 schema:affiliation https://www.grid.ac/institutes/grid.430276.4
    258 schema:familyName Wong
    259 schema:givenName Siew-Cheng
    260 rdf:type schema:Person
    261 Ned64c801f0cf4a0792e3f112e590331c schema:affiliation https://www.grid.ac/institutes/grid.163555.1
    262 schema:familyName Tay
    263 schema:givenName Timothy Kwang Yong
    264 rdf:type schema:Person
    265 Nedb6cfce9ff1443393f1372919d7267e schema:affiliation https://www.grid.ac/institutes/grid.163555.1
    266 schema:familyName Lim
    267 schema:givenName Jeffrey Chun Tatt
    268 rdf:type schema:Person
    269 Nef0239593efe480886479e862efe9b22 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    270 schema:familyName Lim
    271 schema:givenName Ansel Yi Herh
    272 rdf:type schema:Person
    273 Nf9c12636dec3425c8d5165d6822d8995 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
    274 schema:familyName Tan
    275 schema:givenName Puay Hoon
    276 rdf:type schema:Person
    277 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    278 schema:name Medical and Health Sciences
    279 rdf:type schema:DefinedTerm
    280 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    281 schema:name Immunology
    282 rdf:type schema:DefinedTerm
    283 sg:journal.1049249 schema:issn 2051-1426
    284 schema:name Journal for ImmunoTherapy of Cancer
    285 rdf:type schema:Periodical
    286 sg:pub.10.1007/s10549-016-3717-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1021839209
    287 https://doi.org/10.1007/s10549-016-3717-z
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s10549-016-3743-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013411374
    290 https://doi.org/10.1007/s10549-016-3743-x
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s10549-016-4095-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021178743
    293 https://doi.org/10.1007/s10549-016-4095-2
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s10549-018-4807-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103851740
    296 https://doi.org/10.1007/s10549-018-4807-x
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s11912-017-0627-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091143231
    299 https://doi.org/10.1007/s11912-017-0627-0
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/cddis.2015.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023955040
    302 https://doi.org/10.1038/cddis.2015.162
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/modpathol.2009.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026488299
    305 https://doi.org/10.1038/modpathol.2009.145
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/modpathol.2013.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049562019
    308 https://doi.org/10.1038/modpathol.2013.145
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/nature10933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457561
    311 https://doi.org/10.1038/nature10933
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
    314 https://doi.org/10.1038/nature11412
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nature22396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085425411
    317 https://doi.org/10.1038/nature22396
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nbt1385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053259870
    320 https://doi.org/10.1038/nbt1385
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/ncomms11479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050455938
    323 https://doi.org/10.1038/ncomms11479
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/ni1102-991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013709887
    326 https://doi.org/10.1038/ni1102-991
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nm.2795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050979495
    329 https://doi.org/10.1038/nm.2795
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nm.3902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018567687
    332 https://doi.org/10.1038/nm.3902
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/nrc3239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047946992
    335 https://doi.org/10.1038/nrc3239
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/nri3862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019011944
    338 https://doi.org/10.1038/nri3862
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/onc.2017.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090575369
    341 https://doi.org/10.1038/onc.2017.209
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/s41586-018-0130-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103975533
    344 https://doi.org/10.1038/s41586-018-0130-2
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/s41598-017-08479-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091144067
    347 https://doi.org/10.1038/s41598-017-08479-9
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/srep42929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084131191
    350 https://doi.org/10.1038/srep42929
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1186/bcr2234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035269256
    353 https://doi.org/10.1186/bcr2234
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1186/bcr3148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014237989
    356 https://doi.org/10.1186/bcr3148
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1186/gb-2013-14-4-r34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034169227
    359 https://doi.org/10.1186/gb-2013-14-4-r34
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1186/s12967-016-0925-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018850062
    362 https://doi.org/10.1186/s12967-016-0925-6
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1186/s13058-016-0695-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004125643
    365 https://doi.org/10.1186/s13058-016-0695-3
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1186/s13058-016-0783-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042514267
    368 https://doi.org/10.1186/s13058-016-0783-4
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1186/s40064-016-2513-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046340888
    371 https://doi.org/10.1186/s40064-016-2513-x
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1385/ir:32:1-3:231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015039980
    374 https://doi.org/10.1385/ir:32:1-3:231
    375 rdf:type schema:CreativeWork
    376 https://app.dimensions.ai/details/publication/pub.1081897289 schema:CreativeWork
    377 https://doi.org/10.1001/jama.2014.17322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018973821
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1002/cncr.25746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036042314
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1002/ijc.30552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046810495
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1002/jcp.10290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033302383
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1016/j.cell.2015.10.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043947020
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/j.coi.2014.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041557628
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/j.coi.2015.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023772516
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1016/j.humpath.2014.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030577661
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1016/j.humpath.2015.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040675165
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1016/j.pathol.2017.11.087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100913388
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1016/j.ymeth.2014.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002944887
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/s1359-6101(01)00038-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012007571
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1021/acschembio.5b00577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018476151
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1056/nejmoa1507643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000663586
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1056/nejmoa1603702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014027039
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1056/nejmoa1606774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037631694
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1056/nejmra1001389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025958385
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1080/2162402x.2015.1104448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012554752
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1080/2162402x.2016.1257452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043695252
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1080/2162402x.2017.1364828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091307941
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1084/jem.20142237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038520844
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1093/ajcp/aqw134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059380698
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1093/annonc/mdw217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052148972
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1093/jnci/djp090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023191704
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1097/cco.0b013e32835b651e schema:sameAs https://app.dimensions.ai/details/publication/pub.1038549508
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1097/cji.0b013e3181fad2b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023692192
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1097/pas.0000000000000780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083780777
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1111/his.12904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052864697
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1111/tbj.12753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019793378
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1126/science.1229620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015967817
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1126/scitranslmed.aad6352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013700027
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1128/jvi.00409-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038927474
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1136/gutjnl-2015-310814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019647047
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1136/jclinpath-2012-200734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029710694
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1136/jclinpath-2012-201428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047143747
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1136/jclinpath-2017-204495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090879742
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1146/annurev.immunol.22.012703.104803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007787378
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1158/0008-5472-can-04-3913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011326721
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1158/0008-5472.can-16-2684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092343393
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1158/0008-5472.can-16-3167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091691929
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1158/1078-0432.ccr-06-3045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048367977
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1158/1078-0432.ccr-15-1849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024765690
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1158/2159-8290.cd-13-0286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034201112
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1158/2326-6066.cir-13-0127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050783607
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1158/2326-6066.cir-14-0133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039800119
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1159/000453569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031972888
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1159/000464353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084233584
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1172/jci.insight.93652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090809969
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1172/jci65416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018481946
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1172/jci73639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046634997
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1172/jci80445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041643808
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1172/jci91190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086257148
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1177/1758834012475152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054045483
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1182/blood-2008-12-195792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031554317
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1200/jco.2006.05.9584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016311334
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1200/jco.2011.41.0902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021750149
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1200/jco.2013.50.9984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028197158
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1200/jco.2013.55.0491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023387220
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1200/jco.2014.58.1967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006980479
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1200/jco.2015.64.8931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204481
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1200/jco.2016.34.15_suppl.1009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106840881
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1200/jco.2017.35.15_suppl.1008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106845569
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1200/jco.2017.35.15_suppl.3062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106846296
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1200/jco.2017.35.15_suppl.556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106846836
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1200/jco.2017.35.15_suppl.e15609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106848319
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1371/journal.pone.0045831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015410342
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1371/journal.pone.0082870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045482066
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1371/journal.ppat.1004251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032936139
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1371/journal.ppat.1005177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018062329
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1593/neo.05733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013230338
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1593/tlo.13256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043778485
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.18632/oncotarget.12150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045368491
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.18632/oncotarget.14698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028622486
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.18632/oncotarget.15532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083919401
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.18632/oncotarget.5583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052440002
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.21037/cco.2018.04.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103718205
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.3389/fimmu.2017.00760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090275502
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.3389/fimmu.2018.01209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104292641
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.3390/ijms18020459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083860742
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.3816/cbc.2009.n.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006637826
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.4049/jimmunol.1002042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037027991
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.4049/jimmunol.1502635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079244591
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.4049/jimmunol.169.5.2756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075112145
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.5858/arpa.2013-0953-sa schema:sameAs https://app.dimensions.ai/details/publication/pub.1023063099
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.7150/jca.14549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027905230
    552 rdf:type schema:CreativeWork
    553 https://www.grid.ac/institutes/grid.163555.1 schema:alternateName Singapore General Hospital
    554 schema:name Division of Medicine, Singapore General Hospital, Singapore, Singapore
    555 Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore
    556 rdf:type schema:Organization
    557 https://www.grid.ac/institutes/grid.410724.4 schema:alternateName National Cancer Centre Singapore
    558 schema:name National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore, Singapore
    559 rdf:type schema:Organization
    560 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
    561 schema:name Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    562 rdf:type schema:Organization
    563 https://www.grid.ac/institutes/grid.428397.3 schema:alternateName Duke NUS Graduate Medical School
    564 schema:name Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore
    565 Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore
    566 Duke-NUS Medical School, Singapore, Singapore
    567 rdf:type schema:Organization
    568 https://www.grid.ac/institutes/grid.430276.4 schema:alternateName Singapore Immunology Network
    569 schema:name Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, 169856, Singapore, Singapore
    570 Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 8A, Biomedical Grove, Immunos, 138648, Singapore, Singapore
    571 rdf:type schema:Organization
    572 https://www.grid.ac/institutes/grid.443531.4 schema:alternateName Shanghai University of Finance and Economics
    573 schema:name Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore
    574 Shanghai University of Finance and Economics, Shanghai, China
    575 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...