TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Yuxue Jiang, Jintong Chen, Enguang Bi, Yinghua Zhao, Tianxue Qin, Yiming Wang, Alison Wang, Sujun Gao, Qing Yi, Siqing Wang

ABSTRACT

Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers. TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of Th9 cells and antitumor immunity. However, the role of TNF-α, the prototype of the TNF superfamily cytokines, in Th9 cell differentiation and their antitumor efficacy is not defined. Here, we showed that TNF-α potently promoted naïve CD4+ T cells to differentiate into Th9 cells in vitro. Furthermore, the addition of TNF-α during Th9 cell differentiation increased T cell survival and proliferation. More importantly, the adoptive transfer of TNF-α-treated Th9 cells induced more potent antitumor effects than regular Th9 cells in mouse tumor model. TNF-α signals via two cell surface receptors, TNFR1 and TNFR2. Mechanistic studies revealed that TNF-α drove Th9 cell differentiation through TNFR2 but not TNFR1. In addition, under Th9 polarizing condition, TNF-α activated STAT5 and NF-κB pathways in T cells in a TNFR2-dependent manner. Inhibition of STAT5 and NF-κB pathways by their specific inhibitors impaired TNF-α-induced Th9 cell differentiation. Our results identified TNF-α as a new powerful inducer of Th9 cells and clarified the molecular mechanisms underlying TNF-α-induced Th9 cell differentiation. More... »

PAGES

28

References to SciGraph publications

  • 2015-06. Regulation of tumour necrosis factor signalling: live or let die in NATURE REVIEWS IMMUNOLOGY
  • 2012-08. Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells in NATURE MEDICINE
  • 2012-10. OX40 signaling favors the induction of TH9 cells and airway inflammation in NATURE IMMUNOLOGY
  • 2008-12. Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset in NATURE IMMUNOLOGY
  • 2003-09. Signalling pathways of the TNF superfamily: a double-edged sword in NATURE REVIEWS IMMUNOLOGY
  • 2014-05. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells in NATURE IMMUNOLOGY
  • 2008-12. IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells in NATURE IMMUNOLOGY
  • 2010-06. TNF receptor 2 pathway: drug target for autoimmune diseases in NATURE REVIEWS DRUG DISCOVERY
  • 2012-04. Adoptive immunotherapy for cancer: harnessing the T cell response in NATURE REVIEWS IMMUNOLOGY
  • 2012-05. Fine-tuning of dendritic cell biology by the TNF superfamily in NATURE REVIEWS IMMUNOLOGY
  • 2014-06-29. The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells in NATURE IMMUNOLOGY
  • 2016-08-05. Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells in NATURE COMMUNICATIONS
  • 2015-09. Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells in NATURE MEDICINE
  • 2010-06. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation in NATURE IMMUNOLOGY
  • 2010-03. Regulation of IL-9 expression by IL-25 signaling in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40425-018-0494-8

    DOI

    http://dx.doi.org/10.1186/s40425-018-0494-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111916529

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30717817


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "First Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.430605.4", 
              "name": [
                "Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jiang", 
            "givenName": "Yuxue", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.430605.4", 
              "name": [
                "Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Jintong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Cancer Biology, Cleveland Clinic, Lerner Research Institute, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bi", 
            "givenName": "Enguang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.430605.4", 
              "name": [
                "Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Yinghua", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.430605.4", 
              "name": [
                "Department of Hematology, The First Hospital of Jilin University, 130061, Changchun, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qin", 
            "givenName": "Tianxue", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "China-Japan Friendship Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415954.8", 
              "name": [
                "Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Yiming", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.430605.4", 
              "name": [
                "Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Alison", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.430605.4", 
              "name": [
                "Department of Hematology, The First Hospital of Jilin University, 130061, Changchun, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gao", 
            "givenName": "Sujun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Houston Methodist", 
              "id": "https://www.grid.ac/institutes/grid.63368.38", 
              "name": [
                "Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China", 
                "Department of Cancer Biology, Cleveland Clinic, Lerner Research Institute, 44195, Cleveland, OH, USA", 
                "Center for Hematologic Malignancy, Research Institute Houston Methodist Hospital, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yi", 
            "givenName": "Qing", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.430605.4", 
              "name": [
                "Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Siqing", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1182/blood-2007-11-120998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000077375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-051116-052350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002008057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002637053", 
              "https://doi.org/10.1038/nri3193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005877769", 
              "https://doi.org/10.1038/ni.1677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.1.154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007248320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-030409-101212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011226569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.18.6934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012645763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00166-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012694336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013056074", 
              "https://doi.org/10.1038/nri3191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2010.08.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014140313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014512267", 
              "https://doi.org/10.1038/ni.2390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.5.2918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014630077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015102076", 
              "https://doi.org/10.1038/nm.2856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017352538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019012655", 
              "https://doi.org/10.1038/ni.1659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0064612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020303822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1301138111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021118213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021301372", 
              "https://doi.org/10.1038/ni.1867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021301372", 
              "https://doi.org/10.1038/ni.1867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2014.08.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021936560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci65459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024970949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025971962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.169.1.363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026126309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aaf8608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027762490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aaf8608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027762490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms12368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029827560", 
              "https://doi.org/10.1038/ncomms12368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030649255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2010.07.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031862964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.11.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032466890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smim.2014.02.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035482334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812530106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036898767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038103473", 
              "https://doi.org/10.1038/ni.2849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2011.01066.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038585825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039709735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0906988106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040078409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0898-6568(01)00262-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040293050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000289198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041229010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1200690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042896583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044145084", 
              "https://doi.org/10.1038/ni.1846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-11-4567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046622212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046646575", 
              "https://doi.org/10.1038/nrd3030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046646575", 
              "https://doi.org/10.1038/nrd3030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.11-4-397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047097590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0800251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050025318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050114386", 
              "https://doi.org/10.1038/nri3834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050354881", 
              "https://doi.org/10.1038/ni.2925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050400311", 
              "https://doi.org/10.1038/nm.3922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.037341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052856599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.2.1272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077671721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1401220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079058563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2017.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092188099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2018.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104505097"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers. TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of Th9 cells and antitumor immunity. However, the role of TNF-\u03b1, the prototype of the TNF superfamily cytokines, in Th9 cell differentiation and their antitumor efficacy is not defined. Here, we showed that TNF-\u03b1 potently promoted na\u00efve CD4+ T cells to differentiate into Th9 cells in vitro. Furthermore, the addition of TNF-\u03b1 during Th9 cell differentiation increased T cell survival and proliferation. More importantly, the adoptive transfer of TNF-\u03b1-treated Th9 cells induced more potent antitumor effects than regular Th9 cells in mouse tumor model. TNF-\u03b1 signals via two cell surface receptors, TNFR1 and TNFR2. Mechanistic studies revealed that TNF-\u03b1 drove Th9 cell differentiation through TNFR2 but not TNFR1. In addition, under Th9 polarizing condition, TNF-\u03b1 activated STAT5 and NF-\u03baB pathways in T cells in a TNFR2-dependent manner. Inhibition of STAT5 and NF-\u03baB pathways by their specific inhibitors impaired TNF-\u03b1-induced Th9 cell differentiation. Our results identified TNF-\u03b1 as a new powerful inducer of Th9 cells and clarified the molecular mechanisms underlying TNF-\u03b1-induced Th9 cell differentiation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s40425-018-0494-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1049249", 
            "issn": [
              "2051-1426"
            ], 
            "name": "Journal for ImmunoTherapy of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "TNF-\u03b1 enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways", 
        "pagination": "28", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c8ae6c404ec304fc4f36009e924cbb1aedfc3d7ed9d099279adfded9afd0927b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30717817"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101620585"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s40425-018-0494-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111916529"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s40425-018-0494-8", 
          "https://app.dimensions.ai/details/publication/pub.1111916529"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000329_0000000329/records_74692_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs40425-018-0494-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0494-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0494-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0494-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0494-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    298 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s40425-018-0494-8 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N79abbb7f3c324b2493abf05555ef5aca
    4 schema:citation sg:pub.10.1038/ncomms12368
    5 sg:pub.10.1038/ni.1659
    6 sg:pub.10.1038/ni.1677
    7 sg:pub.10.1038/ni.1846
    8 sg:pub.10.1038/ni.1867
    9 sg:pub.10.1038/ni.2390
    10 sg:pub.10.1038/ni.2849
    11 sg:pub.10.1038/ni.2925
    12 sg:pub.10.1038/nm.2856
    13 sg:pub.10.1038/nm.3922
    14 sg:pub.10.1038/nrd3030
    15 sg:pub.10.1038/nri1184
    16 sg:pub.10.1038/nri3191
    17 sg:pub.10.1038/nri3193
    18 sg:pub.10.1038/nri3834
    19 https://doi.org/10.1016/j.ccell.2018.05.004
    20 https://doi.org/10.1016/j.cellsig.2010.08.016
    21 https://doi.org/10.1016/j.cellsig.2014.08.011
    22 https://doi.org/10.1016/j.immuni.2008.11.014
    23 https://doi.org/10.1016/j.immuni.2009.10.011
    24 https://doi.org/10.1016/j.immuni.2010.07.014
    25 https://doi.org/10.1016/j.immuni.2011.09.019
    26 https://doi.org/10.1016/j.immuni.2013.01.007
    27 https://doi.org/10.1016/j.molmed.2017.09.007
    28 https://doi.org/10.1016/j.smim.2014.02.005
    29 https://doi.org/10.1016/s0092-8674(04)00166-7
    30 https://doi.org/10.1016/s0898-6568(01)00262-5
    31 https://doi.org/10.1056/nejmoa0800251
    32 https://doi.org/10.1056/nejmoa1200690
    33 https://doi.org/10.1073/pnas.0812530106
    34 https://doi.org/10.1073/pnas.0906988106
    35 https://doi.org/10.1073/pnas.1301138111
    36 https://doi.org/10.1073/pnas.85.18.6934
    37 https://doi.org/10.1074/jbc.m109.037341
    38 https://doi.org/10.1084/jem.169.1.363
    39 https://doi.org/10.1111/j.1600-065x.2011.01066.x
    40 https://doi.org/10.1126/scisignal.aaf8608
    41 https://doi.org/10.1146/annurev-immunol-030409-101212
    42 https://doi.org/10.1146/annurev-immunol-051116-052350
    43 https://doi.org/10.1158/1078-0432.ccr-11-0503
    44 https://doi.org/10.1159/000289198
    45 https://doi.org/10.1172/jci65459
    46 https://doi.org/10.1182/blood-2005-11-4567
    47 https://doi.org/10.1182/blood-2007-11-120998
    48 https://doi.org/10.1371/journal.pone.0064612
    49 https://doi.org/10.1634/theoncologist.11-4-397
    50 https://doi.org/10.4049/jimmunol.1401220
    51 https://doi.org/10.4049/jimmunol.173.5.2918
    52 https://doi.org/10.4049/jimmunol.179.1.154
    53 https://doi.org/10.4049/jimmunol.181.2.1272
    54 schema:datePublished 2019-12
    55 schema:datePublishedReg 2019-12-01
    56 schema:description Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers. TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of Th9 cells and antitumor immunity. However, the role of TNF-α, the prototype of the TNF superfamily cytokines, in Th9 cell differentiation and their antitumor efficacy is not defined. Here, we showed that TNF-α potently promoted naïve CD4<sup>+</sup> T cells to differentiate into Th9 cells in vitro. Furthermore, the addition of TNF-α during Th9 cell differentiation increased T cell survival and proliferation. More importantly, the adoptive transfer of TNF-α-treated Th9 cells induced more potent antitumor effects than regular Th9 cells in mouse tumor model. TNF-α signals via two cell surface receptors, TNFR1 and TNFR2. Mechanistic studies revealed that TNF-α drove Th9 cell differentiation through TNFR2 but not TNFR1. In addition, under Th9 polarizing condition, TNF-α activated STAT5 and NF-κB pathways in T cells in a TNFR2-dependent manner. Inhibition of STAT5 and NF-κB pathways by their specific inhibitors impaired TNF-α-induced Th9 cell differentiation. Our results identified TNF-α as a new powerful inducer of Th9 cells and clarified the molecular mechanisms underlying TNF-α-induced Th9 cell differentiation.
    57 schema:genre research_article
    58 schema:inLanguage en
    59 schema:isAccessibleForFree true
    60 schema:isPartOf N23e50ab285654eaba592f00b3da44e53
    61 N7be3978b42fe4c9fb1b77bf0d8280ebe
    62 sg:journal.1049249
    63 schema:name TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways
    64 schema:pagination 28
    65 schema:productId N0ed0c6b4ec7b484d9c2d955187a862b2
    66 N19410369e7134ee2b3ed2526824f57c4
    67 Nb917579c65184c9196af18003aa5d3fa
    68 Nf76a2b0694b245869521ede343bf6037
    69 Nf921ce8412634e86b9b53e4edf3a1445
    70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111916529
    71 https://doi.org/10.1186/s40425-018-0494-8
    72 schema:sdDatePublished 2019-04-11T09:01
    73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    74 schema:sdPublisher N5af0e3c2933c4cc5801cded796e5de02
    75 schema:url https://link.springer.com/10.1186%2Fs40425-018-0494-8
    76 sgo:license sg:explorer/license/
    77 sgo:sdDataset articles
    78 rdf:type schema:ScholarlyArticle
    79 N01d8d45d2fca453983180d16af75b695 schema:affiliation https://www.grid.ac/institutes/grid.430605.4
    80 schema:familyName Qin
    81 schema:givenName Tianxue
    82 rdf:type schema:Person
    83 N08bc4188be08442bb5373f1d0c5e60fb schema:affiliation https://www.grid.ac/institutes/grid.430605.4
    84 schema:familyName Wang
    85 schema:givenName Siqing
    86 rdf:type schema:Person
    87 N0e9302e470aa47e7a875957a786f09a3 schema:affiliation https://www.grid.ac/institutes/grid.63368.38
    88 schema:familyName Yi
    89 schema:givenName Qing
    90 rdf:type schema:Person
    91 N0ed0c6b4ec7b484d9c2d955187a862b2 schema:name dimensions_id
    92 schema:value pub.1111916529
    93 rdf:type schema:PropertyValue
    94 N19410369e7134ee2b3ed2526824f57c4 schema:name nlm_unique_id
    95 schema:value 101620585
    96 rdf:type schema:PropertyValue
    97 N1a91dd83e0f643d08676386c39b55607 rdf:first Na7267bdc532d4d4a9ce94704f803752a
    98 rdf:rest Nd5747c9e948643cea2b0f70932efe86b
    99 N1f477c210a384ef881cf587e5fb12d19 schema:affiliation https://www.grid.ac/institutes/grid.430605.4
    100 schema:familyName Wang
    101 schema:givenName Alison
    102 rdf:type schema:Person
    103 N23e50ab285654eaba592f00b3da44e53 schema:issueNumber 1
    104 rdf:type schema:PublicationIssue
    105 N2d6c9235eb6542239db0842336b8363e schema:affiliation https://www.grid.ac/institutes/grid.430605.4
    106 schema:familyName Gao
    107 schema:givenName Sujun
    108 rdf:type schema:Person
    109 N3e68e792cfd44258b35cae2cb3b9af28 rdf:first N2d6c9235eb6542239db0842336b8363e
    110 rdf:rest N7316dbe767334c3587c6753a91ef15cb
    111 N51a37871a6fa40298b555a537fbb5109 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    112 schema:familyName Bi
    113 schema:givenName Enguang
    114 rdf:type schema:Person
    115 N5af0e3c2933c4cc5801cded796e5de02 schema:name Springer Nature - SN SciGraph project
    116 rdf:type schema:Organization
    117 N7316dbe767334c3587c6753a91ef15cb rdf:first N0e9302e470aa47e7a875957a786f09a3
    118 rdf:rest N7831946bcab447bc8238bdafb65c45cb
    119 N7831946bcab447bc8238bdafb65c45cb rdf:first N08bc4188be08442bb5373f1d0c5e60fb
    120 rdf:rest rdf:nil
    121 N79abbb7f3c324b2493abf05555ef5aca rdf:first N7de5cfbc84764f91a89bb86842e6420a
    122 rdf:rest Ne5d3512e74214411b29e552697b71048
    123 N7be3978b42fe4c9fb1b77bf0d8280ebe schema:volumeNumber 7
    124 rdf:type schema:PublicationVolume
    125 N7de5cfbc84764f91a89bb86842e6420a schema:affiliation https://www.grid.ac/institutes/grid.430605.4
    126 schema:familyName Jiang
    127 schema:givenName Yuxue
    128 rdf:type schema:Person
    129 N84319f4cae2e4ba6981c872e873491ca rdf:first N1f477c210a384ef881cf587e5fb12d19
    130 rdf:rest N3e68e792cfd44258b35cae2cb3b9af28
    131 N8b56c02e9aa34b9891814bd2604e050d rdf:first N51a37871a6fa40298b555a537fbb5109
    132 rdf:rest N1a91dd83e0f643d08676386c39b55607
    133 Na7267bdc532d4d4a9ce94704f803752a schema:affiliation https://www.grid.ac/institutes/grid.430605.4
    134 schema:familyName Zhao
    135 schema:givenName Yinghua
    136 rdf:type schema:Person
    137 Nb917579c65184c9196af18003aa5d3fa schema:name readcube_id
    138 schema:value c8ae6c404ec304fc4f36009e924cbb1aedfc3d7ed9d099279adfded9afd0927b
    139 rdf:type schema:PropertyValue
    140 Ncdee18bc272d4453a26046e25da8c7a3 rdf:first Ne702317705fa44329ef63167897ab0ed
    141 rdf:rest N84319f4cae2e4ba6981c872e873491ca
    142 Nd5747c9e948643cea2b0f70932efe86b rdf:first N01d8d45d2fca453983180d16af75b695
    143 rdf:rest Ncdee18bc272d4453a26046e25da8c7a3
    144 Ne3c1dadb276444e6ae366285e41ab235 schema:affiliation https://www.grid.ac/institutes/grid.430605.4
    145 schema:familyName Chen
    146 schema:givenName Jintong
    147 rdf:type schema:Person
    148 Ne5d3512e74214411b29e552697b71048 rdf:first Ne3c1dadb276444e6ae366285e41ab235
    149 rdf:rest N8b56c02e9aa34b9891814bd2604e050d
    150 Ne702317705fa44329ef63167897ab0ed schema:affiliation https://www.grid.ac/institutes/grid.415954.8
    151 schema:familyName Wang
    152 schema:givenName Yiming
    153 rdf:type schema:Person
    154 Nf76a2b0694b245869521ede343bf6037 schema:name doi
    155 schema:value 10.1186/s40425-018-0494-8
    156 rdf:type schema:PropertyValue
    157 Nf921ce8412634e86b9b53e4edf3a1445 schema:name pubmed_id
    158 schema:value 30717817
    159 rdf:type schema:PropertyValue
    160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    161 schema:name Biological Sciences
    162 rdf:type schema:DefinedTerm
    163 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Biochemistry and Cell Biology
    165 rdf:type schema:DefinedTerm
    166 sg:journal.1049249 schema:issn 2051-1426
    167 schema:name Journal for ImmunoTherapy of Cancer
    168 rdf:type schema:Periodical
    169 sg:pub.10.1038/ncomms12368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029827560
    170 https://doi.org/10.1038/ncomms12368
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/ni.1659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019012655
    173 https://doi.org/10.1038/ni.1659
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/ni.1677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005877769
    176 https://doi.org/10.1038/ni.1677
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/ni.1846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044145084
    179 https://doi.org/10.1038/ni.1846
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/ni.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021301372
    182 https://doi.org/10.1038/ni.1867
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/ni.2390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014512267
    185 https://doi.org/10.1038/ni.2390
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/ni.2849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038103473
    188 https://doi.org/10.1038/ni.2849
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/ni.2925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050354881
    191 https://doi.org/10.1038/ni.2925
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nm.2856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015102076
    194 https://doi.org/10.1038/nm.2856
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nm.3922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050400311
    197 https://doi.org/10.1038/nm.3922
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nrd3030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046646575
    200 https://doi.org/10.1038/nrd3030
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nri1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037702320
    203 https://doi.org/10.1038/nri1184
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nri3191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013056074
    206 https://doi.org/10.1038/nri3191
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nri3193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002637053
    209 https://doi.org/10.1038/nri3193
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nri3834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050114386
    212 https://doi.org/10.1038/nri3834
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.ccell.2018.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104505097
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/j.cellsig.2010.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014140313
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.cellsig.2014.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021936560
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/j.immuni.2008.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032466890
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/j.immuni.2009.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030649255
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/j.immuni.2010.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031862964
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/j.immuni.2011.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039709735
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/j.immuni.2013.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017352538
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/j.molmed.2017.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092188099
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/j.smim.2014.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035482334
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/s0092-8674(04)00166-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012694336
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/s0898-6568(01)00262-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040293050
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1056/nejmoa0800251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050025318
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1056/nejmoa1200690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042896583
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1073/pnas.0812530106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036898767
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1073/pnas.0906988106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040078409
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1073/pnas.1301138111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021118213
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1073/pnas.85.18.6934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012645763
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1074/jbc.m109.037341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052856599
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1084/jem.169.1.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026126309
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1111/j.1600-065x.2011.01066.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038585825
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1126/scisignal.aaf8608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027762490
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1146/annurev-immunol-030409-101212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011226569
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1146/annurev-immunol-051116-052350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002008057
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1158/1078-0432.ccr-11-0503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025971962
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1159/000289198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041229010
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1172/jci65459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024970949
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1182/blood-2005-11-4567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046622212
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1182/blood-2007-11-120998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000077375
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1371/journal.pone.0064612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020303822
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1634/theoncologist.11-4-397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047097590
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.4049/jimmunol.1401220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079058563
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.4049/jimmunol.173.5.2918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014630077
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.4049/jimmunol.179.1.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007248320
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.4049/jimmunol.181.2.1272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077671721
    283 rdf:type schema:CreativeWork
    284 https://www.grid.ac/institutes/grid.239578.2 schema:alternateName Cleveland Clinic
    285 schema:name Department of Cancer Biology, Cleveland Clinic, Lerner Research Institute, 44195, Cleveland, OH, USA
    286 rdf:type schema:Organization
    287 https://www.grid.ac/institutes/grid.415954.8 schema:alternateName China-Japan Friendship Hospital
    288 schema:name Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China
    289 rdf:type schema:Organization
    290 https://www.grid.ac/institutes/grid.430605.4 schema:alternateName First Hospital of Jilin University
    291 schema:name Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China
    292 Department of Hematology, The First Hospital of Jilin University, 130061, Changchun, China
    293 rdf:type schema:Organization
    294 https://www.grid.ac/institutes/grid.63368.38 schema:alternateName Houston Methodist
    295 schema:name Center for Hematologic Malignancy, Research Institute Houston Methodist Hospital, 77030, Houston, TX, USA
    296 Department of Cancer Biology, Cleveland Clinic, Lerner Research Institute, 44195, Cleveland, OH, USA
    297 Department of Cancer Immunology, The First Hospital of Jilin University, 519 Dongminzhu St, ChangChun, Jilin, China
    298 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...